ROBOTIC RADIOTHERAPY IS IN THE TREATMENT OF PATIENTS WITH ONCOUROLOGICAL PATHOLOGY

The authors Analyzed the immediate and remote results of treatment of patients with prostate cancer treated by the method - a robotic radiotherapy. Immediate results of treatment were estimated on the level of total PSA, prostate volume, residual urine, change according to the international scale IPSS. The dynamics of the above indicators showed regression of the primary lesion, and the absence of pronounced radiation reactions affect the quality of life of patients. We analyzed the results of overall, relapse-free survival and oncospecific. Three-year disease-free survival in patients receiving radiation therapy is of 88.8%. Overall survival, as well as oncospecific survival rate is 100%.Also presents first experience of using stereotactic radiotherapy in patients of renal cell carcinoma. Treatment received two (one patient carried out the irradiation of both kidneys). In one patient, complete tumor resorption of the right kidney and a decrease in the size and reduction of contrast enhancement of the tumor of the left kidney. Renal function did not deteriorate. The second patient decreased the size of the tumor, but preserved the contrast enhancement in the vascular phase. The only function of the kidney has not deteriorated

Whole Exome Sequencing Study Suggests an Impact of <i>FANCA</i>, <i>CDH1</i> and <i>VEGFA</i> Genes on Diffuse Gastric Cancer Development

Gastric cancer (GC) is one of the most common cancer types in the world with a high mortality rate. Hereditary predisposition for GC is not fully elucidated so far. The aim of this study was identification of possible new candidate genes, associated with the increased risk of gastric cancer development. Whole exome sequencing (WES) was performed on 18 DNA samples from adenocarcinoma specimens and non-tumor-bearing healthy stomach tissue from the same patient. Three pathogenic variants were identified: c.1320+1G>A in the CDH1 gene and c.27_28insCCCAGCCCCAGCTACCA (p.Ala9fs) of the VEGFA gene were found only in the tumor tissue, whereas c.G1874C (p.Cys625Ser) in the FANCA gene was found in both the tumor and normal tissue. These changes were found only in patients with diffuse gastric cancer and were absent in the DNA of healthy donors

Heterocyclic and Open-Chain Carboranes via Transition-Metal-Free C–H Functionalization of Mono- and Diazine‑<i>N</i>‑oxides

For the first time, the direct C­(sp²)–H functionalization methodology has successfully been applied to cause nucleophilic modification of mono- and diazine-<i>N</i>-oxides with the 1,2-<i>closo</i>-carborane moiety. As a result of these cross-coupling reactions uncatalyzed by transition metals, a series of novel C-modified heterocyclic and open-chain (vinyl acetylene) carboranes have been obtained. Complexes of phenanthrolinyl-substituted <i>o</i>-carborane with Cu­(II) of various architectures have been synthesized

Whole Exome Sequencing Study Suggests an Impact of FANCA, CDH1 and VEGFA Genes on Diffuse Gastric Cancer Development

Gastric cancer (GC) is one of the most common cancer types in the world with a high mortality rate. Hereditary predisposition for GC is not fully elucidated so far. The aim of this study was identification of possible new candidate genes, associated with the increased risk of gastric cancer development. Whole exome sequencing (WES) was performed on 18 DNA samples from adenocarcinoma specimens and non-tumor-bearing healthy stomach tissue from the same patient. Three pathogenic variants were identified: c.1320+1G&gt;A in the CDH1 gene and c.27_28insCCCAGCCCCAGCTACCA (p.Ala9fs) of the VEGFA gene were found only in the tumor tissue, whereas c.G1874C (p.Cys625Ser) in the FANCA gene was found in both the tumor and normal tissue. These changes were found only in patients with diffuse gastric cancer and were absent in the DNA of healthy donors

FEATURES OF INFLUENCE OF EMOTIONAL STRESS DURING PREGNANCY ON THE FORMATION OF EATING BEHAVIOR IN THE CHILD

The actuality of the problem of high level of anxiety and the development of psycho-emotional disorders in women during pregnancy currently occupy a leading place in clinical practice. Pregnant "seize" the problem by using a non-adaptive coping and thereby form a similar pattern of behavior in stressful situation and in the fetus, perinatal-formed a similar pattern.Materials and methods. Clinical-descriptive, formulated the concept of the influence psycho-emotional stress and characteristics of the current pregnancy on the background of the formation of patterns of eating behavior in the fetus, followed by implementation after birth under the provisions of the dominant by A. A. Ukhtomsky, the theory of functional systems P. K. Anokhin, the endogeneity of the regularities of pathological processes, the pyramid of needs of A. Maslow.Results. As a result of the establishment of the concept, doctors will be able to identify the maladaptive pattern of eating behavior in pregnant women and to make timely prevention of the formation of this pattern in the fetus.Conclusion. The use of the developed concept could help doctors to identify the maladaptive pattern of eating behavior in pregnant women and make timely prevention of the formation of this pattern in the fetus