El patrimonio urbano de la Iglesia Catedral de Málaga a fines de la edad Media : las casas de los beneficiados de la iglesia

En este trabajo analizamos las propiedades urbanas del cabildo catedralicio de Málaga, centrándonos en las casas que los Reyes Católicos, como patronos fundadores del Real Patronato de Granada, donaron a la mesa capitular para uso y morada de los clérigos de la Catedral de Málaga.In this work we analyze the urban properties of Málaga cathedral chapter, focusing on the houses that the Spanish Catholic Monarchs, as founder patrons of the Royal Board of Granada, donated to the chapter table for use and home of the clergy of Malaga’s Cathedra

El cabildo catedralicio de Málaga a fines de la Edad Media : contribución a su estudio

En esta contribución nos ocupamos de los miembros del primer cabildo catedralicio de Málaga, ofreciendo una relación detallada de sus componentes en los primeros años de su existencia.In this contribution we deal with the members of the first cathedral chapter of Malaga, offering a detailed relation of his components in the first years of his existence

Los judíos en la Málaga de finales del siglo XV

El presente artículo es una contribución al estudio de la Judería de Málaga a partir de los datos contenidos en los Libros del Repartimiento de Málaga, partiendo de la Judería existente en época musulmana y la nueva que se formó tras la incorporación de la ciudad a Castilla. Así mismo, ofrecemos una relación de judíos, en absoluto completa, que vivieron en la Judería.This article is a contribution to the study of the Jewish quarter in Málaga using the Libros del Repartimiento de Málaga, from the Jewish quarter during the muslims time to the new Jewish quarted that developed after Malaga joined the Castilla Kingdom. Therefore we offer a repport of jewish persons who lived in the Jewish quarter, altough it is not a complete list of all of them

Dental profile of a community of recovering drug addicts: biomedical aspects. Retrospective cohort study

Objectives: to obtain a biomedical oral profile of a community of adult drug addicts in treatment by analysing their dental health, with a view to determining whether the state of their oral health could be attributed primarily to their lifestyle and the direct consequences of drug abuse on their overall condition, rather than to the effects of the drugs used. Experimental Design: the study was conducted under the terms of an agreement between the Complutense University of Madrid's (UCM) Odontology Faculty and the City of Madrid's Substance Abuse Institute. Seventy drug addicts and 34 control group subjects were examined. The study assessed oral hygiene habits, systemic pathology, type of drugs used and the duration of use, oral pathology, oral health indices, risk of caries based on saliva tests, oral candidiasis and periodontal microbiology. Results: statistically significant differences (p<0.05) were found between the test and control groups for practically all the variables analysed. In the drug users group, dental hygiene was wanting, systemic and oral pathology prevailed and the decayed/missing/filled teeth or surface (DMFT/S) indices denoted very poor buccodental health. The saliva tests showed a substantial risk of caries and candidiasis rates were high. By contrast, with a single exception, the microbiological studies detected no statistically significant difference between drug users and control groups periodontal flora. Conclusions: drug-dependent patients had poor oral health and a significant increase in oral pathology, essentially caries and periodontal disease. Their risk of caries was high and the presence of candidiasis was representative of their poor general and oral health. Drug users' poor buccodental condition was more closely related to lifestyle than to drug abuse itself

The perception of the peer rejected of teacher-student relationship in their group/ classroom

Comunicación presentada en el Simposio “El rechazo entre iguales: Contextos y situaciones sociales”, coordinado por F. J. García Bacete, duranrre el VI Congreso Internacional de Psicología y Educación (CIPE VI), celebrado en Valladolid (España) del 29 de marzo al 1 de abril 2011.VI Congreso Internacional de Psicología y EducaciónEl objetivo del estudio es identificar diferencias en los patrones interpersonales del profesor en función de diversas medidas de competencia social del niño (tipología sociométrica, autopercepción de la aceptación de los iguales, competencia social estimada por el profesor) en niños de primero de educación primaria. Para medir los patrones de interacción los alumnos contestaron el Cuestionario de la relación profesor-alumnado (QTI-EP, adaptación española). Para medir las medidas de competencia social se emplearon un Cuestionario de Nominaciones Sociométricas, la subescala de Aceptación por los iguales de la Escala Gráfica de Aceptación Social y Competencia Percibida por niños pequeños de Harter y Pike (1983) y una escala de calificación de la competencia social. Todos los instrumentos han sido elaborados o adaptados por el grupo GREI. A nivel de tendencia encontramos que, mientras las competencias sociales estimadas se asocian con comportamientos de proximidad del profesor, la aceptación por los iguales se asocia con comportamientos de control del profesor. El resultado más importante es que los alumnos rechazados perciben más autonomía/libertad en el comportamiento del profesorado que los alumnos preferidos y que los alumnos promedios. Se discuten diferentes interpretaciones y se apuntan implicaciones educativas.The objective of this study is to identify differences in the teacher’s interpersonal patterns according to various measures of children´s social competence (sociometric types, self-perception peer acceptance, social competence assessed by the teacher) in children’s first year at primary school. In order to measure these interaction patterns the students answered the Questionnaire on teacher-student interaction (QTI-EP, Spanish version).To measure the social competence measures they used Sociometric Nomination’s Questionnaire, subscale Peer Acceptance of the The Pictorial Scale of Perceived Competence and Social Acceptance for Young Children (Harter and Pike, 1983) and a rating scale of social competence. All instruments have been developed or adapted by the GREI Group. We find that the trend level, while the estimated social skills are associated with proximity of the teacher behaviors, acceptance by peers is associated with teacher control behavior. The most important result is that students rejected perceive more autonomy/freedom in the behavior of his teachers than favorite and averages students. Different interpretations are discussed and educational implications are pointed ou

Estimates of mpox effective reproduction number in Spain, April-August 2022

We analysed the transmission of the human mpox virus in Spain by estimating the effective reproduction number of the disease from official surveillance data. Our computations show that this decreased steadily after an initial burst phase, dropping below 1 on July 12, and thus the outbreak was expected to reduce in the following weeks. Differences in trends were found across geographical regions of the country and across MSM and heterosexual populations.This research was partially supported by CIBER (Strategic Action for Monkeypox) – Consorcio Centro de Investigación Biomédica en Red – (CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU.S

Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Osteoarthritis (OA) is a prevalent, degenerative joint disease, with knee OA being particularly common and impactful. This systematic review and meta-analysis aimed to assess the efficacy of eggshell membrane (ESM) supplementation in improving joint functionality and reducing pain in individuals with knee OA. A comprehensive search was conducted across PubMed, Scopus, Web of Science, and Cochrane Database up to July 2024, following PRISMA guidelines. Seven randomized controlled trials (RCTs) met the inclusion criteria, with five included in the meta-analysis. The studies compared ESM to a placebo, evaluating outcomes based on assessment tools such as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS), and Knee Injury and Osteoarthritis Outcome Score (KOOS). Results indicated that ESM significantly reduced pain and improved functionality, with notable improvements in total WOMAC score (effect size −0.34; 95% CI: −0.56 to −0.13; p < 0.001) and pain subscale (SMD −0.23; 95% CI: −0.42 to −0.04; p < 0.02). The findings support ESM as a promising adjunctive treatment for knee OA, offering a safe, natural supplement to enhance quality of life. Further high-quality RCTs are needed to confirm these results and explore the long-term effects and mechanisms of ESM.Ciencias de la Alimentació

Web Taiko band

Los juegos basados en el seguimiento de ritmos musicales han tenido un gran impacto en la industria del entretenimiento. La clave de su éxito ha sido la combinación de melodías con el desafío a la destreza de los jugadores a la hora de tocar instrumentos. Uno de sus mayores exponentes es el juego arcade Taiko no Tatsujin lanzado hasta en doce plataformas distintas. Este juego se basa en seguir un ritmo musical establecido acertando las notas sobre un tambor o “taiko”. En este proyecto se propone el desarrollo web de un juego de ritmos musicales basado en este famoso pasatiempo, pues Taiko no Tatsujin todavía no ha sido sacado al mercado como aplicación web. El desarrollo del juego pretende ser un fangame dándole importancia al modo multijugador y ofreciendo a los usuarios la posibilidad de crear sus propios niveles. La implementación de este juego se hará empleando JavaScript como lenguaje principal de la aplicación junto con tecnologías web modernas como es Node.js

Selective Anticancer Therapy Based on a HA-CD44 Interaction Inhibitor Loaded on Polymeric Nanoparticles

This research was funded by the Consejeria de Economia, Conocimiento, Empresas y Universidad of the Junta de Andalucia (grant number Excellence Research Project P18-RT-1679) and the Research Results Transfer Office (OTRI) of the University of Granada (grant number PR/17/006 project). This work was partially supported by grants from the Spanish Ministry of Economy and Competitiveness (MINECO), grant number PID2019.110987RB.I00; the Health Institute Carlos III (ISCIII), grant number DTS18/00121 the Junta de Andalucia-FEDER, Ministry of Economy, Knowledge, Companies, and University (FEDER 2018: ref. B-FQM-475-UGR18, PAIDI2020: ref. PT18-TP-4160); and the Andalusian Regional Government, grant number PAIDI-TC-PVT-PSETC-2.0. C.D. thanks HECBioSim, the UK High End Computing Consortium for Biomolecular Simulation (hecbiosim.ac.uk), which is supported by the EPSRC (EP/L000253/1) for awarding computing time in Jade, a UK Tier-2 resource. B.R.-R. gratefully acknowledges funding from the European Union's Horizon 2020 Research and Innovation Program under Marie Sklodowska-Curie Grant Agreement no. 754446 and UGR Research and Knowledge Transfer Fund-Athenea3i. J.M.E.-R. thanks the Spanish Ministry of Education for PhD funding (scholarship FPU 16/02061). V.C.-C. thanks the Andalusian Regional Government for her postdoctoral fellowship (POSTDOC_21_00118).Hyaluronic acid (HA), through its interactions with the cluster of differentiation 44 (CD44), acts as a potent modulator of the tumor microenvironment, creating a wide range of extracellular stimuli for tumor growth, angiogenesis, invasion, and metastasis. An innovative antitumor treatment strategy based on the development of a nanodevice for selective release of an inhibitor of the HACD44 interaction is presented. Computational analysis was performed to evaluate the interaction of the designed tetrahydroisoquinoline-ketone derivative (JE22) with CD44 binding site. Cell viability, efficiency, and selectivity of drug release under acidic conditions together with CD44 binding capacity, effect on cell migration, and apoptotic activity were successfully evaluated. Remarkably, the conjugation of this CD44 inhibitor to the nanodevice generated a reduction of the dosis required to achieve a significant therapeutic effect.Junta de Andalucia P18-RT-1679Research Results Transfer Office (OTRI) of the University of Granada PR/17/006Spanish Government PID2019.110987RB.I00Health Institute Carlos III (ISCIII) DTS18/00121Junta de Andalucia-FEDER, Ministry of Economy, Knowledge, Companies, and University (FEDER) B-FQM-475-UGR18 PT18-TP-4160Andalusian Regional Government POSTDOC_21_00118UK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) EP/L000253/1European Union's Horizon 2020 Research and Innovation Program under Marie Sklodowska-Curie Grant 754446UGR Research and Knowledge Transfer Fund-Athenea3iSpanish Government FPU 16/0206

A qualitative study about immigrant workers’ perceptions of their working conditions in Spain

Background: Spain has recently become an inward migration country. Little is known about the occupational health of immigrant workers. This study aimed to explore the perceptions that immigrant workers in Spain had of their working conditions. Methods: Qualitative, exploratory, descriptive study. Criterion sampling. Data collected between September 2006 and May 2007 through semi-structured focus groups and individual interviews, with a topic guide. One hundred and fifty-eight immigrant workers (90 men/68 women) from Colombia (n = 21), Morocco (n = 39), sub-Saharan Africa (n = 29), Romania (n = 44) and Ecuador (n = 25), who were authorised (documented) or unauthorised (undocumented) residents in five medium to large cities in Spain. Results: Participants described poor working conditions, low pay and health hazards. Perception of hazards appeared to be related to gender and job sector. Informants were highly segregated into jobs by sex, however, so this issue will need further exploration. Undocumented workers described poorer conditions than documented workers, which they attributed to their documentation status. Documented participants also felt vulnerable because of their immigrant status. Informants believed that deficient language skills, non-transferability of their education and training and, most of all, their immigrant status and economic need left them with little choice but to work under poor conditions. Conclusions: The occupational health needs of immigrant workers must be addressed at the job level, while improving the enforcement of existing health and safety regulations. The roles that documentation status and economic need played in these informants’ work experiences should be considered and how these may influence health outcomes.Garcia Garcia, Ana Maria, [email protected]