Reflexiones en torno al modus operandi de la franquicia en el deporte.

Our paper is aimed at showing other sports business models, covered with contracts legally "franchise" and its various forms, and with a success based on the binomial sport-profit that perhaps we should consider in the not too distant future, no longer with the model in its purest aspect, but at least with some hybrid between the legal formula described and the current, which allow profit generating the best sporting event, especially by adjusting the sport to new trends and market needs

Combined therapies of antithrombotics and antioxidants delay in silico brain tumor progression

Glioblastoma multiforme, the most frequent type of primary brain tumor, is a rapidly evolving and spatially heterogeneous high-grade astrocytoma that presents areas of necrosis, hypercellularity and microvascular hyperplasia. The aberrant vasculature leads to hypoxic areas and results in an increase of the oxidative stress selecting for more invasive tumor cell phenotypes. In our study we assay in silico different therapeutic approaches which combine antithrombotics, antioxidants and standard radiotherapy. To do so, we have developed a biocomputational model of glioblastoma multiforme that incorporates the spatio-temporal interplay among two glioma cell phenotypes corresponding to oxygenated and hypoxic cells, a necrotic core and the local vasculature whose response evolves with tumor progression. Our numerical simulations predict that suitable combinations of antithrombotics and antioxidants may diminish, in a synergetic way, oxidative stress and the subsequent hypoxic response. This novel therapeutical strategy, with potentially low or no toxicity, might reduce tumor invasion and further sensitize glioblastoma multiforme to conventional radiotherapy or other cytotoxic agents, hopefully increasing median patient overall survival time.Comment: 8 figure

Soil health—a new challenge for microbiologists and chemists

Soil health refers to the biological, chemical, and physical features of soil that are essential to long-term, sustainable agricultural productivity with minimal environmental impact. Thus, soil health provides an overall picture of soil functionality. Although it cannot be measured directly, soil health can be inferred by measuring specific soil properties (e.g. organic matter content) and by observing soil status (e.g. fertility). There is also increased interest in studying soil microorganisms in their particular environments, as microbial diversity is intimately related to soil structure and function. One of the key objectives in determining soil health is to acquire indicators that can be used to evaluate the soil’s current status and hence to develop sustainable agricultural systems. In this regard, significant progress has been made over the last few years in the development of specific biomarkers and macromolecular probes, enabling rapid and reliable measurements of soil microbial communities. In addition, modern molecular biological techniques, such as fluorescence in situ hybridization (FISH), reverse transcriptase polymerase chain reaction (RT-PCR), denaturing gradient gel electrophoresis (DGGE), and terminal restriction fragment length polymorphism (T-RFLP), have facilitated the analysis of microbial biodiversity and activity, whereas the application of modern analytical techniques, such as nuclear magnetic resonance (NMR) and pyrolysisgas chromatography-mass spectrometry (Py-GC-MS), have provided data on soil chemistry. The combination of these two approaches offers promise in determining soil health status. [Int Microbiol 2005; 8(1):13-21

Performance Study of Software AER-Based Convolutions on a Parallel Supercomputer

This paper is based on the simulation of a convolution model for bioinspired neuromorphic systems using the Address-Event-Representation (AER) philosophy and implemented in the supercomputer CRS of the University of Cadiz (UCA). In this work we improve the runtime of the simulation, by dividing an image into smaller parts before AER convolution and running each operation in a node of the cluster. This research involves a test cases design in which the optimal parameters are set to run the AER convolution in parallel processors. These cases consist on running the convolution taking an image divided in different number of parts, applying to each part a Sobel filter for edge detection, and based on the AER-TOOL simulator. Execution times are compared for all cases and the optimal configuration of the system is discussed. In general, CRS obtain better performances when the image is divided than for the whole image.Ministerio de Ciencia e Innovación TEC2009-10639-C04-0

Dose-dependent differential effect of neurotrophic factors on in vitro and in iivo regeneration of motor and sensory neurons

Although peripheral axons can regenerate after nerve transection and repair, functional recovery is usually poor due to inaccurate reinnervation. Neurotrophic factors promote directional guidance to regenerating axons and their selective application may help to improve functional recovery. Hence, we have characterized in organotypic cultures of spinal cord and dorsal root ganglia the effect of GDNF, FGF-2, NGF, NT-3, and BDNF at different concentrations on motor and sensory neurite outgrowth. In vitro results show that GDNF and FGF-2 enhanced both motor and sensory neurite outgrowth, NGF and NT-3 were the most selective to enhance sensory neurite outgrowth, and high doses of BDNF selectively enhanced motor neurite outgrowth. Then, NGF, NT-3, and BDNF (as the most selective factors) were delivered in a collagen matrix within a silicone tube to repair the severed sciatic nerve of rats. Quantification of Fluorogold retrolabeled neurons showed that NGF and NT-3 did not show preferential effect on sensory regeneration whereas BDNF preferentially promoted motor axons regeneration. Therefore, the selective effects of NGF and NT-3 shown in vitro are lost when they are applied in vivo, but a high dose of BDNF is able to selectively enhance motor neuron regeneration both in vitro and in vivo

Improving Institutional Repositories through User-Centered Design: Indicators from a Focus Group

User experience with intuitive and flexible digital platforms can be enjoyable and satisfying. A strategy to deliver such an experience is to place the users at the center of the design process and analyze their beliefs and perceptions to add appropriate platform features. This study conducted with focus groups as a qualitative method of data collection to investigate users’ preferences and develop a new landing page for institutional repositories with attractive functionalities based on their information-structural rules. The research question was: What are the motivations and experiences of users in an academic community when publishing scientific information in an institutional repository? The focus group technique used in this study had three sessions. Results showed that 50% of the participants did not know the functionalities of the institutional repository nor its benefits. Users’ perceptions of platforms such as ResearchGate or Google Scholar that provide academic production were also identified. The findings showed that motivating an academic community to use an institutional repository requires technological functions, user guidelines that identify what can or cannot be published in open access, and training programs for open access publication practices and institutional repository use. These measures align with global strategies to strengthen the digital identities of scientific communities and thus benefit open science

Pyrolysis-compound-specific hydrogen isotope analysis (δ2H Py-CSIA) of Mediterranean olive oils

The analysis of the hydrogen stable isotope composition (δ2H) of organic compounds provides information about its geographical origin. In this work, δ2H composition of specific compounds released by direct analytical pyrolysis (Py-CSIA) of extra virgin olive oils EVOOs was studied avoiding the use of any chemical and/or physical treatments, derivatization or previous separation steps. A collection of EVOOs from Mediterranean countries (Portugal, Spain, France, Tunisia and Turkey) was used for authentication of the olive oil samples. The δ2H value for 9 pyrolysis compounds present in all EVOOs, ranged between −112 and −267 mUr. These compounds were selected as possible surrogate descriptors linked to the olive oil geographic origin. Principal Component Analysis showed that δ2H was highly correlated with geographical longitude and annual temperature. Multiple Linear Regression analysis revealed that δ2H value of pyrolysis compounds can significantly (P < 0.05) predicts longitude, mean annual temperature and distance to the sea. The results suggest that the methodology used has a high potential to assess EVOOs geographic origin. This is the first report that evaluates δ2H directly from the pyrolysis products of olive oil using Py-CSIA. The approach used represents an innovative, fast, reproducible and reliable authentication technique

¿Normal o patológico? Antropometría y Paleopatología

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200

Influencia del estado de preservación de los restos óseos en el diagnóstico paleopatológico

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200