58 research outputs found
The influence of binarity on dust obscuration events in the planetary nebula M 2-29 and its analogues
The central star of the planetary nebula (CSPN) M 2-29 shows an extraordinary
R Coronae Borealis-like fading event in its optical lightcurve. The only other
CSPN to show these events are CPD-568032 (Hen 3-1333) and V651 Mon (NGC 2346).
Dust cloud formation in the line of sight appears responsible but the exact
triggering mechanism is not well understood. Understanding how planetary
nebulae (PNe) trigger dust obscuration events may help understand the same
process in a wide range of objects including Population-I WC9 stars, symbiotic
stars and perhaps Asymptotic Giant Branch (AGB) stars with long secondary
periods (LSPs). A binary scenario involving an eccentric, wide companion that
triggers dust formation via interaction at periastron is a potential
explanation that has been suggested for LSP variables. Model fits to the
lightcurves of CPD-568032 and M 2-29 show the dust forms in excess of 70 AU at
the inner edge of a dust disk. In the case of CPD-568032 this radius is far too
large to coincide with a binary companion trigger, although a binary may have
been responsible for the formation of the dust disk. We find no direct evidence
to support previous claims of binarity in M 2-29 either from the OGLE
lightcurve or deep medium-resolution VLT FLAMES spectroscopy of the CSPN. We
classify the CSPN as Of(H) with T_eff=50+-10 kK and log g=4.0+-0.3. We find a
mean distance of 7.4+-1.8 kpc to M 2-29 at which the M_V=-0.9 mag CSPN could
potentially hide a subgiant luminosity or fainter companion. A companion would
help explain the multiple similarities with D'-type symbiotic stars whose outer
nebulae are thought to be bona-fide PNe. The 7.4 kpc distance, oxygen abundance
of 8.3 dex and Galactic coordinates (l=4.0, b=-3.0) prove that M 2-29 is a
Galactic Bulge PN and not a Halo PN as commonly misconceived.Comment: 15 pages, 14 figures, 7 tables. Accepted for publication in A\&
Detection of an asymmetry in the envelope of the carbon Mira R Fornacis using VLTI/MIDI
Aims. We present a study of the envelope morphology of the carbon Mira R For
with VLTI/MIDI. This object is one of the few asymptotic giant branch (AGB)
stars that underwent a dust-obscuration event. The cause of such events is
still a matter of discussion. Several symmetric and asymmetric scenarios have
been suggested in the literature. Methods. Mid-infrared interferometric
observations were obtained separated by two years. The observations probe
different depths of the atmosphere and cover different pulsation phases. The
visibilities and the differential phases were interpreted using GEM-FIND, a
tool for fitting spectrally dispersed interferometric observations with the
help of wavelength-dependent geometric models. Results. We report the detection
of an asymmetric structure revealed through the MIDI differential phase. This
asymmetry is observed at the same baseline and position angle two years later.
The observations are best simulated with a model that includes a uniform-disc
plus a Gaussian envelope plus a point-source. The geometric model can reproduce
both the visibilities and the differential phase signatures. Conclusions. Our
MIDI data favour explanations of the R For obscuration event that are based on
an asymmetric geometry. We clearly detect a photocentre shift between the star
and the strongly resolved dust component. This might be caused by a dust clump
or a substellar companion. However, the available observations do not allow us
to distinguish between the two options. The finding has strong implications for
future studies of the geometry of the envelope of AGB stars: if this is a
binary, are all AGB stars that show an obscuration event binaries as well? Or
are we looking at asymmetric mass-loss processes (i.e. dusty clumps) in the
inner part of a carbon-rich Mira?Comment: accepted for publication as A&A lette
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
The efficacy of topical agents used in wounds for managing chronic biofilm infections:A systematic review
Objectives: Clinicians have increasingly adopted the widespread use of topical agents to manage chronic wound infections, despite limited data on their effectiveness in vivo. This study sought to evaluate the evidence for commonly employed topical agents used in wounds for the purpose of treating chronic infections caused by biofilm.
Method: We included in vitro, animal and human in vivo studies where topical agents were tested for their efficacy against biofilms, for use in wound care. For human studies, we only included those which utilised appropriate identification techniques for visualising and confirming the presence of biofilms.
Result: A total of 640 articles were identified, with 43 included after meeting eligibility. In vitro testing accounted for 90% (n = 39) of all included studies, five studies using animal models and three human in vivo studies. Sixteen different laboratory models were utilised, with the most frequent being the minimum biofilm eradication concentration (MBEC™) / well plate assay (38%, n = 15 of 39). A total of 44 commercially available topical agents were grouped into twelve categories with the most commonly tested agents being silver, iodine and polyhexamethylene biguanide (PHMB). In vitro results on efficacy demonstrated iodine as having the highest mean log10 reductions of all agents (4.81, ±3.14).
Conclusion: There is large disparity in the translation of laboratory studies to researchers undertaking human trials relating to the effectiveness of commercially available topical agents. There is insufficient human in vivo evidence to definitively recommend any commercially available topical agent over another for the treatment of chronic wound biofilms. The heterogeneity identified between study designs (in vitro to in vivo) further limits the generalisability of results
Mitigation and use of biofilms in space for the benefit of human space exploration
Biofilms are self-organized communities of microorganisms that are encased in an extracellular polymeric matrix and often found attached to surfaces. Biofilms are widely present on Earth, often found in diverse and sometimes extreme environments. These microbial communities have been described as recalcitrant or protective when facing adversity and environmental exposures. On the International Space Station, biofilms were found in human-inhabited environments on a multitude of hardware surfaces. Moreover, studies have identified phenotypic and genetic changes in the microorganisms under microgravity conditions including changes in microbe surface colonization and pathogenicity traits. Lack of consistent research in microgravity-grown biofilms can lead to deficient understanding of altered microbial behavior in space. This could subsequently create problems in engineered systems or negatively impact human health on crewed spaceflights. It is especially relevant to long-term and remote space missions that will lack resupply and service. Conversely, biofilms are also known to benefit plant growth and are essential for human health (i.e., gut microbiome). Eventually, biofilms may be used to supply metabolic pathways that produce organic and inorganic components useful to sustaining life on celestial bodies beyond Earth. This article will explore what is currently known about biofilms in space and will identify gaps in the aerospace industry's knowledge that should be filled in order to mitigate or to leverage biofilms to the advantage of spaceflight
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