90 research outputs found
Haut und Psychosomatik – Psychodermatologie heute
ZusammenfassungDie heutige Psychodermatologie beruht auf dem biopsychosozialen Krankheitsmodell der Psychosomatik. Danach sind biologische, psychologische und soziale Faktoren auf verschiedenen Ebenen (von den Molekülen bis zur Biosphäre) durch komplexe, nicht lineare Interaktionen über den gesamten Krankheitsverlauf wesentlich an der Pathogenese jeder Krankheit beteiligt. Es gilt als experimentell gesichert, dass "Emotionen in die Haut gelangen". Die rezente Forschung belegt enge anatomische, physiologische und funktionelle Verbindungen zwischen Haut und Nervensystem; letztere sind ontogenetisch eng verwandt. Diese Verbindungen spiegeln sich in zahlreichen Hautkrankheiten wider, bei denen psychische und somatische ätiologische Faktoren eng miteinander verflochten sind. Dieser Verflechtung sollte ein ganzheitlicher Zugang des Arztes gerecht werden.Bei Anamneseerhebung, Diagnosestellung und Therapiewahl sollten biologische, psychische und soziale Faktoren hinreichend berücksichtigt werden. Die "Sichtbarkeit" des Hautorgans führt dazu, dass die Dermatologie unter den klinischen Fächern eine Sonderstellung einnimmt und dass ein ganzheitlicher psychosomatischer Zugang zum Patienten besonders wichtig ist. Die Lebenslaufperspektive (life course approach) kann zu den Zugangsmethoden der modernen Psychodermatologie gerechnet werden. In Anlehnung an das moderne Konzept der Psychodermatologie gibt es heute weitere entsprechende Teilgebiete wie zum Beispiel Psychogastroenterologie und Psychokardiologie. Im Anschluss an den theoretischen Teil werden einige exemplarisch ausgewählte Hautkrankheiten unter dem psychosomatischen Blickpunkt ausführlicher besprochen
Neuronal Plasticity and the Cholinergic System Are Affected in Atopic Dermatitis and in Response to Acute Experimental Mental Stress in a Randomized Controlled Pilot Study
Rationale In mouse models for atopic dermatitis (AD) hypothalamus pituitary
adrenal axis (HPA) dysfunction and neuropeptide-dependent neurogenic
inflammation explain stress-aggravated flares to some extent. Lately,
cholinergic signaling has emerged as a link between innate and adaptive
immunity as well as stress responses in chronic inflammatory diseases. Here we
aim to determine in humans the impact of acute stress on neuro-immune
interaction as well as on the non-neuronal cholinergic system (NNCS). Methods
Skin biopsies were obtained from 22 individuals (AD patients and matched
healthy control subjects) before and after the Trier social stress test
(TSST). To assess neuro-immune interaction, nerve fiber (NF)-density, NF-mast
cell contacts and mast cell activation were determined by
immunohistomorphometry. To evaluate NNCS effects, expression of secreted
mammal Ly-6/urokinase-type plasminogen activator receptor-related protein
(SLURP) 1 and 2 (endogenous nicotinic acetylcholine receptor ligands) and
their main corresponding receptors were assessed by quantitative RT-PCR.
Results With respect to neuro-immune interaction we found higher numbers of
NGF+ dermal NF in lesional compared to non-lesional AD but lower numbers of
Gap43+ growing NF at baseline. Mast cell-NF contacts correlated with SCORAD
and itch in lesional skin. With respect to the NNCS, nicotinic acetylcholine
receptor α7 (α7nAChR) mRNA was significantly lower in lesional AD skin at
baseline. After TSST, PGP 9.5+ NF numbers dropped in lesional AD as did their
contacts with mast cells. NGF+ NF now correlated with SCORAD and mast cell-NF
contacts with itch in non-lesional skin. At the same time, SLURP-2 levels
increased in lesional AD skin. Conclusions In humans chronic inflammatory and
highly acute psycho-emotional stress interact to modulate cutaneous neuro-
immune communication and NNCS marker expression. These findings may have
consequences for understanding and treatment of chronic inflammatory diseases
in the future
Disease activity and stress are linked in a subpopulation of chronic spontaneous urticaria patients
The psychological burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries.
The contribution of psychological disorders to the burden of skin disease has been poorly explored, and this is a large-scale study to ascertain the association between depression, anxiety, and suicidal ideation with various dermatological diagnoses. This international multicenter observational cross-sectional study was conducted in 13 European countries. In each dermatology clinic, 250 consecutive adult out-patients were recruited to complete a questionnaire, reporting socio-demographic information, negative life events, and suicidal ideation; depression and anxiety were assessed with the Hospital Anxiety and Depression Scale. A clinical examination was performed. A control group was recruited among hospital employees. There were 4,994 participants--3,635 patients and 1,359 controls. Clinical depression was present in 10.1% patients (controls 4.3%, odds ratio (OR) 2.40 (1.67-3.47)). Clinical anxiety was present in 17.2% (controls 11.1%, OR 2.18 (1.68-2.82)). Suicidal ideation was reported by 12.7% of all patients (controls 8.3%, OR 1.94 (1.33-2.82)). For individual diagnoses, only patients with psoriasis had significant association with suicidal ideation. The association with depression and anxiety was highest for patients with psoriasis, atopic dermatitis, hand eczema, and leg ulcers. These results identify a major additional burden of skin disease and have important clinical implications.Peer reviewedFinal Published versio
Attachment styles of dermatological patients in europe : A multicentre study in 13 countries
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License https://creativecommons.org/licenses/by-nc/4.0/. © 2017 Acta Dermato-Venereologica.Attachment styles of dermatological outpatients and satisfaction with their dermatologists were investigated within the framework of a multicentre study conducted in 13 European countries, organized by the European Society for Dermatology and Psychiatry. Attachment style was assessed with the Adult Attachment Scale. Patient satisfaction with the dermatologist was assessed with an 11-degree scale. A total of 3,635 adult outpatients and 1,359 controls participated in the study. Dermatological outpatients were less able to depend on others, were less comfortable with closeness and intimacy, and experienced similar rates of anxiety in relationships as did the controls. Participants who had secure attachment styles reported stressful life events during the last 6 months significantly less often than those who had insecure attachment styles. Patients with secure attachment styles tended to be more satisfied with their dermatologist than did insecure patients. These results suggest that secure attachment of dermatological outpatients may be a protective factor in the management of stress.Peer reviewedFinal Published versio
Exploring the EQ-5D Dimension of Pain/Discomfort in Dermatology Outpatients from a Multicentre Study in 13 European Countries
Pain and discomfort are important symptoms in dermatology. The aim of this cross-sectional, multicentre study was to describe the prevalence of pain/discomfort and its associations in patients with several dermatological conditions across 13 European countries. The outcome was the prevalence of pain/discomfort according to a question of the EQ-5D questionnaire. Data collected from November 2011 to February 2013 were complete for 3,509 consecutive outpatients. Moderate or extreme pain/discomfort was reported by 55.5% of patients and 31.5% of controls with no skin conditions. The highest proportions were reported by patients with hidradenitis suppurativa (92.9%), leg ulcer (81.4%), prurigo (80%) and lichen planus (75.6%). Pain/discomfort was associated with older age, low educational level, clinical severity, flare on scalp or hands, itch, depression, anxiety, low quality of life, and thoughts of suicide. It is important to enquire specifically about pain/discomfort during clinical consultations and to address it when planning a patient's care.publishedVersio
Determinants of psychosocial health in psoriatic patients: a multi-national study
There are limited data on the differences in the impact of psoriasis between various countries with respect to quality of life (QoL). The aim of this study was to explore the psychosocial health of patients with psoriasis in different European countries. A total of 682 patients were recruited in 13 European countries. All patients completed a questionnaire regarding socio-demographic information, negative life events, suicidal ideation and satisfaction with their dermatologist. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS), and QoL with the Dermatology Life Quality Index (DLQI) and EuroQoL (EQ-5D). The lowest anxiety and depression scoring was noted in patients from Denmark, the lowest level of impairment in QoL in subjects from Spain, and the highest level of impairment in QoL in patients from Italy. The most relevant parameters influencing patients' well-being were severity of pruritus and satisfaction with their dermatologist. The level of anxiety and depression symptoms correlated significantly with suicidal ideation
Body dysmorphia in common skin diseases: Results of an observational, cross-sectional multi-centre study among dermatological out-patients in 17 European countries
Background: Body dysmorphic disorder (BDD) is a common psychiatric disorder associated with high costs for healthcare systems as patients may repeatedly ask for different, often not effective interventions. BDD symptoms are more prevalent in patients with dermatological conditions than the general population, but there are no large sample studies comparing the prevalence of BDD symptoms between patients with dermatological conditions and healthy skin controls. Objectives: To compare the prevalence of BDD symptoms between patients with different dermatological conditions and healthy skin controls and to describe sociodemographic, physical and psychological factors associated with BDD symptoms to identify patients who may have a particularly high chance of having this condition. Methods: This observational cross-sectional, comparative multi-centre study included 8295 participants: 5487 consecutive patients with different skin diseases (56% female) recruited among dermatological out-patients at 22 clinics in 17 European countries and 2808 healthy skin controls (66% female). All patients were examined by a dermatologist. BDD symptoms were assessed by the Dysmorphic Concern Questionnaire (DCQ). Sociodemographic data, information on psychological factors and physical conditions were collected. Each patient was given a dermatological diagnosis according to ICD-10 by a dermatologist. Results: The participation rate of invited dermatological patients was 82.4% on average across all centres. BDD symptoms were five times more prevalent in patients with dermatological conditions than in healthy skin controls (10.5% vs. 2.1%). Patients with hyperhidrosis, alopecia and vitiligo had a more than eleven-fold increased chance (adjusted Odds Ratio (OR) > 11) of having BDD symptoms compared to healthy skin controls, and patients with atopic dermatitis, psoriasis, acne, hidradenitis suppurativa, prurigo and bullous diseases had a more than six-fold increased chance (adjusted OR > 6) of having BDD symptoms. Using a logistic regression model, BDD symptoms were significantly related to lower age, female sex, higher psychological stress and feelings of stigmatisation. Conclusions: This study reveals that clinical BDD symptoms are significantly associated with common dermatological diseases. As such symptoms are associated with higher levels of psychological distress and multiple unhelpful consultations, general practitioners and dermatologists should consider BDD and refer patients when identified to an appropriate service for BDD screening and managementpublishedVersio
The psychosocial burden of hand eczema: Data from a European dermatological multicentre study
Background: The essential physical role, visibility and social importance of the hands place a major psychological burden on patients with hand eczema. Objectives: The aim of this study was to identify the psychological, social and clinical characteristics of patients with hand eczema, in particular the prevalences of depression, anxiety, suicidal ideation, and comorbidities. Materials and methods: Data on patients with hand eczema were analysed from a large European multicentre study conducted with dermatology outpatients from 13 countries. Groups of patients and controls were compared to analyse the psychological burden of hand eczema. Results: Female patients with hand eczema had higher Hospital Anxiety and Depression Scale (HADS) scores for anxiety (n = 86, median = 7.0) than controls (n = 900, median = 5.0, P =.02), and for depression (median = 4.0) than controls (3.0, P 1, P =.038, P <.001, and P <.001, respectively]. The median Dermatology Life Quality Index score was 7.0 (n = 68). Discussion: This study identifies a specific psychological burden experienced by hand eczema patients, highlighting the need for focused psychosocial interventions. Physicians in particular should be aware of the need to identify anxiety and depression in female patients.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
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