Influência do gênero e da idade: satisfação no trabalho de profissionais da saúde

OBJECTIVE: to analyze the influence of gender and age on the quality of the professional lives of health care professionals at a university hospital. METHOD: a total of 546 professionals completed a general questionnaire that measured sociodemographic variables and evaluated job satisfaction using a scale adopted from the NTP 394 Job Satisfaction scale and translated into Spanish. RESULTS: overall, 77.2% of the professionals surveyed were satisfied with the work they perform. With regards to gender, we found overwhelming evidence of the feminization of practically all health care professions included in the study, with higher levels of job satisfaction among women than men. Regarding age, 20-30-year-olds and professionals over 61 years old showed higher satisfaction levels than did middle-aged professionals. Higher levels of dissatisfaction were reported by professionals between 41 and 50 years old. CONCLUSIONS: we were able to detect the influence of gender and age on the level of job satisfaction, finding significant associations between job satisfaction and both of these variables. Generally, women expressed more satisfaction than men, and elderly professionals showed higher satisfaction compared to younger professionals. Management policies should focus on taking action to correct the conditions that produce dissatisfaction among certain groups of employees.OBJETIVO: analizar la influencia del género y edad en la satisfacción de la vida laboral en los profesionales sanitarios de un Hospital Universitario. MÉTODO: la muestra quedó constituida por 546 profesionales, administrándose un cuestionario general con variables sociodemográficas y otro específico, el NTP 394 Satisfacción Laboral: escala general de satisfacción adaptada y validada al castellano. RESULTADOS: en general un 77,2% se encuentra satisfecho con el trabajo que desempeña. En relación al género, se evidencia la feminización de prácticamente todas las profesiones sanitarias sin excepción, quedando patente niveles de satisfacción superior en las mujeres. La edad, presenta niveles más elevados de satisfacción en profesionales de edades entre 20 y 30 años y en los mayores de 61; en contrapartida los niveles de insatisfacción se presentan en los profesionales de edades comprendidas entre 41 y 50 años. CONCLUSIONES: podemos delimitar la influencia del género y la edad en los niveles de satisfacción laboral, obteniéndose asociaciones significativas en ambas variables; respecto al género, las mujeres se muestran más satisfechas y en cuanto a la edad los profesionales de mayor edad muestran mayor satisfacción. Así, las líneas de gestión deben orientarse al establecimiento de acciones de mejora en aquellas variables que producen insatisfacción.OBJETIVO: analisar a influência do gênero e da idade na satisfação no trabalho de profissionais da saúde num hospital universitário. MÉTODO: a amostra foi constituída por 546 profissionais, aos quais foi administrado um questionário genérico, contendo variáveis sociodemográficas e um questionário específico, o NTP 394: Satisfação no Trabalho: Escala de Satisfação Global adaptada e validada para o castelhano. RESULTADOS: de modo geral, 77,2% da amostra manifestou estar satisfeita com o trabalho que realiza. Quanto ao gênero, foi evidenciada a feminização de praticamente todas as profissões em saúde, sem exceções, sendo que as mulheres manifestaram níveis mais elevados de satisfação. Com relação à idade, as faixas etárias que manifestaram os níveis mais elevados de satisfação foram entre 20 e 30 anos e acima de 61 anos. Em contrapartida, os profissionais entre 41 e 50 anos de idade apresentaram níveis de insatisfação. CONCLUSÕES: pode-se estabelecer a influência do gênero e da idade nos níveis de satisfação no trabalho da amostra estudada, visto que foram identificadas associações significativas. Em relação ao gênero, as mulheres manifestaram estar mais satisfeitas e, com respeito à idade, os maiores níveis de satisfação foram manifestos pelos participantes mais idosos. Sendo assim, as políticas de gestão devem focar na implantação de ações destinadas a melhorar as variáveis que se associam à insatisfação

Registro, aplicación y pago del impuesto sobre la renta (IR) en la Clínica Santa Fe del municipio de Matagalpa, departamento de Matagalpa en el período 2015

El siguiente Seminario de Graduación aborda lo más relevante sobre la temática Impuesto sobre la Renta (IR) en las empresas de los departamentos de Matagalpa y Jinotega, tiene como propósito realizar un análisis en el registro, aplicación y pago del impuesto sobre la renta (IR) en la Clínica Santa Fe en el periodo 2015. El impuesto sobre la renta es el monto impuesto por el gobierno que paga toda persona nicaragüense o con residencia nicaragüense que genera ingresos y en base a sus utilidades obtenidas se aplica dicho impuesto, el impuesto es una de las fuentes de mayor ingreso con la que cuenta el país. Es importante que las empresas cumplan con su obligación fiscal como lo estipula la Ley NO 822 (Ley de Concertación Tributaria) y el Código Tributario que son las que regulan todo referente a impuesto de igual manera tienen el derecho de conocer cómo se utilizará el pago de estos, porque de esta manera aporta al desarrollo de la sociedad, ya que estos se asignan en gran parte al financiamiento de proyectos de inversión en infraestructura económica y social como; educación, salud, protección a los necesitados entre otros, el incumplimiento de este puede generar consecuencias legales y multas para la entidad, concluyendo que la entidad en estudio registra los procedimientos contables en relación al Impuesto Sobre la Renta según lo estipula la ley, cumpliendo con su periodo fiscal y cada una de sus obligaciones en tiempo y forma. Palabras claves: Impuesto sobre la Renta, registro, aplicación, pag

Prenatal and Postnatal Exposure to DDT by Breast Milk Analysis in Canary Islands

The use of p,p' -dichlorodiphenyltrichloroethane (DDT) has been banned since the late 1970s due to its toxicity. However, its long half-life makes it persistent in the environment and, consequently, almost everyone has DDT residues in the body. Human milk constitutes an ideal non-conventional matrix to investigate environmental chronic exposure to organochlorine compounds (OCs) residues. The study aimed to identify potential population risk factors of exposure to DDT due to the proximity to countries where it is still used. Seventy-two consecutive lactating women were prospectively included in Tenerife, Canary Islands (Spain). A validated questionnaire was used to obtain socioeconomic, demographics data, and daily habits during pregnancy. DDT levels in breast milk were measured by gas chromatography with-electron capture detector (GC-ECD). Anthropometrics measurements in newborns were obtained. Thirty-four out of 72 (47.2%) of the analysed milk samples presented detectable levels of DDT (mean: 0.92 ng/g), ranging between 0.08 to 16.96 ng/g. The socio-demographic variables did not significantly differ between detectable DDT and non-detectable DDT groups. We found positive association between DDT levels and vegetables (OR (95%CI): 1.23 (1.01-1.50)) and poultry meat (OR (95%CI): 2.05 (1.16-3.60)) consumption, and also between the presence of DDT in breast milk and gestational age (OR (95%CI): 0.59 (0.40-0.90)). DDT is present in breast milk of women at the time of delivery. Residual levels and the spread from countries still using DDT explain DDT detection from vegetables and from animal origin food. The presence of this compound in breast milk represents a pre- and postnatal exposure hazard for foetuses and infants due to chronic bioaccumulation and poor elimination, with possible deleterious effects on health. This data should be used to raise awareness of the risks of OCs exposure and to help establish health policies in order to avoid its use worldwide and thus, to prevent its propagation

Sensación térmica percibida en vivienda económica y auto-producida, en periodo cálido, para clima cálido húmedo

El l estudio de la sensación térmica percibida en la vivienda, permite establecer lineamientos de diseño para la habitabilidad térmica, con base en la percepción de los sujetos. En trabajos anteriores, se plantea que la adaptación de las personas en climas cálidos, está  definida por preferencias según el estrato socioeconómico y cultural, basado en su tipología de vivienda. Se presenta la comparación entre dos investigaciones sobre confort térmico desarrolladas en Mérida, Yucatán, México, con clima cálido húmedo. Los sujetos de estudio fueron habitantes de vivienda de tipo económico y auto-producida. Se utilizó el enfoque de adaptación, se trabajó con base en la norma ISO 10551 (1995) y se registraron  temperatura de bulbo seco, temperatura de globo negro, humedad relativa y velocidad de viento. Se estimó la temperatura neutral con el  método de medias por intervalo de sensación térmica, y se compararon preferencia, aceptación y tolerancia del ambiente térmico. Los resultados de ambas investigaciones muestran variaciones en la temperatura neutral y rangos de confort térmico, además se presentan diferencias significativas en el nivel de adaptación, experiencia y expectativa, aún cuando las condiciones del ambiente térmico presentan similitudes

Movilización temprana en pacientes críticos en la unidad de cuidados intensivos revisión temática

Resumen del artículo de revisión: Crear un lugar donde atender de manera prioritaria a los pacientes críticos o en riesgo de muerte, se convierte en una gran necesidad, para el año de 1854 durante la guerra de Crimea cuando Florence nightngale considera que es fundamental separar a los soldados en estados más graves de aquellos que solo tenían heridas menos compromiso, para atenderlos de manera especial es allí donde se logra el nacimiento de las unidades de cuidados intensivos (UCI), unas vez ingresados se pudo demostrar una reducción satisfactoria en la tasa de mortalidad de la batalla, del 40% al 2%. Luego En 1950 el Dr. Peter safar anestesiólogo creo una unidad de cuidados intensivos donde se mantenía a los pacientes sedados y ventilados, a quien consideraron el primer intensivista. Los primeros servicios de respiración artificial se realizaron en Dinamarca por Lassen Dan, Ipsen y Poulsen, en Suecia por Holmdahl y en Francia por malloret. (1) Con el pasar de los tiempos las unidades de cuidados intensivos se han ido creando al mismo tiempo que el desarrollo tecnológico y el avance de la medicina teniendo en cuenta las altas demandas de pacientes críticos. Así como existió la necesidad de crear estos lugares también fue necesario tener un concepto claro de estas

Live lecture screencast recording: a proposal to simplify the tasks associated with content production for video-teaching

Se trata de un resumen (Abstract) de la contribución. El acuerdo de transferencia de copyright del trabajo completo es incompatible con el depósito del mismo en RIUMA.Se describe la implementación inicial de un método simplificado de grabación en directo de sesiones de clase en asignaturas de las Escuelas de Ingeniería de la Universidad de Málaga. La simplificación se logra al incorporar en la actividad diaria del aula ciertas características típicas de la grabación en diferido de mini videos docentes. En una configuración mínima se graba únicamente el audio y el video en pantalla de la clase, evitando los desafíos técnicos y las dificultades que implica la grabación de otros elementos como la pizarra. Esto implica el uso de anotaciones en pantalla en tiempo real para reemplazar completamente las anotaciones en la pizarra.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. I Plan Propio Integral de Docencia. Universidad de Málaga. Universidad de Málaga. Vicerectorado de Personal Docente e Investigador, Proyectos de Innovación Educativa (PIE 17-018

Unlocking Bevacizumab's Potential: rCBVmax as a Predictive Biomarker for Enhanced Survival in Glioblastoma IDH-Wildtype Patients

[EN] Background: Aberrant vascular architecture and angiogenesis are hallmarks of glioblastoma IDH-wildtype, suggesting that these tumors are suitable for antiangiogenic therapy. Bevacizumab was FDA-approved in 2009 following promising results in two clinical trials. However, its use for recurrent glioblastomas remains a subject of debate, as it does not universally improve patient survival. Purposes: In this study, we aimed to analyze the influence of tumor vascularity on the benefit provided by BVZ and propose preoperative rCBVmax at the high angiogenic tumor habitat as a predictive biomarker to select patients who can benefit the most. Methods: Clinical and MRI data from 106 patients with glioblastoma IDH-wildtype have been analyzed. Thirty-nine of them received BVZ, and the remaining sixty-seven did not receive a second-line treatment. The ONCOhabitats method was used to automatically calculate rCBV. Results: We found a median survival from progression of 305 days longer for patients with moderate vascular tumors who received BVZ than those who did not receive any second-line treatment. This contrasts with patients with high-vascular tumors who only presented a median survival of 173 days longer when receiving BVZ. Furthermore, better responses to BVZ were found for the moderate-vascular group with a higher proportion of patients alive at 6, 12, 18, and 24 months after progression. Conclusions: We propose rCBVmax as a potential biomarker to select patients who can benefit more from BVZ after tumor progression. In addition, we propose a threshold of 7.5 to stratify patients into moderate- and high-vascular groups to select the optimal second-line treatment.M.Á-T was supported by DPI2016-80054-R (Programa Estatal de Promoción del Talento y su Empleabilidad en I + D + i). This work was partially supported by the ALBATROSS project (National Plan for Scientific and Technical Research and Innovation 2017 2020, No. PID2019-104978RB-I00). This study was partially funded by the Fundació La Marató TV3 (665/C/2013). Grant PID2021- 127110OA-I00 (PROGRESS) was funded by MCIN/AEI/10.13039/501100011033 and ERDF, a way of making Europe.Alvarez-Torres, MDM.; Balaña, C.; Fuster García, E.; Puig, J.; Garcia-Gomez, JM. (2024). Unlocking Bevacizumab's Potential: rCBVmax as a Predictive Biomarker for Enhanced Survival in Glioblastoma IDH-Wildtype Patients. Cancers. 16(1). https://doi.org/10.3390/cancers1601016116

Lack of Benefit of Extending Temozolomide Treatment in Patients with High Vascular Glioblastoma with Methylated MGMT

[EN] Despite the complete treatment with surgery, chemotherapy and radiotherapy, patients with glioblastoma have a devasting prognosis. Although the role of extending temozolomide treatment has been explored, the results are inconclusive. Recent evidence suggested that tumor vascularity may be a modulating factor in combination with methylation of O6-methylguanine-DNA methyltransferase (MGMT) promotor gene on the effect of temozolomide-based therapies, opening new possibilities for personalized treatments. Before proposing a prospective interventional clinical study, it is necessary to confirm the beneficial effect of the combined effect of MGMT methylation and moderate tumor vascularity, as well as the lack of benefit of temozolomide in patients with a highly vascular tumor.In this study, we evaluated the benefit on survival of the combination of methylation of O6-methylguanine-DNA methyltransferase (MGMT) promotor gene and moderate vascularity in glioblastoma using a retrospective dataset of 123 patients from a multicenter cohort. MRI processing and calculation of relative cerebral blood volume (rCBV), used to define moderate- and high-vascular groups, were performed with the automatic ONCOhabitats method. We assessed the previously proposed rCBV threshold (10.7) and the new calculated ones (9.1 and 9.8) to analyze the association with survival for different populations according to vascularity and MGMT methylation status. We found that patients included in the moderate-vascular group had longer survival when MGMT is methylated (significant median survival difference of 174 days, p = 0.0129*). However, we did not find significant differences depending on the MGMT methylation status for the high-vascular group (p = 0.9119). In addition, we investigated the combined correlation of MGMT methylation status and rCBV with the prognostic effect of the number of temozolomide cycles, and only significant results were found for the moderate-vascular group. In conclusion, there is a lack of benefit of extending temozolomide treatment for patients with high vascular glioblastomas, even presenting MGMT methylation. Preliminary results suggest that patients with moderate vascularity and methylated MGMT glioblastomas would benefit more from prolonged adjuvant chemotherapy.M.A-T was supported by DPI2016-80054-R (Programa Estatal de Promocion del Talento y su Empleabilidad en I+D+i). This work was partially supported by the ALBATROSS project (National Plan for Scientific and Technical Research and Innovation 2017-2020, No. PID2019-104978RB-I00). This study was partially funded by the Fundacio La Marato TV3 (665/C/2013) (http://www.ccma.cat/tv3/marato/projectes-financats/2012/231/ Accessed on 8th September 2021). (JMGG); H2020-SC1-2016-CNECT Project (No. 727560) (JMGG), and H2020-SC1-BHC-2018-2020 (No. 825750) (JMGG). EFG was supported by the European Unions Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 844646 and South-Eastern Norway Regional Health Authority Grant 2021057.Álvarez-Torres, MDM.; Fuster García, E.; Balaña, C.; Puig, J.; Garcia-Gomez, JM. (2021). Lack of Benefit of Extending Temozolomide Treatment in Patients with High Vascular Glioblastoma with Methylated MGMT. Cancers. 13(21):1-14. https://doi.org/10.3390/cancers13215420S114132

Cardiac Bmi1(+) cells contribute to myocardial renewal in the murine adult heart

Introduction: The mammalian adult heart maintains a continuous, low cardiomyocyte turnover rate throughout life. Although many cardiac stem cell populations have been studied, the natural source for homeostatic repair has not yet been defined. The Polycomb protein BMI1 is the most representative marker of mouse adult stem cell systems. We have evaluated the relevance and role of cardiac Bmi1(+) cells in cardiac physiological homeostasis. Methods: Bmi1(CreER/+); Rosa26(YFP/+) (Bmi1-YFP) mice were used for lineage tracing strategy. After tamoxifen (TM) induction, yellow fluorescent protein (YFP) is expressed under the control of Rosa26 regulatory sequences in Bmi1(+) cells. These cells and their progeny were tracked by FACS, immunofluorescence and RT-qPCR techniques from 5 days to 1 year. Results: FACS analysis of non-cardiomyocyte compartment from TM-induced Bmi1-YFP mice showed a Bmi1 (+)-expressing cardiac progenitor cell (Bmi1-CPC: B-CPC) population, SCA-1 antigen-positive (95.9 +/- 0.4 \%) that expresses some stemness-associated genes. B-CPC were also able to differentiate in vitro to the three main cardiac lineages. Pulse-chase analysis showed that B-CPC remained quite stable for extended periods (up to 1 year), which suggests that this Bmi1(+) population contains cardiac progenitors with substantial self-maintenance potential. Specific immunostaining of Bmi1-YFP hearts serial sections 5 days post-TM induction indicated broad distribution of B-CPC, which were detected in variably sized clusters, although no YFP+ cardiomyocytes (CM) were detected at this time. Between 2 to 12 months after TM induction, YFP+ CM were clearly identified (3 +/- 0.6 \% to 6.7 +/- 1.3 \%) by immunohistochemistry of serial sections and by flow cytometry of total freshly isolated CM. B-CPC also contributed to endothelial and smooth muscle (SM) lineages in vivo. Conclusions: High Bmi1 expression identifies a non-cardiomyocyte resident cardiac population (B-CPC) that contributes to the main lineages of the heart in vitro and in vivo.We wish to thank M. Torres, J.M. Perez-Pomares and B.G. Galvez for critical discussions of the manuscript, A. M. Santos for assistance with confocal microscopy and dynamic imaging, R.M. Carmona for help with the animal colony management, F.S. Cabo for bioinformatics and statistical support, J.M Ligos for the sorting strategy, and K. McCreath and C. Mark for editorial support. This study was supported by grants to A.B. from the Ministry of Science and Innovation (SAF2012-34327; PLE2009-0147 and PSE-010000-2009-3), the Research Program of the Comunidad Autonoma de Madrid (S2010/BMD-2420), the Instituto de Salud Carlos III (RETICS-RD12/0019/0018 and RETICS-RD12/0019/0023) and the European Commission (Proposal 242038). The CNB-CSIC and CNIC are supported by the Spanish Ministry of Economy and Competitiveness.S