Building career capital in high technology research and development organisations

Knowledge workers build their career capital through learning experiences throughout their careers. How this occurs for the R&D knowledge worker has not been previously documented. The loss of key R&D personnel in the hightechnology (high-tech) industry contributes to a loss of tacit knowledge and increased costs. A greater understanding of why and how career capital is accumulated by R&D knowledge workers will facilitate the design of career management practices that could reduce voluntary employee turnover. A qualitative investigation into the applicability of eight widely recognised career capital components revealed a new component that is relevant to the high-tech R&D environment. These applicable career capital components and associated accumulation methods were used to build a quantitative questionnaire that measured the perceptions of 59 knowledge workers in the R&D environment. This research has, for the first time, explicitly defined tangible career capital constructs that are relevant to knowledge workers in the high-tech R&D environment. The findings have been used to develop a model to help organisations understand the career needs of the R&D knowledge worker within the context of the business environment. Recommendations are presented to allow organisations and R&D knowledge workers to leverage off this research.Dissertation (MBA)--University of Pretoria, 2010.Gordon Institute of Business Science (GIBS)unrestricte

Sex differences in health at ages 11, 13 and 15

This paper tests the hypothesis of an emerging or increasing female excess in general ill-health and physical symptoms, as well as psychological distress, during early to mid-adolescence. Self-reported data on general health (longstanding illness and health in the last 12 months), recent symptoms (classified as ‘physical’ and ‘malaise’) and depressive mood were obtained from a large, Scottish, school-based cohort at ages 11, 13 and 15. Generally high levels of health problems at age 11 tended to increase with age, these increases being greater for females than males, not only in respect of depression and ‘malaise’ symptoms, but also limiting illness, ‘poor’ self-rated health, headaches, stomach problems and dizziness. The consequence, by age 15, is the emergence of a female excess in general ill-health and depressive mood, and a substantial strengthening of the small excess in both ‘physical’ and ‘malaise’ symptoms already apparent at 11 years. These findings are discussed in relation to explanations for the adult female excess in poorer health, and the emergence of a female excess of depression during adolescence

The components of career capital and how they are acquired by knowledge workers across different industries

The literature shows that the way in which knowledge workers manage their careers in the global economy has changed fundamentally in the last twenty years. Career capital is a tradable commodity between and within organisations which impacts both human resource managers and knowledge workers. There is insufficient empirical evidence of the components of career capital and how these are acquired and there has been a dearth of investigation as to whether career capital is managed differently in different industries. The research was conducted in two phases. The first qualitative phase via 21 in-depth interviews identified 27 components of career capital and 23 methods of career capital accrual. In phase two quantitative data was collected, using those constructs, from 200 knowledge workers in four sectors: the public service sector and in manufacturing, financial and high tech research and development industries. The research determined the most important career capital components and methods of their accrual and showed these to differ greatly between the four employment sectors. The data raises questions with regard to two important themes in the career literature

Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy

Introduction: The endothelial glycocalyx degrading enzyme heparanase-1 (HPSE1) is a major contributor to kidney diseases, such as glomerulonephritis and diabetic nephropathy. Therefore, inhibition of HPSE1 could be an interesting therapeutic strategy to treat glomerular diseases. A possible HPSE1 inhibitor is heparanase-2 (HPSE2) because HPSE2 is a structural homolog of HPSE1 without enzymatic activity. The importance of HPSE2 has been recently demonstrated in HPSE2-deficient mice, since these mice developed albuminuria and died within a few months after birth. We postulate that inhibition of HPSE1 activity by HPSE2 is a promising therapeutic strategy to target albuminuria and resulting renal failure.Methods: First, we evaluated the regulation of HPSE2 expression in anti-GBM and LPS-induced glomerulonephritis, streptozotocin-induced diabetic nephropathy, and adriamycin nephropathy by qPCR and ELISA. Second, we measured the HPSE1 inhibiting capacity of HPSE2 protein and 30 different HPSE2 peptides and assessed their therapeutic potential in both experimental glomerulonephritis and diabetic nephropathy using kidney function and cortical mRNA expression of HPSE1 and cytokines as outcome parameters.Results: HPSE2 expression was downregulated under inflammatory and diabetic conditions, whereas this effect on HPSE2 expression was absent with HPSE1 inhibition and in HPSE1-deficient mice. Both HPSE2 protein and a mixture of the three most potent HPSE1 inhibitory HPSE2 peptides could prevent LPS and streptozotocin induced kidney injury.Discussion: Taken together, our data suggest a protective effect of HPSE2 in (experimental) glomerular diseases and support the therapeutic potential of HPSE2 as HPSE1 inhibitor in glomerular diseases

Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia

ABSTARCT: The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of heparan sulfate by heparanase significantly increases the permeability of albumin passage through the glomerular endothelium, event that originates proteinuria. This review aims to show the importance of the structural domains of heparan sulfate in the process of selective permeability and to demonstrate how these domains may be altered during the glomerular inflammation processes that occur in preeclampsia

Children and Their Parents: A Comparative Study of the Legal Position of Children with Regard to Their Intentional and Biological Parents in English and Dutch Law

This is a book about children and their parents. There are many different kinds of children and at least about as many different kinds of parents. In addition to the many different disciplines that study children and their parents, such as sociology, psychology, child studies and gender studies, to name but a few, this study concerns a legal question with regard to the parent-child relationship, namely how the law assigns parents to children. This subject is approached in a comparative legal perspective and covers England and The Netherlands. The book contains a detailed comparison and analysis of the manner in which the law in the two jurisdictions assigns the status of legal parent and/or attributes parental responsibility to the child’s biological and intentional parents. The concept ‘procreational responsibility’, which is introduced in the concluding chapter of the book, may be used as a tool to assess and reform existing regulations on legal parent-child relationships. The structure of the book, which is based on a categorisation of different family types in a ‘family tree’, enables the reader to have easy access to family-specific information.FdR – Publicaties zonder aanstelling Universiteit Leide

Heparanase: an essential factor for the development of proteinuria

Contains fulltext : 160306.pdf (publisher's version ) (Open Access)RU Radboud Universiteit, 11 oktober 2016Promotor : Berden, J.H.M. Co-promotor : Vlag, J. van de

Froebel usulü ile küçük çocukların terbiyesi

Metin eski harfli Türkçedir