Caractérisation et sélection sanitaire de la variété d'orange 'Navelina'

Rappel de l'origine de cette 'Navel' et des méthodes utilisées pour la caractériser morphologiquement (arbre et fruit) et biométriquement. Comparaison avec 'Washington Navel'. Mesures prises pour assurer la sélection sanitaire à court terme et à moyen terme (nucellaires)

The Gaia-ESO Survey::the first abundance determination of the pre-main-sequence cluster Gamma Velorum

Knowledge of the abundance distribution of star forming regions and young clusters is critical to investigate a variety of issues, from triggered star formation and chemical enrichment by nearby supernova explosions to the ability to form planetary systems.In spite of this, detailed abundance studies are currently available for relatively few regions. In this context, we present the analysis of the metallicity of the Gamma Velorum cluster, based on the products distributed in the first internal release of the Gaia-ESO Survey. The Gamma Velorum candidate members have been observed with FLAMES, using both UVES and Giraffe, depending on the target brightness and spectral type. In order to derive a solid metallicity determination for the cluster, membership of the observed stars must be first assessed. To this aim, we use several membership criteria including radial velocities, surface gravity estimates, and the detection of the photospheric lithium line. Out of the 80 targets observed with UVES, we identify 14 high-probability members. We find that the metallicity of the cluster is slightly subsolar, with a mean [Fe/H]=-0.057+/-0.018 dex. Although J08095427-4721419 is one of the high-probability members, its metallicity is significantly larger than the cluster average. We speculate about its origin as the result of recent accretion episodes of rocky bodies of ~60 M_Sun hydrogen-depleted material from the circumstellar disk.Comment: 13 pages, 10 figures, 7 tables, Accepted for publication in Astronomy & Astrophysic

Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.

Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3–5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited

Evolution after Anti-TNF Discontinuation in Patients with Inflammatory Bowel Disease: A Multicenter Long-Term Follow-Up Study

OBJECTIVES:The aims of this study were to assess the risk of relapse after discontinuation of anti-tumor necrosis factor (anti-TNF) drugs in patients with inflammatory bowel disease (IBD), to identify the factors associated with relapse, and to evaluate the overcome after retreatment with the same anti-TNF in those who relapsed.METHODS:This was a retrospective, observational, multicenter study. IBD patients who had been treated with anti-TNFs and in whom these drugs were discontinued after clinical remission was achieved were included.RESULTS:A total of 1, 055 patients were included. The incidence rate of relapse was 19% and 17% per patient-year in Crohn''s disease and ulcerative colitis patients, respectively. In both Crohn''s disease and ulcerative colitis patients in deep remission, the incidence rate of relapse was 19% per patient-year. The treatment with adalimumab vs. infliximab (hazard ratio (HR)=1.29; 95% confidence interval (CI)=1.01-1.66), elective discontinuation of anti-TNFs (HR=1.90; 95% CI=1.07-3.37) or discontinuation because of adverse events (HR=2.33; 95% CI=1.27-2.02) vs. a top-down strategy, colonic localization (HR=1.51; 95% CI=1.13-2.02) vs. ileal, and stricturing behavior (HR=1.5; 95% CI=1.09-2.05) vs. inflammatory were associated with a higher risk of relapse in Crohn''s disease patients, whereas treatment with immunomodulators after discontinuation (HR=0.67; 95% CI=0.51-0.87) and age (HR=0.98; 95% CI=0.97-0.99) were protective factors. None of the factors were predictive in ulcerative colitis patients. Retreatment of relapse with the same anti-TNF was effective (80% responded) and safe.CONCLUSIONS:The incidence rate of inflammatory bowel disease relapse after anti-TNF discontinuation is relevant. Some predictive factors of relapse after anti-TNF withdrawal have been identified. Retreatment with the same anti-TNF drug was effective and safe

Barcode housing system: Integrating floor plan layout generation processes within an open and collaborative system to design and build customized housing

The goal of the project has been to design and implement an ICT environment which facilitates the interaction of the different actors (architects, builders, manufacturers, occupants) involved in the design, construction and use of affordable housing built with industrialized methods. The interwoven working environments which form the structure of the system enable the actors to carry out their activities in a synchronous and asynchronous manner. As well as providing a structure that supports collaboration, the system automatically generates housing units and buildings

T Tauri candidates and accretion rates using IPHAS : method and application to IC 1396

The definitive version can be found at : http://onlinelibrary.wiley.com/ Copyright Royal Astronomical SocietyThe Isaac Newton Telescope (INT) Photometric H-Alpha Survey (IPHAS) is a 1800 deg(2) survey of the Northern Galactic Plane, reaching down to r' similar to 21. We demonstrate how the survey can be used to (1) reliably select classical T Tauri star candidates and (2) constrain the mass accretion rates with an estimated relative uncertainty of 0.6 dex. IPHAS is a necessary addition to spectroscopic surveys because it allows large and uniform samples of accretion rates to be obtained with a precise handle on the selection effects. We apply the method on a region of 7 deg(2) towards the H II region IC 1396 in Cepheus OB2 and identify 158 pre-main-sequence candidates with masses between 0.2 and 2.0 M-circle dot and accretion rates between 10(-9.2) and 10(-7.0) M-circle dot yr(-1). We find a power-law dependency between the stellar mass and the accretion rates with a slope of alpha = 1.1 +/- 0.2, which is less steep than indicated by previous studies. We discuss the influence of method-dependent systematic effects on the determination of this relationship. The majority of our sample consists of faint, previously unknown, low-mass T Tauri candidates (56 per cent between 0.2 and 0.5 M-circle dot). Many candidates are clustered in front of three bright-rimmed molecular clouds, which are being ionized by the massive star HD206267 (O6.5V). We discover a spatio-temporal gradient of increasing accretion rates, increasing Spitzer infrared excess, and younger ages away from the ionizing star, providing a strong indication that the formation of these clusters has been sequentially triggered by HD206267 during the last similar to 1 Myr.Peer reviewe

Utilidad terapéutica del agonista de la hormona liberadora de gonadotrofinas D-Trp-6-LHRH en el tratamiento de la pubertad precoz

Efficacy and safety of a superactive gonadotrophin-releasing hormone analogue (D-Trp-6-LHRH, decapeptyl) was assessed in seven girls, aged two to seven years with precocious puberty (four idiopathic, two associated to McCune-Albright syndrome and one with myelomeningocele). A further case of a seven year old male was treated with a delayed release formulation of the analogue combined with cyproterone acetate for the first two weeks of therapy. Three cases had previously been unsuccessfully treated with cyproterone acetate (2% or medroxyprogesterone (1) but this conventional therapy was discontinued three months prior entering the trial. Decapeptyl was given at a dose of 100 mcg sc daily for 10 days, followed by a dose of 1-2 mcg/kg daily thereafter. One patient required a sustained dose of 7 mcg/kg for effective control. The male patient received a biodegradable depot preparation of decapeptyl at a dose of 1.5 mg IM monthly, calculated to release circa 100 mcg of the analogue daily. He was also treated with cyproterone acetate. 100 mg/m2/day 15 days before and for two weeks during decapeptyl administration. Treatment was well tolerated without significant side effects. After six months on treatment, both LH and FSH levels were undetectable and showed no response to LHRH. Plasma oestradiol levels were reduced from 230 +/- 40 to 13 +/- 4 pg/ml. Total testosterone in the male patient was suppressed from 7 ng/ml to undetectable levels. This was accompanied by a cessation in the progression of the development of secondary sexual characteristics. All female patients developed amenorrhoea and their Tanner stage regressed to I or prepubertad after treatment.(ABSTRACT TRUNCATED AT 250 WORDS