922 research outputs found
Insulinoma : a propósito de un caso clínico
Se describe un caso de insulinoma en un perro. La presentación clínica inicial, algo oscura, permite realizar un protocolo diagnóstico diferencial primero del síndrome de debilidad, luego de hipoglucemia, y finalmente confirmar el insulinoma por las correspondientes pruebas endocrinológicas, incluido el test de la fructosamina, y visualización de nódulos característicos en páncreas gracias a la exploración ecográfica.A case of insulinoma in the dog is described. Due to the initially unclear clinical picture, a differential diagnosis of weakness is carried out at first, of hypoglycemia later, and after the endocrinologycal tests (including the fructosamine test) and ultrasonographic examination (visualizing characteristic pancreatic nodules) a final diagnosis of insulinoma is made
Social pharmacology: expanding horizons
In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of “social pharmacology” is not covered by the so‑called “Phase IV” alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the “life cycle” of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far‑reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of
therapy, while minimizing negative social consequences
Social pharmacology: expanding horizons
In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of “social pharmacology” is not covered by the so‑called “Phase IV” alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the “life cycle” of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far‑reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of
therapy, while minimizing negative social consequences
TAPAS: Tricks to Accelerate (encrypted) Prediction As a Service
Machine learning methods are widely used for a variety of prediction
problems. \emph{Prediction as a service} is a paradigm in which service
providers with technological expertise and computational resources may perform
predictions for clients. However, data privacy severely restricts the
applicability of such services, unless measures to keep client data private
(even from the service provider) are designed. Equally important is to minimize
the amount of computation and communication required between client and server.
Fully homomorphic encryption offers a possible way out, whereby clients may
encrypt their data, and on which the server may perform arithmetic
computations. The main drawback of using fully homomorphic encryption is the
amount of time required to evaluate large machine learning models on encrypted
data. We combine ideas from the machine learning literature, particularly work
on binarization and sparsification of neural networks, together with
algorithmic tools to speed-up and parallelize computation using encrypted data.Comment: Accepted at International Conference in Machine Learning (ICML), 201
Context unification is in PSPACE
Contexts are terms with one `hole', i.e. a place in which we can substitute
an argument. In context unification we are given an equation over terms with
variables representing contexts and ask about the satisfiability of this
equation. Context unification is a natural subvariant of second-order
unification, which is undecidable, and a generalization of word equations,
which are decidable, at the same time. It is the unique problem between those
two whose decidability is uncertain (for already almost two decades). In this
paper we show that the context unification is in PSPACE. The result holds under
a (usual) assumption that the first-order signature is finite.
This result is obtained by an extension of the recompression technique,
recently developed by the author and used in particular to obtain a new PSPACE
algorithm for satisfiability of word equations, to context unification. The
recompression is based on performing simple compression rules (replacing pairs
of neighbouring function symbols), which are (conceptually) applied on the
solution of the context equation and modifying the equation in a way so that
such compression steps can be in fact performed directly on the equation,
without the knowledge of the actual solution.Comment: 27 pages, submitted, small notation changes and small improvements
over the previous tex
Reconstruction and numerical modelling of the abdominal wall. Application to hernia surgery
Routine hernia repair surgery involves the implant of synthetic mesh. However, this proceduremay give rise to several problems causing considerable patient disability. With the aim ofimproving surgical procedures, the healthy and the herniated human abdomen are simulatedusing finite element (FE) simulations. For that purpose, a reconstruction of the physiologicalgeometry of a human abdomen was created using magnetic resonance images. Besides,following the anatomy of the abdomen, the different muscles and aponeurosis were defined.Furthermore, collagen fibres were included in each muscle layer and their passive anisotropicmechanical contribution was modelled within the framework of hyperelasticity. In the FEsimulation of the abdomen, the constraint imposed by the shoulder is applied and an internalpressure of 23 kPa was applied to the interior abdominal wall to reproduce the abdominal loadwhen standing jumping. After generating a hernia in the front of the abdomen, differentprostheses (Surgipro®, Optilene® and Infinit®), modelled using a membrane model, are placedin the defect to simulate the behaviour of the abdomen after the surgical procedure. In thehealthy abdomen, maximal principal stresses (MPS) and displacements (MD) appear in thefront of the belly. On the other hand, once the hernia is created and the mesh is placed, theMD and MPS are higher than those attained in the healthy abdomen. Thus, just after surgery,surgical repair procedure does not fully restore normal physiological conditions and the risk ofhernia recurrence by the suture is high due to the stress concentration
Validación del Cuestionario de Autoevaluación de la Creatividad en la Enseñanza Universitaria CACEU-2010
La creatividad es un vector formativo de la
enseñanza y de las relaciones entre estudiantes y profesores
en la Educación Superior. A tal fin, el Cuestionario
de Autoevaluación de la Creatividad en la Enseñanza
Universitaria (CACEU-2010) se ha diseñado para
conocer cómo comprenden los profesores universitarios
la creatividad aplicada a su enseñanza y facilitar su autoevaluación.
Se estructuró como una escala de autoinforme,
conformada por 44 ítemes. Se estudió la validez
de contenido, realizada por jueces expertos. La
fiabilidad se obtuvo con el método Alpha de Cronbach,
y el parámetro obtuvo valores entre 0,70 y 0,94 para
las diferentes subescalas utilizadas
Métodos de enriquecimiento de glicoproteínas bacterianas para su posterior análisis y caracterización mediante espectrometría de masas
Comunicaciones a congreso
«Cuatro varas de sangre». Patria, comunidad política y creación de identidad colectiva en el Aragón de los siglos XVI y XVII
Diversas fuentes aragonesas de época moderna mencionan la idea de patria, entendida como lugar de nacimiento, pero también como comunidad política. En el segundo caso, la noción está ligada a la existencia de un ordenamiento jurídico y un sistema institucional propios, así como a referentes simbólicos como las «cuatro varas de sangre» representadas en el escudo del reino de Aragón. Estas construcciones culturales se enmarcan en el proceso de definición de una identidad colectiva aragonesa, asunto que será objeto de análisis en el presente artículo. Para ello se atenderá a los contenidos con que trató de perfilarse dicha identidad, a los promotores de su elaboración, a los mecanismos de creación y difusión que utilizaron y a la extensión que sus formulaciones alcanzaron en la población. Y también se subrayará que el esfuerzo por definir tal identidad cultural se produjo de forma simultánea a la inclusión del reino de Aragón en una unidad política de dimensiones universales, en la que se estaban produciendo fenómenos similares. De hecho, se procurará establecer comparaciones con otros casos, como el navarro o el catalán, con los que la identidad aragonesa compartió referentes históricos e ideológicos. Diverse Early Modern Aragonese sources allude to the idea of “homeland”, both as a place of birth and a political community. In this second case, the concept is tied to the existence of legal and institutional systems, and to symbolic referents like the “four rods of blood” represented in the coat of arms of the Kingdom of Aragon. These cultural constructions are part of the process of defining an Aragonese collective identity, which this paper will analyse. For this purpose, we shall examine the contents used to shape this identity, the people who contributed to its elaboration, the mechanisms of its creation and dissemination, and the extent to which these formulations reached the general population. Also emphasised is the extent to which the effort that went into defining such a cultural identity was simultaneous to the Kingdom of Aragon''s inclusion within a political unit of universal dimensions where similar phenomena were taking place. Indeed, we seek to establish comparisons with other instances, such as the Navarrese or Catalan cases, with which the Aragonese identity shared historical and ideological referents
Thermal performance analysis of the double sided-linear switched reluctance motor
This paper presents an exhaustive study about the propulsion force and the thermal performance of the double-sided flat Linear Switched Reluctance Motor (LSRM) according to the number of phases (m) and the pole stroke (PS). The analysis is performed by means of the Finite Element Method (FEM) for electromagnetic computations and a lumped parameter for thermal model (LPT) both linked to an optimization algorithm based on the Response Surface Methodology (RSM) in order to reduce the computing time. The results show the optimal design of LSRM from the point of view of the thermo-mechanical performance for a given insulation class and a duty cycle operating conditions
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