Association between chronic irritability and depressive symptoms in children and adolescents.

Association between chronic irritability and depressive symptoms in children and adolescents. Busto-Garrido, M.; Gutierrez-Castillo, D; Navas- Gonzalez, JR; Gutierrez-Bedmar, M; Gutierrez-Casares, JR; Martin-Lunar, MT; Rodríguez-Rosado, A; Pena-Andreu, JM. European Psychiatry 415(2017) 5221.Chronic irritability is the most frequently reported symptom in child and adolescent depression. The association of both has been linked with high rates of chronicity, comorbility and impairment. Objectives To study the association between chronic irritability and depressive symptoms in children and adolescents. Methods We have studied 857 participants recruited from the only Child and Adolescent Mental Health Clinic in a catchment area of 122968 people under 18 (2004-2010). A sample of 677 participants (57 controls and 620 patients) was included to carry out a cross-sectional study. Chronic irritability was measured by a Visual Analog Scale (VAS irritability) -scored from 0 to 10-, and depressive symptoms by the Children's Depression Inventory (CDI). The participants were categorized into controls and patients, and according to their chronic irritability (≤4 [I],5 [II] and ≥6 [III]). The mean of CDI score was calculated for each of the groups, adjusted by sex and age, and analyzed by ANCOVA. Results The following means were obtained from the controls: 13,71 (group I), 9,82 (group II) and 17,45 (group III). Regarding to the patients: 13,92 (group I), 11,54 (group II) and 15,64 (group III). A quadratic association (p <0,0015) was found between VAS irritability score and CDI score. Conclussions There is not a lineal association between chronic irritability and depressive symptoms in children and adolescent. High rates of depressive symptoms were associated both with high and low rates of irritability. Several questions remain unexplained about the status of irritability in psychiatry as Stringaris group has been pointed out. Disclosure statement I have no potential conflict of interest to discloseUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Topological evaluation of volume reconstructions by voxel carving

Space or voxel carving [1, 4, 10, 15] is a technique for creating a three-dimensional reconstruction of an object from a series of two-dimensional images captured from cameras placed around the object at different viewing angles. However, little work has been done to date on evaluating the quality of space carving results. This paper extends the work reported in [8], where application of persistent homology was initially proposed as a tool for providing a topological analysis of the carving process along the sequence of 3D reconstructions with increasing number of cameras. We give now a more extensive treatment by: (1) developing the formal framework by which persistent homology can be applied in this context; (2) computing persistent homology of the 3D reconstructions of 66 new frames, including different poses, resolutions and camera orders; (3) studying what information about stability, topological correctness and influence of the camera orders in the carving performance can be drawn from the computed barcodes

La calidad de vida en adultos con diabetes mellitus tipo 2 en centros de salud de Guadalajara, Jalisco (México)

Objetivo: Evaluar la percepción de Calidad de Vida Relacionada con la Salud (CVRS) de Objetivos: Evaluar la relación de la diabetes sobre la calidad de vida, utilizando el cuestionario Diabetes 39 en pacientes diagnosticados como diabéticos que acuden a visita ambulatoria a centros de salud. Materiales y métodos: Con un diseño transversal en una muestra no probabilística determinada por un periodo de tiempo en cuatro centros de salud de la Secretaría de Salud Jalisco (SSJ) en la Zona Metropolitana de Guadalajara, en pacientes que acuden a control de diabetes. Se estudiaron tres variables: calidad de vida, socio-demográficas y específicas de la enfermedad. Resultados: En la muestra de 198 pacientes ambulatorios con diabetes tipo 2 y con un tiempo de evolución de 9.51 ± 8 años, un 76.7% sin complicaciones relacionadas con la diabetes, una mitad (47.9%) fueron tratados con dieta. Con base en los dominios medidos con el Diabetes 39, las puntuaciones más altas se dan en la "calidad de vida" con un dete- rioro en la misma seguida de la percepción que se tiene sobre la "severidad de la diabetes", de los cinco dominios los de "energía y movilidad" y el de "funcionamiento sexual" fueron los que tienen una mayor media del total de la muestra. Las diferencias significativas por género se dan en el dominio de "funcionamiento sexual" para los hombres. Conclusiones: La calidad de vida se ve afectada en pacientes con diabetes, especialmen- te en el dominio de energía y movilidad y en el funcionamiento sexual, lo que indica la necesidad de un programa de intervención en actividades física-recreativas y en asesoría educativa-psicológica. Palabras clave: Diabetes 39, Calidad de vida, Diabetes mellitus, Adultos. Abstract Objectives: To evaluate the relationships of the diabetes on the quality of life, being used questionnaire Diabetes 39 to patients diagnosed like diabetics who go ambulatory visit to health centers. Materials and methods: With a transversal design in a nonrandom sampling determi- ned by a time period in four centers of health of the salubrity secretary was made (SSA) in the Metropolitan Zone of Guadalajara, in patients attending diabetic control. Three variables were studied: quality of life, socio-demographics and the disease specific. Results: In the sample of 198 ambulatory patients with diabetes type 2 iand with a du- ration of 9.51 ± 8 years, 76,7% without diabetes-related complications, one half (47.95) were treated with diet. Based on the dominions measured with Diabetes 39, the highest scores occur in the dominion of "quality of life" with a followed deterioration in their lives and in their perception about the "severity of the diabetes", of the five dominions those of "energy and mobility" and the one of "sexual operation" was those that they have a greater average of the total of the sample. The significant differences by gender differences exist in the domain of "sexual performance" for men. Conclusions: The quality of life is affected in patients with diabetes, especially in the do- minion of energy and mobility and in the sexual operation, which indicates the necessity of a program of intervention in physical-recreational activities and educative-psychological consultant's office. The greater negative impact of the diabetes in the quality of life was associated with man, low entrance to the average and with presence of complications by the diabetes. Keywords: Diabetes 39, Quality of life, Diabetes mellitus, Adults

Assessing Creativity In Engineering Students: A Comparative Between Degrees and Sudents In First And Last Year

An online open access test (CREAX self-assessment) has been used in this work so that students from degrees in engineering in the Universidad Polite¿cnica of Madrid (UPM) could self-assess their creative competence after several classroom activities. Different groups from the first year course have been statistically compared using data from their assessment. These first year students had different professors in the subject ?Technical Drawing? and belonged to several degrees in the UPM. They were as well compared regarding sex and a group of first year students was also compared to another last year group of the degree so as to observe possible differences in the achievement of this competence. Only one difference was detected concerning sex in one of the degrees. Among degrees, the higher marks obtained by students who had done specific exercises for the development of creativity in class is highlighted. Finally, a significantly high mark was observed in students during their last year of degree with respect to first year students. The tool CREAX has become very useful in the assessment of this competence in the UPM degrees in which it has been implemented

Velocidad media de infiltración en un vertisol bajo distintos sistemas de labranza

Soil compaction is regarded as the most serious environmental problem caused by conventional agriculture. Few studies are concerned with the assessment of soil compaction using infiltration speed, specifically in the Vertisol soil characteristic of the main maize producing area of the Toluca-Atlacomulco Valley in central Mexico. The aim of this research was to examine the effect on infiltration speed and penetration resistance of a Vertisol soil when compacted by wheeled agricultural traffic in three different types of tillage systems: zero, minimal and conventional. Penetration resistance was measured on the wheel track with a portable digital penetrometer, and the mean infiltration speed was determined according to the double cylinder infiltrometer method. The pressure exerted by the number of wheeled traffic passes increased Vertisol soil compaction at 30 cm depth. Even though the benefits of zero tillage were similar to those showed by mínimum tillage during the experimental period, minimum tillage reported the highest infiltration spee

Association of cortisol serum levels as a prognostic factor in threat of pre-term birth

Background: Prematurity is one of the leading causes of death in children. In Mexico there is a frequency of 12% of preterm birth and this leads to significant maternal-fetal complications comprising 31.5% of neonatal morbidity and mortality. The patient who receives obstetric care in the gynecology service at the naval medical center requires prevention, diagnosis and treatment of threat of preterm birth to reduce perinatal and neonatal complications. Serum cortisol levels was determined as a prognostic factor for the threat of preterm birth in patients with obstetric care at the Naval Medical Center, it is a relatively easy parameter to obtain and would support a timely treatment.Methods: We used a quantitative, non-experimental, retrospective descriptive study of 30 patients with risk factors to develop preterm birth threats in gynecology service of the naval medical center from January to December 2018, which were taken 3 milliliters of peripheral blood to measure serum cortisol concentrations for later analysis. For statistical analysis of the present study, it was used Shapiro Wilk test. Likewise, Pearson's test was performed to measure the degree of association between the dependent and independent variable. Student's t-test was implemented to compare cortisol levels of pregnant women.Results: A total of 30 patients of these were analyzed, the mean age was 30.4 years (SD±5.184). The gestation weeks the average value was 30.63 weeks (SD±4.781). A student t test was performed where the cortisol values of pregnant women were compared with an average value of 2,586 (95% CI 0.45-472) and a t value=2,476 and a p=0.019 lower value of the significance value of 0.05 rejecting the null hypothesis. Which indicates that cortisol levels can be used as a predictive marker of the threat of preterm birth, considering it as an independent factor for this situation to occur in pregnant patients. The variables of the cortisol level and the weeks of gestation Pearson=-0.061 and a significance of p=0.747 were correlated (there being no strong enough relationship between the study variables). Regarding the triggers, it is observed that the highest factor was for urinary tract infection 40% n=12, abnormal uterine activity 20% n=6, followed by premature membrane rupture 16.7% n=5.Conclusions: The risk factors associated with the threat of preterm birth can be multiple, encompassing them in three important areas such as socioeconomic, psycho-emotional and clinicopathological, of the latter, nine of which are most frequent in our population are urinary infection, abnormal uterine activity and premature rupture of membranes. Regarding the association of cortisol levels as a prognostic factor for the threat of preterm birth taking it into account as an independent factor, it can be concluded that it is not statistically significant, however, according to what is reported in the literature, It should be considered as one of the multiple risk factors, considering this timely premise to boost the development of new research in the field

The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection

.CD160 is a member of the immunoglobulin superfamily with a pattern of expression mainly restricted to cytotoxic cells. To assess the functional relevance of the HVEM/CD160 signaling pathway in allogeneic cytotoxic responses, exon 2 of the CD160 gene was targeted by CRISPR/Cas9 to generate CD160 deficient mice. Next, we evaluated the impact of CD160 deficiency in the course of an alloreactive response. To that aim, parental donor WT (wild-type) or CD160 KO (knock-out) T cells were adoptively transferred into non-irradiated semiallogeneic F1 recipients, in which donor alloreactive CD160 KO CD4 T cells and CD8 T cells clonally expanded less vigorously than in WT T cell counterparts. This differential proliferative response rate at the early phase of T cell expansion influenced the course of CD8 T cell differentiation and the composition of the effector T cell pool that led to a significant decreased of the memory precursor effector cells (MPECs) / short-lived effector cells (SLECs) ratio in CD160 KO CD8 T cells compared to WT CD8 T cells. Despite these differences in T cell proliferation and differentiation, allogeneic MHC class I mismatched (bm1) skin allograft survival in CD160 KO recipients was comparable to that of WT recipients. However, the administration of CTLA-4.Ig showed an enhanced survival trend of bm1 skin allografts in CD160 KO with respect to WT recipients. Finally, CD160 deficient NK cells were as proficient as CD160 WT NK cells in rejecting allogeneic cellular allografts or MHC class I deficient tumor cells. CD160 may represent a CD28 alternative costimulatory molecule for the modulation of allogeneic CD8 T cell responses either in combination with costimulation blockade or by direct targeting of alloreactive CD8 T cells that upregulate CD160 expression in response to alloantigen stimulation.S

Association of biparietal diameter growth rate with neurodevelopment in infants with fetal growth restriction

横浜市立大学2015年

The H-NS regulator plays a role in the stress induced by carbapenemase expression in acinetobacter baumannii

Disruption of the histone-like nucleoid structuring protein (H-NS) was shown to affect the ability of Gram-negative bacteria to regulate genes associated with virulence, persistence, stress response, quorum sensing, biosynthesis pathways, and cell adhesion. Here, we used the expression of metallo-β-lactamases (MBLs), known to elicit envelope stress by the accumulation of toxic precursors in the periplasm, to interrogate the role of H-NS in Acinetobacter baumannii, together with other stressors. Using a multidrug-resistant A. baumannii strain, we observed that H-NS plays a role in alleviating the stress triggered by MBL toxic precursors and counteracts the effect of DNA-damaging agents, supporting its role in stress response. IMPORTANCE Carbapenem-resistant A. baumannii (CRAB) is recognized as one of the most threatening Gram-negative bacilli. H-NS is known to play a role in controlling the transcription of a variety of different genes, including those associated with the stress response, persistence, and virulence. In the present work, we uncovered a link between the role of H-NS in the A. baumannii stress response and its relationship with the envelope stress response and resistance to DNA-damaging agents. Overall, we posit a new role of H-NS, showing that H-NS serves to endure envelope stress and could also be a mechanism that alleviates the stress induced by MBL expression in A. baumannii. This could be an evolutionary advantage to further resist the action of carbapenems.Fil: Huang, Fanny. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Fitchett, Noelle. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Razo Gutierrez, Chelsea. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Le, Casin. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Martinez, Jasmine. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Ra, Grace. California State University. College Of Natural Science And Mathematics; Estados UnidosFil: Lopez, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Gonzalez, Lisandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Sieira, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Bonomo, Robert A.. Louis Stokes Cleveland Va Medical Center; Estados Unidos. Case Western Reserve University School of Medicine; Estados UnidosFil: Ramirez, Maria Soledad. California State University. College Of Natural Science And Mathematics; Estados Unido

Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt's lymphoma. A cytogenetic and comparative genomic hybridization study

Comparative genomic hybridization (CGH) studies have demonstrated a high incidence of chromosomal imbalances in non-Hodgkin's lymphoma. However, the information on the genomic imbalances in Burkitt's Lymphoma (BL) is scanty. Conventional cytogenetics was performed in 34 cases, and long-distance PCR for t(8;14) was performed in 18 cases. A total of 170 changes were present with a median of four changes per case (range 1-22). Gains of chromosomal material (143) were more frequent than amplifications (5) or losses (22). The most frequent aberrations were gains on chromosomes 12q (26%), Xq (22%), 22q (20%), 20q (17%) and 9q (15%). Losses predominantly involved chromosomes 13q (17%) and 4q (9%). High-level amplifications were present in the regions 1q23-31 (three cases), 6p12-p25 and 8p22-p23. Upon comparing BL vs Burkitt's cell leukemia (BCL), the latter had more changes (mean 4.3 +/- 2.2) than BL (mean 2.7 +/- 3.2). In addition, BCL cases showed more frequently gains on 8q, 9q, 14q, 20q, and 20q, 9q, 8q and 14q, as well as losses on 13q and 4q. Concerning outcome, the presence of abnormalities on 1q (ascertained either by cytogenetics or by CGH), and imbalances on 7q (P=0.01) were associated with a short survival