Influencia de la red social Instagram en la percepción de estereotipos físicos presentes en los estudiantes de primer año de la carrera de Comunicación para el Desarrollo durante el primer semestre 2022

Los medios de comunicación han comenzado un proceso de expansión y globalización y gracias al desarrollo de la tecnología el ideal de la belleza se ha homogeneizando, y eso a pesar que la belleza física sea prioridad subjetiva y cambiante, el concepto de esta se ha visto premiado a lo largo de la historia por estereotipos para que se desee una imagen con características no reales que corresponden a un imaginario colectivo, comúnmente aceptado a cómo debe verse una mujer o un hombre que muchas veces te lo imponen las redes sociales y la sociedad (Díaz Muñoz, 2012). Los estereotipos son transmitidos, promovidos y aprendidos con frecuencia con familiares, amigos, medios de comunicación y redes sociales, como la televisión, las revistas y redes sociales es de resaltar el consumo de las redes sociales, se ha venido incrementando en la población en los últimos años destacándose Facebook, Instagram y Twitter como las redes sociales que dominan el mercado (Castro, 2015). Considerando lo anterior la presente investigación pretende descubrir la influencia de la red social Instagram en la percepción de estereotipos físicos presentes en los estudiantes de primer año de la carrera de Comunicación para el Desarrollo durante el primer semestre del año 202

Drug-refractory myasthenia gravis : Clinical characteristics, treatments, and outcome

Altres ajuts: R. Alvarez-Velasco was supported by grant SLT008/18/00207 from the Health Research and Innovation Strategic Plan (PERIS). The NMD-ES Project and F. PlaJunca (data curator) are partially funded by the Centro de Investigacion Biomédica en Red de Enfermedades Raras (CIBERER).To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment. This observational retrospective cross-sectional multicenter study was based on data from the Spanish MG Registry (NMD-ES). Patients were considered refractory when their MG Foundation of America post-interventional status (MGFA-PIS) was unchanged or worse after corticosteroids and two or more other immunosuppressive agents. Clinical and immunologic characteristics of drug-refractory patients, efficiency and toxicity of drugs used, and outcome (MGFA-PIS) at end of follow-up were studied. We included 990 patients from 15 hospitals. Eighty-four patients (68 of 842 anti-acetylcholine receptor [AChR], 5 of 26 anti-muscle-specific tyrosine kinase [MusK], 10 of 120 seronegative, and 1 of 2 double-seropositive patients) were drug refractory. Drug-refractory patients were more frequently women (p < 0.0001), younger at onset (p < 0.0001), and anti-MuSK positive (p = 0.037). Moreover, they more frequently presented a generalized form of the disease, bulbar symptoms, and life-threatening events (p < 0.0001; p = 0.018; and p = 0.002, respectively) than non-drug-refractory patients. Mean follow-up was 9.8 years (SD 4.5). Twenty-four (50%) refractory patients had side effects to one or more of the drugs. At the end of follow-up, 42.9% of drug-refractory patients (42.6% of anti-AChR, 100% of anti-MuSK, and 10% of seronegative patients) and 79.8% of non-drug-refractory patients (p < 0.0001) achieved remission or had minimal manifestations. Eighty percent of drug-refractory-seronegative patients did not respond to any drug tested. In this study, 8.5% of MG patients were drug-refractory. New more specific drugs are needed to treat drug-refractory MG patients

Implementation of a roadmap for the comprehensive diagnosis, follow-up, and research of childhood leukemias in vulnerable regions of Mexico: results from the PRONAII Strategy

The main objective of the National Project for Research and Incidence of Childhood Leukemias is to reduce early mortality rates for these neoplasms in the vulnerable regions of Mexico. This project was conducted in the states of Oaxaca, Puebla, and Tlaxcala. A key strategy of the project is the implementation of an effective roadmap to ensure that leukemia patients are the target of maximum benefit of interdisciplinary collaboration between researchers, clinicians, surveyors, and laboratories. This strategy guarantees the comprehensive management of diagnosis and follow-up samples of pediatric patients with leukemia, centralizing, managing, and analyzing the information collected. Additionally, it allows for a precise diagnosis and monitoring of the disease through immunophenotype and measurable residual disease (MRD) studies, enhancing research and supporting informed clinical decisions for the first time in these regions through a population-based study. This initiative has significantly improved the diagnostic capacity of leukemia in girls, boys, and adolescents in the regions of Oaxaca, Puebla, and Tlaxcala, providing comprehensive, high-quality care with full coverage in the region. Likewise, it has strengthened collaboration between health institutions, researchers, and professionals in the sector, which contributes to reducing the impact of the disease on the community

Mis casos clínicos de especialidades odontológicas

Libro que muestra la atención de casos clínicos particulares referente a las diferentes especialidades odontológicasLibro que muestra la atención de casos clínicos particulares referente a las diferentes especialidades odontológicasUniversidad Autónoma de Campeche Universidad Autónoma del Estado de Hidalgo Universidad Autónoma del Estado de Méxic

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure &lt; 100 mmHg (n = 1127), estimated glomerular filtration rate &lt; 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population

Exercise-induced irisin, a recently discovered myokine, has been linked to insulin resistance, obesity, and other diseases in adults; however, information in children is scarce and contradictory. We analyzed the limited evidence of irisin&#8217;s effects in children and adolescents, and its association with body composition, exercise training, cardiovascular risk factors, and metabolic diseases, as well as the results of dietetic interventions. Both positive and negative correlations between irisin concentrations and body mass index, fat mass, fat-free mass, and other anthropometric parameters were found. Likewise, contradictory evidence was shown associating irisin plasma levels with cardiovascular and metabolic parameters such as glucose, insulin resistance, and cholesterol and other lipid and fatty acid plasma levels in healthy children, as well as in those with obesity and the metabolic syndrome. Gender, puberty, and hormonal differences were also examined. Furthermore, important contradictory findings according to the type and duration of exercise and of dietetic interventions in healthy and unhealthy subjects were demonstrated. In addition, correlations between mother&#8315;infant relations and circulating irisin were also identified. This review discusses the potential role of irisin in health and disease in the pediatric population

Factores climáticos, geográficos y fisiográficos que contribuyen a la distribución potencial del orégano (Lippia spp.) en México

The presence of Lippia graveolens is widely distributed in different sites in some cases confirming an association between the presence of the species and climate, soil and geographical factors. In the state of Tamaulipas, humidity and temperature determine the distribution; in Durango the soil characteristics play that role. In Yucatan, bioclimatic factors have no influence on the distribution of the species, but have an effect on the chemotypes. In the states of Zacatecas, Coahuila and Chihuahua, where more than 80% of oregano is collected, there is no data available on the condition and diversity of this species. Using the Maxent version 3.3.3k program an analysis of information was carried out to estimate the potential distribution of three species of oregano, two of which are considered synonymous: Lippia graveolens and L. berlandieri.La presencia de Lippia graveolens es muy amplia, se distribuye en sitios diversos y confirma en algunos casos una asociación entre la presencia de la especie y factores climáticos, edáficos y geográficos. En Tamaulipas la humedad y la temperatura determinaron la distribución; en Durango, las características edáficas jugaron ese papel. En Yucatán los factores bioclimáticos no tienen influencia en la distribución de la especie, pero sí influyeron en los quimiotipos de la misma. En Zacatecas, Coahuila y Chihuahua, estados donde se recolecta más de 80% del orégano se carece de datos disponibles de condición y diversidad de esta especie. Con el programa Maxent versión 3.3.3k se realizó el análisis de la información y se estimó la distribución potencial de las tres especies de orégano, dos de las cuales son consideradas como sinónimos: Lippia graveolens y L. berlandieri

Tendencias nacionales e internacionales en la formación de abogados

Desde hace mucho tiempo, la Educación en Latinoamérica se encuentra en crisis. Por ello, las Instituciones de Educación Superior, las entidades del Estado y los organismos internacionales han asumido la responsabilidad de establecer una cultura de educar en y para lo superior en términos de calidad, lo cual ha permitido realizar programas, proyectos, convenciones y demás, que contribuyan al mejoramiento de la educación. Igualmente, en las facultades de Derecho también se observa latente esta situación, evidenciándose, en su gran mayoría, en los profesionales que al salir de la academia se encuentran con un mundo diferente al aprendido. Es por esto que se reflexiona –por parte de los estudiosos del Derecho e investigadores en el área de la formación de abogados– sobre los principales inconvenientes en el proceso educativo de futuros jurídicos, hasta replantear el paradigma para la enseñanza del Derecho, y así responder a la dinámica social con un currículo flexible y transdisciplinar