Political participation and social capital at the subnational level in Colombia - a case study from the Department of Cundinamarca

Esta comunicación presenta los resultados de la primera fase de la investigación sobre participación política y capital social, a partir de las evidencias empíricas de los 116 municipios que hacen parte del departamento de Cundinamarca, con el fin de tener una mejor comprensión de la relación existente, teniendo en cuenta que los planteamientos teóricos son aún limitados e incluso contradictorios, pues si bien la gran mayoría de autores que estudian el tema reconoce la existencia de una correlación, para algunos esta es directa y para otros, no hay una relación. Los resultados nos permiten concluir que estas variablesno son independientes y, por el contrario, guardan una relación, sin embargo, también se establece que este comportamiento no es homogéneo, y que éste efecto se esparce en forma diferenciada por el territorio departamental. Es importante comprender esta relación ya que en la generación de confianza y en el fortalecimiento del capital social, puede estar la clave para el fortalecimiento de los procesos políticos y de la calidad democrática en general.This communication presents the results of the first phase of the research on political participation and social capital, based on the empirical evidence of the 116 municipalities that are part of the department of Cundinamarca, in order to have a better understanding of the existing relationship. taking into account that the theoretical approaches are still limited and even contradictory, because although the vast majority of authors who study the subject recognize the existence of a correlation, for some it is direct and for others, there is no relationship. The results allow us to conclude that these variables are not independent and, on the contrary, are related; however, it is also established that this behavior is not homogeneous, and that this effect spreads in a differentiated way throughout the departmental territory. It is important to understand this relationship since the generation of trust and the strengthening of social capital may be the key to strengthening political processes and democratic quality in general

Experimental Assessment of a Centralised Controller for High-RES Active Distribution Networks

This paper assesses the behaviour of active distribution networks with high penetration of renewable energy sources when the control is performed in a centralised manner. The control assets are the on-load tap changers of transformers at the primary substation, the reactive power injections of the renewable energy sources, and the active and reactive power exchanged between adjacent feeders when they are interconnected through a DC link. A scaled-down distribution network is used as the testbed to emulate the behaviour of an active distribution system with massive penetration of renewable energy resources. The laboratory testbed involves hardware devices, real-time control, and communication infrastructure. Several key performance indices are adopted to assess the effects of the different control actions on the system’s operation. The experimental results demonstrate that the combination of control actions enables the optimal integration of a massive penetration of renewable energy.Ministerio de Economía y Competitividad ENE2015-69597-RMinisterio de Economía y Competitividad PCIN-2015-043Ministerio de Economía y Competitividad ENE2017-84813-

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA

The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 1.0E-4 sensitivity. This approach was validated with a well-stablished RNA-based nested NGS method. The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-DeepNGS a sensitivity of 92% and specificity of 82%. The clinical impact was studied in a cohort of 129 patients (n = 67 for CML and n = 62 for B-ALL patients). A total of 162 samples (n = 86 CML and n = 76 B-ALL) were studied. Of them, 27 out of 86 harbored mutations (6 in warning and 21 in failure) for CML, and 13 out of 76 (2 diagnostic and 11 relapse samples) did in B-ALL patients. In addition, in four cases were detected mutation despite BCR::ABL1 < 1%. In conclusion, we were able to detect KD ABL1 mutations with a 1.0E-4 sensitivity by NGS using DNA as starting material even in patients with low levels of disease

Guía de práctica clínica para la prevención, diagnóstico, tratamiento y rehabilitación de la falla cardiaca en población mayor de 18 años, clasificación B, C y D

La falla cardíaca es un síndrome clínico caracterizado por síntomas y signos típicos de insuficiencia cardíaca, adicional a la evidencia objetiva de una anomalía estructural o funcional del corazón. Guía completa 2016. Guía No. 53Población mayor de 18 añosN/

Modelo de gestión de redes de distribución mediante UML y BPL

This paperproposes amodelof the clearance processmanagementin systems powered byconventional electricand distributedgeneration, therebyimplementinga systemwhichallowto dynamicallyadapt toscenariosofvarying loads, randomnessof the parametersof efficiency andpower qualityof the systemtechnical constraints, economic and regulatory, as well as the active participation ofagentsdistributed generators

Modelo de gestión de redes de distribución mediante UML y BPL

En este artículo se propone un modelo de gestión del proceso de despacho en sistemas alimentados por generación eléctrica convencional y distribuida, implementando para ello un sistema automatizado que permita de manera dinámica adaptarse a escenarios de cargas variables, aleatoriedad de los parámetros de eficiencia y calidad de energía del sistema, restricciones técnicas, económicas y regulatorias, y la inclusión activa de agentes generadores distribuidos

Participación política y capital social en el nivel subnacional de Colombia -estudio de caso del Departamento de Cundinamarca

Esta comunicaci&oacute;n presenta los resultados de la primera fase de la investigaci&oacute;n sobre participaci&oacute;n pol&iacute;tica y capital social, a partir de las evidencias emp&iacute;ricas de los 116 municipios que hacen parte del departamento de Cundinamarca, con el fin de tener una mejor comprensi&oacute;n de la relaci&oacute;n existente, teniendo en cuenta que los planteamientos te&oacute;ricos son a&uacute;n limitados e incluso contradictorios, pues si bien la gran mayor&iacute;a de autores que estudian el tema reconoce la existencia de una correlaci&oacute;n, para algunos esta es directa y para otros, no hay una relaci&oacute;n. Los resultados nos permiten concluir que estas variablesno son independientes y, por el contrario, guardan una relaci&oacute;n, sin embargo, tambi&eacute;n se establece que este comportamiento no es homog&eacute;neo, y que &eacute;ste efecto se esparce en forma diferenciada por el territorio departamental. Es importante comprender esta relaci&oacute;n ya que en la generaci&oacute;n de confianza y en el fortalecimiento del capital social, puede estar la clave para el fortalecimiento de los procesos pol&iacute;ticos y de la calidad democr&aacute;tica en general

Cervical dissection diagnoses increase following endovascular treatments

[Objectives] The detection of cervical arterial dissection (CAD) has been rising in recent years owing to advanced imaging techniques. The aim of this study was to explore whether wide implementation of endovascular treatment for ischemic stroke has an impact on the diagnosis of CAD.[Methods] We included all patients with CAD diagnosed at two university hospitals in Seville, Spain from January 2015 to December 2017. We collected clinical variables and information on imaging techniques used for the diagnosis. Implementation of 24 hour/365 day mechanical thrombectomy began in Seville on 15 August 2016. We compared diagnosis rates of CAD performed before and after this date.[Results] We identified 41 patients with CAD. We found 13 patients diagnosed before (1.1% of all ischemic strokes) and 28 (2.2%) after implementation of neurointerventional therapy. In 17 patients, diagnosis was made in the acute phase. Dissection was not suspected according to computed tomography angiography in 11 patients owing to small dissections (n = 2) or total occlusion (n = 9).[Conclusions] CAD diagnoses have been rising in recent years, essentially owing to continuous improvement in imaging techniques. Rapid access to arteriography for thrombectomy is increasing the diagnoses of CAD, even in patients with a low suspicion of dissection

Origin and pathways of the mineral dust transport to two Spanish EARLINET sites: effect on the observed columnar and range-resolved dust optical properties

In this paper, is presented a method for estimation of the effect of the transport process to aerosol optical properties. Aerosol optical data retrieved by lidars and sun-photometer measurements, are applied to Saharan dust events observed simultaneously at the two EARLINET/AERONET sites of Barcelona and Granada during the periods of June–September of 2012 and 2013. For this purpose, elastic lidar profiles and sun-photometer columnar retrievals are analyzed together with satellite observations and dust forecast models. Granada presents more than twice Saharan dust outbreaks compared to Barcelona. The scenarios favoring the Saharan dust outbreaks are identified in both places. The mineral dust originating in the Sahara region and arriving at both stations is usually transport wither over the Atlas Mountains or through an Atlantic pathway. Analyses of dust events affecting both stations reveal how differences in the transport process lead to differences in the aerosol optical properties measured at each station. Mean dust related Ångström exponent is 1.8 times higher in Barcelona than in Granada. This difference is a result of the additional contribution of anthropogenic aerosol, mainly in the aerosol fine mode, during the transport of the mineral dust plume over the Iberian Peninsula.Peer Reviewe

Enhanced, coordinated conservation efforts required to avoid extinction of critically endangered Eastern Pacific leatherback turtles

Failure to improve the conservation status of endangered species is often related to inadequate allocation of conservation resources to highest priority issues. Eastern Pacific (EP) leatherbacks are perhaps the most endangered sea turtle population in the world, and continue on a path to regional extinction. To provide coherent, regional conservation targets, we developed a population viability analysis and examined hypothetical scenarios describing effects of conservation activities that either reduced mortality or increased production of hatchlings (or both). Under status quo conditions, EP leatherbacks will be extirpated in <60 yr. To ensure a positive, long-term population trajectory, conservation efforts must increase adult survivorship (i.e., reduce adult mortality) by ≥20%, largely through reduction of fisheries bycatch mortality. Positive trajectories can be accelerated by increased production of hatchlings through enhanced nest protection and treatment. We estimate that these efforts must save approximately 200–260 adult and subadult leatherbacks and produce approximately 7,000–8,000 more hatchlings annually. Critically, reductions in late-stage mortality must begin within 5 years and reach 20% overall within the next 10–15 years to ensure population stabilization and eventual increase. These outcomes require expanded, sustained, coordinated, high-priority efforts among several entities working at multiple scales. Fortunately, such efforts are underway.Peer reviewe