Submarine record of volcanic island construction and collapse in the Lesser Antilles arc: First scientific drilling of submarine volcanic island landslides by IODP Expedition 340

IODP Expedition 340 successfully drilled a series of sites offshore Montserrat, Martinique and Dominica in the Lesser Antilles from March to April 2012. These are among the few drill sites gathered around volcanic islands, and the first scientific drilling of large and likely tsunamigenic volcanic island-arc landslide deposits. These cores provide evidence and tests of previous hypotheses for the composition and origin of those deposits. Sites U1394, U1399, and U1400 that penetrated landslide deposits recovered exclusively seafloor-sediment, comprising mainly turbidites and hemipelagic deposits, and lacked debris avalanche deposits. This supports the concepts that i/ volcanic debris avalanches tend to stop at the slope break, and ii/ widespread and voluminous failures of pre-existing low-gradient seafloor sediment can be triggered by initial emplacement of material from the volcano. Offshore Martinique (U1399 and 1400), the landslide deposits comprised blocks of parallel strata that were tilted or micro-faulted, sometimes separated by intervals of homogenized sediment (intense shearing), while Site U1394 offshore Montserrat penetrated a flat-lying block of intact strata. The most likely mechanism for generating these large-scale seafloor-sediment failures appears to be propagation of a decollement from proximal areas loaded and incised by a volcanic debris avalanche. These results have implications for the magnitude of tsunami generation. Under some conditions, volcanic island landslide deposits comprised of mainly seafloor sediment will tend to form smaller magnitude tsunamis than equivalent volumes of subaerial block-rich mass flows rapidly entering water. Expedition 340 also successfully drilled sites to access the undisturbed record of eruption fallout layers intercalated with marine sediment which provide an outstanding high-resolution dataset to analyze eruption and landslides cycles, improve understanding of magmatic evolution as well as offshore sedimentation processes. This article is protected by copyright. All rights reserved

Volcanic Evolution of the Back-Arc Pleistocene Payun Matru Volcanic Field (Argentina)

For the first time, about 30 volcanic formations of the back-arc Payun Matru volcanic field (Payun Matru volcanic field, Argentina, 36°S, 69°W) have been sampled for K–Ar geochronology and geochemistry in order to reconstruct the eruptive history of this key province in the Andean back-arc. The Payun Matru volcanic field has been built since final Pleistocene until present with ages ranging from 280 ± 5 to 7 ± 1 ka. Erupted lavas belong to calc-alkaline series, with characteristics of both arc and intraplate magmas. From previous studies, three main units are distinguished: (1) a basaltic field (Los Volcanes), which covers a large surface of the Payun Matru volcanic field, composed of strombolian cones and associated lava flows emitted from 300 ka to Holocene times, (2) the stratovolcano Payun, with intermediate compositions, built around 265 ka, and (3) the shield volcano Payun Matru s.s. characterized by trachytic compositions and a large summit caldera. The earlier stages of the Payun Matru volcano are not dated, but we constrain the major explosive event, related to the eruption of a widespread ignimbrite and to the formation of the caldera, between 168 ± 4 ka (internal wall of caldera) and 82 ± 1 ka (flow within the caldera). Based on the geochemical similarities of the ignimbrite and the upper lava flow of the pre-caldera cone, we suggest that the age of this event is most probably at the older end of this interval. Numerical modeling using a GIS program has been used to reconstruct the morphological evolution for Payun Matru volcano before and after the caldera collapse. The ancient edifice could be modeled as a flattened cone, 2300 m high, with a volume of about 240 km3. The ignimbrite eruption associated with the Payun Matru caldera formation could be related to the regional tectonic environment, which is characterized by multiple Plio-Pleistocene extensional stages during the last 5 Myr. The evolution of the Nazca plate subduction from a flat slab to a normal dip induced an input of fluid mobile elements and asthenosphere plume-like mantle source beneath the Patagonian lithosphere, which yields the observed intraplate signature. We also interpret this geodynamic evolution as the influence of extensive processes in the upper crust leading to caldera-forming eruptions as observed throughout this province

2-18fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) for postchemotherapy seminoma residual lesions : a retrospective validation of the SEMPET trial

Background: 2-18fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) has been recommended in international guidelines in the evaluation of postchemotherapy seminoma residuals. Our trial was designed to validate these recommendations in a larger group of patients. Patients and methods: FDG-PET studies in patients with metastatic seminoma and residual masses after platinum-containing chemotherapy were correlated with either the histology of the resected lesion(s) or the clinical outcome. Results: One hundred and seventy seven FDG-PET results were contributed. Of 127 eligible PET studies, 69% were true negative, 11% true positive, 6% false negative, and 15% false positive. We compared PET scans carried out before and after a cut-off level of 6 weeks after the end of the last chemotherapy cycle. PET sensitivity, specificity, negative predictive value (NPV), and positive predictive value were 50%, 77%, 91%, and 25%, respectively, before the cut-off and 82%, 90%, 95%, and 69% after the cut-off. PET accuracy significantly improved from 73% before to 88% after the cut-off (P = 0.032). Conclusion: Our study confirms the high specificity, sensitivity, and NPV of FDG-PET for evaluating postchemotherapy seminoma residuals. When carried out at an adequate time point, FDG-PET remains a valuable tool for clinical decision-making in this clinical setting and spares patients unnecessary therapy

Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial

Background: In MONALEESA-2, ribociclib plus letrozole showed improved progression-free survival compared with letrozole alone as first-line treatment for postmenopausal patients with hormone receptor (HR)-positive, HER2-negative, advanced breast cancer. MONALEESA-7 aimed to assess the efficacy and safety of ribociclib plus endocrine therapy in premenopausal women with advanced, HR-positive breast cancer. Methods: This phase 3, randomised, double-blind, placebo-controlled trial was done at 188 centres in 30 countries. Eligible patients were premenopausal women aged 18–59 years who had histologically or cytologically confirmed HR-positive, HER2-negative, advanced breast cancer; an Eastern Cooperative Oncology Group performance status of 0 or 1; measurable disease as per Response Evaluation Criteria in Solid Tumors version 1.1 criteria, or at least one predominantly lytic bone lesion; and had not received previous treatment with cyclin-dependent kinases 4 and 6 inhibitors. Endocrine therapy and chemotherapy in the adjuvant or neoadjuvant setting was permitted, as was up to one line of chemotherapy for advanced disease. Patients were randomly assigned (1:1) via interactive response technology to receive oral ribociclib (600 mg/day on a 3-weeks-on, 1-week-off schedule) or matching placebo with either oral tamoxifen (20 mg daily) or a non-steroidal aromatase inhibitor (letrozole 2·5 mg or anastrozole 1 mg, both oral, daily), all with goserelin (3·6 mg administered subcutaneously on day 1 of every 28-day cycle). Patients and investigators were masked to treatment assignment. Efficacy analyses were by intention to treat, and safety was assessed in all patients who received at least one dose of any study treatment. The primary endpoint was investigator-assessed progression-free survival. MONALEESA-7 is registered with ClinicalTrials.gov, NCT02278120 and is ongoing, but no longer enrolling patients. Findings: Between Dec 17, 2014, and Aug 1, 2016, 672 patients were randomly assigned: 335 to the ribociclib group and 337 to the placebo group. Per investigator's assessment, median progression-free survival was 23·8 months (95% CI 19·2–not reached) in the ribociclib group compared with 13·0 months (11·0–16·4) in the placebo group (hazard ratio 0·55, 95% CI 0·44–0·69; p<0·0001). Grade 3 or 4 adverse events reported in more than 10% of patients in either group were neutropenia (203 [61%] of 335 patients in the ribociclib group and 12 [4%] of 337 in the placebo group) and leucopenia (48 [14%] and four [1%]). Serious adverse events occurred in 60 (18%) of 335 patients in the ribociclib group and 39 (12%) of 337 in the placebo group, of which 15 (4%) and six (2%), respectively, were attributed to the study regimen. 12 (4%) of 335 patients in the ribociclib group and ten (3%) of 337 in the placebo group discontinued treatment because of adverse events. No treatment-related deaths occurred. 11 deaths occurred (five [1%] in the ribociclib group and six [2%] in the placebo group) during or within 30 days after treatment, most of which were due to progression of the underlying breast cancer (three [1%] and six [2%]). The remaining two deaths in the ribociclib group were due to an intracranial haemorrhage in an anticoagulated patient, and a pre-existing wound haemorrhage in another patient. Interpretation: Ribociclib plus endocrine therapy improved progression-free survival compared with placebo plus endocrine therapy, and had a manageable safety profile in patients with premenopausal, HR-positive, HER2-negative, advanced breast cancer. The combination could represent a new first-line treatment option for these patients. Funding: Novartis

Active tectonics in Quito, Ecuador, assessed by geomorphological studies, GPS data, and crustal seismicity

International audienceThe Quito Fault System (QFS) extends over 60km along the Interandean Depression in northern Ecuador. Multidisciplinary studies support an interpretation in which two major contemporaneous fault systems affect Quaternary volcanoclastic deposits. Hanging paleovalleys and disruption of drainage networks attest to ongoing crustal deformation and uplift in this region, further confirmed by 15 years of GPS measurements and seismicity. The resulting new kinematic model emphasizes the role of the N-S segmented, en echelon eastward migrating Quito Fault System (QFS). Northeast of this major tectonic feature, the strike-slip Guayllabamba Fault System (GFS) aids the eastward transfer of the regional strain toward Colombia. These two tectonic fault systems are active, and the local focal mechanisms are consistent with the direction of relative GPS velocities and the regional stress tensor. Among active features, inherited N-S direction sutures appear to play a role in confining the active deformation in the Interandean Depression. The most frontal of the Quito faults formed at the tip of a blind thrust, dipping 40 degrees W, is most probably connected at depth to inactive suture to the west. A new GPS data set indicates active shortening rates for Quito blind thrust of up to 4mm/yr, which decreases northward along the fold system as it connects to the strike-slip Guayllabamba Fault System. The proximity of these structures to the densely populated Quito region highlights the need for additional tectonic studies in these regions of Ecuador to generate further hazard assessments