Newspaper Ownership and the Weekly Editorial in Illinois

The independently owned newspaper is fast disappearing in the United States. ~1uch like other American businesses, American newspapers have become an industry dominated by huge corporations. Ownership of newspapers in the United States is becoming more concentrated because of newspaper groups, also known as newspaper chains. A group can be defined as ownership and publication of several different newspapers in more than one location. During the twentieth century, groups have become the dominant form of ownership in the American newspaper industry. They control almost three-fourths of total daily newspaper circulation in the United States. And groups are estimated to own as much as one-third of all weekly newspapers published in the nation. The study compares editorials printed in independent and group owned weeklies. Newspaper observers are concerned about the growth of newspaper groups. Observers are especially concerned about the potential threat groups pose to the editorial freedom and local autonomy of · the newspapers the groups have acquired. Some critics, including Ben H. Bagdikian, United States Senator Larry Pressler of South Dakota, Congressman Morris Udall of Arizona and the late Supreme Court Justice William 0. Douglas, believe freedom of the press is endangered when newspaper ownership is concentrated among fewer owners. The effect of ownership on the editorial content of weekly newspapers also deserves study for historical reasons. Newspapers are the only business mentioned in the Bill of Rights. Press time, the journal of the American Newspaper Publishers Association, said newspapers were mentioned because of the important role they play in providing crucial information needed by a free society to make effective decisions. Economics Professor Bruce M. Owen said he believes newspapers are America\u27s most important media link with the framers of the Constitution. Weeklies are an important medium in American journalism. There are nearly 9,000 weekly newspapers published in the United States. These weeklies are sometimes looked upon as the bedrock of American journalism. Therefore, this study attempts to determine what effects ownership has on the editorial freedom and local autonomy of weekly newspapers. Studies have been done concerning the effect of ownership on the editorial independence and local autonomy of daily newspapers. Thrift said the editorials of independently owned newspapers declined in vigor” after the newspapers were -purchased by groups. However, the decline was not statistically significant

Reducing auditory nerve excitability by acute antagonism of Ca2+-permeable AMPA receptors

Hearing depends on glutamatergic synaptic transmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). AMPARs are tetramers, where inclusion of the GluA2 subunit reduces overall channel conductance and C

On the mass-radius relation of hot stellar systems

Most globular clusters have half-mass radii of a few pc with no apparent correlation with their masses. This is different from elliptical galaxies, for which the Faber-Jackson relation suggests a strong positive correlation between mass and radius. Objects that are somewhat in between globular clusters and low-mass galaxies, such as ultra-compact dwarf galaxies, have a mass-radius relation consistent with the extension of the relation for bright ellipticals. Here we show that at an age of 10 Gyr a break in the mass-radius relation at ~10^6 Msun is established because objects below this mass, i.e. globular clusters, have undergone expansion driven by stellar evolution and hard binaries. From numerical simulations we find that the combined energy production of these two effects in the core comes into balance with the flux of energy that is conducted across the half-mass radius by relaxation. An important property of this `balanced' evolution is that the cluster half-mass radius is independent of its initial value and is a function of the number of bound stars and the age only. It is therefore not possible to infer the initial mass-radius relation of globular clusters and we can only conclude that the present day properties are consistent with the hypothesis that all hot stellar systems formed with the same mass-radius relation and that globular clusters have moved away from this relation because of a Hubble time of stellar and dynamical evolution.Comment: 5 pages, 3 figures, MNRAS Letters (accepted

Outer density profiles of 19 Galactic globular clusters from deep and wide-field imaging

Using deep photometric data from WFC@INT and [email protected] we measure the outer number density profiles of 19 stellar clusters located in the inner region of the Milky Way halo (within a Galactocentric distance range of 10-30 kpc) in order to assess the impact of internal and external dynamical processes on the spatial distribution of stars. Adopting power-law fitting templates, with index $-\gamma$ in the outer region, we find that the clusters in our sample can be divided in two groups: a group of massive clusters ($\ge 10^5$ M_sun) that has relatively flat profiles with $2.5 < \gamma < 4$ and a group of low-mass clusters ($\le 10^5$ M_sun), with steep profiles ($\gamma > 4$) and clear signatures of interaction with the Galactic tidal field. We refer to these two groups as 'tidally unaffected' and 'tidally affected', respectively. Our results also show a clear trend between the slope of the outer parts and the half-mass density of these systems, which suggests that the outer density profiles may retain key information on the dominant processes driving the dynamical evolution of Globular Clusters.Comment: 17 pages, 14 figures, 2 tables; accepted for publication in MNRA

Mass Assembly of Stellar Systems and Their Evolution with the SMA (MASSES)-Full Data Release

We present and release the full dataset for the Mass Assembly of Stellar Systems and their Evolution with the SMA (MASSES) survey. This survey used the Submillimeter Array (SMA) to image the 74 known protostars within the Perseus molecular cloud. The SMA was used in two array configurations to capture outflows for scales $>$30$^{\prime\prime}$ ($>$9000 au) and to probe scales down to $\sim$1$^{\prime\prime}$ ($\sim$300 au). The protostars were observed with the 1.3 mm and 850 $\mu$m receivers simultaneously to detect continuum at both wavelengths and molecular line emission from CO(2-1), $^{13}$CO(2-1), C$^{18}$O(2-1), N$_2$D$^+$(3-2), CO(3-2), HCO$^+$(4-3), and H$^{13}$CO$^+$(4-3). Some of the observations also used the SMA's recently upgraded correlator, SWARM, whose broader bandwidth allowed for several more spectral lines to be observed (e.g., SO, H$_2$CO, DCO$^+$, DCN, CS, CN). Of the main continuum and spectral tracers observed, 84% of the images and cubes had emission detected. The median C$^{18}$O(2-1) linewidth is $\sim$1.0 km s$^{-1}$, which is slightly higher than those measured with single-dish telescopes at scales of 3000-20000 au. Of the 74 targets, six are suggested to be first hydrostatic core candidates, and we suggest that L1451-mm is the best candidate. We question a previous continuum detection toward L1448 IRS2E. In the SVS13 system, SVS13A certainly appears to be the most evolved source, while SVS13C appears to be hotter and more evolved than SVS13B. The MASSES survey is the largest publicly available interferometric continuum and spectral line protostellar survey to date, and is largely unbiased as it only targets protostars in Perseus. All visibility ($uv$) data and imaged data are publicly available at https://dataverse.harvard.edu/dataverse/full_MASSES/.Comment: Accepted to ApJ

Indoor Residual Spraying in Combination with Insecticide-Treated Nets Compared to Insecticide-Treated Nets Alone for Protection against Malaria: A Cluster Randomised Trial in Tanzania.

Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) of houses provide effective malaria transmission control. There is conflicting evidence about whether it is more beneficial to provide both interventions in combination. A cluster randomised controlled trial was conducted to investigate whether the combination provides added protection compared to ITNs alone. In northwest Tanzania, 50 clusters (village areas) were randomly allocated to ITNs only or ITNs and IRS. Dwellings in the ITN+IRS arm were sprayed with two rounds of bendiocarb in 2012. Plasmodium falciparum prevalence rate (PfPR) in children 0.5-14 y old (primary outcome) and anaemia in children <5 y old (secondary outcome) were compared between study arms using three cross-sectional household surveys in 2012. Entomological inoculation rate (secondary outcome) was compared between study arms. IRS coverage was approximately 90%. ITN use ranged from 36% to 50%. In intention-to-treat analysis, mean PfPR was 13% in the ITN+IRS arm and 26% in the ITN only arm, odds ratio = 0.43 (95% CI 0.19-0.97, n = 13,146). The strongest effect was observed in the peak transmission season, 6 mo after the first IRS. Subgroup analysis showed that ITN users were additionally protected if their houses were sprayed. Mean monthly entomological inoculation rate was non-significantly lower in the ITN+IRS arm than in the ITN only arm, rate ratio = 0.17 (95% CI 0.03-1.08). This is the first randomised trial to our knowledge that reports significant added protection from combining IRS and ITNs compared to ITNs alone. The effect is likely to be attributable to IRS providing added protection to ITN users as well as compensating for inadequate ITN use. Policy makers should consider deploying IRS in combination with ITNs to control transmission if local ITN strategies on their own are insufficiently effective. Given the uncertain generalisability of these findings, it would be prudent for malaria control programmes to evaluate the cost-effectiveness of deploying the combination.\ud \u

2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137753/1/acr23274.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137753/2/acr23274_am.pd

D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data

Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear. Objective: To clarify whether DCS is superior to placebo in augmenting the effects of cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders and to evaluate whether antidepressants interact with DCS and the effect of potential moderating variables. Data Sources: PubMed, EMBASE, and PsycINFO were searched from inception to February 10, 2016. Reference lists of previous reviews and meta-analyses and reports of randomized clinical trials were also checked. Study Selection: Studies were eligible for inclusion if they were (1) double-blind randomized clinical trials of DCS as an augmentation strategy for exposure-based cognitive behavior therapy and (2) conducted in humans diagnosed as having specific phobia, social anxiety disorder, panic disorder with or without agoraphobia, obsessive-compulsive disorder, or posttraumatic stress disorder. Data Extraction and Synthesis: Raw data were obtained from the authors and quality controlled. Data were ranked to ensure a consistent metric across studies (score range, 0-100). We used a 3-level multilevel model nesting repeated measures of outcomes within participants, who were nested within studies. Results: Individual participant data were obtained for 21 of 22 eligible trials, representing 1047 of 1073 eligible participants. When controlling for antidepressant use, participants receiving DCS showed greater improvement from pretreatment to posttreatment (mean difference, -3.62; 95% CI, -0.81 to -6.43; P = .01; d = -0.25) but not from pretreatment to midtreatment (mean difference, -1.66; 95% CI, -4.92 to 1.60; P = .32; d = -0.14) or from pretreatment to follow-up (mean difference, -2.98, 95% CI, -5.99 to 0.03; P = .05; d = -0.19). Additional analyses showed that participants assigned to DCS were associated with lower symptom severity than those assigned to placebo at posttreatment and at follow-up. Antidepressants did not moderate the effects of DCS. None of the prespecified patient-level or study-level moderators was associated with outcomes. Conclusions and Relevance: D-cycloserine is associated with a small augmentation effect on exposure-based therapy. This effect is not moderated by the concurrent use of antidepressants. Further research is needed to identify patient and/or therapy characteristics associated with DCS response.2018-05-0

2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137769/1/art40149.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137769/2/art40149_am.pd

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides

The enoyl acyl-carrier protein reductase (ENR) enzyme is harbored within the apicoplast of apicomplexan parasites providing a significant challenge for drug delivery, which may be overcome through the addition of transductive peptides, which facilitates crossing the apicoplast membranes. The binding site of triclosan, a potent ENR inhibitor, is occluded from the solvent making the attachment of these linkers challenging. Herein, we have produced 3 new triclosan analogs with bulky A- and B-ring motifs, which protrude into the solvent allowing for the future attachment of molecular transporters for delivery