Alien Registration- Gauthier, Helene (Lewiston, Androscoggin County)

https://digitalmaine.com/alien_docs/29857/thumbnail.jp

Renal tubular absorption of β2 microglobulin

Renal tubular absorption of β2 microglobulin. 125Iodinated human β2 microglobulin (β2m, 5 to 30 mg) was administered to anesthetized rats. Clearance studies showed a low threshold of excretion of injected β2m and a high Tm of 400 to 600 µg · min-1 · kg-1. A glomerular sieving coefficient of 0.97 was calculated as the slope of the curve: β2m excretion rate = F (plasma β2m × glomerular filtration rate) for values above saturation. Electrophoresis analysis of proteinuria in agarose gel and sodium dodecyl sulfate polyacrylamide gel showed that injection of saturating doses of β2m induced the excretion of proteins of similar size but different charge and that of other proteins of different size. Among the latter, some were excreted transiently in association with β2m, whereas others had a delayed excretion suggesting existence of a complex mechanism of reabsorption whose steps remain to be elucidated.Absorption tubulaire rénale de la β2 microglobuline. De 5 à30 mg de β2 microglobuline (β2m) humaine marquée à l'Iode 125 ont été injectés à des rats anesthésiés. Des études de clairance ont montré un seuil d'excrétion bas et un Tm élevé de 400 à 600 µg · min-1 · kg-1. Un coefficient de tamisage de 0,97 a été mesuré à partir de la pente de la courbe: excretion de β2m = F (concentration plasmatique de β2m × filtration glomérulaire) pour les points au-dessus de la saturation. L'analyse de la protéinurie par électrophorèse sur gel d'agarose et sur gel de polyacrylamide avec dodecyl-sulfate de sodium a montré que l'injection de doses saturantes de β2m provoque l'excretion de protéines de même taille mais de charge différente, ainsi que de protéines de taille différente. Parmi ces dernières, certaines sont excrétées de manière transitoire et en même temps que la β2m, tandis que d'autres ont une excrétion retardée suggérant l'existence d'un mécanisme de réabsorption complexe dont les étapes restent à étudier

The Dark Matter Haloes and Host Galaxies of MgII Absorbers at z~1

Strong foreground absorption features from singly-ionized Magnesium (Mg II) are commonly observed in the spectra of quasars and are presumed to probe a wide range of galactic environments. To date, measurements of the average dark matter halo masses of intervening Mg II absorbers by way of large-scale cross-correlations with luminous galaxies have been limited to z<0.7. In this work we cross-correlate 21 strong (W{\lambda}2796>0.6 {\deg}A) Mg II absorption systems detected in quasar spectra from the Sloan Digital Sky Survey Data Release 7 with ~32,000 spectroscopically confirmed galaxies at 0.7<z<1.45 from the DEEP2 galaxy redshift survey. We measure dark matter (DM) halo biases of b_G=1.44\pm0.02 and b_A=1.49\pm0.45 for the DEEP2 galaxies and Mg II absorbers, respectively, indicating that their clustering amplitudes are roughly consistent. Haloes with the bias we measure for the Mg II absorbers have a corresponding mass of 1.8(+4.2/-1.6) \times 10^12h-1M_sun, although the actual mean absorber halo mass will depend on the precise distribution of absorbers within DM haloes. This mass estimate is consistent with observations at z=0.6, suggesting that the halo masses of typical Mg II absorbers do not significantly evolve from z~1. We additionally measure the average W{\lambda}2796>0.6 \AA gas covering fraction to be f =0.5 within 60 h-1kpc around the DEEP2 galaxies, and we find an absence of coincident strong Mg II absorption beyond a projected separation of ~40 h-1kpc. Although the star-forming z>1 DEEP2 galaxies are known to exhibit ubiquitous blueshifted Mg II absorption, we find no direct evidence in our small sample linking W{\lambda}2796>0.6 \AA absorbers to galaxies with ongoing star formation.Comment: 12 pages, 5 figures, Accepted to MNRA

Beach litter sources around Nuuk, Greenland: An analysis by UArctic summer school graduate course students

Modeling studies illustrate the potential for long-range transport of plastics into the Arctic, although the degree to which this occurs remains relatively undocumented. We utilised a teaching exercise at a UArctic summer school graduate course in Nuuk, Greenland to conduct a preliminary in-depth analysis of beach litter sources in the Nuup Kangerlua fjord. Students and instructors collected and analysed 1800 litter items weighing 200 kg from one location in the fjord and another at its mouth. The results suggest a predominance of local sources to macrolitter, rather than long-range transport from Europe. Fisheries-related items and rope were common. Packaging which could be identified was largely suspected to be products distributed in Greenland, and soft plastics, which rarely disperse far from its source, were also common. The results suggest local measures to reduce mismanaged waste and emissions from fisheries are important for reducing marine litter in West Greenland.publishedVersio

The Influence of Number and Timing of Pregnancies on Breast Cancer Risk for Women With BRCA1 or BRCA2 Mutations

International audienceBACKGROUND:Full-term pregnancy (FTP) is associated with a reduced breast cancer (BC) risk over time, but women are at increased BC risk in the immediate years following an FTP. No large prospective studies, however, have examined whether the number and timing of pregnancies are associated with BC risk for BRCA1 and BRCA2 mutation carriers.METHODS:Using weighted and time-varying Cox proportional hazards models, we investigated whether reproductive events are associated with BC risk for mutation carriers using a retrospective cohort (5707 BRCA1 and 3525 BRCA2 mutation carriers) and a prospective cohort (2276 BRCA1 and 1610 BRCA2 mutation carriers), separately for each cohort and the combined prospective and retrospective cohort.RESULTS:For BRCA1 mutation carriers, there was no overall association with parity compared with nulliparity (combined hazard ratio [HRc] = 0.99, 95% confidence interval [CI] = 0.83 to 1.18). Relative to being uniparous, an increased number of FTPs was associated with decreased BC risk (HRc = 0.79, 95% CI = 0.69 to 0.91; HRc = 0.70, 95% CI = 0.59 to 0.82; HRc = 0.50, 95% CI = 0.40 to 0.63, for 2, 3, and ≥4 FTPs, respectively, P trend < .0001) and increasing duration of breastfeeding was associated with decreased BC risk (combined cohort P trend = .0003). Relative to being nulliparous, uniparous BRCA1 mutation carriers were at increased BC risk in the prospective analysis (prospective hazard ration [HRp] = 1.69, 95% CI = 1.09 to 2.62). For BRCA2 mutation carriers, being parous was associated with a 30% increase in BC risk (HRc = 1.33, 95% CI = 1.05 to 1.69), and there was no apparent decrease in risk associated with multiparity except for having at least 4 FTPs vs. 1 FTP (HRc = 0.72, 95% CI = 0.54 to 0.98).CONCLUSIONS:These findings suggest differential associations with parity between BRCA1 and BRCA2 mutation carriers with higher risk for uniparous BRCA1 carriers and parous BRCA2 carriers

Correction to: Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers.

After publication of the original article [1], we were notified that columns in Table 2 were erroneously displayed

Ambient-noise tomography of the wider Vienna Basin region

We present a new 3-D shear-velocity model for the top 30 km of the crust in the wider Vienna Basin region based on surface waves extracted from ambient-noise cross-correlations. We use continuous seismic records of 63 broad-band stations of the AlpArray project to retrieve interstation Green’s functions from ambient-noise cross-correlations in the period range from 5 to 25 s. From these Green’s functions, we measure Rayleigh group traveltimes, utilizing all four components of the cross-correlation tensor, which are associated with Rayleigh waves (ZZ, RR, RZ and ZR), to exploit multiple measurements per station pair. A set of selection criteria is applied to ensure that we use high-quality recordings of fundamental Rayleigh modes. We regionalize the interstation group velocities in a 5 km × 5 km grid with an average path density of ∼20 paths per cell. From the resulting group-velocity maps, we extract local 1-D dispersion curves for each cell and invert all cells independently to retrieve the crustal shear-velocity structure of the study area. The resulting model provides a previously unachieved lateral resolution of seismic velocities in the region of ∼15 km. As major features, we image the Vienna Basin and Little Hungarian Plain as low-velocity anomalies, and the Bohemian Massif with high velocities. The edges of these features are marked with prominent velocity contrasts correlated with faults, such as the Alpine Front and Vienna Basin transfer fault system. The observed structures correlate well with surface geology, gravitational anomalies and the few known crystalline basement depths from boreholes. For depths larger than those reached by boreholes, the new model allows new insight into the complex structure of the Vienna Basin and surrounding areas, including deep low-velocity zones, which we image with previously unachieved detail. This model may be used in the future to interpret the deeper structures and tectonic evolution of the wider Vienna Basin region, evaluate natural resources, model wave propagation and improve earthquake locations, among others

Arrival angles of teleseismic fundamental mode Rayleigh waves across the AlpArray

The dense AlpArray network allows studying seismic wave propagation with high spatial resolution. Here we introduce an array approach to measure arrival angles of teleseismic Rayleigh waves. The approach combines the advantages of phase correlation as in the two-station method with array beamforming to obtain the phase-velocity vector. 20 earthquakes from the first two years of the AlpArray project are selected, and spatial patterns of arrival-angle deviations across the AlpArray are shown in maps, depending on period and earthquake location. The cause of these intriguing spatial patterns is discussed. A simple wave-propagation modelling example using an isolated anomaly and a Gaussian beam solution suggests that much of the complexity can be explained as a result of wave interference after passing a structural anomaly along the wave paths. This indicates that arrival-angle information constitutes useful additional information on the Earth structure, beyond what is currently used in inversions