Interactive comment on CO2 radiative forcing during the Holocene Thermal Maximum revealed by stomatal frequency of Iberian oak leaves (2)

Here we analyse radiocarbon-dated Quercus leaf assemblages from northern Spain to obtain past atmospheric CO2 mixing ratios for the time period 9000–1100 cal BP by means of stomatal frequency analysis. Normalized, stomata based CO2 records show fluctuations of 20 ppmv during the Holocene that parallel Northern 5 Hemisphere palaeotemperature reconstructions. The calculated radiative forcing of CO2 indicates a CO2 contribution of +0.1_C to the Holocene Thermal Maximum from 7 to 5 kyr BP, and −0.05_C to the Neoglacial cooling around 4 kyr BP. Derived northern hemispheric air-temperature anomalies forced by atmospheric CO2 variation suggest an active role 10 of this trace gas as an amplifier of initial orbital forcing of Holocene climate

The impact of a large object with Jupiter in July 2009

On 2009 July 19, we observed a single, large impact on Jupiter at a planetocentric latitude of 55^{\circ}S. This and the Shoemaker-Levy 9 (SL9) impacts on Jupiter in 1994 are the only planetary-scale impacts ever observed. The 2009 impact had an entry trajectory opposite and with a lower incidence angle than that of SL9. Comparison of the initial aerosol cloud debris properties, spanning 4,800 km east-west and 2,500 km north-south, with those produced by the SL9 fragments, and dynamical calculations of pre-impact orbit, indicate that the impactor was most probably an icy body with a size of 0.5-1 km. The collision rate of events of this magnitude may be five to ten times more frequent than previously thought. The search for unpredicted impacts, such as the current one, could be best performed in 890-nm and K (2.03-2.36 {\mu}m) filters in strong gaseous absorption, where the high-altitude aerosols are more reflective than Jupiter's primary cloud.Comment: 15 pages, 5 figure

STAG3 is a strong candidate gene for male infertility

Oligo- and azoospermia are severe forms of male infertility. However, known genetic factors account only for a small fraction of the cases. Recently, whole-exome sequencing in a large consanguineous family with inherited premature ovarian failure (POF) identified a homozygous frameshift mutation in the STAG3 gene leading to a premature stop codon. STAG3encodes a meiosis-specific subunit of the cohesin complex, alarge proteinaceous ring with DNA-entrapping ability that ensures sister chromatid cohesion and enables correct synapsis and segregation of homologous chromosomes during meiosis. The pathogenicity of the STAG3 mutations was functionally validated with a loss- of-function mouse model for STAG3 in oogenesis.However,and sincenone of the male members of this family was homozygous for the mutant allele, we only could hypothesized its putative involvement inmale infertility. In this report,we show that male mice devoid of Stag3 display a severe meiotic phenotype that includes a meiotic arrest at zygonema-like shortening of their chromosome axial elements/lateral elements, partial loss of centromeric cohesion at early prophase and maintenance of the ability to initiate but not complete RAD51- and DMC1-mediated double-strand break repair,demonstrating that STAG3 is a crucial cohesin subunit in mammalian gametogenesis and supporting our proposal that STAG3 is a strong candidate gene for human male infertility. © The Author 2014. Published by Oxford University Press. All rights reserved.This work was supported by grant SAF2011-25252 and Junta de Castilla y León (EL and AMP). SC and RAV are supported by the University Paris Diderot-Paris7, the Ligue Nationale contre le Cancer, the Centre National de la Recherche Scientifique (CNRS) and the GIS-Institut des Maladies Rares.Peer Reviewe

Estudio sobre el comportamiento de presas de escollera ante vertidos por coronación.

Como consecuencia del desarrollo de un Proyecto de Investigación, el CEDEX, la Universidad Politécnica de Madrid y el CIMNE han trabajado conjuntamente en el desarrollo de un método para el estudio del proceso de rotura de presas de escollera por sobrevertido combinando técnicas de elementos finitos y partículas. Para ello se han realizado y analizado 80 ensayos en modelo físico en las instalaciones del CEDEX y UPM, utilizando seis tamaños de material, cuatro taludes distintos (1,5H:1V; 2,2H:1V; 3,0H:1V y 3,5H:1V) y tres opciones de impermeabilización (sin pantalla, núcleo interno y pantalla externa). Estos ensayos están permitiendo conocer mejor el fenómeno y calibrar el modelo matemático. El modelo matemático basa su desarrollo en el acoplamiento de dos fenómenos: la filtración del agua en un medio granular (simulada mediante una malla euleriana) y la erosión del propio material granular (simulada mediante una malla lagrangiana). Durante 2010 se prevé finalizar la construcción, en el CEDEX, de un canal de grandes dimensiones que permitirá ensayar presas de hasta 4 m de altura en condiciones de laboratorio, que servirán como prototipo para el análisis del efecto de escala. Este prototipo aumentará considerablemente la fiabilidad de las conclusiones obtenidas

D-Brane Chemistry

We study several different kinds of bound states built from D-branes and orientifolds. These states are to atoms what branonium - the bound state of a brane and its anti-brane - is to positronium, inasmuch as they typically involve a light brane bound to a much heavier object with conserved charges which forbid the system's decay. We find the fully relativistic motion of a probe Dp'-brane in the presence of source Dp-branes is integrable by quadratures. Keplerian conic sections are obtained for special choices for p and p' and the systems are shown to be equivalent to nonrelativistic systems. Their quantum behaviour is also equivalent to the corresponding non-relativistic limit. In particular the p=6, p'=0 case is equivalent to a non-relativistic dyon in a magnetic monopole background, with the trajectories in the surface of a cone. We also show that the motion of the probe branes about D6-branes in IIA theory is equivalent to the motion of the corresponding probes in the uplift to M-theory in 11 dimensions, for which there are no D6-branes but their fields are replaced by a particular Taub-NUT geometry. We further discuss the interactions of D-branes and orientifold planes having the same dimension. this system behaves at large distances as a brane-brane system but at shorter distances it does not have the tachyon instability.Comment: ref. added and typos correcte

An Improved Brane Anti-Brane Action from Boundary Superstring Field Theory and Multi-Vortex Solutions

We present an improved effective action for the D-brane-anti-D-brane system obtained from boundary superstring field theory. Although the action looks highly non-trivial, it has simple explicit multi-vortex (i.e. codimension-2 multi-BPS D-brane) multi-anti-vortex solutions. The solutions have a curious degeneracy corresponding to different ``magnetic'' fluxes at the core of each vortex. We also generalize the brane anti-brane effective action that is suitable for the study of the inflationary scenario and the production of defects in the early universe. We show that when a brane and anti-brane are distantly separated, although the system is classically stable it can decay via quantum tunneling through the barrier.Comment: 24 pages, 1 figure, JHEP3.cls; v2: references added, tunneling rate discussion expande

Branonium

We study the bound states of brane/antibrane systems by examining the motion of a probe antibrane moving in the background fields of N source branes. The classical system resembles the point-particle central force problem, and the orbits can be solved by quadrature. Generically the antibrane has orbits which are not closed on themselves. An important special case occurs for some Dp-branes moving in three transverse dimensions, in which case the orbits may be obtained in closed form, giving the standard conic sections but with a nonstandard time evolution along the orbit. Somewhat surprisingly, in this case the resulting elliptical orbits are exact solutions, and do not simply apply in the limit of asymptotically-large separation or non-relativistic velocities. The orbits eventually decay through the radiation of massless modes into the bulk and onto the branes, and we estimate this decay time. Applications of these orbits to cosmology are discussed in a companion paper.Comment: 34 pages, LaTeX, 4 figures, uses JHEP

The spatial distribution of star and cluster formation in M51

Aims. We study the connection between spatially resolved star formation and young star clusters across the disc of M51. Methods. We combine star cluster data based on B, V, and I-band Hubble Space Telescope ACS imaging, together with new WFPC2 U-band photometry to derive ages, masses, and extinctions of 1580 resolved star clusters using SSP models. This data is combined with data on the spatially resolved star formation rates and gas surface densities, as well as Halpha and 20cm radio-continuum (RC) emission, which allows us to study the spatial correlations between star formation and star clusters. Two-point autocorrelation functions are used to study the clustering of star clusters as a function of spatial scale and age. Results. We find that the clustering of star clusters among themselves decreases both with spatial scale and age, consistent with hierarchical star formation. The slope of the autocorrelation functions are consistent with projected fractal dimensions in the range of 1.2-1.6, which is similar to other galaxies, therefore suggesting that the fractal dimension of hierarchical star formation is universal. Both star and cluster formation peak at a galactocentric radius of 2.5 and 5 kpc, which we tentatively attribute to the presence of the 4:1 resonance and the co-rotation radius. The positions of the youngest (<10 Myr) star clusters show the strongest correlation with the spiral arms, Halpha, and the RC emission, and these correlations decrease with age. The azimuthal distribution of clusters in terms of kinematic age away from the spiral arms indicates that the majority of the clusters formed 5-20 Myr before their parental gas cloud reached the centre of the spiral arm.Comment: 14 pages, 21 figures, accepted for publication in A&

BioJS: An open source standard for biological visualisation - its status in 2014

BioJS is a community-based standard and repository of functional components to represent biological information on the web. The development of BioJS has been prompted by the growing need for bioinformatics visualisation tools to be easily shared, reused and discovered. Its modular architecture makes it easy for users to find a specific functionality without needing to know how it has been built, while components can be extended or created for implementing new functionality. The BioJS community of developers currently provides a range of functionality that is open access and freely available. A registry has been set up that categorises and provides installation instructions and testing facilities at http://www.ebi.ac.uk/tools/biojs/. The source code for all components is available for ready use at https://github.com/biojs/biojs

The biota of the Upper Cretaceous site of Lo Hueco (Cuenca, Spain)

The Late Cretaceous (Campanian-Maastrichtian) fossil site of Lo Hueco was recently discovered close to the village of Fuentes (Cuenca, Spain) during the cutting of a little hill for installation of the railway of the Madrid-Levante high-speed train. To date, it has yielded a rich collection of well-preserved Cretaceous macrofossils, including plants, invertebrates, and vertebrates. The recovered fossil assemblage is mainly composed of plants, molluscs (bivalves and gastropods), actinopterygians and teleosteans fishes, amphibians, panpleurodiran (bothremydids) and pancryptodiran turtles, squamate lizards, eusuchian crocodyliforms, rhabdodontid ornithopods, theropods (mainly dromaeosaurids), and titanosaur sauropods. This assemblage was deposited in a near-coast continental muddy floodplain crossed by distributary sandy channels, exposed intermittently to brackish or marine and freshwater flooding as well as to partial or total desiccation events.The Konzentrat-Lagerstatt of Lo Hueco constitutes a singular accumulation of fossils representing individuals of some particular lineages of continental tetrapods, especially titanosaurs, eusuchians and bothremydid turtles. In the case of the titanosaurs, the site has yielded multiple partial skeletons in anatomical connection or with a low dispersion of their skeletal elements. A combination of new taxa, new records of taxa previously known in the Iberian Peninsula, and relatively common taxa in the European record compose the Lo Hueco biota. The particular conditions of the fossil site of Lo Hueco and the preliminary results indicate that the analysis of the geological context, the floral and faunal content, and the taphonomical features of the site provide elements that will be especially useful for reassess the evolutionary history of some lineages of European Late Cretaceous reptiles.Peer reviewe