La comunicación institucional local en el desarrollo de comunidades rurales

Análisis de la política en el ámbito municipal

Synthesis of Bioactive Speciosins G and P from Hexagonia speciosa

The first total synthesis of speciosins P and G, previously isolated from Hexagonia speciosa, is reported. These compounds have been synthesized by Sonogashira coupling from readily available starting materials. Siccayne was also synthesized from the same starting material in two steps along with a number of other derivatives. The compounds were tested in the wheat coleoptile bioassay. The most active compound was the intermediate 18, followed by 29 and 17. The structural requirements for activity in these compounds are the presence of methoxy groups in the aromatic ring and a formyl or hydroxy group in the side chain

Dynamic semantic ontology generation: a proposal for social robots

[Abstract] During a human-robot interaction by dialogue/voice, the robot cannot extract semantic meaning from the words used, limiting the intervention itself. Semantic knowledge could be a solution by structuring information according to its meaning and its semantic associations. Applied to social robotics, it could lead to a natural and fluid human-robot interaction. Ontologies are useful representations of semantic knowledge, as they capture the relationships between objects and entities. This paper presents new ideas for ontology generation using already generated ontologies as feedback in an iterative way to do it dynamically. This paper also collects and describes the concepts applied in the proposed methodology and discusses the challenges to be overcome.Ministerio de Ciencia, Innovación y Universidades; RTI2018-096338-B-I0

Reflection on Migration Scenarios 2G and 3G Mobile Networks to Fourth Generation in Colombia

En el desarrollo del siguiente artículo se realiza un estudio de los escenarios de migración de tecnologías móviles de tercera generación a tecnologías móviles de cuarta generación, para analizar el escenario de migración más propicio para los operadores móviles en Colombia, para que se adapten de forma más recomendable a las necesidades de los operadores móviles en el país. Este estudio está enfocado en operadores que cuentan con infraestructura propia, es decir, no se analizan las características de migración para los operadores móviles virtuales.In the development of the following article is an analysis of some of the migration scenarios third generation mobile technologies for fourth generation mobile technologies, in order to select which is the most suitable migration scenario for mobile operators Colombia, taking into account the characteristics of the market and the needs that are more optimally suited for the needs of mobile operators in the country, the whole development of the article is based on operators with own infrastructure is not analyzed migration characteristics of mobile virtual network operators

Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment

17 pags., 6 figs., 2 tabs.Sanchez-Martin et al. report a mode of action for naphthalene-diimides, a well-known class of G-quadruplexes ligands. Their work provides evidence of naphthalene-diimides targeting G-quadruplexes in ribosomal DNA, inducing a blockade of RNA polymerase I-mediated transcription and cell death. These compounds could be exploited in colorectal cancer treatment.This work was supported by the European Commission (TAR- BRAINFECT to J.A.G.-S.) and the National Institutes of Health (GM084946 to D.A.S.). The Government of Spain granted with PhD fellowships FPU16/ 05822 to V.S.-M. and FPU17/05413 to A.S.-L. The University of Almeria granted with PhD fellowship to M.O.-G. Funding for open access charge: Eu- ropean Commissio

Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients

Introduction: Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACP1 polymorphisms to susceptibility to rheumatoid arthritis (RA), as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease (CV) observed in RA patients. Methods: A set of 1,603 Spanish RA patients and 1,877 healthy controls were included in the study. Information related to the presence/absence of CV events was obtained from 1,284 of these participants. All individuals were genotyped for four ACP1 single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247, and rs3828329, using a predesigned TaqMan SNP genotyping assay. Classical ACP1 alleles (*A, *B and *C) were imputed with SNP data. Results: No association between ACP1 gene polymorphisms and susceptibility to RA was observed. However, when RA patients were stratified according to the presence or absence of CV events, an association between rs11553742*T and CV events was found (P = 0.012, odds ratio (OR) = 2.62 (1.24 to 5.53)). Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA (P = 0.024, OR = 2.43). Conclusions: Our data show that the ACP1*C allele influences the risk of CV events in patients with R

CARD8 rs2043211 (p.C10X) polymorphism is not associated with disease susceptibility or cardiovascular events in Spanish rheumatoid arthritis patients

Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis, which is the main cause of increased cardiovascular (CV) morbidity and mortality in RA patients. CARD8 is a constituent of inflammasome, which regulates interleukin 1-beta production, and has been associated with a worse disease course in early RA. One thousand six hundred twenty-one patients fulfilling the 1987 ACR classification criteria for RA and 1300 matched controls, were genotyped for the CARD8 rs2043211 (30T > A, p.C10X) single-nucleotide polymorphism (SNP) using predesigned TaqMan SNP genotyping assay. The genotyping success rate in our study was greater than 94%. We assessed CARD8 rs2043211 gene polymorphism results in 1530 Spanish RA patients in whom information on CV disease and CV risk factors was available at the time of the study. Also, a subgroup of patients with no history of CV events (n = 276) was assessed for the potential influence of the rs2043211 variant in the development of subclinical atherosclerosis, by measurement of carotid intima-media thickness (IMT) and presence of carotid plaques. No statistically significant differences in allele or genotype frequencies for the rs2043211 CARD8 gene variant between patients with RA and controls were seen. Similarly, CARD8 rs2043211 (30T > A, p.C10X) SNP did not influence the development of CV events or the risk of CV events throughout the time. Likewise, no significant association between this gene variant and carotid IMT or the presence of plaques was found. In summary, our results do not support a role of the CARD8 rs2043211 gene variant in susceptibility to RA or in the development of CV disease in patients with RA

Non-static Dimensional Reduction of QED_3 at Finite Temperature

We study an extreme non-static limit of 2+1-dimensional QED obtained by making a dimensional reduction so that all fields are spatially uniform but time dependent. This dimensional reduction leads to a 0+1-dimensional field theory that inherits many of the features of the 2+1-dimensional model, such as Chern-Simons terms, time-reversal violation, an analogue of parity violation, and global U(2) flavor symmetry. At one-loop level, interactions induce a Chern-Simons term at finite T with coefficient tanh(beta m_F/2), where m_F is the fermion mass. The finite temperature two loop self-energies are also computed, and are non-zero for all temperatures.Comment: 28 pp, 11 figures, uses axodraw.st

Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis

Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87-0.93, Poverall = 2.1×10−10). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk

Initial therapy, regimen change, and persistence in a spanish cohort of newly treated type 2 diabetes patients: A retrospective, observational study using real-world data

The World Health Organization considers the non-adherence to medication a significant issue with global impact, especially in chronic conditions such as type 2 diabetes. We aim to study antidiabetic treatment initiation, add-on, treatment switching, and medication persistence. We conducted an observational study on 4247 individuals initiating antidiabetic treatment between 2013 and 2014 in the EpiChron Cohort (Spain). We used Cox regression models to estimate the likelihood of non-persistence after a one-year follow-up, expressed as hazard ratios (HRs). Metformin was the most frequently used first-line antidiabetic (80% of cases); combination treatment was the second most common treatment in adults aged 40–79 years, while dipeptidyl peptidase-4 inhibitors were the second most common in individuals in their 80s and over, and in patients with renal disease. Individuals initiated on metformin were less likely to present addition and switching events compared with any other antidiabetic. Almost 70% of individuals initiated on monotherapy were persistent. Subjects aged 40 and over (HR 0.53–0.63), living in rural (HR 0.79) or more deprived areas (HR 0.77–0.82), or receiving polypharmacy (HR 0.84), were less likely to show discontinuation. Our findings could help identify the population at risk of discontinuation, and offer them closer monitoring for proper integrated management to improve prognosis and health outcomes