OncoLog Volume 49, Number 12, December 2004

Advances in Prostate Cancer Treatment Everyday Drugs Show New Promise for Cancer Are COX-2 Inhibitors Safe? House Call: Myths & Facts about Cancer Prevention DiaLog: Neoadjuvant Trials in Prostate Cancer, by Paul Mathew, MD, Assistant Professor, Department of Genitourinary Medical Oncologyhttps://openworks.mdanderson.org/oncolog/1135/thumbnail.jp

Foreground Separation and Constraints on Primordial Gravitational Waves with the PICO Space Mission

PICO is a concept for a NASA probe-scale mission aiming to detect or constrain the tensor to scalar ratio $r$, a parameter that quantifies the amplitude of inflationary gravity waves. We carry out map-based component separation on simulations with five foreground models and input $r$ values $r_{in}=0$ and $r_{in} = 0.003$. We forecast $r$ determinations using a Gaussian likelihood assuming either no delensing or a residual lensing factor $A_{\rm lens}$ = 27%. By implementing the first full-sky, post component-separation, map-domain delensing, we show that PICO should be able to achieve $A_{\rm lens}$ = 22% - 24%. For four of the five foreground models we find that PICO would be able to set the constraints r < 1.3 \times 10^{-4} \,\, \mbox{to} \,\, r <2.7 \times 10^{-4}\, (95\%) if $r_{in}=0$, the strongest constraints of any foreseeable instrument. For these models, $r=0.003$ is recovered with confidence levels between $18\sigma$ and $27\sigma$. We find weaker, and in some cases significantly biased, upper limits when removing few low or high frequency bands. The fifth model gives a $3\sigma$ detection when $r_{in}=0$ and a $3\sigma$ bias with $r_{in} = 0.003$. However, by correlating $r$ determinations from many small 2.5% sky areas with the mission's 555 GHz data we identify and mitigate the bias. This analysis underscores the importance of large sky coverage. We show that when only low multipoles $\ell \leq 12$ are used, the non-Gaussian shape of the true likelihood gives uncertainties that are on average 30% larger than a Gaussian approximation.Comment: 34 pages, 13 figures, published in JCA

Internet fragmentation, political structuring, and organizational concentration in transnational engineering networks

Is the internet at risk of fragmentation? Whereas the literature has examined this question with a focus on domestic policies, communication standards, and internet governance institutions, we analyze fragmentation and alternative outcomes in transnational engineering networks. These networks constitute the social foundations of the unified or ‘global’internet. Our contributions include (1) broadening the debate beyond fragmentation-related network outcomes to include political structuring and organizational concentration, and (2) new evidence from an important engineering network around the Internet Engineering Task Force comprising thousands of participants and over four decades. Our analyses reveal fast and continuous network growth as well as clear signs of growing concentration of the network around a few major companies. A key implication is that, at the level of engineering networks, concerns about internet fragmentation might be unfounded and might distract from more salient developments such as organizational concentration

Design of 280 GHz feedhorn-coupled TES arrays for the balloon-borne polarimeter SPIDER

We describe 280 GHz bolometric detector arrays that instrument the balloon-borne polarimeter SPIDER. A primary science goal of SPIDER is to measure the large-scale B-mode polarization of the cosmic microwave background in search of the cosmic-inflation, gravitational-wave signature. 280 GHz channels aid this science goal by constraining the level of B-mode contamination from galactic dust emission. We present the focal plane unit design, which consists of a 16$\times$16 array of conical, corrugated feedhorns coupled to a monolithic detector array fabricated on a 150 mm diameter silicon wafer. Detector arrays are capable of polarimetric sensing via waveguide probe-coupling to a multiplexed array of transition-edge-sensor (TES) bolometers. The SPIDER receiver has three focal plane units at 280 GHz, which in total contains 765 spatial pixels and 1,530 polarization sensitive bolometers. By fabrication and measurement of single feedhorns, we demonstrate 14.7$^{\circ}$ FHWM Gaussian-shaped beams with $<$1% ellipticity in a 30% fractional bandwidth centered at 280 GHz. We present electromagnetic simulations of the detection circuit, which show 94% band-averaged, single-polarization coupling efficiency, 3% reflection and 3% radiative loss. Lastly, we demonstrate a low thermal conductance bolometer, which is well-described by a simple TES model and exhibits an electrical noise equivalent power (NEP) = 2.6 $\times$ 10$^{-17}$ W/$\sqrt{\mathrm{Hz}}$, consistent with the phonon noise prediction.Comment: Proceedings of SPIE Astronomical Telescopes + Instrumentation 201

Multiwavelength studies of MHD waves in the solar chromosphere: An overview of recent results

The chromosphere is a thin layer of the solar atmosphere that bridges the relatively cool photosphere and the intensely heated transition region and corona. Compressible and incompressible waves propagating through the chromosphere can supply significant amounts of energy to the interface region and corona. In recent years an abundance of high-resolution observations from state-of-the-art facilities have provided new and exciting ways of disentangling the characteristics of oscillatory phenomena propagating through the dynamic chromosphere. Coupled with rapid advancements in magnetohydrodynamic wave theory, we are now in an ideal position to thoroughly investigate the role waves play in supplying energy to sustain chromospheric and coronal heating. Here, we review the recent progress made in characterising, categorising and interpreting oscillations manifesting in the solar chromosphere, with an impetus placed on their intrinsic energetics.Comment: 48 pages, 25 figures, accepted into Space Science Review

Model evaluation in relation to soil N2O emissions: An algorithmic method which accounts for variability in measurements and possible time lags

AbstractThe loss of nitrogen from fertilised soils in the form of nitrous oxide (N2O) is a side effect of modern agriculture and the focus of many model-based studies. Due to the spatial and temporal heterogeneity of soil N2O emissions, the measured data can introduce limitations to the use of those statistical methods that are most commonly employed in the evaluation of model performance. In this paper, we describe these limitations and present an algorithm developed to address them. We implement the algorithm using simulated and measured N2O data from two UK arable sites. We show that possible time lags between the measured and simulated data can affect model evaluation and that their consideration in the evaluation process can reduce measures such as the Mean Squared Error (MSE) by 30%. We also analyse the algorithm's results to identify patterns in the estimated lags and to narrow down their possible causes

Auto-tuned thermal control on stratospheric balloon experiments

Balloon-borne experiments present unique thermal design challenges, which are a combination of those present for both space and ground experiments. Radiation and conduction are the predominant heat transfer mechanisms with convection effects being minimal and difficult to characterize at 35-40 km. This greatly constrains the thermal design options and makes predicting flight thermal behaviour very difficult. Due to the limited power available on long duration balloon flights, efficient heater control is an important factor in minimizing power consumption. SuperBIT, or the Super-Pressure Balloon-borne Imaging Telescope, aims to study weak gravitational lensing using a 0.5m modified Dall-Kirkham telescope capable of achieving 0.02" stability and capturing deep exposures from visible to near UV wavelengths. To achieve the theoretical stratospheric diffraction-limited resolution of 0.25", mirror deformation gradients must be kept to within 20 nm. The thermal environment must be stable on time scales of an hour and the thermal gradients on the telescope must be minimized. During its 2018 test-flight, SuperBIT will implement two types of thermal parameter solvers: one for post-flight characterization and one for in-flight control. The payload has 85 thermistors as well as pyranometers and far-infrared sensors which will be used post-flight to further understand heat transfer in the stratosphere. This document describes the in-flight thermal control method, which predicts the thermal circuit of components and then auto-tunes the heater PID gains. Preliminary ground testing shows the ability to control the components to within 0.01 K

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe