Impact of Congo Basin deforestation

The interactions between land cover change in Central Africa and the Africa monsoon is investigated using a regional climate model simulation (2000–2007) under a Congo Basin deforestation scenario. Decreased evaporation over the deforested area locally produces a heat low and reduced precipitation. In JJA, this low strengthens the West Africa monsoon causing increased precipitation over the Sahel and decreased precipitation over the Guinea coast. In DJF, it strengthens the south-equatorial African monsoon causing an increase of precipitation over south-equatorial Africa. Therefore our simulations indicate that the biosphere-state in Central Africa may play an important role locally but also remotely via interactions with regional monsoon dynamics. Copyright © 2012 Royal Meteorological Societ

Numerical framework and performance of the new multiple-phase cloud microphysics scheme in RegCM4.5: precipitation, cloud microphysics, and cloud radiative effects

Abstract. We implement and evaluate a new parameterization scheme for stratiform cloud microphysics and precipitation within regional climate model RegCM4. This new parameterization is based on a multiple-phase one-moment cloud microphysics scheme built upon the implicit numerical framework recently developed and implemented in the ECMWF operational forecasting model. The parameterization solves five prognostic equations for water vapour, cloud liquid water, rain, cloud ice, and snow mixing ratios. Compared to the pre-existing scheme, it allows a proper treatment of mixed-phase clouds and a more physically realistic representation of cloud microphysics and precipitation. Various fields from a 10-year long integration of RegCM4 run in tropical band mode with the new scheme are compared with their counterparts using the previous cloud scheme and are evaluated against satellite observations. In addition, an assessment using the Cloud Feedback Model Intercomparison Project (CFMIP) Observational Simulator Package (COSP) for a 1-year sub-period provides additional information for evaluating the cloud optical properties against satellite data. The new microphysics parameterization yields an improved simulation of cloud fields, and in particular it removes the overestimation of upper level cloud characteristics of the previous scheme, increasing the agreement with observations and leading to an amelioration of a long-standing problem in the RegCM system. The vertical cloud profile produced by the new scheme leads to a considerably improvement of the representation of the longwave and shortwave components of the cloud radiative forcing

Adolescents' Utilization of a Tertiary-Level Pediatric Emergency Department in Italy

AimDescribe the use of the emergency department of a tertiary-level children's hospital in Italy by adolescents. MethodsThis retrospective study was based on the medical records of patients aged 13 to 17 years, who accessed the emergency department of the Institute for Maternal and Child Health of Trieste, from 1 January to 31 December 2018. The primary outcome was to describe the leading causes of access, diagnoses, rate of hospitalization, and ward of destination among adolescent patients. ResultsDuring the study period, 24,599 patients accessed the department. Among them, 3,062 were adolescents, for a total of 3,895 unscheduled visits. The principal causes of access were trauma (45.3%) and organic diseases (38.8%). Two hundred and forty nine adolescents (6.4%) had mental health problems. One hundred and forty two adolescents (3.6%) Were Admitted to the Hospital, 54 of Whom (38%) to the Neuropsychiatric Ward, for Mental Health Problems. ConclusionsAmong adolescents seen in this Italian tertiary-level children's hospital, mental health problems represented a small proportion of emergency department visits but were the leading cause of urgent hospitalization

A quasi randomized-controlled trial to evaluate the effectiveness of clowntherapy on children\u2019s anxiety and pain levels in emergency department

The aim of the study is to investigate if the presence of medical clowns during painful procedures in the emergency department (ED) affects children's anxiety and pain. Forty children (4-11 years) admitted to the ED with the need of painful procedures were prospectively enrolled. They were randomly assigned to the clown group, where children interacted with clowns or to the control group in which they were entertained by parents and ED nurses. The children's anxiety was assessed by the Children's Anxiety and Pain Scales; pain was evaluated with the Numerical Rating Scale and Wong-Backer Scale, according to the children's age. Staff and clown's opinions were evaluated by means of dedicated questionnaires. Children's anxiety levels in the clown group were significantly lower than those compared with the control group, while children's pain levels did not change between the two groups. CONCLUSION: The presence of clowns in the ED before and during painful procedures was effective in reducing children's anxiety. WHAT IS KNOWN: \u2022 Anxiety and fear caused by medical procedures exacerbate children's pain and may interfere with the procedure. \u2022 To reduce anxiety, fear, and pain and to facilitate patient's evaluation, different non-pharmacological approaches have been proposed and positive effects of laughter and humor have been reported. What is New: \u2022 The presence of clowns in the waiting room and in the ED during medical evaluation and painful procedures helps to reduce children's anxiet

The archaeological evidence of sea level change in the Mediterranean: guidelines and reappraisals

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Lateglacial and Holocene climate and environmental change in the northeastern Mediterranean region: Diatom evidence from Lake Dojran (Republic of Macedonia/Greece)

The juncture between the west-east and north-south contrasting Holocene climatic domains across the Mediterranean is complex and poorly understood. Diatom analysis of Lake Dojran (Republic of Macedonia/Greece) provides a new insight into lake levels and trophic status during the Lateglacial and Holocene periods in the northeastern Mediterranean. Following a very shallow or even desiccated state at the core base at ca. 12,500 cal yr BP, indicated by sedimentological and hydro-acoustic data, diatoms indicate lake infilling, from a shallow state with abundant benthos to a plankton-dominated relatively high lake level and eutrophic state thereafter. Diatom-inferred shallowing between ca. 12,400 - 12,000 cal yr BP and a very low lake level and eutrophic, oligosaline state between ca. 12,000 - 11,500 cal yr BP provide strong evidence for Younger Dryas aridity. The earliest Holocene (ca. 11,500 - 10,700 cal yr BP) was characterised by a high lake level, followed by a lake-level reduction and increased trophic level between ca. 10,700-8,500 cal yr BP. The lake was relatively deep and exhibited peak Holocene trophic level between ca. 8,500-3,000 cal yr BP, becoming shallow thereafter. The diatom data provide more robust evidence and strengthen previous lake-level interpretation based on sedimentological and geochemical data during the earliest, mid and late Holocene, and also clarify previous uncertainty in interpretation of Lateglacial and early-Holocene lake-level change. Our results are also important in disentangling regional climate effects from local catchment dynamics during the Holocene, and to this end we exploit extant regional palynological evidence for vegetation change in the highlands and lowlands. The importance of seasonality in driving Holocene climate change is assessed by reference to the summer and winter latitudinal temperature gradient (LTG) model of Davis and Brewer (2009). We suggest that increased precipitation drove the high lake level during the earliest Holocene. The early- Holocene low lake level and relatively high trophic state may result climatically from high seasonality of precipitation and locally from limited, nutrient-rich catchment runoff. We argue that the mid- Holocene relatively deep and eutrophic state was driven mainly by local vegetation succession and associated changes in catchment processes, rather than showing a close relationship to climate change. The late-Holocene shallow state may have been influenced by a temperature-induced increase in evaporative concentration, but was coupled with clear evidence for intensified human impact. This study improves understanding of Lateglacial and Holocene climate change in the northeastern Mediterranean, suggests the important role of the LTG on moisture availability during the Holocene, and clarifies the influence of catchment processes on palaeohydrology

Pro Libris: Lubuskie Pismo Literacko-Kulturalne, nr 3 (2008)

152 s. : il.

The first multi-model ensemble of regional climate simulations at kilometer-scale resolution, part I: Evaluation of precipitation

Here we present the first multi-model ensemble of regional climate simulations at kilometer-scale horizontal grid spacing over a decade long period. A total of 23 simulations run with a horizontal grid spacing of ∼ 3 km, driven by ERA-Interim reanalysis, and performed by 22 European research groups are analysed. Six different regional climate models (RCMs) are represented in the ensemble. The simulations are compared against available high-resolution precipitation observations and coarse resolution (∼ 12 km) RCMs with parameterized convection. The model simulations and observations are compared with respect to mean precipitation, precipitation intensity and frequency, and heavy precipitation on daily and hourly timescales in different seasons. The results show that kilometer-scale models produce a more realistic representation of precipitation than the coarse resolution RCMs. The most significant improvements are found for heavy precipitation and precipitation frequency on both daily and hourly time scales in the summer season. In general, kilometer-scale models tend to produce more intense precipitation and reduced wet-hour frequency compared to coarse resolution models. On average, the multi-model mean shows a reduction of bias from ∼ −40% at 12 km to ∼ −3% at 3 km for heavy hourly precipitation in summer. Furthermore, the uncertainty ranges i.e. the variability between the models for wet hour frequency is reduced by half with the use of kilometer-scale models. Although differences between the model simulations at the kilometer-scale and observations still exist, it is evident that these simulations are superior to the coarse-resolution RCM simulations in the representing precipitation in the present-day climate, and thus offer a promising way forward for investigations of climate and climate change at local to regional scales.Fil: Ban, Nikolina. Universidad de Innsbruck; AustriaFil: Caillaud, Cécile. Université de Toulouse; FranciaFil: Coppola, Erika. The Abdus Salam. International Centre for Theoretical Physics; Italia. The Abdus Salam; ItaliaFil: Pichelli, Emanuela. The Abdus Salam; Italia. The Abdus Salam. International Centre for Theoretical Physics; ItaliaFil: Sobolowski, Stefan. Norwegian Research Centre; NoruegaFil: Adinolfi, Marianna. Fondazione Centro Euro-Mediterraneo sui cambiamenti climatici; ItaliaFil: Ahrens, Bodo. Goethe Universitat Frankfurt; AlemaniaFil: Alias, Antoinette. Université de Toulouse; FranciaFil: Anders, Ivonne. German Climate Computing Center; AlemaniaFil: Bastin, Sophie. Universite Paris-Saclay;Fil: Belušić, Danijel. Swedish Meteorological and Hydrological Institute; SuizaFil: Berthou, Ségolène. Met Office Hadley Centre; Reino UnidoFil: Brisson, Erwan. Université de Toulouse; FranciaFil: Cardoso, Rita M.. Universidade Nova de Lisboa; PortugalFil: Chan, Steven C.. University of Newcastle; Reino UnidoFil: Christensen, Ole Bøssing. Danish Meteorological Institute; DinamarcaFil: Fernández, Jesús. Universidad de Cantabria; EspañaFil: Fita Borrell, Lluís. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones del Mar y la Atmósfera. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la Atmósfera; Argentina. Instituto Franco-Argentino sobre Estudios del Clima y sus Impactos; ArgentinaFil: Frisius, Thomas. Helmholtz Gemeinschaft; AlemaniaFil: Gaparac, Goran. Croatia Control Ltd.; CroaciaFil: Giorgi, Filippo. The Abdus Salam. International Centre for Theoretical Physics; Italia. The Abdus Salam; ItaliaFil: Goergen, Klaus. Centre for High-Performance Scientific Computing in Terrestrial Systems; Alemania. Helmholtz Gemeinschaft. Forschungszentrum Jülich; AlemaniaFil: Haugen, Jan Erik. Norwegian Meteorological Institute; NoruegaFil: Hodnebrog, Øivind. Center for International Climate and Environmental Research-Oslo; NoruegaFil: Kartsios, Stergios. Aristotle University Of Thessaloniki; GreciaFil: Katragkou, Eleni. Aristotle University Of Thessaloniki; GreciaFil: Kendon, Elizabeth J.. Met Office Hadley Centre; Reino UnidoFil: Keuler, Klaus. Brandenburg University of Technology Cottbus-Senftenberg; AlemaniaFil: Lavin Gullon, Alvaro. Universidad de Cantabria; EspañaFil: Lenderink, Geert. Royal Netherlands Meteorological Institute; Países Bajo

Major Depletion of Plasmacytoid Dendritic Cells in HIV-2 Infection, an Attenuated Form of HIV Disease

Plasmacytoid dendritic cells (pDC) provide an important link between innate and acquired immunity, mediating their action mainly through IFN-α production. pDC suppress HIV-1 replication, but there is increasing evidence suggesting they may also contribute to the increased levels of cell apoptosis and pan-immune activation associated with disease progression. Although having the same clinical spectrum, HIV-2 infection is characterized by a strikingly lower viremia and a much slower rate of CD4 decline and AIDS progression than HIV-1, irrespective of disease stage. We report here a similar marked reduction in circulating pDC levels in untreated HIV-1 and HIV-2 infections in association with CD4 depletion and T cell activation, in spite of the undetectable viremia found in the majority of HIV-2 patients. Moreover, the same overexpression of CD86 and PD-L1 on circulating pDC was found in both infections irrespective of disease stage or viremia status. Our observation that pDC depletion occurs in HIV-2 infected patients with undetectable viremia indicates that mechanisms other than direct viral infection determine the pDC depletion during persistent infections. However, viremia was associated with an impairment of IFN-α production on a per pDC basis upon TLR9 stimulation. These data support the possibility that diminished function in vitro may relate to prior activation by HIV virions in vivo, in agreement with our finding of higher expression levels of the IFN-α inducible gene, MxA, in HIV-1 than in HIV-2 individuals. Importantly, serum IFN-α levels were not elevated in HIV-2 infected individuals. In conclusion, our data in this unique natural model of “attenuated” HIV immunodeficiency contribute to the understanding of pDC biology in HIV/AIDS pathogenesis, showing that in the absence of detectable viremia a major depletion of circulating pDC in association with a relatively preserved IFN-α production does occur

Assessment of the ensembles regional climate models in the representation of precipitation variability and extremes over Portugal

A new data set of daily gridded observations of precipitation, computed from over 400 stations in Portugal, is used to assess the performance of 12 regional climate models at 25 km resolution, from the ENSEMBLES set, all forced by ERA-40 boundary conditions, for the 1961-2000 period. Standard point error statistics, calculated from grid point and basin aggregated data, and precipitation related climate indices are used to analyze the performance of the different models in representing the main spatial and temporal features of the regional climate, and its extreme events. As a whole, the ENSEMBLES models are found to achieve a good representation of those features, with good spatial correlations with observations. There is a small but relevant negative bias in precipitation, especially in the driest months, leading to systematic errors in related climate indices. The underprediction of precipitation occurs in most percentiles, although this deficiency is partially corrected at the basin level. Interestingly, some of the conclusions concerning the performance of the models are different of what has been found for the contiguous territory of Spain; in particular, ENSEMBLES models appear too dry over Portugal and too wet over Spain. Finally, models behave quite differently in the simulation of some important aspects of local climate, from the mean climatology to high precipitation regimes in localized mountain ranges and in the subsequent drier regions