Non-O1 Vibrio cholerae inguinal skin and soft tissue infection with bullous skin lesions in a patient with a penis squamous cell carcinoma

Vibrio spp. is a pathogen rarely isolated in cancer patients, and in most cases it is associated with haematological diseases. Cutaneous manifestations of this organism are even rarer. We report a case of Non-O1 Vibrio cholerae inguinal skin and soft tissue infection presenting bullous skin lesions in a young type II diabetic patient with a penis squamous cell carcinoma having a seawater exposure history

TRATAMIENTO DE DATOS TLS MEDIANTE EL EMPLEO DE IMÁGENES ESFÉRICAS: APLICACIÓN A LA DOCUMENTACIÓN DE LA SALA CAPITULAR DE LA CATEDRAL DE JAÉN

[EN] Nowadays, one of the techniques more used for documentation of cultural heritage is terrestrial laser scanner (TLS). This kind of instrumental has become essential in this kind of heritage projects. However, in many projects, the captured information by these systems are excessive, which hinders its data processing and information extraction. But when the documentation purpose is limited to the visualization or dissemination, the final products can be simpler than those obtained from the dense point clouds and the resulting detailed models. In this paper it is presented an approach based on TLS data processed with spherical images algorithms. TLS point clouds are used to simulate spherical images allowing the storage, processing, visualization and dissemination of both data and products. This approach has been applied to a real study case in the documentation of the chapterhouse of the Cathedral of Jaén.[ES] En la actualidad, una de las técnicas más utilizadas para la documentación del patrimonio cultural es el escáner láser terrestre, instrumental que se ha convertido en imprescindible en cualquier empresa que se dedique a estos fines. Sin embargo, en muchos casos la información capturada por estos sistemas es excesiva, lo que dificulta su procesado y la posterior extracción de información. Por otro lado, cuando el fin es solo la visualización o la divulgación del monumento, los productos necesarios son más simples que la nube de puntos densa o una modelización de gran precisión obtenida a partir de esta nube. En este trabajo se presenta una filosofía de trabajo con datos TLS basada en el uso de imágenes esféricas obtenidas a partir de las nubes de puntos provenientes del escaneado, que facilita su almacenamiento, procesado, visualización y divulgación. Finalmente se presenta la metodología llevada a cabo y los resultados obtenidos en un caso de estudio real, más concretamente en la documentación de la Sala Capitular de la Catedral de Jaén.Gomez-Lopez, J.; Pérez-García, JL.; Colomo, C.; Cardenal, J.; Mata, E. (2016). TRATAMIENTO DE DATOS TLS MEDIANTE EL EMPLEO DE IMÁGENES ESFÉRICAS: APLICACIÓN A LA DOCUMENTACIÓN DE LA SALA CAPITULAR DE LA CATEDRAL DE JAÉN. En 8th International congress on archaeology, computer graphics, cultural heritage and innovation. Editorial Universitat Politècnica de València. 118-124. https://doi.org/10.4995/arqueologica8.2015.3535OCS11812

Effects of COVID-19 vaccination on disease activity in patients with rheumatoid arthritis and psoriatic arthritis on targeted therapy in the COVIDSER study

COVID-19; Artritis psoriásica; VacunaciónCOVID 19; Artritis psoriàsica; VacunacióCOVID-19; Psoriatic arthritis; VaccinationObjective: To investigate the influence of COVID-19 vaccination on disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients under targeted therapies. Patients and methods: 1765 vaccinated patients COVID-19, 1178 (66.7%) with RA and 587 (33.3%) with PsA from the COVID-19 registry in patients with rheumatic diseases (COVIDSER) project, were included. Demographics, disease characteristics, Disease Activity Score in 28 joints (DAS28) and targeted treatments were collected. DAS28-based flare rates and categorised disease activity distribution prevaccination and post vaccination were analysed by log-linear regression and contingency analyses, respectively. The influence of vaccination on DAS28 variation as a continuous measure was evaluated using a random coefficient model. Results: The distribution of categorised disease activity and flare rates was not significantly modified by vaccination. Log-linear regression showed no significant changes in the rate of flares in the 6-month period after vaccination compared with the same period prior to vaccination in neither patients with RA nor patients with PsA. When DAS28 variations were analysed using random coefficient models, no significant variations in disease activity were detected after vaccination for both groups of patients. However, patients with RA treated with Janus kinase inhibitors (JAK-i) (1) and interleukin-6 inhibitor (IL-6-i) experienced a worsening of disease activity (1.436±0.531, p=0.007, and 1.201±0.550, p=0.029, respectively) in comparison with those treated with tumour necrosis factor inhibitor (TNF-i). Similarly, patients with PsA treated with interleukin-12/23 inhibitor (IL-12/23-i) showed a worsening of disease activity (4.476±1.906, p=0.019) compared with those treated with TNF-i. Conclusion: COVID-19 vaccination was not associated with increased rate of flares in patients with RA and PsA. However, a potential increase in disease activity in patients with RA treated with JAK-i and IL-6-i and in patients with PsA treated with IL-12/23-i warrants further investigation

Drug Repurposing for Cancers With Limited Survival: Protocol for a Retrospective Cohort Study

Only 5% of the molecules tested in oncology phase 1 trials reach the market after an average of 7.5 years of waiting and at a cost of tens of millions of dollars. To reduce the cost and shorten the time of discovery of new treatments, drug repurposing (research with molecules already approved for another indication) and the use of secondary data (not collected for the purpose of research) have been proposed. Due to advances in informatics in clinical care, secondary data can, in some cases, be of equal quality to primary data generated through prospective studies.Objective: The objective of this study is to identify drugs currently marketed for other indications that may have an effect on the prognosis of patients with cancer.Methods: We plan to monitor a cohort of patients with high-lethality cancers treated in the public health system of Catalonia between 2006 and 2012, retrospectively, for survival for 5 years after diagnosis or until death. A control cohort, comprising people without cancer, will also be retrospectively monitored for 5 years. The following study variables will be extracted from different population databases: type of cancer (patients with cancer cohort), date and cause of death, pharmacological treatment, sex, age, and place of residence. During the first stage of statistical analysis of the patients with cancer cohort, the drugs consumed by the long-term survivors (alive at 5 years) will be compared with those consumed by nonsurvivors. In the second stage, the survival associated with the consumption of each relevant drug will be analyzed. For the analyses, groups will be matched for potentially confounding variables, and multivariate analyses will be performed to adjust for residual confounding variables if necessary. The control cohort will be used to verify whether the associations found are exclusive to patients with cancer or whether they also occur in patients without cancer.Results: We anticipate discovering multiple significant associations between commonly used drugs and the survival outcomes of patients with cancer. We expect to publish the initial results in the first half of 2024.Conclusions: This retrospective study may identify several commonly used drugs as candidates for repurposing in the treatment of various cancers. All analyses are considered exploratory; therefore, the results will have to be confirmed in subsequent clinical trials. However, the results of this study may accelerate drug discovery in oncology

Treinta años de investigación y desarrollo de boyas Lagrangianas en el Instituto de Ciencias del Mar

Since the mid-1980s, physical oceanographers at the Institute of Marine Sciences have been involved in the use of Lagrangian drifters as a complementary technology for their oceanographic research. As Lagrangian observations became more feasible, these researchers continued developing their own drifters in what was to be the seed of current technological activities at the Physical and Technological Oceanography Department. In this paper we overview the work done during the last 30 years with special focus on Lagrangian developments from the initial activities to the latest developments. In addition to basic oceanography research applications, Lagrangian technological developments include prototypes for measuring surface and subsurface ocean properties, for tracking purposes in search and rescue operations and pollution events, and for monitoring ice motion and thickness in the Arctic. The paper emphasizes original and unpublished technical aspects related to the latest developments.Desde mediados de la década de los 80, los oceanógrafos físicos en el Instituto de Ciencias del Mar se involucraron en el uso de boyas Lagrangianas como una tecnología complementaria para su investigación oceanográfica. A medida que las observaciones Lagrangianas se volvieron más factibles, los investigadores continuaron desarrollando sus propios flotadores en lo que se convirtió en la semilla de las actuales actividades tecnológicas llevadas a cabo en el Departamento de Oceanografía Física y Tecnológica. En este artículo se presenta una visión general del trabajo realizado durante los últimos 30 años, con especial énfasis en el uso de flotadores a la deriva y desarrollos propios desde su inicio hasta las aplicaciones más recientes. Además de estudios básicos de investigación oceanográfica, los desarrollos tecnológicos llevados a cabo incluyen prototipos para medir las propiedades superficiales y sub-superficiales, para tareas de seguimiento en operaciones de búsqueda y rescate y eventos de contaminación marina o para monitorizar el grosor de la capa de hielo y su movimiento en el Ártico. En este trabajo se hace hincapié en aspectos técnicos originales e inéditos relacionados con los últimos desarrollos

Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial

Background: There is no established insulin regimen in T2DM patients receiving parenteral nutrition. Aims: To compare the effectiveness (metabolic control) and safety of two insulin regimens in patients with diabetes receiving TPN. Design: Prospective, open-label, multicenter, clinical trial on adult inpatients with type 2 diabetes on a non-critical setting with indication for TPN. Patients were randomized on one of these two regimens: 100% of RI on TPN or 50% of Regular insulin added to TPN bag and 50% subcutaneous Gl. Data were analyzed according to intention-to-treat principle. Results: 81 patients were on RI and 80 on GI. No differences were observed in neither average total daily dose of insulin, programmed or correction, nor in capillary mean blood glucose during TPN infusion (165.3 +/- 35.4 in RI vs 172.5 +/- 43.6 mg/dL in GI; p = 0.25). Mean capillary glucose was significantly lower in the GI group within two days after TPN interruption (160.3 +/- 45.1 in RI vs 141.7 +/- 43.8 mg/dL in GI; p = 0.024). The percentage of capillary glucose above 180 mg/dL was similar in both groups. The rate of capillary glucose <= 70 mg/dL, the number of hypoglycemic episodes per 100 days of TPN, and the percentage of patients with non-severe hypoglycemia were significantly higher on GI group. No severe hypoglycemia was detected. No differences were observed in length of stay, infectious complications, or hospital mortality. Conclusion: Effectiveness of both regimens was similar. GI group achieved better metabolic control after TPN interruption but non-severe hypoglycemia rate was higher in the GI group. (C) 2019 The Author(s). Published by Elsevier Ltd

Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020.

Background: This paper aims to assess temporal trends (2016–2020) in incidence, patient’s characteristics, complications, length of hospital stay (LOHS) and in-hospital mortality (IHM) among patients with and without idiopathic pulmonary fibrosis (IPF) undergoing lung transplantation (LTx). We also analyse the effect of the COVID-19 pandemic on LTx in these populations. (2) Methods: A retrospective, population-based observational study was conducted using the Spanish National Hospital Discharge Database. Multivariable adjustment was conducted with logistic regression to analyse the IHM. (3) Results: We identified 1777 admissions for LTx during the study period, of which 573 (32.2%) were performed in patients with IPF. The number of hospital admissions for LTx rose from 2016 to 2020, both in patients with and without IPF, but a marked reduction was observed from year 2019 to year 2020. Over time, the proportion of single LTx decreased and bilateral LTx increased significantly in both groups. The incidence of LTx complications increased significantly over time along with the increase in the incidence of IPF. No significant differences in the incidence of complications or in the IHM between patients with and without IPF were found. Suffering any complication of the LTx and pulmonary hypertension were conditions positively associated with IHM in patients with and without IPF. The IHM remained stable from 2016 to 2020 in both study populations and was not affected by the COVID pandemic. (4) Conclusions: Patients with IPF account for almost a third of all lung transplants. The number of LTx increased over time in patients with and without IPF, but a marked reduction was observed from 2019 to 2020. Although the proportion of LTx complications increased significantly over time in both groups, the IHM did not change. IPF was not associated with increased complications or IHM after LTx.Partial funding for open access charge: Universidad de Málag

Guía de las actividades de los contenidos del segundo cuatrimestre de la asignatura de Citología e Histología Vegetal y Animal

En este trabajo recogemos las principales pautas y metodología seguida para la elaboración de la Guía de Estudio de parte de los contenidos del segundo cuatrimestre de la asignatura de Citología e Histología Animal y Vegetal de los estudios de Biología. En dicha guía se recoge el desarrollo de las actividades docentes que han sido llevadas a cabo utilizando la plataforma informática Campos Virtual de la Universidad de Alicante. Se trata del ensayo de una nueva manera de abordar el proceso de enseñanza/aprendizaje de nuestros alumnos, tendente a la adaptación de los contenidos de Histología al Espacio Europeo de Educación Superior (EEES). El método empleado ha sido introducir a nuestros alumnos a ser los artífices de su propia formación, mediante la realización tanto de tareas de autoaprendizaje como la exposición de sus resultados al resto de sus compañeros en una serie de seminarios. La metodología empleada se expone en cada uno de los apartados de esta guía