Propuesta en Supply Chain Management y Logística en la empresa Grupo MCM Ambiental

La gestión de la cadena de suministro o Supply Chain Management (SCM) contempla todos los actores y procesos implicados en el abastecimiento, producción y distribución de un determinado bien o servicio, que proporciona a las compañías que lo aplican a sus procesos logísticos de una mayor competitividad y capacidad de globalización, ante la posibilidad de enfocar las políticas de sus integrantes a las necesidades cada vez más exigentes y cambiantes de los clientes y consumidores, en el desarrollo de este documento tomaremos los conceptos concernientes a cada etapa de la cadena de suministro, los analizaremos y aplicaremos de forma hipotética a los proceso de la empresa Grupo MCM ambiental S.A.C., con el fin de determinar y demostrar su aplicabilidad tanto en empresa manufactureras como de servicios, y los posibles efectos en el funcionamiento de la compañía, para tal fin empezaremos por aplicar los procesos de acuerdo con los enfoques desde lo estratégico y lo transaccional, analizaremos los procesos y propondremos estrategias aplicadas al modelo desde la gestión del inventario, el almacenaje y el transporte, brindando también atención a los procesos logísticos de aprovisionamiento y distribución.Supply chain management or Supply Chain Management (SCM) contemplates all the actors and processes involved in the supply, production and distribution of a certain good or service, provided by the companies that use it for their logistics processes. greater competitiveness and globalization capacity, given the possibility of focusing the policies of its members on the increasingly demanding and changing needs of customers and consumers, in the development of this document we will take the concepts concerning each stage of the chain of supply, analysis and hypothetical applications in the process of the company Grupo MCM ambiental SAC, in order to determine and demonstrate its applicability both in the manufacturing company and services, and the possible effects on the operation of the company, for To this end we will start by applying the processes according to the approaches from the strategic and the transactional, we will analyze s processes and we will propose strategies applied to the model from inventory management, warehousing and transportation, also paying attention to the logistics processes of supply and distribution

Anosmin-1 over-expression increases adult neurogenesis in the subventricular zone and neuroblast migration to the olfactory bulb

New subventricular zone (SVZ)-derived neuroblasts that migrate via the rostral migratory stream are continuously added to the olfactory bulb (OB) of the adult rodent brain. Anosmin-1 (A1) is an extracellular matrix protein that binds to FGF receptor 1 (FGFR1) to exert its biological effects. When mutated as in Kallmann syndrome patients, A1 is associated with severe OB morphogenesis defects leading to anosmia and hypogonadotropic hypogonadism. Here, we show that A1 over-expression in adult mice strongly increases proliferation in the SVZ, mainly with symmetrical divisions, and produces substantial morphological changes in the normal SVZ architecture, where we also report the presence of FGFR1 in almost all SVZ cells. Interestingly, for the first time we show FGFR1 expression in the basal body of primary cilia in neural progenitor cells. Additionally, we have found that A1 over-expression also enhances neuroblast motility, mainly through FGFR1 activity. Together, these changes lead to a selective increase in several GABAergic interneuron populations in different OB layers. These specific alterations in the OB would be sufficient to disrupt the normal processing of sensory information and consequently alter olfactory memory. In summary, this work shows that FGFR1-mediated A1 activity plays a crucial role in the continuous remodelling of the adult OB.This research was supported by grants from the Spanish Ministerio de Economía, Innovación y Competitividad MINECO (SAF2009-07842, ADE10-0010, RD07-0060-2007, RD12-0032-12 and SAF2012-40023 to FdC; and BFU2010-18284 to JMG-V), FISCAM (Gobierno de Castilla-La Mancha, Spain—Grant Number PI2007-66), the Junta de Castilla y León (Spain, to EW), and from the Fundación Eugenio Rodríguez Pascual (Spain) to FdC. DGG and VMB were PhD students hired by Gobierno de Castilla-La Mancha (MOV2010-JI/11 and MOV2007-JI/19, respectively). FdCS is a CSIC staff scientist in special permission hired by SESCAM (Gobierno de Castilla-La Mancha, Spain). PFE was a researcher hired by SESCAM (Gobierno de Castilla-La Mancha) and ADE10-0010.Peer reviewe

Expedición cangrejo negro : informe técnico

El huracán Iota que pasó por las islas de providencia y Santa catalina el 16 de noviembre de 2020 produjo efectos importantes en los ecosistemas de las islas, así como en los servicios que estos ofrecen a las comunidades locales y que dan lugar a un atractivo turístico que se constituye en la principal actividad económica de las islas. Este trabajo corresponde a un esfuerzo por identificar áreas importantes para la prestación de los servicios ecosistémicos (SSE) en especial aquellas que pudieron haber resultado especialmente afectadas como resultado de Iota, para tal fin se aborda un enfoque basado en el análisis de datos geoespaciales, apoyado por la consulta de información secundaria. La revisión de la información secundaria permitió identificar SSE relevantes en la isla fundamentalmente relacionados con protección frente a desastres naturales y servicios de provisión y regulación hídrica, mientras que los análisis espaciales permitieron identificar cuencas importantes frente a estos servicios como Freshwater, Bailey, Bowden y Santa Catalina Sur, los análisis de imágenes satelitales por su parte permitieron identificar áreas afectadas por la pérdida de vegetación y acumulación de biomasa.Bogot

Impact of COVID-19 Lockdown in Eating Disorders: A Multicentre Collaborative International Study

Background. The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable. Aims. (1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography. Methods. The sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES). Results. Patients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient. Conclusions. The psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients

UNIMINUTO: Cinco Años Cambiando Vidas en el Sur del país.

UNIMINUTO: Cinco años cambiando vidas en el sur del país, es construido de manera colectiva por la Corporación Universitaria Minuto de Dios a través del Centro Regional Neiva, sistematiza retos, limitaciones, fortalezas y la prospectiva de la Universidad en el siglo XXI desde los ejes de la docencia, la investigación y la proyección social. El texto contiene cuatro apartados y trece capítulos que dan cuenta de los procesos investigativos adelantados en el Centro Regional, aporta reflexiones en temas educativos, sociales, políticos, económicos y psicológicos . Este libro ofrece al lector la posibilidad de pensar los retos que presenta la Universidad en la formación de ciudadanos y ciudadanas acordes a las realidades contemporáneas, logrando un despliegue significativo de metodologías novedosas y pertinentes para el país y la región Surcolombiana

UNIMINUTO: Cinco Años Cambiando Vidas en el Sur del país.

UNIMINUTO: Cinco años cambiando vidas en el sur del país, es construido de manera colectiva por la Corporación Universitaria Minuto de Dios a través del Centro Regional Neiva, sistematiza retos, limitaciones, fortalezas y la prospectiva de la Universidad en el siglo XXI desde los ejes de la docencia, la investigación y la proyección social. El texto contiene cuatro apartados y trece capítulos que dan cuenta de los procesos investigativos adelantados en el Centro Regional, aporta reflexiones en temas educativos, sociales, políticos, económicos y psicológicos . Este libro ofrece al lector la posibilidad de pensar los retos que presenta la Universidad en la formación de ciudadanos y ciudadanas acordes a las realidades contemporáneas, logrando un despliegue significativo de metodologías novedosas y pertinentes para el país y la región Surcolombiana

All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997Ł2010

Abstract Background: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIVinfected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. Methods: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 personyears (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. Results: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997. Conclusion: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection

Machine Learning approaches to investigate neurophysiological markers in language and perceptual tasks

Poster presentation at the Jornadas de Investigación CIMCYC 2023 (Granada, Spain) The use of machine learning (ML) techniques applied to cognitive neuroscience, especially for neuroimaging analyses, has seen exponential growth. A recent research line of our group focuses on the application of ML techniques to decode two different cognitive processes, perception, and speech, from neuroimaging data. In both lines, electroencephalography (EEG) was recorded from participants while performing either perceptual or language tasks. We applied ML algorithms to decode distinct parameters related to the task from the EEG data. For the perceptual tasks, participants had to detect near-threshold Gabor stimuli and report the orientation of said stimulus and whether they were able to see it or not. Preliminary results from the decoding analyses show that it is possible to discriminate these task responses from the recorded EEG data, with the peak decoding accuracy at around 500 milliseconds after stimulus presentation and in frequency bands such as alpha and beta. For the speech decoding tasks, we collected intracranial EEG data from epilepsy patients while they performed word recognition and picture naming tasks, where the participant produced spoken as well as imagined speech. The data went through a meticulous preprocessing procedure, which is now automatised. Preliminary evaluations suggest differences in high-gamma EEG features corresponding to spoken and imagined words, leading us towards gaining an understanding of brain regions involved in language production. Linear regression and deep learning algorithms were employed to decode speech from iEEG and to classify picture categories and the presence of vowels in the spoken words

Respiratory Subsets in Patients with Moderate to Severe Acute Respiratory Distress Syndrome for Early Prediction of Death.

Introduction: In patients with acute respiratory distress syndrome (ARDS), the PaO2/FiO2 ratio at the time of ARDS diagnosis is weakly associated with mortality. We hypothesized that setting a PaO2/FiO2 threshold in 150 mm Hg at 24 h from moderate/severe ARDS diagnosis would improve predictions of death in the intensive care unit (ICU). Methods: We conducted an ancillary study in 1303 patients with moderate to severe ARDS managed with lung-protective ventilation enrolled consecutively in four prospective multicenter cohorts in a network of ICUs. The first three cohorts were pooled (n = 1000) as a testing cohort; the fourth cohort (n = 303) served as a confirmatory cohort. Based on the thresholds for PaO2/FiO2 (150 mm Hg) and positive end-expiratory pressure (PEEP) (10 cm H2O), the patients were classified into four possible subsets at baseline and at 24 h using a standardized PEEP-FiO2 approach: (I) PaO2/FiO2 ≥ 150 at PEE