1,857 research outputs found
Habituation of the C-start response in larval zebrafish exhibits several distinct phases and sensitivity to NMDA receptor blockade.
The zebrafish larva has been a valuable model system for genetic and molecular studies of development. More recently, biologists have begun to exploit the surprisingly rich behavioral repertoire of zebrafish larvae to investigate behavior. One prominent behavior exhibited by zebrafish early in development is a rapid escape reflex (the C-start). This reflex is mediated by a relatively simple neural circuit, and is therefore an attractive model behavior for neurobiological investigations of simple forms of learning and memory. Here, we describe two forms of short-lived habituation of the C-start in response to brief pulses of auditory stimuli. A rapid form, persisting for ≥1 min but <15 min, was induced by 120 pulses delivered at 0.5-2.0 Hz. A more extended form (termed "short-term habituation" here), which persisted for ≥25 min but <1 h, was induced by spaced training. The spaced training consisted of 10 blocks of auditory pulses delivered at 1 Hz (5 min interblock interval, 900 pulses per block). We found that these two temporally distinguishable forms of habituation are mediated by different cellular mechanisms. The short-term form depends on activation of N-methyl-d-aspartate receptors (NMDARs), whereas the rapid form does not
Early Fermi Gamma-ray Space Telescope Observations of the Quasar 3C 454.3
This is the first report of Fermi Gamma-ray Space Telescope observations of
the quasar 3C 454.3, which has been undergoing pronounced long-term outbursts
since 2000. The data from the Large Area Telescope (LAT), covering 2008 July 7
- October 6, indicate strong, highly variable gamma-ray emission with an
average flux of ~3 x 10^{-6} photons cm^{-2} s^{-1}, for energies above 100
MeV. The gamma-ray flux is variable, with strong, distinct,
symmetrically-shaped flares for which the flux increases by a factor of several
on a time scale of about three days. This variability indicates a compact
emission region, and the requirement that the source is optically thin to
pair-production implies relativistic beaming with Doppler factor delta > 8,
consistent with the values inferred from VLBI observations of superluminal
expansion (delta ~ 25). The observed gamma-ray spectrum is not consistent with
a simple power-law, but instead steepens strongly above ~2 GeV, and is well
described by a broken power-law with photon indices of ~2.3 and ~3.5 below and
above the break, respectively. This is the first direct observation of a break
in the spectrum of a high luminosity blazar above 100 MeV, and it is likely
direct evidence for an intrinsic break in the energy distribution of the
radiating particles. Alternatively, the spectral softening above 2 GeV could be
due to gamma-ray absorption via photon-photon pair production on the soft X-ray
photon field of the host AGN, but such an interpretation would require the
dissipation region to be located very close (less than 100 gravitational radii)
to the black hole, which would be inconsistent with the X-ray spectrum of the
source.Comment: Accepted by the Astrophysical Journal; corresponding authors: Greg
Madejski ([email protected]) and Benoit Lott ([email protected]
Fermi observations of TeV-selected AGN
We report on observations of TeV-selected AGN made during the first 5.5
months of observations with the Large Area Telescope (LAT) on-board the Fermi
Gamma-ray Space Telescope (Fermi). In total, 96 AGN were selected for study,
each being either (i) a source detected at TeV energies (28 sources) or (ii) an
object that has been studied with TeV instruments and for which an upper-limit
has been reported (68 objects). The Fermi observations show clear detections of
38 of these TeV-selected objects, of which 21 are joint GeV-TeV sources and 29
were not in the third EGRET catalog. For each of the 38 Fermi-detected sources,
spectra and light curves are presented. Most can be described with a power law
of spectral index harder than 2.0, with a spectral break generally required to
accommodate the TeV measurements. Based on an extrapolation of the Fermi
spectrum, we identify sources, not previously detected at TeV energies, which
are promising targets for TeV instruments. Evidence for systematic evolution of
the -ray spectrum with redshift is presented and discussed in the
context of interaction with the EBL.Comment: 51 pages, 6 figures, accepted for The Astronomical Journa
Fermi Large Area Telescope Measurements of the Diffuse Gamma-Ray Emission at Intermediate Galactic Latitudes
The diffuse Galactic gamma-ray emission is produced by cosmic rays (CRs)
interacting with the interstellar gas and radiation field. Measurements by the
Energetic Gamma-Ray Experiment Telescope (EGRET) instrument on the Compton
Gamma-Ray Observatory indicated excess gamma-ray emission > 1 GeV relative to
diffuse Galactic gamma-ray emission models consistent with directly measured CR
spectra (the so-called ``EGRET GeV excess''). The excess emission was observed
in all directions on the sky, and a variety of explanations have been proposed,
including beyond-the-Standard-Model scenarios like annihilating or decaying
dark matter. The Large Area Telescope (LAT) instrument on the Fermi Gamma-ray
Space Telescope has measured the diffuse gamma-ray emission with improved
sensitivity and resolution compared to EGRET. We report on LAT measurements of
the diffuse gamma-ray emission for energies 100 MeV to 10 GeV and Galactic
latitudes 10 deg. <= |b| <= 20 deg. The LAT spectrum for this region of the sky
is well reproduced by a diffuse Galactic gamma-ray emission model that is
consistent with local CR spectra and inconsistent with the EGRET GeV excess.Comment: 2 figures, 1 table, accepted by Physical Review Letters, available
online Dec. 18th, 200
Search for Early Gamma-ray Production in Supernovae Located in a Dense Circumstellar Medium with the Fermi LAT
Supernovae (SNe) exploding in a dense circumstellar medium (CSM) are
hypothesized to accelerate cosmic rays in collisionless shocks and emit GeV
gamma rays and TeV neutrinos on a time scale of several months. We perform the
first systematic search for gamma-ray emission in Fermi LAT data in the energy
range from 100 MeV to 300 GeV from the ensemble of 147 SNe Type IIn exploding
in dense CSM. We search for a gamma-ray excess at each SNe location in a one
year time window. In order to enhance a possible weak signal, we simultaneously
study the closest and optically brightest sources of our sample in a
joint-likelihood analysis in three different time windows (1 year, 6 months and
3 months). For the most promising source of the sample, SN 2010jl (PTF10aaxf),
we repeat the analysis with an extended time window lasting 4.5 years. We do
not find a significant excess in gamma rays for any individual source nor for
the combined sources and provide model-independent flux upper limits for both
cases. In addition, we derive limits on the gamma-ray luminosity and the ratio
of gamma-ray-to-optical luminosity ratio as a function of the index of the
proton injection spectrum assuming a generic gamma-ray production model.
Furthermore, we present detailed flux predictions based on multi-wavelength
observations and the corresponding flux upper limit at 95% confidence level
(CL) for the source SN 2010jl (PTF10aaxf).Comment: Accepted for publication in ApJ. Corresponding author: A. Franckowiak
([email protected]), updated author list and acknowledgement
Gamma-ray flaring activity from the gravitationally lensed blazar PKS 1830-211 observed by Fermi LAT
The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope
routinely detects the highly dust-absorbed, reddened, and MeV-peaked flat
spectrum radio quasar PKS 1830-211 (z=2.507). Its apparent isotropic gamma-ray
luminosity (E>100 MeV) averaged over 3 years of observations and peaking
on 2010 October 14/15 at 2.9 X 10^{50} erg s^{-1}, makes it among the brightest
high-redshift Fermi blazars. No published model with a single lens can account
for all of the observed characteristics of this complex system. Based on radio
observations, one expects time delayed variability to follow about 25 days
after a primary flare, with flux about a factor 1.5 less. Two large gamma-ray
flares of PKS 1830-211 have been detected by the LAT in the considered period
and no substantial evidence for such a delayed activity was found. This allows
us to place a lower limit of about 6 on the gamma rays flux ratio between the
two lensed images. Swift XRT observations from a dedicated Target of
Opportunity program indicate a hard spectrum and with no significant
correlation of X-ray flux with the gamma-ray variability. The spectral energy
distribution can be modeled with inverse Compton scattering of thermal photons
from the dusty torus. The implications of the LAT data in terms of variability,
the lack of evident delayed flare events, and different radio and gamma-ray
flux ratios are discussed. Microlensing effects, absorption, size and location
of the emitting regions, the complex mass distribution of the system, an
energy-dependent inner structure of the source, and flux suppression by the
lens galaxy for one image path may be considered as hypotheses for
understanding our results.Comment: 14 pages, 6 figures, 2 tables. Accepted by the The Astrophysical
Journal. Corresponding authors: S. Ciprini (ASI ASDC & INAF OAR, Rome,
Italy), S. Buson (INAF Padova & Univ. of Padova, Padova, Italy), J. Finke
(NRL, Washington, DC, USA), F. D'Ammando (INAF IRA, Bologna, Italy
The Spectral Energy Distribution of Fermi bright blazars
(Abridged) We have conducted a detailed investigation of the broad-band
spectral properties of the \gamma-ray selected blazars of the Fermi LAT Bright
AGN Sample (LBAS). By combining our accurately estimated Fermi gamma-ray
spectra with Swift, radio, infra-red, optical and other hard X-ray/gamma-ray
data, collected within three months of the LBAS data taking period, we were
able to assemble high-quality and quasi-simultaneous Spectral Energy
Distributions (SED) for 48 LBAS blazars.The SED of these gamma-ray sources is
similar to that of blazars discovered at other wavelengths, clearly showing, in
the usual Log - Log F representation, the typical broad-band
spectral signatures normally attributed to a combination of low-energy
synchrotron radiation followed by inverse Compton emission of one or more
components. We have used these SEDs to characterize the peak intensity of both
the low and the high-energy components. The results have been used to derive
empirical relationships that estimate the position of the two peaks from the
broad-band colors (i.e. the radio to optical and optical to X-ray spectral
slopes) and from the gamma-ray spectral index. Our data show that the
synchrotron peak frequency is positioned between 10 and
10 Hz in broad-lined FSRQs and between and Hz in
featureless BL Lacertae objects.We find that the gamma-ray spectral slope is
strongly correlated with the synchrotron peak energy and with the X-ray
spectral index, as expected at first order in synchrotron - inverse Compton
scenarios. However, simple homogeneous, one-zone, Synchrotron Self Compton
(SSC) models cannot explain most of our SEDs, especially in the case of FSRQs
and low energy peaked (LBL) BL Lacs. (...)Comment: 85 pages, 38 figures, submitted to Ap
Fermi LAT Search for Photon Lines from 30 to 200 GeV and Dark Matter Implications
Dark matter (DM) particle annihilation or decay can produce monochromatic
-rays readily distinguishable from astrophysical sources. -ray
line limits from 30 GeV to 200 GeV obtained from 11 months of Fermi Large Area
Space Telescope data from 20-300 GeV are presented using a selection based on
requirements for a -ray line analysis, and integrated over most of the
sky. We obtain -ray line flux upper limits in the range , and give corresponding DM annihilation
cross-section and decay lifetime limits. Theoretical implications are briefly
discussed.Comment: 6 pages, 1 figure. Accepted for publication by The Physical Review
Letter
Bright AGN Source List from the First Three Months of the Fermi Large Area Telescope All-Sky Survey
The first three months of sky-survey operation with the Fermi Gamma Ray Space
Telescope (Fermi) Large Area Telescope (LAT) reveals 132 bright sources at
|b|>10 deg with test statistic greater than 100 (corresponding to about 10
sigma). Two methods, based on the CGRaBS, CRATES and BZCat catalogs, indicate
high-confidence associations of 106 of these sources with known AGNs. This
sample is referred to as the LAT Bright AGN Sample (LBAS). It contains two
radio galaxies, namely Centaurus A and NGC 1275, and 104 blazars consisting of
57 flat spectrum radio quasars (FSRQs), 42 BL Lac objects, and 5 blazars with
uncertain classification. Four new blazars were discovered on the basis of the
LAT detections. Remarkably, the LBAS includes 10 high-energy peaked BL Lacs
(HBLs), sources which were so far hard to detect in the GeV range. Another 10
lower-confidence associations are found. Only thirty three of the sources, plus
two at |b|>10 deg, were previously detected with EGRET, probably due to the
variable nature of these sources. The analysis of the gamma-ray properties of
the LBAS sources reveals that the average GeV spectra of BL Lac objects are
significantly harder than the spectra of FSRQs. No significant correlation
between radio and peak gamma-ray fluxes is observed. Blazar log N - log S and
luminosity functions are constructed to investigate the evolution of the
different blazar classes, with positive evolution indicated for FSRQs but none
for BLLacs. The contribution of LAT-blazars to the total extragalactic
gamma-ray intensity is estimated.Comment: Submitted to ApJ. Not yet refereed. 61 pages, 26 figure
Detection of 16 Gamma-Ray Pulsars Through Blind Frequency Searches Using the Fermi LAT
Pulsars are rapidly-rotating, highly-magnetized neutron stars emitting
radiation across the electromagnetic spectrum. Although there are more than
1800 known radio pulsars, until recently, only seven were observed to pulse in
gamma rays and these were all discovered at other wavelengths. The Fermi Large
Area Telescope makes it possible to pinpoint neutron stars through their
gamma-ray pulsations. We report the detection of 16 gamma-ray pulsars in blind
frequency searches using the LAT. Most of these pulsars are coincident with
previously unidentified gamma-ray sources, and many are associated with
supernova remnants. Direct detection of gamma-ray pulsars enables studies of
emission mechanisms, population statistics and the energetics of pulsar wind
nebulae and supernova remnants.Comment: Corresponding authors: Michael Dormody, Paul S. Ray, Pablo M. Saz
Parkinson, Marcus Ziegle
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