Improved 1000-m running performance and pacing strategy with caffeine and placebo effect: a balanced placebo design study

Purpose: To investigate the placebo effect of caffeine on pacing strategy and performance over 1000-m running time-trials using a balanced placebo design. Methods: Eleven well-trained male middle-distance athletes performed seven 1000-m time-trials (one familiarisation, two baseline and four experimental). Experimental trials consisted of the administration of four treatments: informed caffeine/received caffeine (CC), informed caffeine/received placebo (CP), informed placebo/received caffeine (PC), and informed placebo/received placebo (PP). Treatments were randomized. Split times were recorded at 200-, 400-, 600-, 800- and 1000-m and peak heart rate (HRpeak) and rating of perceived exertion (RPE) were recorded at the completion of the trial. Results: Relative to baseline, participants ran faster during CC (d = 0.42) and CP (d = 0.43). These changes were associated with an increased pace during the first half of the trial. No differences were shown in pacing or performance between baseline and the PC (d = 0.21) and open administration of placebo (d = 0.10). No differences were reported between treatments for HRpeak (η2 = 0.084) and RPE (η2 = 0.009). Conclusions: Our results indicate that the effect of believing to have ingested caffeine improved performance to the same magnitude as actually receiving caffeine. These improvements were associated with an increase in pace during the first half of the time-trial

Lattice and spin excitations in multiferroic h-YMnO3

We used Raman and terahertz spectroscopies to investigate lattice and magnetic excitations and their cross-coupling in the hexagonal YMnO3 multiferroic. Two phonon modes are strongly affected by the magnetic order. Magnon excitations have been identified thanks to comparison with neutron measurements and spin wave calculations but no electromagnon has been observed. In addition, we evidenced two additional Raman active peaks. We have compared this observation with the anti-crossing between magnon and acoustic phonon branches measured by neutron. These optical measurements underly the unusual strong spin-phonon coupling

Periodic mass loss episodes due to an oscillation mode with variable amplitude in the hot supergiant HD50064

We aim to interpret the photometric and spectroscopic variability of the luminous blue variable supergiant HD\,50064 ($V=8.21$).CoRoT space photometry and follow-up high-resolution spectroscopy, with a time base of 137\,d and 169\,d, respectively, was gathered, analysed and interpreted using standard time series analysis and light curve modelling methods as well as spectral line diagnostics.The space photometry reveals one period of 37\,d, which undergoes a sudden amplitude change with a factor 1.6. The pulsation period is confirmed in the spectroscopy, which additionally reveals metal line radial velocity values differing by $\sim 30\,$km\,s$^{-1}$ depending on the spectral line and on the epoch. We estimate \teff$\sim$13\,500\,K, \logg$\sim$1.5 from the equivalent width of Si lines. The Balmer lines reveal that the star undergoes episodes of changing mass loss on a time scale similar to the changes in the photometric and spectroscopic variability, with an average value of $\log\dot{\rm M}\simeq-5$ (in M$_\odot$\,yr$^{-1}$). We tentatively interpret the 37\,d period as due to a strange mode oscillation.Comment: 4 pages, accepted for publication in Astronomy & Astrophysics Letter

CoRoT observations of O stars: diverse origins of variability

Six O-type stars were observed continuously by the CoRoT satellite during a 34.3-day run. The unprecedented quality of the data allows us to detect even low-amplitude stellar pulsations in some of these stars (HD 46202 and the binaries HD 46149 and Plaskett's star). These cover both opacity-driven modes and solar-like stochastic oscillations, both of importance to the asteroseismological modelling of O stars. Additional effects can be seen in the CoRoT light curves, such as binarity and rotational modulation. Some of the hottest O-type stars (HD 46223, HD 46150 and HD 46966) are dominated by the presence of red-noise: we speculate that this is related to a sub-surface convection zone.Comment: 5 pages, 3 figures, conference paper. To be published in "Four decades of Research on Massive Stars", Astronomical Society of the Pacific. Eds. C. Robert, N. St-Louis and L. Drisse

Plaskett's Star: Analysis of the CoRoT photometric data

The SRa02 of the CoRoT space mission for Asteroseismology was partly devoted to stars belonging to the Mon OB2 association. An intense monitoring was performed on Plaskett's Star (HD47129) and the unprecedented quality of the light curve allows us to shed new light on this very massive, non-eclipsing binary system. We particularly aimed at detecting periodic variability which might be associated with pulsations or interactions between both components. We also searched for variations related to the orbital cycle which could help to constrain the inclination and the morphology of the binary system. A Fourier-based prewhitening and a multiperiodic fitting procedure were applied to analyse the time series and extract the frequencies of variations. We describe the noise properties to tentatively define an appropriate significance criterion, to only point out the peaks at a certain significance level. We also detect the variations related to the orbital motion and study them by using the NIGHTFALL program. The periodogram exhibits a majority of peaks at low frequencies. Among these peaks, we highlight a list of about 43 values, including notably two different sets of harmonic frequencies whose fundamental peaks are located at about 0.07 and 0.82d-1. The former represents the orbital frequency of the binary system whilst the latter could probably be associated with non-radial pulsations. The study of the 0.07d-1 variations reveals the presence of a hot spot most probably situated on the primary star and facing the secondary. The investigation of this unique dataset constitutes a further step in the understanding of Plaskett's Star. These results provide a first basis for future seismic modelling. The existence of a hot region between both components renders the determination of the inclination ambiguous.Comment: Accepted in A&A, 13 pages, 7 figures, 2 table

Consensus statement on placebo effects in sports and exercise: the need for conceptual clarity, methodological rigour, and the elucidation of neurobiological mechanisms.

In June 2017 a group of experts in anthropology, biology, kinesiology, neuroscience, physiology, and psychology convened in Canterbury, UK, to address questions relating to the placebo effect in sport and exercise. The event was supported exclusively by Quality Related (QR) funding from the Higher Education Funding Council for England (HEFCE). The funder did not influence the content or conclusions of the group. No competing interests were declared by any delegate. During the meeting and in follow-up correspondence, all delegates agreed the need to communicate the outcomes of the meeting via a brief consensus statement. The two specific aims of this statement are to encourage researchers in sport and exercise science to: 1. Where possible, adopt research methods that more effectively elucidate the role of the brain in mediating the effects of treatments and interventions. 2. Where possible, adopt methods that factor for and/or quantify placebo effects that could explain a percentage of inter-individual variability in response to treatments and interventio

Platypnea-orthodeoxia associated with a fenestrated atrial septal aneurysm: Case Report

BACKGROUND: Platypnea-orthodeoxia describes the condition of combined dyspnea and hypoxia respectively, whilst in the upright position, which improves in the recumbent position. CASE REPORT: We present a case of platypnea-orthodeoxia due to a fenestrated atrial septal defect associated with an atrial septal aneurysm. Due to the fenestrated nature of the atrial septal defect, surgical rather than percutaneous correction was performed. CONCLUSION: A high index of suspicion is required to diagnose the syndrome of platypnea-orthodeoxia. Careful echocardiographic evaluation is required to identify the syndrome, and to determine suitability for percutaneous repair

Variability in the CoRoT photometry of three hot O-type stars. HD 46223, HD 46150 and HD 46966

The detection of pulsational frequencies in stellar photometry is required as input for asteroseismological modelling. The second short run (SRa02) of the CoRoT mission has provided photometric data of unprecedented quality and time-coverage for a number of O-type stars. We analyse the CoRoT data corresponding to three hot O-type stars, describing the properties of their light curves and we search for pulsational frequencies, which we then compare to theoretical model predictions. We determine the amplitude spectrum of the data, using the Lomb-Scargle and a multifrequency HMM-like technique. Frequencies are extracted by prewhitening, and their significance is evaluated under the assumption that the light curve is dominated by red noise. We search for harmonics, linear combinations and regular spacings among these frequencies. We use simulations with the same time sampling as the data as a powerful tool to judge the significance of our results. From the theoretical point of view, we use the MAD non-adiabatic pulsation code to determine the expected frequencies of excited modes. A substantial number of frequencies is listed, but none can be convincingly identified as being connected to pulsations. The amplitude spectrum is dominated by red noise. Theoretical modelling shows that all three O-type stars can have excited modes but the relation between the theoretical frequencies and the observed spectrum is not obvious. The dominant red noise component in the hot O-type stars studied here clearly points to a different origin than the pulsations seen in cooler O stars. The physical cause of this red noise is unclear, but we speculate on the possibility of sub-surface convection, granulation, or stellar wind inhomogeneities being responsible.Comment: 13 pages, 8 figures, A&A accepted. Tables 2, 3 and 4 available on ftp://omaftp.oma.be/dist/astro/Blomme.R/CoRoT

The placebo and nocebo effect on sports performance: A systematic review

This is an accepted manuscript of an article published by Taylor and Francis in European Journal of Sport Science on 20/08/2019, available online: https://www.tandfonline.com/doi/full/10.1080/17461391.2019.1655098 The accepted version of the publication may differ from the final published version.The aim of this review was to determine the magnitude of the placebo and nocebo effect on sport performance. Articles published before March 2019 were located using Medline, Web of Science, PubMed, EBSCO, Science Direct, and Scopus. Studies that examined placebo and nocebo effects of an objective dependent variable on sports performance, which included a control or baseline condition, were included in the analysis. Studies were classified into two categories of ergogenic aids: 1) nutritional and 2) mechanical. Cohen’s d effect sizes were calculated from 32 studies involving 1,513 participants. Small to moderate placebo effects were found for both placebo (d = 0.36) and nocebo (d = 0.37) effects and when separated by nutritional (d = 0.35) and mechanical (d = 0.47) ergogenic aids. The pooled effect size revealed a small to moderate effect size across all studies (d = 0.38). Results suggest that placebo and nocebo effects can exert a small to moderate effect on sports performance

Superconductivity in Ce- and U-based "122" heavy-fermion compounds

This review discusses the heavy-fermion superconductivity in Ce- and U-based compounds crystallizing in the body-centered tetragonal ThCr2Si2 structure. Special attention will be paid to the theoretical background of these systems which are located close to a magnetic instability.Comment: 12 pages, 9 figures. Invited topical review (special issue on "Recent Developments in Superconductivity") Metadata and references update