54 research outputs found

    Price of information in games of chance

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    We consider a game where NN players bet on the outcome of a biased coin and share the entry fees pot if successful. We assume that one player holds information about past outcomes of the game, which they may either use exclusively to improve their betting strategy or offer to sell to another player. We determine analytically the optimal price curves for the data seller and the prospective buyer. We find a sharp transition in the number NN of players that separates a phase where the transaction is always profitable for the seller from one where it may not be. In both phases, different regimes are possible, depending on the "quality" of information being put up for sale: we observe symbiotic regimes, where both parties collude effectively to rig the game in their favor, competitive regimes, where the transaction is unappealing to the data holder as it overly favors a competitor for scarce resources, and even prey-predator regimes, where the data holder is eager to give away bad-quality data to undercut a competitor. Our framework can be generalized to more complex settings and constitutes a flexible tool to address the rich and timely problem of pricing information in games of chance.Comment: 18 pages, 6 figure

    Graphie: A network-based visual interface for the UK's primary legislation [version 1; peer review: 2 approved]

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    Background: legislation.gov.uk is a platform that enables users to explore and navigate the many sections of the UK’s legal corpus through its well-designed searching and browsing features. However, there is room for improvement as it lacks the ability to easily move between related sections or Acts and only presents a text-only rendering of provisions. With Graphie, our novel navigational tool (graphie.quantlaw.co.uk), we aim to address this limitation by presenting alternative visualizations of legal documents using both text and graphs. Methods: The building block of Graphie is Sofia, an offline data pipeline designed to support different data visualizations by parsing and modelling data provided by legislation.gov.uk in open access form. Results: Graphie provides a network representation of the hierarchical structure of an Act of Parliament, which is typically organized in a tree-like fashion according to the content and information contained in each sub-branch. Nodes in Graphie represent sections of an Act (or individual provisions), while links embody the hierarchical connections between them. The legal map provided by Graphie is easily navigable by hovering on nodes, which are also color-coded and numbered to provide easily accessible information about the underlying content. The full textual content of each node is also available on a dedicated hyperlinked canvas. Conclusions: While we focus on the Housing Act 2004 for illustrative purposes, our platform is scalable, versatile, and provides users with a unified toolbox to visualize and explore the UK legal corpus in a fast and user-friendly way

    Data on protein abundance alteration induced by chronic exercise in mdx mice model of Duchenne muscular dystrophy and potential modulation by apocynin and taurine

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    Here we present original data related to the research paper entitled “Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of Key Metabolic and Contractile Proteins after chronic exercise and the potential modulation by anti-oxidant compounds” (Gamberi et al., 2018) [1]. The dystrophin-deficient mdx mouse is the most common animal model for Duchenne muscular dystrophy. The mdx mice phenotype of the disorder is milder than in human sufferers and it can be worsened by chronic treadmill exercise. Apocynin and taurine are two antioxidant compounds proved to be beneficial on some pathology related parameters (Schröder and Schoser, 2009) [2]. This article reports the detailed proteomic data on protein abundance alterations, in tibialis anterior muscle of mdx mice, induced by chronic exercise protocol. A selected group of mdx mice was also treated with apocynin and taurine during this protocol. Detailed MS data, comparison between mdx vs wild type, exercised mdx vs wild type, and complete analysis of spot variation are provided. Furthermore, in wild type mice subjected to the same exercise protocol, the abundance of key proteins, resulted modified in exercised mdx, were analyzed by western blot

    Proteomic and carbonylation profile analysis of rat skeletal muscles following acute swimming exercise.

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    Previous studies by us and other groups characterized protein expression variation following long-term moderate training, whereas the effects of single bursts of exercise are less known. Making use of a proteomic approach, we investigated the effects of acute swimming exercise (ASE) on protein expression and carbonylation patterns in two hind limb muscles: the Extensor Digitorum Longus (EDL) and the Soleus, mostly composed of fast-twitch and slow-twitch fibres, respectively. Carbonylation is one of the most common oxidative modifications of proteins and a marker of oxidative stress. In fact, several studies suggest that physical activity and the consequent increase in oxygen consumption can lead to increase in reactive oxygen and nitrogen species (RONS) production, hence the interest in examining the impact of RONS on skeletal muscle proteins following ASE. Results indicate that protein expression is unaffected by ASE in both muscle types. Unexpectedly, the protein carbonylation level was reduced following ASE. In particular, the analysis found 31 and 5 spots, in Soleus and EDL muscles respectively, whose carbonylation is reduced after ASE. Lipid peroxidation levels in Soleus were markedly reduced as well. Most of the decarbonylated proteins are involved either in the regulation of muscle contractions or in the regulation of energy metabolism. A number of hypotheses may be advanced to account for such results, which will be addressed in future studies

    A database solution for the quantitative characterisation and comparison of deep-marine siliciclastic depositional systems

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    In sedimentological investigations, the ability to conduct comparative analyses between deep-marine depositional systems is hindered by the wide variety in methods of data collection, scales of observation, resolution, classification approaches and terminology. A relational database, the Deep-Marine Architecture Knowledge Store (DMAKS), has been developed to facilitate such analyses, through the integration of deep-marine sedimentological data collated to a common standard. DMAKS hosts data on siliciclastic deep-marine system boundary conditions, and on architectural and facies properties, including spatial, temporal and hierarchical relationships between units at multiple scales. DMAKS has been devised to include original and literature-derived data from studies of the modern sea-floor, and from ancient successions studied in the sub-surface and in outcrop. The database can be used as a research tool in both pure and applied science, allowing the quantitative characterisation of deep-marine systems. The ability to synthesise data from several case studies and to filter outputs on multiple parameters that describe the depositional systems and their controlling factors enables evaluation of the degree to which certain controls affect sedimentary architectures, thereby testing the validity of existing models. In applied contexts, DMAKS aids the selection and application of geological analogues to hydrocarbon reservoirs, and permits the development of predictive models of reservoir characteristics that account for geological uncertainty. To demonstrate the breadth of research applications, example outputs are presented on: (i) the characterisation of channel geometries, (ii) the hierarchical organisation of channelised and terminal deposits, (iii) temporal trends in the deposition of terminal lobes, (iv) scaling relationships between adjacent channel and levee architectural elements, (v) quantification of the likely occurrence of elements of different types as a function of the lateral distance away from an element of known type, (vi) proportions and transition statistics of facies in elements and beds, (vii) variability in net-to-gross ratios among element types

    Addition of elotuzumab to lenalidomide and dexamethasone for patients with newly diagnosed, transplantation ineligible multiple myeloma (ELOQUENT-1): an open-label, multicentre, randomised, phase 3 trial

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    Information retrieval and structural complexity of legal trees

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    We introduce a model for the retrieval of information hidden in legal texts. These are typically organised in a hierarchical (tree) structure, which a reader interested in a given provision needs to explore down to the "deepest" level (articles, clauses,...). We assess the structural complexity of legal trees by computing the mean first-passage time a random reader takes to retrieve information planted in the leaves. The reader is assumed to skim through the content of a legal text based on their interests/keywords, and be drawn towards the sought information based on keywords affinity, i.e. how well the Chapters/Section headers of the hierarchy seem to match the informational content of the leaves. Using randomly generated keyword patterns, we investigate the effect of two main features of the text -- the horizontal and vertical coherence -- on the searching time, and consider ways to validate our results using real legal texts. We obtain numerical and analytical results, the latter based on a mean-field approximation on the level of patterns, which lead to an explicit expression for the complexity of legal trees as a function of the structural parameters of the model. Policy implications of our results are briefly discussed.Comment: 47 pages, 17 figure
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