Age, growth and preliminary estimates of maturity of bigeye tuna, Thunnus obesus, in the Australian region

Biological parameters such as age, growth and age (or size) at maturity are vital for accurate stock assessments and management plans to ensure that fisheries develop sustainably. Despite this, very few validated age studies have been conducted for large tropical pelagic species within the Australian region. Age and growth parameters were estimated for bigeye tuna, Thunnus obesus (Lowe, 1839), sampled from longline fisheries in the Australian region using validated techniques based on counts of annual increments. Poor increment clarity reduced the number of otoliths included in the final analysis to only 50% of the 3200 selected for reading (39–178-cm fork length). Microincrement analysis confirmed the position of the first two annual increments in these otoliths. A maximum age of 16 years was obtained, but over 80% of fish in the Australian catch were <5 years old. Growth is most rapid in the first few years of life and asymptotic length is reached at about age 9 to 10 years. The von Bertalanffy growth parameters were estimated at L∞ = 169.09, k = 0.238, and to = –1.706 for the south-west Pacific Ocean and L∞ = 178.41, k = 0.176, and to = –2.500 for the eastern Indian Ocean. These parameters were significantly different, suggesting that there is little mixing between populations in the Pacific and Indian Oceans. Length at 50% maturity for females sampled in northern Queensland was estimated to be 102.4-cm fork length

Herbal Medicine for Hot Flushes Induced by Endocrine Therapy in Women with Breast Cancer: A Systematic Review and Meta-Analysis

Objective. This systematic review was conducted to evaluate the clinical effectiveness and safety of herbal medicine (HM) as an alternative management for hot flushes induced by endocrine therapy in breast cancer patients. Methods. Key English and Chinese language databases were searched from inception to July 2015. Randomized Controlled Trials (RCTs) evaluating the effects of HM on hot flushes induced by endocrine therapy in women with breast cancer were retrieved. We conducted data collection and analysis in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Statistical analysis was performed with the software (Review Manager 5.3). Results. 19 articles were selected from the articles retrieved, and 5 articles met the inclusion criteria for analysis. Some included individual studies showed that HM can relieve hot flushes as well as other menopausal symptoms induced by endocrine therapy among women with breast cancer and improve the quality of life. There are minor side effects related to HM which are well tolerated. Conclusion. Given the small number of included studies and relatively poor methodological quality, there is insufficient evidence to draw positive conclusions regarding the objective benefit of HM. Additional high quality studies are needed with more rigorous methodological approach to answer this question

Development and psychometric properties of the client's assessment of treatment scale for supported accommodation (CAT-SA)

This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research scheme (RP-PG-0610-10097)

Adaptation of the Quality Indicator for Rehabilitative Care (QuIRC) for use in mental health supported accommodation services (QuIRC-SA).

BACKGROUND: No standardised tools for assessing the quality of specialist mental health supported accommodation services exist. To address this, we adapted the Quality Indicator for Rehabilitative care-QuIRC-that was originally developed to assess the quality of longer term inpatient and community based mental health facilities. The QuIRC, which is completed by the service manager and gives ratings of seven domains of care, has good psychometric properties. METHODS: Focus groups with staff of the three main types of supported accommodation in the UK (residential care, supported housing and floating outreach services) were carried out to identify potential amendments to the QuIRC. Additional advice was gained from consultation with three expert panels, two of which comprised service users with lived experience of mental health and supported accommodation services. The amended QuIRC (QuIRC-SA) was piloted with a manager of each of the three service types. Item response variance, inter-rater reliability and internal consistency were assessed in a random sample of 52 services. Factorial structure and discriminant validity were assessed in a larger random sample of 87 services. RESULTS: The QuIRC-SA comprised 143 items of which only 18 items showed a narrow range of response and five items had poor inter-rater reliability. The tool showed good discriminant validity, with supported housing services generally scoring higher than the other two types of supported accommodation on most domains. Exploratory factor analysis showed that the QuIRC-SA items loaded onto the domains to which they had been allocated. CONCLUSIONS: The QuIRC-SA is the first standardised tool for quality assessment of specialist mental health supported accommodation services. Its psychometric properties mean that it has potential for use in research as well as audit and quality improvement programmes. A web based application is being developed to make it more accessible which will produce a printable report for the service manager about the performance of their service, comparison data for similar services and suggestions on how to improve service quality

The Art of Research: A Divergent/Convergent Framework and Opportunities for Science-Based Approaches

Applying science to the current art of producing engineering and research knowledge has proven difficult, in large part because of its seeming complexity. We posit that the microscopic processes underlying research are not so complex, but instead are iterative and interacting cycles of divergent (generation of ideas) and convergent (testing and selecting of ideas) thinking processes. This reductionist framework coherently organizes a wide range of previously disparate microscopic mechanisms which inhibit these processes. We give examples of such inhibitory mechanisms and discuss how deeper scientific understanding of these mechanisms might lead to dis-inhibitory interventions for individuals, networks and institutional levels

Impacts on cooling energy consumption due to the UHI and vegetation changes in Manchester, UK

Climate change projections estimate a rise of approximately 3°C by the 2080s for most of the UK (medium emissions scenario at 50% probability level, 1961-1990 baseline). Warming is a particular concern for urban areas due to urban densification and the Urban Heat Island (UHI) effect. To counteract the UHI, one adaptation strategy for urban areas is increasing the proportion of greenspace, such as parks, street tree plantings, and green roofs. This research employed an interdisciplinary approach to measure and model fine-scale microclimate changes due to greenspace and explore the implications for building energy demand in Manchester, UK. Both the modelled and measured microclimate data informed development of a series of weather files for building energy modelling of three commercial building types. For a scenario adding 5% mature trees to the urban case study, the combination of microclimate modelling and data analysis estimated a maximum hourly air temperature reduction of nearly 1.0°C under peak UHI conditions and wind speed reductions up to 1.0 m/s. These results were used to change the weather files in the building energy modelling, which estimated a reduction of 2.7% in July chiller energy due to the combination of reduced UHI peak hours and eight additional trees shading a three-storey shallow plan building. Energy savings increased to 4.8% under a three-day period of peak UHI conditions.</p

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

The mental health service needs of the Deaf and the development of a National Plan

Issues surrounding the mental health of Deaf people receive little attention from practitioners in mental health services. International studies have shown that Deaf people are vulnerable to misdiagnosis of mental illness, denial of services and inappropriate services. In particular mental health services are unwilling or unable to recognise the relationship between Deaf culture and language and the delivery of adequate mental health promotion, and prevention and treatment of mental illness in the Deaf population. At present, most Deaf clients requiring mental health services only have access to those services provided by hearing professionals, the majority of whom have only superficial knowledge of Deaf culture, New Zealand Sign Language and the dynamics of the Deaf community. In Auckland and Northland, there are no qualified Deaf mental health professionals to deal with major illness such as schizophrenia, depression, and substance abuse and personality disorders within the Deaf community

Fish eating bats: predators of native and exotic species

[Extract] In 1984 Australia's big footed bat, Myotis macropus (from a recent DNA assessment for better or worse and variously known as Myotis adversus and Myotis mallacorum), previously thought to eat insects such as water boatmen and mayflies, was also thought to be a fish eater. The search was initiated after one of us (Simon) found fish scales in a greeting card left in his hand by a nervous bat. In 1970 Peter Dwyer (UQld) observed this species flying over water and dragging its long recurved toes through the water to collect fallen insects, and suggested that it might also catch the occasional fish