Photodegradation of nimodipine and felodipine in microheterogeneous systems

Indexación: Web of Science; ScieloThe photochemical behavior of nimodipine (NIMO) and felodipine (FELO), photolabile drugs widely used as antihypertensive calcium channel blockers, is studied in constrained media. Specifically, we are interested in the kinetic analysis of 4-aryl-1,4-dihydropyridine photodegradation processes when they are incorporated in biological-mimicking systems like micelles or liposomes. In order to establish if the nature of the head of surfactant (ionic or nonionic) could be important modulating the photo-reactivity of these drugs, we studied the photodegradation of NIMO and FELO incorporated in micelles formed with sodium dodecyl sulfate (SDS, anionic), dodecyl-pyridinium chloride (DPC, cationic) and mono lauryl sucrose ester (MLS, nonionic) as surfactants. Additionally, the results of the photodegradation of these compounds in liposomes were also included. The results clearly indicate that both dihydropyridines studied, NIMO and FELO, are located near to the interface, but the surface charge of micelles does not affect neither, the photodegradation rate constant nor the photodegradation products profile. The absence of singlet oxygen generation in micellar media is consistent with the proposition of these 4-aryl-1,4-dihidropyridines located near to the interface of the micelle, where a polar environment is sensed. In addition, the ethanol preferential location on membranes and dihydropyridine enhanced photodegradation by alcohol presence are interesting results to consider in future research.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300025&nrm=is

Squeezing spectra from s-ordered quasiprobability distributions. Application to dispersive optical bistability

It is well known that the squeezing spectrum of the field exiting a nonlinear cavity can be directly obtained from the fluctuation spectrum of normally ordered products of creation and annihilation operators of the cavity mode. In this article we show that the output field squeezing spectrum can be derived also by combining the fluctuation spectra of any pair of s-ordered products of creation and annihilation operators. The interesting result is that the spectrum obtained in this way from the linearized Langevin equations is exact, and this occurs in spite of the fact that no s-ordered quasiprobability distribution verifies a true Fokker-Planck equation, i.e., the Langevin equations used for deriving the squeezing spectrum are not exact. The (linearized) intracavity squeezing obtained from any s-ordered distribution is also exact. These results are exemplified in the problem of dispersive optical bistability.Comment: 15 pages, no figures, to be published in Journal of Modern Optic

Parameterization, Analysis, and Risk Management in a Comprehensive Management System with Emphasis on Energy and Performance (ISO 50001: 2018)

[EN] The future of business development relies on the effective management of risks, opportunities, and energy and water resources. Here, we evaluate the application of best practices to identify, analyze, address, monitor, and control risks and opportunities (R/O) according to ISO 31000 and 50000. Furthermore, we shed light on tools, templates, ISO guides, and international documents that contribute to classifying, identifying, formulating control, and managing R/O parameterization in a comprehensive management system model, namely CMS QHSE3+, which consists of quality (Q), health and safety (HS), environmental management (E), energy efficiency (E2), and other risk components (+) that include comprehensive biosecurity and biosafety. By focusing on the deployment of R/O-based thinking (ROBT) at strategic and operational levels, we show vulnerability reduction in CMS QHSE3+ by managing energy, efficiency, and sustainability.We express our gratitude for the support from Cajacopi Atlantico, QUARA Technology, ASTEQ Technology, Universidad Simon Bolivar, Universitat Politecnica de Valencia and to all the personnel and companies who offered us their contributions and their valuable points of view.Poveda-Orjuela, PP.; García-Díaz, JC.; Pulido-Rojano, A.; Cañón-Zabala, G. (2020). Parameterization, Analysis, and Risk Management in a Comprehensive Management System with Emphasis on Energy and Performance (ISO 50001: 2018). Energies. 13(21):1-44. https://doi.org/10.3390/en13215579S1441321SDBS Business Demography Indicatorshttps://stats.oecd.org/index.aspx?queryid=70734The World Economy on a Tightrope. OECD Economic Outlook, June 2020http://www.oecd.org/economic-outlook/Strategic Plan 2016–2020www.https://trade.ec.europa.eu/doclib/docs/2016/august/tradoc_154919.pdfSMEs, and Their Business Problems. Case Analysishttps://www.redalyc.org/pdf/206/20605209.pdfMuñoz, P. (2013). The Distinctive Importance of Sustainable Entrepreneurship. Current Opinion in Creativity, Innovation and Entrepreneurship, 2(1). doi:10.11565/cuocient.v2i1.26Parrish, B. D. (2010). Sustainability-driven entrepreneurship: Principles of organization design. Journal of Business Venturing, 25(5), 510-523. doi:10.1016/j.jbusvent.2009.05.005Chaos Report 2015http://www.laboratorioti.com/2016/05/16/informe-del-caos-2015-chaos-report-2015/Dirección de Marketing. Ciudad de México: Pearson and Prentice Hall, 12a Ediciónhttp://biblio.econ.uba.ar/opac-tmpl/bootstrap/tc/148262_TC.pdfPoveda-Orjuela, P. P., García-Díaz, J. C., Pulido-Rojano, A., & Cañón-Zabala, G. (2019). ISO 50001: 2018 and Its Application in a Comprehensive Management System with an Energy-Performance Focus. Energies, 12(24), 4700. doi:10.3390/en12244700Continuity Planning for Your Businesshttps://www.westpac.com.au/content/dam/public/wbc/documents/pdf/help/disaster/WBC_business_continuity_planning_covid-19_checklist.pdfCOVID-19: Five Ways to Maintain Continuity and Reshape for Resiliencehttps://www.ey.com/en_be/transactions/companies-can-reshape-results-and-plan-forcovid-19-recoveryAven, T. (2012). The risk concept—historical and recent development trends. Reliability Engineering & System Safety, 99, 33-44. doi:10.1016/j.ress.2011.11.006Oliva, F. L. (2016). A maturity model for enterprise risk management. International Journal of Production Economics, 173, 66-79. doi:10.1016/j.ijpe.2015.12.007Aven, T., & Zio, E. (2011). Some considerations on the treatment of uncertainties in risk assessment for practical decision making. Reliability Engineering & System Safety, 96(1), 64-74. doi:10.1016/j.ress.2010.06.001The ISO 27k Forumhttps://www.iso27001security.com/html/iso27000.htmlKaya, İ. (2017). Perspectives on Internal Control and Enterprise Risk Management. Eurasian Studies in Business and Economics, 379-389. doi:10.1007/978-3-319-67913-6_26Barafort, B., Mesquida, A.-L., & Mas, A. (2017). Integrating risk management in IT settings from ISO standards and management systems perspectives. Computer Standards & Interfaces, 54, 176-185. doi:10.1016/j.csi.2016.11.010Aven, T. (2016). Risk assessment and risk management: Review of recent advances on their foundation. European Journal of Operational Research, 253(1), 1-13. doi:10.1016/j.ejor.2015.12.023Thekdi, S., & Aven, T. (2016). An enhanced data-analytic framework for integrating risk management and performance management. Reliability Engineering & System Safety, 156, 277-287. doi:10.1016/j.ress.2016.07.010Aven, T., & Zio, E. (2013). Foundational Issues in Risk Assessment and Risk Management. Risk Analysis, 34(7), 1164-1172. doi:10.1111/risa.12132Labodová, A. (2004). Implementing integrated management systems using a risk analysis based approach. Journal of Cleaner Production, 12(6), 571-580. doi:10.1016/j.jclepro.2003.08.008World trends and the future of Latin America; ECLAC UNIDO, 2016–Public Management Series, No 85. ISSN 1680-8827, LC/L.4246 LC/IP/L.348https://repositorio.cepal.org/bitstream/handle/11362/40788/S1600740_es.pdf?sequence=1&isAllowed=yBudhi, M. K. S., Lestari, N. P. N. E., Suasih, N. N. R., & Wijaya, P. Y. (2020). Strategies and policies for developing SMEs based on creative economy. Management Science Letters, 2301-2310. doi:10.5267/j.msl.2020.3.005Melly, D., & Hanrahan, J. (2020). Tourism biosecurity risk management and planning: an international comparative analysis and implications for Ireland. Tourism Review, 76(1), 88-102. doi:10.1108/tr-07-2019-0312Guide for Business Continuity during COVID-19http://www.andi.com.co/Uploads.pdfLa Danse, 1910. Musee de l’Hermitage, Saint-Pétersbourg, Russie. Consulté le 28 Juillet 2020https://www.hermitagemuseum.org/wps/portal/hermitage/Uriarte-Romero, R., Gil-Samaniego, M., Valenzuela-Mondaca, E., & Ceballos-Corral, J. (2017). Methodology for the Successful Integration of an Energy Management System to an Operational Environmental System. Sustainability, 9(8), 1304. doi:10.3390/su9081304Cosgrove, J., Littlewood, J., & Wilgeroth, P. (2017). Development of a framework of key performance indicators to identify reductions in energy consumption in a medical devices production facility. International Journal of Ambient Energy, 39(2), 202-210. doi:10.1080/01430750.2017.1278718Wu, J., Cheng, B., Wang, M., & Chen, J. (2017). Quality-Aware Energy Optimization in Wireless Video Communication With Multipath TCP. IEEE/ACM Transactions on Networking, 25(5), 2701-2718. doi:10.1109/tnet.2017.2701153Biosecurity. Madridhttps://www.insst.es/-/bioseguridadArvanitis, S., Loukis, E., & Diamantopoulou, V. (2013). The effect of soft ICT capital on innovation performance of Greek firms. Journal of Enterprise Information Management, 26(6), 679-701. doi:10.1108/jeim-07-2013-0048ICT in small firms: Factors affecting the adoption and use of ICT in Southeast England SMEshttps://aisel.aisnet.org/ecis2008/167Legg, S. J., Olsen, K. B., Laird, I. S., & Hasle, P. (2015). Managing safety in small and medium enterprises. Safety Science, 71, 189-196. doi:10.1016/j.ssci.2014.11.007Podgórski, D. (2015). Measuring operational performance of OSH management system – A demonstration of AHP-based selection of leading key performance indicators. Safety Science, 73, 146-166. doi:10.1016/j.ssci.2014.11.018Cagno, E., Micheli, G. J. L., Masi, D., & Jacinto, C. (2013). Economic evaluation of OSH and its way to SMEs: A constructive review. Safety Science, 53, 134-152. doi:10.1016/j.ssci.2012.08.016Badri, A., Gbodossou, A., & Nadeau, S. (2012). Occupational health and safety risks: Towards the integration into project management. Safety Science, 50(2), 190-198. doi:10.1016/j.ssci.2011.08.008Carlson, R., Erixon, M., Forsberg, P., & Pålsson, A.-C. (2001). System for integrated business environmental information management. Advances in Environmental Research, 5(4), 369-375. doi:10.1016/s1093-0191(01)00088-0Florio, C., & Leoni, G. (2017). Enterprise risk management and firm performance: The Italian case. The British Accounting Review, 49(1), 56-74. doi:10.1016/j.bar.2016.08.003Aven, T., & Ylönen, M. (2018). A risk interpretation of sociotechnical safety perspectives. Reliability Engineering & System Safety, 175, 13-18. doi:10.1016/j.ress.2018.03.004Skorupinska, A., & Torrent-Sellens, J. (2017). ICT, Innovation and Productivity: Evidence Based on Eastern European Manufacturing Companies. Journal of the Knowledge Economy, 8(2), 768-788. doi:10.1007/s13132-016-0441-1Benitez‐Amado, J., Llorens‐Montes, F. J., & Nieves Perez‐Arostegui, M. (2010). Information technology‐enabled intrapreneurship culture and firm performance. Industrial Management & Data Systems, 110(4), 550-566. doi:10.1108/02635571011039025González-Posada, D. M., & Reyes-Bedoya, N. (2019). Herramientas de gestión al alcance: caso red de hostales de la ciudad de Medellín. Revista CEA, 5(9), 113-129. doi:10.22430/24223182.1261Hernandis Ortuño, B., & Briede Westermeyer, J. C. (2009). AN EDUCATIONAL APPLICATION FOR A PRODUCT DESIGN AND ENGINEERING SYSTEMS USING INTEGRATED CONCEPTUAL MODELS. Ingeniare. Revista chilena de ingeniería, 17(3). doi:10.4067/s0718-3305200900030001

Strategies for fostering autonomous language learning through the use of mobile devices (mobile learning)

La autonomía del aprendizaje ha cobrado gran importancia debido a la necesidad de satisfacer la demanda de formación continua de los profesionales. En un escenario tan dinámico como el mundo actual, parece que los modelos educativos clásicos no son suficientemente flexibles para que este aprendizaje permanente sea, por una parte, compatible con el resto de obligaciones y, por otra, ajustado a las necesidades formativas individuales. Por tanto, se promueve el uso de estrategias que permitan que las personas aprendan de manera autónoma.Nos acercaremos al concepto de aprendizaje autónomo desde las definiciones de (Esch, 1996) o (Holec, 1981), para unirlo al concepto de aprendizaje móvil, siguiendo a (Godwin-Jones, 2011), quien entiende que es el complemento ideal, pues posibilita llevar a cabo formación en distintos contextos (seamless learning), y que, además, permite la creación de entornos personales de aprendizaje en un paradigma integrador de distintos escenarios formativos (Park, 2001) (Sharples et al., 2008).Estos dos conceptos son la base del proyecto europeo SEAGULL.  El proyecto parte de la convicción de que el aprendizaje de una lengua es un proceso dependiente de la capacidad de cooperación comunicativa y de la autonomía de sus participantes (Escribano Ortega & González Casares, 2013).Se propone el trabajo en tándem con base tecnológica de comunicación síncrona a través de Internet: parejas de alumnos que se apoyan mutuamente en el aprendizaje de una lengua extranjera, siendo cada uno de los participantes nativo de la lengua que está aprendiendo su compañero (Grümpel, Orduña, & Ruipérez, 2014).El presente artículo es resultado del siguiente proyecto de investigación: SEAGULL, Smart Educational Autonomy through Guided Language Learning (European Commission's Lifelong Learning Programme).European Commission's Lifelong Learning ProgrammeArtículo revisado por pare

Efecto de Xoconostle (Opuntia matudae Scheinvar) sobre la concentración de metano y las variables ruminales durante una fermentación in vitro de rastrojo de maíz

The effect of the addition of xoconostle on in vitro ruminal fermentation of corn stover was determined in order to reduce methane emission. Previous studies have shown that xoconostle contains bioactive compounds with potential antimicrobial activity that enhance ruminal fermentation. Zero point zero percent, 2.0 %, 4.0 % and 6.0 % of xoconostle were added. The following were determined: chemical composition of the substrates, phenolic compounds, antioxidant capacity, in vitro disappearance of dry matter (IVDDM), the production of volatile fatty acids (VFAs) and the kinetic variables of gas production. The volume of methane was measured using the technique of capturing carbon dioxide in sodium hydroxide solution. The content of protein, ether extract, total phenols and antioxidant activity significantly increased (P<0.05) with the addition of xoconostle. The IVDDM also increased with the addition of xoconostle. Regarding the production of propionic acid, it increased significantly (P<0.05) with 6.0 % of xoconostle. The kinetic parameters obtained by the best fit of the experimental data showed a higher digestion rate and lower methane production with the addition of 4.0 and 6.0 % of xoconostle. The use of xoconostle as an additive in ruminant diets decreases methane production in vitro so it can be an alternative to mitigate the increase in the greenhouse effect and benefit the cultivation of a commercially not very appreciated fruit.Se determinó el efecto de la adición de xoconostle en la fermentación ruminal in vitro de rastrojo de maíz con objeto de reducir la emisión de metano. Estudios previos han demostrado que el xoconostle contiene compuestos bioactivos con actividad antimicrobiana potencial que mejoran la fermentación ruminal. Se adicionaron el 0.0%, 2.0%, 4.0% y 6.0% de xoconostle. Se determinó la composición química de los sustratos, compuestos fenólicos, capacidad antioxidante, desaparición in vitro de la materia seca (DIVMS), la producción de ácidos grasos volátiles (AGV) y las variables de cinética de producción de gas. El volumen de metano se midió utilizando la técnica de captura de bióxido de carbono en solución de hidróxido de sodio. Con la adición del xoconostle se incrementó significativamente (P<0.05) el contenido de proteína, extracto etéreo, fenoles totales y actividad antioxidante. La DIVMS también se incrementó con la adición del xoconostle. Respecto a la producción de ácido propiónico, ésta se incrementó significativamente (P<0.05) con el 6.0 % de xoconostle. Los parámetros cinéticos obtenidos mediante el mejor ajuste de los datos experimentales mostraron una mayor tasa de digestión y menor producción de metano con la adición del 4.0 y 6.0 % de xoconostle. El uso de xoconostle como aditivo en dietas para rumiantes disminuye la producción de metano in vitro por lo que puede ser una alternativa para mitigar el incremento del efecto invernadero y beneficiar el cultivo de un fruto comercialmente no muy apreciado.

Environmental assessment of electrochemical energy storage device manufacturing to identify drivers for attaining goals of sustainable materials 4.0

Electricity from the combination of photovoltaic panels and wind turbines exhibits potential benefits towards the sustainable cities transition. Nevertheless, the highly fluctuating and intermittent character limits an extended applicability in the energy market. Particularly, batteries represent a challenging approach to overcome the existing constraints and to achieve sustainable urban energy development. On the basis of the market roll-out and level of technological maturity, five commercially available battery technologies are assessed in this work, namely, lead-acid, lithium manganese oxide, nickel-cadmium, nickel-metal hydride, and vanadium redox flow. When considering sustainable development, environmental assessments provide valuable information. In this vein, an environmental analysis of the technologies is conducted using a life cycle assessment methodology from a cradle-to-gate perspective. A comparison of the environmental burden of battery components identified vanadium redox flow battery as the lowest environmental damage battery. In terms of components, electrodes; the electrolyte; and the set of pumps, motors, racks, and bolts exhibited the greatest environmental impact related to manufacturing. In terms of materials, copper, steel, sulphuric acid, and vanadium were identified as the main contributors to the midpoint impact categories. The results have highlighted that challenging materials 4.0 are still needed in battery manufacturing to provide sustainable technology designs required to the future urban planning based on circular economy demands

Embodied Learning for Well-Being, Self-Awareness, and Stress Regulation: A Randomized Trial with Engineering Students Using a Mixed-Method Approach.

post-print1502 K

Propuesta para la implementación de un programa de extensión aplicado al monitoreo hidrológico

La creciente demanda de datos hidrológicos para el desarrollo de los trabajos aplicados contenidos fundamentalmente, en las PPS y el Trabajo Final, constituyó el punto de partida de un profundo análisis sobre la disponibilidad de la información hidrológica y las posibilidades para acceder a ella. Las inquietudes e ideas de un grupo de alumnos de las carreras de Ingeniería Civil e Hidráulica derivaron, en reflexiones sobre aspectos problemáticos de las redes de medición, su manejo y operatividad: escasa información en algunos casos, y/o mucha información dispersa y no integrada en una base única, en el otro extremo. A ello se suma la dificultad para acceder a los datos que, en muchos casos, resultaron sospechados por falta de homogeneidad (en calidad y con inapropiada distribución espacial, a los fines requeridos). Con la finalidad de fortalecer esa área, con vistas a un mejor conocimiento y seguimiento de fenómenos climáticos e hidrometeorológicos, alumnos y docentes de la Facultad de Ingeniería de la UNLP (Universidad Nacional de La Plata) proponen la creación de un centro de información hidrometeorológica que, bajo la supervisión de los autores, desarrolle capacidades para adquirir, manejar y autenticar datos útiles en la previsión y evaluación de eventos. El alcance de la propuesta está acotada, a los efectos de su aplicación, a la región de La Plata y sus alrededores. La escala del trabajo hace referencia a las cuencas de los principales arroyos de la región, sobre una superficie aproximada de más de 500 km².Sección: Hidráulica.Facultad de Ingenierí

Fracturas periprotésicas postoperatorias de tibia.

Pese a su baja frecuencia las fracturas periprotésicas de tibia son una complicación grave cuya incidencia probablemente aumente en los próximos años. Es fundamental clasificar adecuadamente estas fracturas en función de su localización y presencia de af lojamiento para plantear un correcto tratamiento en cada caso. Se podrá realizar un tratamiento conservador, síntesis o revisión de la prótesis en función del tipo de fractura. En caso de fijación de la fractura, las placas de estabilidad angular, preferiblemente poliaxiales pueden ser una buena opción debido al limitado stock óseo en la metáfisis proximal que aloja un componente protésico. En caso de revisión se produce una importante perdida de hueso que necesita una adecuada reconstrucción. La utilización de sistemas de navegación y la colocación de prótesis unicompartimentales se ha relacionado con esta complicación.The incidence of periprosthetic tibia fractures is expected to increase although still being rare. It is paramount to classify these fractures properly, based on level and loosening in order to plan an adequate treatment in each case. Conservative treatment, fracture fixation and prosthetic revision can be performed depending on the fracture type. In case of fracture fixation, locking plates, preferable polyaxial, can be a good option due to the limited bone stock in the proximal metaphysis hosting a prosthetic component. Revision can result in relevant bone lose that will need of adequate reconstruction. Navigation systems as well as unicompartmental knee arthroplasty have been related to this complication

A trifactorial model of detection of deception using thermography

[EN]Most theories of detection of deception relate lying to three factors: (1) cognitive load, (2) subjective arousal, and (3) convincing impression. The evidence suggests that a higher temperature of the forehead is related to cognitive load, and lower temperature of the nose is associated with subjective arousal, and a higher temperature of the cheeks is related to convincing impression.Here, we took into account these three factors and, at the same time, associated the thermal change in specific facial regions of interest (RIOIs) with each one of them. More importantly, we studied the combination of the thermal changes in the ROIs to establish the best combination to detect deception. Our results confirm an association between thermal changes in different ROIs and the three factor above. The best combination in the thermal changes of the ROIs for detecting deception (producind 83% accuracy and 13% false alarms in Experiment 1) is the one that was termed "at least two of the three ROIs" where there is a lower temperature of the nose and/or a higher forehead temperature. This finding constitutes an advance for detecting deception in multiple forensic contexts