Advances in the Analysis of Properties Behaviour of Cement-Based Grouts with High Substitution of Cement with Blast Furnace Slags

This article presents a study of the main properties (consistency, workability, leaching, unsoundness, and mechanical properties) of cement grouts prepared with cement replacement by blast furnace slag (GGBS). Mixtures have been analyzed in the absence of additives and reached high replacement percentages. As shown in the different tests presented, the observed evolution of the resistance and workability of the mixtures makes them very interesting for its application. Different types of cement (CEM-I 42.5 and CEM-I 52.5 R) and different water/binder values (1 and 0.67) are used. The results present opportunities for the steel industry by the intensive valorization of slag waste. The reduction of the use of cement in construction is also one of the key aims of this line of research. Results show improvements in the mechanical response with good fresh state properties for substitution percentages up to 70%. It is verified with leaching analysis that these products have less impact on the environmen

Study of the Suitability of Different Types of Slag and Its Influence on the Quality of Green Grouts Obtained by Partial Replacement of Cement

This paper is part of a research line focused on the reduction of the use of cement in the industry. In this work, the study of work methodologies for the manufacture of green cementitious grout mixtures is studied. Grout is widely used in construction and it requires an important use of raw materials. On the other hand, the steel industry faces the problem of the growing generation of slag wastes due to the increase in steel manufacturing. The green grout aims to achieve the dual objective of reducing the demand for cement and improve the slag waste valorization. Slag is not introduced as an aggregate but through the direct replacement of cement and no additives. The research seeks a product where we can use steel slag intensively, guaranteeing minimum resistance and workability. Results with substitutions between a 25% to 50% and water/cement ratio of 1 are presented. In particular, the suitability of different slags (two Ladle Furnace Slag (LFS) and one Blast Furnace Slag (GGBS)) in the quality of the final product are analyzed. The feasibility of replacing cement with slag and the importance of the origin and pretreatment are highlighted

Elucidating pyrolysis oil oligomeric chemical structures: Experimental studies and DFT calculations

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Propuesta metodológica para la evaluación de sostenibilidad multiescala en paisajes productivos, aplicada en al menos un paisaje colombiano

Para el cumplimiento de la meta 7.1: Evaluación de sostenibilidad en paisajes productivos, la línea de Sostenibilidad y Economía verde presenta en este documento los resultados del trabajo realizado en el año, haciendo énfasis en un proceso metodológico, secuencial, que integra, a partir de un marco conceptual propuesto, diversas disciplinas y herramientas útiles y versátiles para aplicación de las ciencias de la sostenibilidad en paisajes productivos con usos agropecuarios, en el marco de las Transiciones Socioecológicas hacia la Sostenibilidad (TSS). El documento registra además una serie de experiencias que, en el ámbito nacional, se consideran exitosas en su camino hacia la construcción de estrategias de sostenibilidad con diferentes aproximaciones y a diferentes escalas, así como un ejercicio piloto de aplicación preliminar de la metodología en un caso de estudio en el Valle de Sibundoy-Putumayo-Colombia.BogotáGestión Territorial de la Biodiversida

El vino como parte de una cultura

Today, I let you know that it is very difficult to determine the Origin of fossil vine leaves because they are confused with other plant leaves, Example: Banana Leaves, such as linden leaves and maple leaves. For the Scientists, they state that it is much easier to reconstruct history from the wood of the bush, since it is better preserved today, a series of investigations is carried out in which the antiquity can be determined in the palinogram and although you cannot imagine When our archaeologists and anthropologists discover a site where many grape seeds accumulate, the researchers immediately have the indication that a very possible vineyard could have existed in this place in a much later period or a space in which the settlers of ancestral culture they made the wine. We could consider a clue to lead to more reliable evidence, keeping in mind that in some way it is said that the ancestors counted on the grapes for the merchandise that entered as a guide for income and expenditure accounts.Hoy en día, dejo saber que se está muy difícil determinar el Origen de las hojas de viña fósiles porque se confunden con otras hojas de plantas, Ejemplo: Las Hojas de los Plátanos, como las hojas de los tilos y las hojas de los arces. Para los Científicos manifiestan que es mucho más fácil reconstruir la historia a partir de la madera del arbusto ya que se conserva mejor hoy en día se hace una serie de investigaciones en la cual se puede determinar la antigüedad en el palinograma y aunque Ustedes no se imaginan que nuestros investigadores arqueólogos y antropólogos descubren un yacimiento en donde se acumulan muchas  semillas de la uva los investigadores inmediatamente tienen el indicio que pudo existir en este lugar un viñedo muy posible en época mucho más tardía o un espacio en el cual los pobladores de cultura ancestrales elaboraban el vino. Podríamos considerar   un indicio para llevarlo a una evidencia más fiable, teniendo presente que de alguna forma se dice que los ancestros contaban con las uvas por las mercaderías que ingresaban como una guía de cuentas ingreso y egresos

Apoyo a la biodiversidad en relación con las abejas

This work previously reviewed by the double blind modality, in case you require information about the process, contact the email [email protected] The total or partial reproduction of this work by any means (electronic, mechanical, photocopying, recording or others), without the prior written authorization of the copyright holder, under the sanctions established by law. The content of this publication may be reproduced citing the source. The published work expresses exclusively the opinion of the authors, so it does not compromise the thought or responsibility of the Editorial.Esta obra revisada previamente por la modalidad doble par ciego, en caso de requerir información sobre el proceso comunicarse al correo electrónico [email protected] Queda prohibida  la  reproducción  total  o  parcial  de  esta  obra  por  cualquier  medio (electrónico,  mecánico,  fotocopia,  grabación  u  otros),  sin  la  previa  autorización  por escrito del titular de los derechos de autor, bajo las sanciones establecidas por la ley. El contenido de esta publicación puede ser reproducido citando la fuente. El trabajo publicado expresa exclusivamente la opinión de los autores, de manera que no compromete el pensamiento ni la responsabilidad de la Editorial

Apoyo a la biodiversidad en relación con las abejas

This work previously reviewed by the double blind modality, in case you require information about the process, contact the email [email protected] The total or partial reproduction of this work by any means (electronic, mechanical, photocopying, recording or others), without the prior written authorization of the copyright holder, under the sanctions established by law. The content of this publication may be reproduced citing the source. The published work expresses exclusively the opinion of the authors, so it does not compromise the thought or responsibility of the Editorial.Esta obra revisada previamente por la modalidad doble par ciego, en caso de requerir información sobre el proceso comunicarse al correo electrónico [email protected] Queda prohibida  la  reproducción  total  o  parcial  de  esta  obra  por  cualquier  medio (electrónico,  mecánico,  fotocopia,  grabación  u  otros),  sin  la  previa  autorización  por escrito del titular de los derechos de autor, bajo las sanciones establecidas por la ley. El contenido de esta publicación puede ser reproducido citando la fuente. El trabajo publicado expresa exclusivamente la opinión de los autores, de manera que no compromete el pensamiento ni la responsabilidad de la Editorial

El vino como parte de una cultura

Today, I let you know that it is very difficult to determine the Origin of fossil vine leaves because they are confused with other plant leaves, Example: Banana Leaves, such as linden leaves and maple leaves. For the Scientists, they state that it is much easier to reconstruct history from the wood of the bush, since it is better preserved today, a series of investigations is carried out in which the antiquity can be determined in the palinogram and although you cannot imagine When our archaeologists and anthropologists discover a site where many grape seeds accumulate, the researchers immediately have the indication that a very possible vineyard could have existed in this place in a much later period or a space in which the settlers of ancestral culture they made the wine. We could consider a clue to lead to more reliable evidence, keeping in mind that in some way it is said that the ancestors counted on the grapes for the merchandise that entered as a guide for income and expenditure accounts.Hoy en día, dejo saber que se está muy difícil determinar el Origen de las hojas de viña fósiles porque se confunden con otras hojas de plantas, Ejemplo: Las Hojas de los Plátanos, como las hojas de los tilos y las hojas de los arces. Para los Científicos manifiestan que es mucho más fácil reconstruir la historia a partir de la madera del arbusto ya que se conserva mejor hoy en día se hace una serie de investigaciones en la cual se puede determinar la antigüedad en el palinograma y aunque Ustedes no se imaginan que nuestros investigadores arqueólogos y antropólogos descubren un yacimiento en donde se acumulan muchas  semillas de la uva los investigadores inmediatamente tienen el indicio que pudo existir en este lugar un viñedo muy posible en época mucho más tardía o un espacio en el cual los pobladores de cultura ancestrales elaboraban el vino. Podríamos considerar   un indicio para llevarlo a una evidencia más fiable, teniendo presente que de alguna forma se dice que los ancestros contaban con las uvas por las mercaderías que ingresaban como una guía de cuentas ingreso y egresos

Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept

Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized treatments. The genetic biomarkers associated with the response to TNF inhibitors (TNFi) are among the most studied. They include 12 SNPs exhibiting promising results in the three largest genome-wide association studies (GWAS). However, they still require further validation. With this aim, we assessed their association with response to TNFi in a replication study, and a meta-analysis summarizing all nonredundant data. The replication involved 755 patients with RA that were treated for the first time with a biologic drug, which was either infliximab (n = 397), etanercept (n = 155) or adalimumab (n = 203). Their DNA samples were successfully genotyped with a single-base extension multiplex method. Lamentably, none of the 12 SNPs was associated with response to the TNFi in the replication study (p > 0.05). However, a drug-stratified exploratory analysis revealed a significant association of the NUBPL rs2378945 SNP with a poor response to etanercept (B = -0.50, 95% CI = -0.82, -0.17, p = 0.003). In addition, the metaanalysis reinforced the previous association of three SNPs: rs2378945, rs12142623, and rs4651370. In contrast, five of the remaining SNPs were less associated than before, and the other four SNPs were no longer associated with the response to treatment. In summary, our results highlight the complexity of the pharmacogenetics of TNFi in RA showing that it could involve a drug-specific component and clarifying the status of the 12 GWAS-drawn SNPsThis work was supported by the Instituto de Salud Carlos III (ISCIII, Spain) through grants PI14/01651, PI17/01606 and RD16/0012/0014 to AG and PI12/01909 to JJG-R. These grants are partially financed by the European Regional Development Fund of the EU (FEDER

Validation Study Of Genetic Biomarkers Of Response To Tnf Inhibitors In Rheumatoid Arthritis

Genetic biomarkers are sought to personalize treatment of patients with rheumatoid arthritis (RA), given their variable response to TNF inhibitors (TNFi). However, no genetic biomaker is yet sufficiently validated. Here, we report a validation study of 18 previously reported genetic biomarkers, including 11 from GWAS of response to TNFi. The validation was attempted in 581 patients with RA that had not been treated with biologic antirheumatic drugs previously. Their response to TNFi was evaluated at 3, 6 and 12 months in two ways: change in the DAS28 measure of disease activity, and according to the EULAR criteria for response to antirheumatic drugs. Association of these parameters with the genotypes, obtained by PCR amplification followed by single-base extension, was tested with regression analysis. These analyses were adjusted for baseline DAS28, sex, and the specific TNFi. However, none of the proposed biomarkers was validated, as none showed association with response to TNFi in our study, even at the time of assessment and with the outcome that showed the most significant result in previous studies. These negative results are notable because this was the first independent validation study for 12 of the biomarkers, and because they indicate that prudence is needed in the interpretation of the proposed biomarkers of response to TNFi even when they are supported by very low p values. The results also emphasize the requirement of independent replication for validation, and the need to search protocols that could increase reproducibility of the biomarkers of response to TNFi