Санкции против России: эффективность и влияние на национальную безопасность России

The current stage of development of the entire world community, including Russia, is associated with such a thing as “sanction wars”. As an example, one can recall the introduction of US sanctions against China, Iran, Venezuela, and other countries, European sanctions, as well as various countersanctions of countries subjected to sanction pressure.As part of this paper, the sanctions imposed against Russia in connection with the Ukrainian crisis in 2014 and countersanctions imposed by Russia are considered. The purpose of this study is to identify the impact of sanctions and countersanctions on the national security of Russia. In this regard, the following tasks were set: to identify the list of sanctions of Western countries imposed against Russia and their impact on the national security of Russia, to identify the list of countersanctions of Russia against Western countries and their impact on the national security of Russia, to identify further actions of Russia to ensure the national security of Russia under the conditions of sanction pressure.The study is based on the dialectical, historical and systematic approach, analysis, synthesis and comparison, induction and deduction. The study analyzed Russian and international literature on the topic of sanctions and their impact on national security.Based on the results of the study, the directions of economic development based on the promotion of import substitution, innovation and public-private partnerships with the aim of ensuring the national security of Russia under the conditions of sanction pressure have been proposed. The findings of the study may be of interest to the academic community, studying the impact of sanctions on the national security of the country. The experience of Russia may be of interest to countries subjected to sanction pressure from the United States and its allies.La etapa actual de desarrollo de toda la comunidad mundial, incluida Rusia, está asociada con cosas como "guerras de sanciones", por ejemplo, podemos recordar la introducción de sanciones de Estados Unidos contra China, Irán, Venezuela y otros países, sanciones europeas, así como varios países. sometido a presión de sanción. Como parte de este artículo, se consideran las sanciones impuestas contra Rusia en relación con la crisis ucraniana en 2014 y las sanciones contrarias impuestas por Rusia. El propósito de este estudio es determinar el impacto de las sanciones y contra-sanciones en la seguridad nacional de Rusia. En este sentido, se establecieron las siguientes tareas: determinar la lista de sanciones de los países occidentales impuestas contra Rusia, y su impacto en la seguridad nacional de Rusia, determinar la lista de contra-sanciones de Rusia contra los países occidentales y su impacto en la seguridad nacional de Rusia, para determinar acciones adicionales de Rusia para garantizar la seguridad nacional de Rusia bajo condiciones de presión de sanción. El estudio se basa en un enfoque dialéctico, histórico y sistemático, análisis, síntesis y comparación, inducción y deducción. El estudio analizó la literatura rusa e internacional sobre el tema de las sanciones y su impacto en la seguridad nacional. Sobre la base de los resultados del estudio, se proponen las direcciones del desarrollo económico basadas en la promoción de la sustitución de importaciones, la innovación y las asociaciones público-privadas con el objetivo de garantizar la seguridad nacional de Rusia en condiciones de presión de sanción. Los hallazgos del estudio pueden ser de interés para la comunidad científica, al estudiar el impacto de las sanciones en la seguridad nacional del país, la experiencia de Rusia puede ser de interés para los países sujetos a la presión de las sanciones de los Estados Unidos y sus aliados.современный этап развития всего мирового сообщества, в том числе России, связан с таким явлением как «санкционные войны», в качестве примера можно вспомнить введение санкции США против Китая, Ирана, Венесуэлы и других стран, европейские санкции, а также различные контрсанкции стран, подвергшихся санкционному давлению.В рамках данной статьи рассмотрены санкции, введенные против России в связи с украинским кризисом в 2014 году, и контрсанкции введенные Россией. Целью данного исследования является определение влияния санкций и контрсанкций на национальную безопасность России. В этой связи были поставлены следующие задачи: определить перечень санкции западных стран, введенных против России, и их влияние на национальную безопасность России, определить перечень контрсанкций России против западных стран и их влияние на национальную безопасность России, определить дальнейшее действия России по обеспечению национальной безопасности России в условиях санкционного давления.Исследование основано на диалектическом, историческом и системном подходе, анализе, синтезе и сравнении, индукции и дедукции. В исследовании проанализирована российская и международная литература на тему санкций и их влияния на национальную безопасность.По итогам исследования предложены направления экономического развития, основанные на стимулировании импортозамещения, инноваций и государственно-частного партнерства с целью обеспечения национальной безопасности России в условиях санкционного давления. Выводы, полученные в ходе исследования, могут быть интересны научному сообществу, изучающие влияние санкций на национальную безопасность страны, опыт России может быть интересен странам, подвергшимся санкционному давлению США и их союзников

Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects

Zolotareva O, Saik OV, Königs C, et al. Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. Scientific Reports. 2019;9(1): 16302.Asthma and hypertension are complex diseases coinciding more frequently than expected by chance. Unraveling the mechanisms of comorbidity of asthma and hypertension is necessary for choosing the most appropriate treatment plan for patients with this comorbidity. Since both diseases have a strong genetic component in this article we aimed to find and study genes simultaneously associated with asthma and hypertension. We identified 330 shared genes and found that they form six modules on the interaction network. A strong overlap between genes associated with asthma and hypertension was found on the level of eQTL regulated genes and between targets of drugs relevant for asthma and hypertension. This suggests that the phenomenon of comorbidity of asthma and hypertension may be explained by altered genetic regulation or result from drug side effects. In this work we also demonstrate that not only drug indications but also contraindications provide an important source of molecular evidence helpful to uncover disease mechanisms. These findings give a clue to the possible mechanisms of comorbidity and highlight the direction for future research

Genes of the Glutamatergic System and Tardive Dyskinesia in Patients with Schizophrenia

Background: Tardive dyskinesia (TD) is an extrapyramidal side effect of the long-term use of antipsychotics. In the present study, the role of glutamatergic system genes in the pathogenesis of total TD, as well as two phenotypic forms, orofacial TD and limb-truncal TD, was studied. Methods: A set of 46 SNPs of the glutamatergic system genes (GRIN2A, GRIN2B, GRIK4, GRM3, GRM7, GRM8, SLC1A2, SLC1A3, SLC17A7) was studied in a population of 704 Caucasian patients with schizophrenia. Genotyping was performed using the MassARRAY Analyzer 4 (Agena Bioscience™). Logistic regression analysis was performed to test for the association of TD with the SNPs while adjusting for confounders. Results: No statistically significant associations between the SNPs and TD were found after adjusting for multiple testing. Since three SNPs of the SLC1A2 gene demonstrated nominally significant associations, we carried out a haplotype analysis for these SNPs. This analysis identified a risk haplotype for TD comprising CAT alleles of the SLC1A2 gene SNPs rs1042113, rs10768121, and rs12361171. Nominally significant associations were identified for SLC1A3 rs2229894 and orofacial TD, as well as for GRIN2A rs7192557 and limb-truncal TD. Conclusions: Genes encoding for mGlu3, EAAT2, and EAAT1 may be involved in the development of TD in schizophrenia patients

Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism. Methods: We recruited 517 clinically admitted white patients (269M/248F) with a verified diagnosis of schizophrenia (ICD-10) and with a stable physical condition. Participants were classified for having or not having MetS and genotyped for 20 single-nucleotide polymorphisms (SNPs) in the genes encoding insulin-induced gene 2 (INSIG2), ghrelin (GHRL), leptin (LEP), and leptin receptor (LEPR). Results: The 139 patients (26.9%) with MetS were significantly more likely to be women, older, and ill longer, and had a larger body mass index (BMI). Four polymorphisms (rs10490624, rs17587100, rs9308762, and rs10490816) did not meet the Hardy–Weinberg equilibrium (HWE) criterion and were excluded. Only genotypes and alleles of the rs3828942 of LEP gene (chi2 = 7.665, p = 0.022; chi2 = 5.136, p = 0.023) and the genotypes of the rs17047718 of INSIG2 gene (chi2 = 7.7, p = 0.021) had a significant association with MetS. Conclusions: The results of our study suggest that the LEP and INSIG2 genes play a certain causal role in the development of MetS in patients with schizophrenia

The Gender-Specific Association of DRD2 Polymorphism with Metabolic Syndrome in Patients with Schizophrenia

BACKGROUND: Metabolic syndrome is widespread in patients with schizophrenia receiving long-term antipsychotic therapy. Dopamine D2 receptors play an important role in mediating both the therapeutic actions of antipsychotics and their side effects. The present study examined the association of two polymorphisms of the DRD2 gene with metabolic syndrome in patients with schizophrenia. METHODS: We examined 517 patients from several regions of Siberia (Russia) with a clinical diagnosis of schizophrenia. Genotyping of two single nucleotide polymorphisms rs1799732 and rs4436578 of the dopamine D2 receptor gene (DRD2) was performed in a population of 471 patients. The results were analyzed using chi-square tests. RESULTS: Functional polymorphism rs1799732 of the DRD2 gene is associated with drug-induced metabolic syndrome in women with schizophrenia. CONCLUSIONS: Our results show that the DRD2 gene may be involved in the pathogenesis of metabolic disorders in patients with schizophrenia. Further analysis of possible genetic markers will allow for personalized treatment with minimal side effects and optimal efficacy. This which seems relevant in light of the recent focus on improving the quality of life and ensuring a high level of social adaptation of patients with schizophrenia

EUNIS Habitat Classification: Expert system, characteristic species combinations and distribution maps of European habitats

Aim: The EUNIS Habitat Classification is a widely used reference framework for European habitat types (habitats), but it lacks formal definitions of individual habitats that would enable their unequivocal identification. Our goal was to develop a tool for assigning vegetation‐plot records to the habitats of the EUNIS system, use it to classify a European vegetation‐plot database, and compile statistically‐derived characteristic species combinations and distribution maps for these habitats. Location: Europe. Methods: We developed the classification expert system EUNIS‐ESy, which contains definitions of individual EUNIS habitats based on their species composition and geographic location. Each habitat was formally defined as a formula in a computer language combining algebraic and set‐theoretic concepts with formal logical operators. We applied this expert system to classify 1,261,373 vegetation plots from the European Vegetation Archive (EVA) and other databases. Then we determined diagnostic, constant and dominant species for each habitat by calculating species‐to‐habitat fidelity and constancy (occurrence frequency) in the classified data set. Finally, we mapped the plot locations for each habitat. Results: Formal definitions were developed for 199 habitats at Level 3 of the EUNIS hierarchy, including 25 coastal, 18 wetland, 55 grassland, 43 shrubland, 46 forest and 12 man‐made habitats. The expert system classified 1,125,121 vegetation plots to these habitat groups and 73,188 to other habitats, while 63,064 plots remained unclassified or were classified to more than one habitat. Data on each habitat were summarized in factsheets containing habitat description, distribution map, corresponding syntaxa and characteristic species combination. Conclusions: EUNIS habitats were characterized for the first time in terms of their species composition and distribution, based on a classification of a European database of vegetation plots using the newly developed electronic expert system EUNIS‐ESy. The data provided and the expert system have considerable potential for future use in European nature conservation planning, monitoring and assessment

Structuring of Surface Films Formed on Magnesium in Hot Chlorobenzotriazole Vapors

Chamberprotection of metals from atmospheric corrosion is a variety of vapor-phase inhibition. It is based on the effect of adsorption films formed in the vapors of low-volatile corrosion inhibitors at elevated temperatures. The paper analyzes the specific features of the chamber protection of a magnesium alloy with chlorobenzotriazole. It has been found that the protective properties of surface films formed in hot vapors of this compound increase upon exposure of the metal to air. The processes of structuring of protective films that occur in this case have been studied by a set of corrosion, electrochemical and physical methods. It has been shown that chamber treatment of the alloy is accompanied by chlorobenzotriazole adsorption and uniform thickening of the surface oxide-hydroxide layer. In this case, the corrosion processes slow down by a factor of up to 10. Prolonged exposure of the samples in air after the chamber treatment results in additional oxidation of magnesium and hydroxylation of the oxide. However, the oxide-hydroxide layer does not grow on the entire surface, but as separate islets. Such a change in the structure of the surface films results in an additional 10-fold increase in the corrosion resistance of the magnesium alloy

Mutual Effect of Components of Protective Films Applied on Copper and Brass from Octadecylamine and 1,2,3-Benzotriazole Vapors

It has been shown by a set of corrosion, electrochemical and physical methods that a chamber corrosion inhibitor that consists of a mixture of octadecylamine (ODA) and benzotriazole (BTA) efficiently protects copper and brass from atmospheric corrosion and can be used for the temporary protection of metal items. The optimum temperatures of treatment with the ODA + BTA mixed inhibitor is 120 °C for brass and 100 °C for copper. One-hour treatment in ODA + BTA vapors at these temperatures results in the formation of nanosized adsorption films on the surface of these metals. These films stabilize the passive state and provide efficient temporary protection of metal items. The ODA + BTA inhibitor is superior to its components in terms of protective aftereffect. Our analysis of the mutual effect of BTA and ODA indicated that they show an antagonism of protective action on copper, but there is also a synergistic enhancement in the case of brass. Electrochemical impedance spectroscopy studies demonstrate that the inhibitors in question mainly act by using a blocking mechanism on copper and brass. Chamber treatment of the metals studied in vapors of the ODA + BTA mixture resulted in a noticeable hydrophobization of the copper surface and an insignificant effect on the brass surface. Chamber treatment of copper samples with artificially created polymodal roughness made it possible to obtain a superhydrophobic surface

Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases

Bragina EY, Goncharova IA, Garaeva AF, et al. Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases. JOURNAL OF INTEGRATIVE BIOINFORMATICS. 2018;15(4): 20180052.Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARDS); comorbidity between asthma and hypertension was found to be associated with o rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is En different from genetic backgrounds of both diseases manifesting isolated

Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases

Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARD8); comorbidity between asthma and hypertension was found to be associated with rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is different from genetic backgrounds of both diseases manifesting isolated