Phenolic screening by HPLC–DAD–ESI/MSn and antioxidant capacity of leaves, flowers and berries of Rubus grandifolius Lowe

In Madeira Island (Macaronesia Island), Rubus grandifolius Lowe berries, locally known by amoras, are widely consumed fresh or processed as jam, juice or liquor. Folk medicine describes R. grandifolius Lowe fruits and leaves being used to treat diabetes, as depurative, diuretic and to relieve sore throat. The aim of this study was to investigate phenolic composition and antioxidant capacity of the different edible parts of the plant (berries, leaves and flowers). HPLC–DAD–ESI/MSn was used to establish the phe nolic profile. Phenolic monomers such as flavonol O-glycosilated (quercetin and kaempferol), quinic acid and caffeic acid conjugates were characterized using the electrospray source in the negative mode; while positive mode was employed to detect glycosylated anthocyanins (cyanidin, delphinin and petunidin). The berries presented a higher radical scavenger capacity (DPPH and ABTS assays) and reducing prop erties (FRAP) than the leaves and the flowers. Ethanolic extracts showed highest antioxidant capacity when compared with water based extracts: DPPH values of 147.9 ± 0.7 mol eq Trolox/g DM; ABTS value of 255.8 ± 1.9 mol eq Trolox/g DM and FRAP value 9455 ± 29 mmol Fe(II)/mgDM).Mrs. Conceic¸ ão Pires is recognized for excellent assistance in sample collection.info:eu-repo/semantics/publishedVersio

Sistema para prestador de serviços de confiança eIDAS

A Global Trusted Sign é uma entidade certificadora que comercializa serviços de confiança, nomeadamente selos temporais, certificados de assinatura eletrónica e selos eletrónicos que podem ser tanto qualificados como avançados, e ainda certificados de autenticação de websites(TLS/SSL). É proposto o desenvolvimento do backend do portal para a major v3.0.0, utilizando a framework Laravel na construção de uma Application Programming Interface (API) que inclua todos os seguintes requisitos: o registo de novos utilizadores, autenticação OAuth 2.0, aquisição de produtos e serviços por um sistema de carrinho de compras, integração com sistemas para geração de pagamentos e fatura, gestão dos produtos comprados e a aplicação dos certificados digitais em documentos. Como linguagem de consulta de dados à API, foi utilizado o GraphQL, possibilitando o frontend a solicitar apenas os dados necessários numa única chamada à API. Neste relatório irá ser abordado o processo de desenvolvimento seguido um método formal de Engenharia de Software, desde a arquitetura do sistema, a análise dosrequisitos, a modelação da base de dados, até à implementação final. Este projeto visa implementar testes unitários oferecendo confiança do correto funcionamento em cada lançamento, com uma single-page application realizado pelo frontend, com um layout elegante e moderno face à plataforma online atual. Nesse sentido, o objetivo deste projeto de mestrado consiste em melhorar a rapidez nos pedidos, clareza no código concebido de backend e aumentar o número de vendas da plataforma.Global Trusted Sign is a certifying entity that sells trusted services, namely timestamps, digital signature certificates, electronic stamps, website authentication (TLS/SSL), certificates that can be qualified as well as advanced. The proposal entails developing the backend of the portal for the major version v3.0.0, using the Laravel framework to build an Application Programming Interface (API), therefore includes all the following requirements: the registration of new users, OAuth 2.0 authentication, purchase of products and services through a shopping cart system, integration with systems for generating payments and invoices, management of the purchased products, and applying digital certificates to documents. The API utilizes GraphQL as the data query language, allowing the frontend to request only the necessary data in a single API call. This document addresses the development process followed by a formal method of Software Engineering, from system architecture, requirements analysis, database modeling, to the implementation. This project also aims at the implementation of unit tests, offering confidence in the correct functioning in each release, with a single page application conducted by the frontend, with an elegant and modern layout compared to the current online platform. In this context, the objective of this master's project is to improve the of speed in requests, clarity in the backend code and increase the number of platform sales

Serum levels of oxylipins in achilles tendinopathy: An exploratory study

Background: Linoleic acid-derived oxidation products are found in experimental pain models. However, little is known about the levels of such oxylipins in human pain. In consequence, in the present study, we have undertaken a lipidomic profiling of oxylipins in blood serum from patients with Achilles tendinopathy and controls. Methodology/Principal findings: A total of 34 oxylipins were analysed in the serum samples. At a significance level of P<0.00147 (<0.05/34), two linoleic acid-derived oxylipins, 13-hydroxy-10E,12Z-octadecadienoic (13-HODE) and 12(13)-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) were present at significantly higher levels in the Achilles tendinopathy samples. This difference remained significant when the dataset was controlled for age, gender and body-mass index. In contrast, 0/21 of the arachidonic acid- and 0/4 of the dihomo-γ-linolenic acid, eicosapentaenoic acid or docosahenaenoic acid-derived oxylipins were higher in the patient samples at this level of significance. The area under the Receiver-Operator Characteristic (ROC) curve for 12,13-DiHOME was 0.91 (P<0.0001). Levels of four N-acylethanolamines were also analysed and found not to be significantly different between the controls and the patients at the level of P<0.0125 (<0.05/4). Conclusions/Significance: It is concluded from this exploratory study that abnormal levels of linoleic acid-derived oxylipins are seen in blood serum from patients with Achilles tendinopathy. Given the ability of two of these, 9- and 13-HODE to activate transient receptor potential vanilloid 1, it is possible that these changes may contribute to the symptoms seen in Achilles tendinopathy

Cinesiterapia en Rehabilitación gerontológica: análisis de la literatura

Perante o envelhecimento populacional e a decorrente demanda para os cuidados de saúde, do ponto de vista da Enfermagem de Reabilitação importa responder às determinantes do envelhecimento que afetam a mobilidade, com estratégias fundamentadas nos resultados da investigação mais atual. A cinesioterapia constitui um recurso do enfermeiro especialista em reabilitação, todavia são escassos os trabalhos sobre a sua fundamentação e aplicabilidade em reabilitação gerontológica. Este artigo teórico teve por objetivos: (1) descrever as relações entre a postura, a marcha e a capacidade funcional dos idosos e a cinesioterapia, e (2) identificar referências à intervenção do enfermeiro especialista em reabilitação neste domínio. Foi realizada uma revisão de literatura através de uma pesquisa bibliográfica nas revistas de saúde incluídas na base de dados eletrónica EBSCO HOST, publicadas entre 1995 e 2010. A análise dos resultados foi qualitativa, tendo-se identificado 168 artigos, dos quais 11 atenderam aos critérios de inclusão. Os estudos analisados apresentaram resultados complementares, descrevendo associações entre técnicas cinesioterápicas e benefícios na postura, marcha e capacidade funcional do idoso. Não foram encontradas referências à intervenção do enfermeiro em reabilitação. Pesquisas são necessárias para descrever o papel da cinesioterapia em reabilitação gerontológica e documentar a intervenção do enfermeiro especialista em reabilitação

Приватизация государственной собственности в агропромышленном комплексе Республике Беларусь

Материалы межвуз. науч. конф. студентов, магистрантов и аспирантов, Гомель, 15 мая 2008 г

Gravidez e tabagismo : uma oportunidade para mudar comportamentos

Introduction: Maternal smoking during pregnancy is related not only to perinatal adverse events but also to important postnatal problems. Smoking is very prevalent in women with several socio-demographic factors playing an important role. Aims: To assess the frequency of smoking as well as mothers’ change in behaviours during pregnancy. To identify socio-demographic factors associated to smoking and to assess women’s knowledge and sources of information about adverse effects of smoking during pregnancy.Methods: We started a cohort study between March and October 2003 at the Maternity, Hospital Santa Maria. After an informed consent the mothers in the post natal ward were asked to fill in a questionnaire. Results: Four hundred and seventy five mothers responded to the questionnaire and among them 30% were smokers before pregnancy. Thirty five percent stopped smoking during pregnancy and those who continued significantly reduced the number of cigarrettes per day. Smoking was less prevalent in married women, with higher educational level and with stable employment (statistically significant correlations). Forty five percent of the mothers were misinformed or had no information about the adverse effects of smoking during pregnancy. Their main source of information were the media. Discussion: Smoking prevalence was high (30%) among the respondents but the pregnancy lowered the numbers of cigarrettes per day. The percentage of misinformed mothers concerned about the adverse effects of smoking during pregnancy was high (45%), which also showed that doctors’ role as a source of information was surpassed by the media. The study also brought to light the need for the health professionals to improve their competences in their role on prevention of smoking during pregnancy and the postnatal period

ENGAGEMENT E AMBIENTE DE PRÁTICA DE ENFERMAGEM DOS ENFERMEIROS DE REABILITAÇÃO DA REGIÃO AUTÓNOMA DA MADEIRA

A investigação científica tem manifestado um grande interesse pelo engagement no trabalho dos enfermeiros, procurando determinar os seus níveis de expressão e os fatores que contribuem para a sua manifestação. Por ser um tema de incontornável relevância para as organizações de saúde, objetivamos: I) conhecer os níveis de engagement dos Enfermeiros Especialistas em Enfermagem de Reabilitação (EEER); II) descrever a sua perceção relativamente à favorabilidade do ambiente de prática de enfermagem (APE) e III) analisar a relação entre as características do APE e o engagement. À uma amostra de 113 EEER foram aplicadas as escalas Utrecht Work Engagement Scale (UWES) e Practice Environment Scale of the Nursing Work Index (PES-NWI). Os resultados revelaram níveis moderados a elevados de vigor, absorção e dedicação que variaram significativamente em função da idade e do tempo de profissão. O ambiente de prática de enfermagem foi percecionado como misto, com três dimensões avaliadas favoravelmente e duas avaliadas desfavoravelmente. Foram encontradas correlações significativas entre o APE e o engagement. O estudo reforça a importância de assegurar ambientes favoráveis à prestação de cuidados de enfermagem e, com isso, contribuir para o reforçar do vínculo à profissão e elevar os níveis de dedicação, foco e energia no trabalho

Individual wellness according to college students

Aims:This study aims to identify the values of the dimension Individual Well-being, defended by the students of the University of Madeira (Uma), Portugal and the University of Fortaleza (UNIFOR), Brazil. Methods: this is a representative sample of University students (n = 605) 225 of the University of Madeira (UMa) and 380 of the University of Fortaleza (UNIFOR). The data were collected in the year 2017 in all centres of universities. As inclusion criteria 18-24 years’students the students of 18-24 years attending graduate courses. We used the structured questionnaire on values (adapted from the European Values Survey), composed of 30 questions, grouped by 6 dimensions: Individual well-being; Interpersonal Relationships; Participation and Social intervention; Ethics and Sense of life; Family and socio-political values. Ethical issues and ethical rules were respected. This article focuses only one-dimension well-being encompassing issues of personal satisfaction, physical/psychological well-being and conception of success in life. Results: the majority are female (65.3% UMa and 74.2% UNIFOR) and single (96.0% UMa and 96.3% UNIFOR). With regard to the Individual well-being much of the population refers to feelings of instability (53.8% UMa and 53.2% UNIFOR) and anxiety (36.1% UMa and 41.6% UNIFOR). As for the personal satisfaction a significant percentage of students are not satisfied with your luck (UMa 48.8% and 38.4% UNIFOR), health (UMa 47.6% and UNIFOR 23.4%), work (42.6% UMa and 42.4% UNIFOR) and your social position (UMa 37.4% and UNIFOR 24.8%), being the most valued satisfaction aspects the family (UMa 92.4% and 93.4% UNIFOR), health (Uma 92% and UNIFOR 76.6%) and have a good job (UMa 91.6% and UNIFOR 96.8%). In contrast, the less valuable is to have influence and power (UMa 52.5% and UNIFOR 57.9%). The majority considers to be people with success in life (UMA57.8% and UNIFOR 85.8%), on the understanding that the success in life is to have a happy family (Uma 72.4%) and to be a good person (57.8% UMa). Conclusions: this study is intended as a contribution to further research in this field, because the knowledge of the Individual well-being of college students provides the establishment of programs directed to mental health, with interventions of prevention and promotion of health that are aimed at improving the quality of life and well-being.info:eu-repo/semantics/publishedVersio

Classificação Internacional de funcionalidade, incapacidade e saúde para Acidente Vascular Cerebral

Background: Stroke is a cardiovascular disease with the highest prevalence worldwide, with impact on the functionality of survivors. Objective: To identify the Score Set of the International Classification of Functioning, Disability and Health (ICF) for people after stroke. Material and Methods: The research question was performed according to the Joanna Briges Institute (JBI) recommendations and PICo framework (Population, Interest phenomenon, Context). Each dimension of the PICo contributed to the definition of inclusion criteria, namely Population (P) Person after stroke; Interest phenomenon (I) Score set ICF; Context (Co) Community. The electronic research was done in the Medline, SciELO, virtual health library and EBSCO databases, between 2013 and 2017 Results: Of the identified articles 11 were selected and 160 ICF codes were identified, which characterize the functionality of people after stroke. Of these 160 codes, it was verified that 21, divided by 3 ICF categories, presented a frequency greater than or equal to 50%. Conclusions: The ICF score set for people after stroke is distributed as follows: 6 Body Functions (29%), 13 Activity and Participation (61%) and 2 Environmental Factors (10%).Contexto: el Accidente Vascular Cerebral (AVC) es una enfermedad cardiovascular con mayor prevalencia a nivel mundial, con impacto en la funcionalidad de las personas sobrevivientes. Objetivo: identificar el Score Set de la Clasificación Internacional de Funcionalidad, Incapacidad y Salud (CIF) para personas después del AVC. Material y Métodos: la pregunta de investigación, fue elaborada según las recomendaciones del Joanna Briges Institute (JBI) a partir de la estrategia PICo (Population, Interés, Context). Cada dimensión del PICo contribuyó a la definición de criterios de inclusión, en particular Population (P) Persona después de AVC; (I) Score set CIF; Context (Co) Comunidad. La pesquisa electrónica se realizó en las bases de datos Medline, SciELO, Biblioteca Virtual em Saúde y EBSCO, de publicaciones entre 2013 a 2017. Resultados: De los artículos identificados,han sido seleccionados 11 artículos donde fueron identificados 160 códigos de la CIF, que caracterizan la funcionalidad de las personas después del AVC. De estos 160 códigos, se verificó que 21 están divididos por 3 categorías CIF, presentan una frecuencia mayor o igual al 50%.. Conclusiones: El score set de la CIF para personas después de AVC está distribuido de la siguiente forma: 6 códigos de las Funciones del Cuerpo (29%), 13 códigos de las Actividades y Participación (61%) y 2 códigos de los Factores Ambientales (10%).Contexto: O Acidente Vascular Cerebral (AVC) é uma das doenças com maior prevalência a nível mundial, com impacto na funcionalidade das pessoas sobreviventes. Objetivo: identificar o Score Set da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF) para pessoas após AVC. Material e Métodos: A pergunta de investigação, foi elaborada segundo as recomendações do Joanna Briges Institute (JBI) a partir da estratégia PICo (Population, Interest phenomenon, Context). Cada dimensão do PICo contribuiu para a definição de critérios de inclusão, nomeadamente Population (P) Pessoa após AVC; Interest phenomenon (I) Score set CIF; Context (Co) Comunidade. A pesquisa eletrónica foi feita nas bases de dados Medline, SciELO, biblioteca virtual em saúde e EBSCO, de publicações entre 2013 a 2017. Resultados: Dos artigos identificados, foram selecionados 11, tendo sido identificados 160 códigos da CIF, que caraterizam a funcionalidade das pessoas após AVC. Destes 160 códigos, verificou-se que 21, divididos por 3 categorias CIF, apresentam uma frequência maior ou igual a 50%. Conclusões: O score set da CIF para pessoas após AVC está distribuído da seguinte forma: 6 códigos das Funções do Corpo (29%), 13 códigos das Atividades e Participação (61%) e 2 códigos dos Fatores Ambientais (10%)