Lanzamiento de bebida energizante “Boom Power”

El presente trabajo tiene como objetivo el lanzamiento al mercado de la bebida energizante “Boom Power” hecha a base de insumos naturales como la maca, el ginseng y el extracto de Yacón, productos que funcionan como excelentes estimulantes y antioxidantes para el consumo humano. Boom Power está dirigido al segmento de consumidores del nivel socioeconómico A, B y C, los cuales están interesados en repotenciar su energía y aumentar su resistencia física y mental manteniendo su estilo de vida saludable y natural. Según el informe de Tendencias clave 2022 de Lima, Perú, Passport Euromonitor, los niveles de conciencia sobre la salud, acelerados por el covid -19, influyeron en la compra de bebidas reducidas en azúcar y naturales. [Además], alentó a las personas a practicar deportes y ejercicios. Aprovechando tales oportunidades que brinda el mercado, una bebida energética con insumos naturales como Boom Power, cumplirá la función de ofrecer la misma energía con el valor agregado de presentar menos calorías. Para lo cual se ha desarrollado un análisis del público objetivo, y basados en sus preferencias, se ha realizado una propuesta de estrategia integral de lanzamiento, una campaña publicitaria y un spot.The objective of this work is to launch the energy drink "Boom Power" made from natural ingredients such as maca, ginseng and Yacon extract, products that work as excellent stimulants and antioxidants for human consumption. Boom Power is aimed at the consumer segment of socioeconomic level A, B and C, who are interested in boosting their energy and increasing their physical and mental resistance while maintaining their healthy and natural lifestyle. According to Passport Euromonitor's Key Trends 2022 report from Lima, Peru, levels of health awareness, accelerated by covid -19, influenced the purchase of lowsugar and natural beverages. [In addition], he encouraged people to play sports and exercises. Taking advantage of such opportunities offered by the market, an energy drink with natural inputs such as Boom Power will fulfill the function of offering the same energy with the added value of presenting fewer calories. For which an analysis of the target audience has been developed, and based on their preferences, a comprehensive launch strategy proposal, an advertising campaign and a spot have been made

Factors associated with perception and expectations to work in the area of primary health care at five facilities of the first level care in Lima, Peru

Aim: To identify the frequency of perception and expectations to work in the area of primary health care(PHC) as well as theirassociated factors with personnel at five health facilities. Method: Cross-sectional study on five health facilities of PHC. Perception and expectations to work in PHC were measured, and their association with social-work variables was investigated. Simple and multiple regression analysis was performed to estimate prevalence ratios (PR), using the Poisson family, robust variance and having a health facility as a cluster. Results: Out of 94 participants, 64.9% did not have an adequate perceptionabout working in the area of PHC. The 60.6% had an expectation to work in PHC 10 years from now. A positive association was found between female gender and perception about working in the area of PHC (PR = 3.24). There was a negative association between being divorced and/or widowed and the expectation to work in PHC (PR: 0.51). Conclusions: Perception about working in PHC is low, but more than half of the sample expect to work in PHC10 years from now. Being a woman increases the prevalence job perception in PHC. Working time over 5 years was positively associated with having expectations to work in PHC. On the contrary, divorced/widowed marital status was negatively associated

The Importance of Lactose in the Human Diet:Outcomes of a Mexican Consensus Meeting

Lactose is a unique component of breast milk, many infant formulas and dairy products, and is widely used in pharmaceutical products. In spite of that, its role in human nutrition or lactose intolerance is generally not well-understood. For that reason, a 2-day-long lactose consensus meeting with health care professionals was organized in Mexico to come to a set of statements for which consensus could be gathered. Topics ranging from lactase expression to potential health benefits of lactose were introduced by experts, and that was followed by a discussion on concept statements. Interestingly, lactose does not seem to induce a neurological reward response when consumed. Although lactose digestion is optimal, it supplies galactose for liver glycogen synthesis. In infants, it cannot be ignored that lactose-derived galactose is needed for the synthesis of glycosylated macromolecules. At least beyond infancy, the low glycemic index of lactose might be metabolically beneficial. When lactase expression decreases, lactose maldigestion may lead to lactose intolerance symptoms. In infancy, the temporary replacing of lactose by other carbohydrates is only justified in case of severe intolerance symptoms. In those who show an (epi)genetic decrease or absence of lactase expression, a certain amount (for adults mostly up to 12 g per portion) of lactose can still be consumed. In these cases, lactose shows beneficial intestinal-microbiota-shaping effects. Avoiding lactose-containing products may imply a lower intake of other important nutrients, such as calcium and vitamin B-12 from dairy products, as well as an increased intake of less beneficial carbohydrates

ANÁLISE DA PRESENÇA DE OBESIDADE, COMPORTAMENTOS E FATORES DE RISCO CARDIOVASCULAR EM INDIVÍDUOS HIPERTENSOS

A hipertensão arterial (HA) é o principal fator de risco (FR) para a morbidade e mortalidade precoces causadas por doenças cardiovasculares. O objetivo desse estudo é avaliar a presença de obesidade, comportamentos e FR cardiovascular em indivíduos hipertensos na FCT UNESP de Presidente Prudente. Foram avaliados três comportamentos de risco à saúde: tabagismo, etilismo e sedentarismo, e os fatores de risco avaliados foram obesidade, hipertensão arterial, dislipidemias e diabetes mellitus. O principal achado desse estudo é que há uma alta prevalência da obesidade, comportamentos e FR cardiovascular nesses indivíduos, aumentando a chance de desenvolver doenças cardiovasculares (DCV). Conclui-se que a presença de obesidade, comportamentos e FR cardiovascular em indivíduos hipertensos é elevada, sendo o histórico familiar de DCV e o sedentarismo, o comportamento e o fator de risco mais encontrados respectivamente

La mirada desde quienes producen en el noreste bonaerense durante los primeros meses de la pandemia de COVID-19

PosterEl debate en torno a la pandemia de Covid 19 ha tenido múltiples abordajes, desde el origen del virus hasta sus impactos en la salud, economía y política de los países (Delprino, 2020). El Instituto Nacional de Tecnología Agropecuaria (INTA) de Argentina también realizó aportes, como el caso del “Observatorio territorial de la costa noreste bonaerense para el desarrollo y la sostenibilidad del sistema agroalimentario” que tras los dos primeros meses de implementación del Distanciamiento Social Preventivo y Obligatorio (DISPO) concretó una encuesta para conocer su impacto en el corredor San Nicolás-Zárate, con foco en la visión de la producción agropecuaria. El objetivo fue relevar los posibles cambios ocurridos en las prácticas y perspectivas de productoras y productores del territorio en esta etapa. La indagación incluyó preguntas abiertas y cerradas sobre un formulario digital. El muestreo fue no probabilístico por conveniencia. La rápida e inesperada incorporación de tecnologías de la información y comunicación y la incorporación de prácticas vinculadas con la higiene para la prevención, fueron los aspectos con más coincidencias en las respuestas.EEA San PedroFil: Piola, Mariana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro; ArgentinaFil: Delprino, María Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro; ArgentinaFil: Albarracin, Fedra Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro; ArgentinaFil: Ibern, Danila Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Pedro; ArgentinaFil: Marcozzi, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Pedro; ArgentinaFil: Garcia, Leonardo Martin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural Zárate; ArgentinaFil: Gutiérrez, Rosana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural Zárate; ArgentinaFil: Glaría, Oscar Juan José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Nicolás; ArgentinaFil: Ros, Patricio Guillermo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Nicolás; ArgentinaFil: Andino, Bernardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Nicolás; Argentin

Mono- and biallelic germline variants of DNA glycosylase genes in colon adenomatous polyposis families from two continents

Recently, biallelic germline variants of the DNA glycosylase genes MUTYH and NTHL1 were linked to polyposis susceptibility. Significant fractions remain without a molecular explanation, warranting searches for underlying causes. We used exome sequencing to investigate clinically well-defined adenomatous polyposis cases and families from Finland (N=34), Chile (N=21), and Argentina (N=12), all with known susceptibility genes excluded. Nine index cases (13%) revealed germline variants with proven or possible pathogenicity in the DNA glycosylase genes, involving NEIL1 (mono- or biallelic) in 3 cases, MUTYH (monoallelic) in 3 cases, NTHL1 (biallelic) in 1 case, and OGG1 (monoallelic) in 2 cases. NTHL1 was affected with the well-established, pathogenic c.268C>T, p.(Gln90Ter) variant. A recurrent heterozygous NEIL1 c.506G>A, p.(Gly169Asp) variant was observed in two families. In a Finnish family, the variant occurred in trans with a truncating NEIL1 variant (c.821delT). In an Argentine family, the variant co-occurred with a genomic deletion of exons 2 - 11 of PMS2. Mutational signatures in tumor tissues complied with biological functions reported for NEIL1. Our results suggest that germline variants in DNA glycosylase genes may occur in a non-negligible proportion of unexplained colon polyposis cases and may predispose to tumor development.Peer reviewe

Impact of pre- and/or post-autologous stem cell transplantation exposure to brentuximab vedotin on survival outcomes in patients with high-risk Hodgkin lymphoma

The AETHERA trial demonstrated that brentuximab vedotin (BV) consolidation after autologous stem cell transplantation (ASCT) in patients with Hodgkin lymphoma (HL) at high risk of relapse/progression increases progression-free survival (PFS). Patients previously exposed to BV were excluded from that trial. However, BV alone or in combination with chemotherapy is frequently used as front-line treatment and/or pre-ASCT salvage therapy. We analyzed data from 156 patients with high-risk HL who underwent ASCT with (BV-CON, n?=?62) or without (non-BV, n?=?94) BV consolidation. Fifty-seven patients received BV-based salvage regimens before ASCT. The 3-year overall survival and PFS for all patients were 91.6% and 70.0%, respectively. Multivariate analysis showed that BV-CON was associated with better PFS (HR 0.39, p?=?0.01), whereas positive PET at transplant leaded to worse PFS (HR 2.71, p?=?0.001). BV-CON improved PFS in PET-positive patients (72.2% vs. 43.0%, p?=?0.05), with a beneficial trend observed in PET negative (88.8% vs. 75.2%, p?=?0.09). BV-CON patients with or without BV exposure pre-ASCT had a significantly better PFS than non-BV with or without BV pretransplant treatment (HR 0.36, p?=?0.004). The efficacy of real-life BV consolidation therapy was similar to that in the AETHERA trial. This therapeutic strategy improves survival independently of BV exposure prior to ASCT.© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature

Allogeneic Stem Cell Transplantation in Mature T Cell and Natural Killer/T Neoplasias: A Registry Study from Spanish GETH/GELTAMO Centers

Despite advances in understanding the biology of mature T and natural killer (NK)/T cell neoplasia, current therapies, even the most innovative ones, are still far from ensuring its cure. The only treatment to date that has been shown to control aggressive T cell neoplasms in the long term is allogeneic stem cell transplantation (alloSCT). We aim to report the results of alloSCT for advanced mature T and NK/T neoplasias performed in centers from our national GELTAMO/GETH (Grupo Español de Linfoma y Trasplante de Médula Ósea/Grupo Español de Trasplante Hematopoyético y Terapia Celular) over the past 25 years. As a secondary objective, we analyzed the results of alloSCT from haploidentical donors. We performed a retrospective analysis of all patients who received an alloSCT in Spanish centers (n = 201) from September 1995 to August 2018. The 2-year overall survival (OS) and disease-free survival (DFS) were 65.5% and 58.2%, respectively. The univariate for OS and DFS showed statistically different hazard ratios for conditioning intensity, response pre-alloSCT, comorbidity index, donor/receptor cytomegalovirus status and Eastern Cooperative Oncology Group (ECOG) pre-alloSCT, but only a better ECOG pre-alloSCT remained significant in the multivariate analysis. There was an increased incidence of relapse in those patients who did not develop chronic graft-versus-host disease (GVHD) and an increased risk of death in those developing moderate to severe acute GVHD. The 1-year nonrelapse mortality was 21.9% and was mainly due to GVHD (30%) and bacterial infections (17%). When comparing unrelated donors with haploidentical donors, we found similar results in terms of OS and DFS. There was, however, a reduction of acute GVHD in the haploidentical group (P = .04) and trend to a reduction of chronic GVHD. In conclusion, alloSCT is the only curative option for most aggressive T cell neoplasias. Haploidentical donors offer similar results to related donors in terms of survival with a reduction of acute GVHD

Un observatorio territorial como dispositivo dinámico y colaborativo para la gestión del conocimiento

Al principio de la pandemia de Covid 19, un grupo de profesionales del INTA San Pedro conformó el “Observatorio territorial de la costa noreste bonaerense para el desarrollo y la sostenibilidad del sistema agroalimentario”. El dispositivo sociotécnico se fijó 5 objetivos asociados a la sistematización de conocimiento, seguimiento de problemas del territorio, despliegue metodológico y diálogo territorial. El trabajo describe los objetivos propuestos, la estrategia implementada y los resultados obtenidos en los primeros 18 meses de desarrollo.EEA San PedroFil: Delprino, María Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro; ArgentinaFil: Piola, Mariana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro; ArgentinaFil: Ibern, Danila Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Pedro; ArgentinaFil: Marcozzi, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Pedro; ArgentinaFil: García, Leonardo Martín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural Zárate; ArgentinaFil: Albarracin, Fedra Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro; ArgentinaFil: Ros, Patricio Guillermo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Nicolás; ArgentinaFil: Glaría, Oscar Juan José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Nicolás; ArgentinaFil: Hansen, Laura. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro; ArgentinaFil: Barbieri, Martín Osvaldo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro; ArgentinaFil: Liljesthröm, Verónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Pedro; ArgentinaFil: Marcozzi, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Pedro; ArgentinaFil: Andino, Bernardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural San Nicolás; ArgentinaFil: Gutiérrez, Rosana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Pedro. Agencia de Extensión Rural Zárate; Argentin