Small and Large Scale Dynamics in the Milky Way

This thesis contains dynamical analysis on four different scales: the Solar system, the Sun itself, the Solar neighbourhood, and the central region of the Milky Way galaxy. All of these topics have been handled through methods of potential theory and statistics. The central topic of the thesis is the orbits of stars in the Milky Way. An introduction into the general structure of the Milky Way is presented, with an emphasis on the evolution of the observed value for the scale-length of the Milky Way disc and the observations of two separate bars in the Milky Way. The basics of potential theory are also presented, as well as a developed potential model for the Milky Way. An implementation of the backwards restricted integration method is shown, rounding off the basic principles used in the dynamical studies of this thesis. The thesis looks at the orbit of the Sun, and its impact on the Oort cloud comets (Paper IV), showing that there is a clear link between these two dynamical systems. The statistical atypicalness of the orbit of the Sun is questioned (Paper I), concluding that there is some statistical typicalness to the orbit of the Sun, although it is not very significant. This does depend slightly on whether one includes a bar, or not, as a bar has a clear effect on the dynamical features seen in the Solar neighbourhood (Paper III). This method can be used to find the possible properties of a bar. Finally, we look at the effect of a bar on a statistical system in the Milky Way, seeing that there are not only interesting effects depending on the mass and size of the bar, but also how bars can capture disc stars (Paper II).Siirretty Doriast

Probing the Galaxy's bars via the Hercules stream

It has been suggested that a resonance between a rotating bar and stars in the solar neighbourhood can produce the so called 'Hercules stream'. Recently, a second bar may have been identified in the Galactic centre, the so called 'long bar', which is longer and much flatter than the traditional Galactic bar, and has a similar mass. We looked at the dynamical effects of both bars, separately and together, on orbits of stars integrated backwards from local position and velocities, and a model of the Galactic potential which includes the bars directly. Both bars can produce Hercules like features, and allow us to measure the rotation rate of the bar(s). We measure a pattern speed, for both bars, of 1.87 +/- 0.02 times the local circular frequency. This is on par with previous measurements for the Galactic bar, although we do adopt a slightly different Solar motion. Finally, we identify a new kinematic feature in local velocity space, caused by the long bar, which is tempting to identify with the high velocity 'Arcturus' stream.Comment: 9 pages, 10 figures, Accepted to MNRAS, Corrected for errat

The detection of solid phosphorus and fluorine in the dust from the coma of comet 67P/Churyumov-Gerasimenko

Here, we report the detection of phosphorus and fluorine in solid particles collected from the inner coma of comet 67P/Churyumov-Gerasimenko measured with the COmetary Secondary Ion Mass Analyser (COSIMA) instrument on-board the Rosetta spacecraft, only a few kilometers away from the comet nucleus. We have detected phosphorus-containing minerals from the presented COSIMA mass spectra, and can rule out e.g. apatite minerals as the source of phosphorus. This result completes the detection of life-necessary CHNOPS-elements in solid cometary matter, indicating cometary delivery as a potential source of these elements to the young Earth. Fluorine was also detected with CF+ secondary ions originating from the cometary dust. </p

N-body simulation insights into the X-shaped bulge of the Milky Way: kinematics and distance to the Galactic Centre

Using simulations of box/peanut- (B/P-) shaped bulges, we explore the nature of the X-shape of the Milky Way's bulge. An X-shape can be associated with a B/P-shaped bulge driven by a bar. By comparing in detail the simulations and the observations we show that the principal kinematic imprint of the X-shape is a minimum in the difference between the near and far side mean line-of-sight velocity along the minor axis. This minimum occurs at around |b| = 4°, which is close to the lower limit at which the X-shape can be detected. No coherent signature of an X-shape can be found in Galactocentric azimuthal velocities, vertical velocities or any of the dispersions. After scaling our simulations, we find that a best fit to the Bulge Radial Velocity Assay data leads to a bar angle of 15°. We also explore a purely geometric method for determining the distance to the Galactic Centre by tracing the arms of the X-shape. We find that we are able to determine this ill-known distance to an accuracy of about 5 per cent with sufficiently accurate distance measurements for the red clump stars in the arm

A comprehensive comparison of the Sun to other stars: searching for self-selection effects

If the origin of life and the evolution of observers on a planet is favoured by atypical properties of a planet's host star, we would expect our Sun to be atypical with respect to such properties. The Sun has been described by previous studies as both typical and atypical. In an effort to reduce this ambiguity and quantify how typical the Sun is, we identify eleven maximally-independent properties that have plausible correlations with habitability, and that have been observed by, or can be derived from, sufficiently large, currently available and representative stellar surveys. By comparing solar values for the eleven properties, to the resultant stellar distributions, we make the most comprehensive comparison of the Sun to other stars. The two most atypical properties of the Sun are its mass and orbit. The Sun is more massive than 95 -/+ 2% of nearby stars and its orbit around the Galaxy is less eccentric than 93 +/- 1% of FGK stars within 40 parsecs. Despite these apparently atypical properties, a chi^2 -analysis of the Sun's values for eleven properties, taken together, yields a solar chi^2 = 8.39 +/- 0.96. If a star is chosen at random, the probability that it will have a lower value (be more typical) than the Sun, with respect to the eleven properties analysed here, is only 29 +/- 11%. These values quantify, and are consistent with, the idea that the Sun is a typical star. If we have sampled all reasonable properties associated with habitability, our result suggests that there are no special requirements for a star to host a planet with life.Comment: Published in the Astrophysical Journal, 684:691-706, 2008 September 1. This version corrects two small errors the press could not correct before publication - the errors are addressed in an erratum ApJ will release on Dec 1, 200

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

: Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci associated with either number of children ever born (NEB) or childlessness. These loci span diverse aspects of reproductive biology, including puberty timing, age at first birth, sex hormone regulation, endometriosis and age at menopause. Missense variants in ARHGAP27 were associated with higher NEB but shorter reproductive lifespan, suggesting a trade-off at this locus between reproductive ageing and intensity. Other genes implicated by coding variants include PIK3IP1, ZFP82 and LRP4, and our results suggest a new role for the melanocortin 1 receptor (MC1R) in reproductive biology. As NEB is one component of evolutionary fitness, our identified associations indicate loci under present-day natural selection. Integration with data from historical selection scans highlighted an allele in the FADS1/2 gene locus that has been under selection for thousands of years and remains so today. Collectively, our findings demonstrate that a broad range of biological mechanisms contribute to reproductive success

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease