Os problemas do desenvolvimento do campo legal na Rússia dos primeiros tempos recentes (finais de XV - o comienzo del siglo XVII)

The article deals with the problems associated with the peculiarities of a single legal field development in the Russian state during the epoch of the early modern era (traditionally associated in Russian historiography with the times of a single centralized state formation and development and the emergence of autocracy as a kind of early absolutism). Using a number of provisions of modern concepts for the development of early modern states in Europe, the authors of the article put forward the thesis of a single legal field development in the Russian state during the period under consideration based on the analysis of Russian law monuments at the end of the XVth century (The Code of Law of Ivan III in 1497) and the 16th century (first of all, the code of law by Ivan IV, as well as a number of other legislative and legal acts) and judicial practice. In their opinion, this incompleteness was related with the following circumstances. First of all, the development of political and legal institutions in the early modern Russian state was of an evolutionary nature and, therefore, denied radical changes. Secondly, the poverty of the state caused the relative weakness and a slow development of "sinews of power" and, therefore, prevented the establishment of a more stringent administrative and legal control by the supreme power over the actions of local authorities. Finally, the weakness of the mentioned "sinews of power" conditioned the need of cooperation mode establishment between the supreme authority and local elites, while retaining the access to the exercise of power functions on the ground - also through the preservation of the old legal customs and traditions. Naturally, all this contributed to the preservation and the reproduction of the legal "antiquity" and, consequently, the incompleteness of legal centralization process and the formation of a single legal field throughout the country. The legal field, in the opinion of the authors of the article, had at least 2-level character all this time, the fragmented nature and the dispersion at the low-rank level.El artículo trata los problemas asociados con las peculiaridades de un desarrollo de campo legal único en el estado ruso durante la época moderna temprana (tradicionalmente asociado en la historiografía rusa con los tiempos de una formación y desarrollo estatal centralizado único y el surgimiento de la autocracia como una especie de absolutismo temprano). Usando una serie de disposiciones de conceptos modernos para el desarrollo de los estados modernos tempranos en Europa, los autores del artículo presentaron la tesis de un desarrollo de campo legal único en el estado ruso durante el período bajo consideración basado en el análisis de monumentos de derecho rusos a fines del siglo XV (El Código de Derecho de Iván III en 1497) y el siglo XVI (ante todo, el código de leyes de Iván IV, así como una serie de otros actos legislativos y jurídicos) y la práctica judicial . En su opinión, este estado incompleto estaba relacionado con las siguientes circunstancias. En primer lugar, el desarrollo de las instituciones políticas y legales en el estado ruso moderno temprano fue de naturaleza evolutiva y, por lo tanto, negó los cambios radicales. En segundo lugar, la pobreza del estado causó la debilidad relativa y un lento desarrollo de "tendones de poder" y, por lo tanto, impidió el establecimiento de un control administrativo y legal más estricto por parte del poder supremo sobre las acciones de las autoridades locales. Finalmente, la debilidad de los mencionados "nervios de poder" condicionó la necesidad del establecimiento del modo de cooperación entre la autoridad suprema y las elites locales, mientras se mantiene el acceso al ejercicio de las funciones de poder sobre el terreno, también a través de la preservación de las viejas costumbres legales y tradiciones Naturalmente, todo esto contribuyó a la preservación y reproducción de la "antigüedad" legal y, en consecuencia, a la incompletitud del proceso de centralización legal y la formación de un solo campo legal en todo el país. El campo legal, en opinión de los autores del artículo, tenía al menos un carácter de dos niveles todo este tiempo, la naturaleza fragmentada y la dispersión en el nivel de bajo rango. O artigo trata os problemas associados com as peculiaridades de um curso de campo legal no estado ruso durante a época moderna temático (tradicionalmente associado à historiografia rusa com os tempos de uma formação e desenvolvimento estatal centralizado único e o surgimento da autocracia como una especie de absolutismo temprano). Using una serie de disposiciones de conceptos modernes para o desenvolvimento dos estados modernos templos na Europa, os autores do artigo apresentando a tese de um curso de campo legal no estado do ruso durante o período considerado de base na análise de pontos de vista ruses a fins del siglo XV (O código de direito de Iván III em 1497) e o século XVI (ante, o código de leyes de Iván IV, como uma série de atos legislativos e jurídicos) e a prática judicial. Em sua opinião, este estado incompleto está relacionado com as circunstâncias circunstanciadas. Em primeiro lugar, o desenvolvimento das instituições políticas e jurídicas no estado atual temprano naturalidade evolutiva e, por isso, os dois cambios radicais. Em segundo lugar, a pobreza do estado causou a debilidade relativa e um lento desenvolvimento de "tendões de poder" e, por que tanto, impiedoso o estabelecimento de um controle administrativo e jurídico mais estrito por parte do poder supremo sobre as ações das autoridades locales. Finalmente, a debilidad das perdas "nervos de poder" é a necessidade do estabelecimento do modo de cooperação entre a supremacia e as elites locais, mientras se mantém o acceso ao exercicio das funções de poder sobre o terreno, tambem a través de la preservación de las viejas costumbres legales y tradiciones Naturalmente, todo esto contribuído a la preservación y reproducción de la "antigüedad" legal y, en consecuencia, a incompletitud del proceso de centralización legal y la formación de un solo campo legal en todo el país . O campo legal, na opinião dos autores do artigo, com o menos um carácter dos niveles todo este tempo, a natureza fragmentada e a dispersão no nivel de bajo rango

Accounting of geomechanical layer properties in multi-layer oil field development

Amid the ever-increasing urgency to develop oil fields with complex mining and geological conditions and low-efficiency reservoirs, in the process of structurally complex reservoir exploitation a number of problems arise, which are associated with the impact of layer fractures on filtration processes, significant heterogeneity of the structure, variability of stress-strain states of the rock mass, etc. Hence an important task in production engineering of such fields is a comprehensive accounting of their complex geology. In order to solve such problems, the authors suggest a methodological approach, which provides for a more reliable forecast of changes in reservoir pressure when constructing a geological and hydrodynamic model of a multi-layer field. Another relevant issue in the forecasting of performance parameters is accounting of rock compressibility and its impact on absolute permeability, which is the main factor defining the law of fluid filtration in the productive layer. The paper contains analysis of complex geology of a multi-layer formation at the Alpha field, results of compression test for 178 standard core samples, obtained dependencies between compressibility factor and porosity of each layer. By means of multiple regression, dependencies between permeability and a range of parameters (porosity, density, calcite and dolomite content, compressibility) were obtained, which allowed to take into account the impact of secondary processes on the formation of absolute permeability. At the final stage, efficiency of the proposed methodological approach for construction of a geological and hydrodynamic model of an oil field was assessed. An enhancement in the quality of well-by-well adaptation of main performance parameters, as well as an improvement in predictive ability of the adjusted model, was identified

Bacterial formate dehydrogenase. Increasing the enzyme thermal stability by hydrophobization of alpha-helices

AbstractNAD+-dependent formate dehydrogenase (EC 1.2.1.2, FDH) from methylotrophic bacterium Pseudomonas sp.101 exhibits the highest stability among the similar type enzymes studied. To obtain further increase in the thermal stability of FDH we used one of general approaches based on hydrophobization of protein α-helices. Five serine residues in positions 131, 160, 168, 184 and 228 were selected for mutagenesis on the basis of (i) comparative studies of nine FDH amino acid sequences from different sources and (ii) with the analysis of the ternary structure of the enzyme from Pseudomonas sp.101. Residues Ser-131 and Ser-160 were replaced by Ala, Val and Leu. Residues Ser-168, Ser-184 and Ser-228 were changed into Ala. Only Ser/Ala mutations in positions 131, 160, 184 and 228 resulted in an increase of the FDH stability. Mutant S168A was 1.7 times less stable than the wild-type FDH. Double mutants S(131,160)A and S(184,228)A and the four-point mutant S(131,160,184,228)A were also prepared and studied. All FDH mutants with a positive stabilization effect had the same kinetic parameters as wild-type enzyme. Depending on the position of the replaced residue, the single point mutation Ser/Ala increased the FDH stability by 5–24%. Combination of mutations shows near additive effect of each mutation to the total FDH stabilization. Four-point mutant S(131,160,184,228)A FDH had 1.5 times higher thermal stability compared to the wild-type enzyme

Observation of the ^1P_1 State of Charmonium

The spin-singlet P-wave state of charmonium, hc(1P1), has been observed in the decay psi(2S) -> pi0 hc followed by hc -> gamma etac. Inclusive and exclusive analyses of the M(hc) spectrum have been performed. Two complementary inclusive analyses select either a range of energies for the photon emitted in hc -> gamma etac or a range of values of M(etac). These analyses, consistent with one another within statistics, yield M(h_c) =[3524.9 +/- 0.7 (stat) +/- 0.4 (sys)]MeV/c^2 and a product of the branching ratios B_psi(psi(2S) -> pi0 hc) x B_h(hc -> gamma etac) = [3.5 +/- 1.0 (stat) +/- 0.7 (sys)] x 10^{-4}. When the etac is reconstructed in seven exclusive decay modes, 17.5 +/- 4.5 hc events are seen with an average mass M(hc) = [3523.6 +/- 0.9 (stat) +/- 0.5 (sys)] MeV/c^2, and B_psi x B_h = [5.3 +/- 1.5 (stat) +/- 1.0 (sys)] x 10^{-4}. Because the inclusive and exclusive data samples are largely independent they are combined to yield an overall mass M(hc) = [3524.4 +/- 0.6 (stat) +/- 0.4 (sys)]MeV/c^2 and product of branching ratios B_psi x B_h = [4.0 +/- 0.8 (stat) +/- 0.7 (sys)] x 10^{-4}. The hc mass implies a P-wave hyperfine splitting Delta M_{HF}(1P) \equiv M(1^3P)-M(1^1P_1) = [1.0 +/- 0.6 (stat) +/- 0.4 (sys)] MeV/c^2.Comment: 38 pages postscript,also available through http://www.lns.cornell.edu/public/CLNS/2005/, Submitted to PR

Nutrition and the ageing brain: moving towards clinical applications

The global increases in life expectancy and population have resulted in a growing ageing population and with it a growing number of people living with age-related neurodegenerative conditions and dementia, shifting focus towards methods of prevention, with lifestyle approaches such as nutrition representing a promising avenue for further development. This overview summarises the main themes discussed during the 3 Symposium on "Nutrition for the Ageing Brain: Moving Towards Clinical Applications" held in Madrid in August 2018, enlarged with the current state of knowledge on how nutrition influences healthy ageing and gives recommendations regarding how the critical field of nutrition and neurodegeneration research should move forward into the future. Specific nutrients are discussed as well as the impact of multi-nutrient and whole diet approaches, showing particular promise to combatting the growing burden of age-related cognitive decline. The emergence of new avenues for exploring the role of diet in healthy ageing, such as the impact of the gut microbiome and development of new techniques (imaging measures of brain metabolism, metabolomics, biomarkers) are enabling researchers to approach finding answers to these questions. But the translation of these findings into clinical and public health contexts remains an obstacle due to significant shortcomings in nutrition research or pressure on the scientific community to communicate recommendations to the general public in a convincing and accessible way. Some promising programs exist but further investigation to improve our understanding of the mechanisms by which nutrition can improve brain health across the human lifespan is still required

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery