Real-World Engagement with Controversial Issues in History and Social Studies: Teaching for Transformative Experiences and Conceptual Change

Controversial issues have been established within the larger framework of civic education as an effective pedagogical approach to developing critical thinking in the classroom, preparing students with intellectual habits necessary for participation in scholarship, civic life and democracy. In this study, we found that a pedagogical intervention, Teaching for Transformative Experience in History, in some cases led to significantly higher engagement with political concepts beyond the classroom, and in other cases, the intervention led to significantly improved conceptual change. The study addresses some of the challenges presented by the research on civic education, providing a potential framework for developing pedagogical practice in history and social studies education that grounds a participatory, meaning-making process in curriculum design and assessment framed by controversial issues

A computer simulation study of the effect of pressure on Mg diffusion in forsterite

Computer simulation techniques were used to investigate the effect of pressure on magnesium diffusionin forsterite between 0 and 10 GPa. We studied the diffusion path along the c crystallographic axis (we always refer to the Pbnm system) via a vacancy mechanism. Using a Mott-Littleton approach withinthe code GULP, we were able to precisely map the diffusion path of a Mg vacancy and we found theactivation energy, E = 3.97 eV at 0 GPa (with Ef = 3.35 eV for the formation energy and Em = 0.62 eV for the migration) and E = 4.46 eV at 10 GPa (Ef = 3.81 eV and Em = 0.65 eV). Preliminary results using the supercell technique gave the same saddle point coordinates and energies. This saddle point of the Mg vacancy diffusion found with GULP was then introduced in an ab initio code, confirming the values of the migration energy both at 0 and 10 GPa. We were therefore able to estimate the activation volume (V) to be around 5 cm3/mol and d(V)/dP = 0. The effect of pressure applies mostly on defect formation and little on migration

Good-for-games ω-Pushdown Automata

We introduce good-for-games $\omega$-pushdown automata ($\omega$-GFG-PDA). These are automata whose nondeterminism can be resolved based on the input processed so far. Good-for-gameness enables automata to be composed with games, trees, and other automata, applications which otherwise require deterministic automata. Our main results are that $\omega$-GFG-PDA are more expressive than deterministic $\omega$- pushdown automata and that solving infinite games with winning conditions specified by $\omega$-GFG-PDA is EXPTIME-complete. Thus, we have identified a new class of $\omega$-contextfree winning conditions for which solving games is decidable. It follows that the universality problem for $\omega$-GFG-PDA is in EXPTIME as well. Moreover, we study closure properties of the class of languages recognized by $\omega$-GFG- PDA and decidability of good-for-gameness of $\omega$-pushdown automata and languages. Finally, we compare $\omega$-GFG-PDA to $\omega$-visibly PDA, study the resources necessary to resolve the nondeterminism in $\omega$-GFG-PDA, and prove that the parity index hierarchy for $\omega$-GFG-PDA is infinite. This is a corrected version of the paper arXiv:2001.04392v6 published originally on January 7, 2022

Interferon-Gamma Release Assays Differentiate between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children

Spanish Pediatric TB Research Network (pTBred) and the European NontuberculouS MycoBacterial Lymphadenitis in childrEn (ENSeMBLE) Study.[Objectives] To assess the performance of interferon-gamma release assays (IGRAs) in the differential diagnosis between Mycobacterium avium complex (MAC) and tuberculosis (TB) in children affected with subacute/chronic submandibular/cervical lymphadenitis.[Study design] Multicenter observational study comparing children with microbiologically confirmed MAC lymphadenitis from the European NontuberculouS MycoBacterial Lymphadenitis in childrEn study with children with TB lymphadenitis from the Spanish Network for the Study of Pediatric TB database.[Results] Overall, 78 patients with MAC and 34 with TB lymphadenitis were included. Among MAC cases, 44 out of 74 (59.5%) had positive tuberculin skin test (TST) results at the 5-mm cut-off, compared with 32 out of 33 (97%) TB cases (P < .001); at the 10-mm cut-off TST results were positive in 23 out of 74 (31.1%) vs 26 out of 31 (83.9%), respectively (P < .001). IGRA results were positive in only 1 out of 32 (3.1%) patients with MAC who had undergone IGRA testing, compared with 21 out of 23 (91.3%) TB cases (P < .001). Agreement between TST and IGRA results was poor in MAC (23.3%; κ = 0.017), but good in TB cases (95.6%; κ = 0.646). IGRAs had a specificity of 96.9% (95% CI 84.3%-99.8%), positive predictive value of 95.4% (95% CI 78.2%-99.8%), and negative predictive value of 93.9% (95% CI 80.4%-98.9%) for TB lymphadenitis.[Conclusions] In contrast to TST, IGRAs have high specificity, negative predictive value, and positive predictive value for TB lymphadenitis in children with subacute/chronic lymphadenopathy, and consequently can help to discriminate between TB and MAC disease. Therefore, IGRAs are useful tools in the diagnostic work-up of children with lymphadenopathy, particularly when culture and polymerase chain reaction results are negative.Peer reviewe

Metabolic syndrome and lung function in schizophrenia: a pilot study

This pilot study aimed to explore relationships between metabolic and lung functions in patients with schizophrenia. Eighty patients with schizophrenia (55♂; 36.8±10.0 years) underwent a spirometry, were screened for metabolic syndrome (MetS), performed a 6-minute walk test (6MWT), and completed the International Physical Activity Questionnaire and the Psychosis evaluation tool for common use by caregivers. Patients with MetS (according to the International Diabetes Federation criteria) (n=28; 35%) had a reduced predicted forced expiratory volume for 1 second (77.4±13.2 versus 87.3±12.1%) and predicted forced vital capacity (75.3±11.1 versus 85.4±11.4%). Significantly more patients with MetS were diagnosed with restrictive lung dysfunction (RLD) (according to the Global Initiative for Chronic Obstructive Lung Disease criteria) (13 versus 8). Schizophrenia patients with RLD (n=21; 26.2%) had a significantly larger waist circumference (90.7±12.5 versus, 105.6±14.7 cm), were less physically active (653.6±777.9 versus 1517.9±1248.7 metabolic equivalent-min/week) and walked less on the 6MWT (502.6±92.3 versus 612.4±101.2 m) than patients without RLD. The present data suggest that in patients with schizophrenia RLD might be associated with metabolic dysfunctions. Further prospective analyses are required to elucidate the complex interrelationships between lung and metabolic functions in patients with schizophrenia

Review of Alternatives to Incarceration Efforts Worldwide

Despite global interest in treating substance use disorders as a health issue, many countries choose a criminal justice response instead. The goal of this project was to research the readiness of countries to establish or expand alternatives to incarceration (ATIs) for persons with substance use disorders (SUDs) in countries around the globe. This report gathers, compiles and analyzes information on alternatives to incarceration for persons involved in the criminal justice with substance use disorders, worldwide (193 UN Member States plus Greenland, Kosovo, Palestine and Taiwan). As such, this report presents the first attempt to compile this information globally and completely. A video of the webinar meeting with the presentation of results is available at: https://www.youtube.com/watch?v=p3_h6hMOvTc

The autocrine role of tumor necrosis factor in the proliferation and functional differentiation of human lymphokine-activated T killer cells (T-LAK) in vitro

The autocrine role of tumor necrosis factor alpha (TNF) in the proliferation and functional differentiation of human lymphokine-activated T-killer cells (T-LAK) in vitro was investigated. Human peripheral blood lymphocytes initially stimulated with IL-2 and phytohemagglutinin-P (PHA) for 48 h will proliferate for long periods in vitro in the presence of IL-2. These T-LAK cells have been shown to be 95% CD3 positive. Employing ELISA techniques, greater than 500 pg/ml of TNF was found to be released in the supernatants of these cells during the first 5 days of culture. However, the levels dropped to 100-200 pg/ml by days 7-10. T-LAK cells grown from days 7 to 10 in the presence of IL-2 and rabbit anti-TNF were significantly growth inhibited (up to 23%). The cytolytic activity of T-LAK cells grown from days 0 to 7 in the presence of anti-TNF was also decreased (up to 75%). Phenotypic analysis of these anti-TNF treated T-LAK cells revealed a decrease in CD8 expression (up to 12%) and increase in CD4 expression (up to 27%) when compared with control cells. The data suggest that TNF has a regulatory role in the growth and functional differentiation of these human T-LAK cells