72 research outputs found
A combined analysis technique for the search for fast magnetic monopoles with the MACRO detector
We describe a search method for fast moving ()
magnetic monopoles using simultaneously the scintillator, streamer tube and
track-etch subdetectors of the MACRO apparatus. The first two subdetectors are
used primarily for the identification of candidates while the track-etch one is
used as the final tool for their rejection or confirmation. Using this
technique, a first sample of more than two years of data has been analyzed
without any evidence of a magnetic monopole. We set a 90% CL upper limit to the
local monopole flux of in the
velocity range and for nucleon decay
catalysis cross section smaller than .Comment: 29 pages (12 figures). Accepted by Astroparticle Physic
The Observation of Up-going Charged Particles Produced by High Energy Muons in Underground Detectors
An experimental study of the production of up-going charged particles in
inelastic interactions of down-going underground muons is reported, using data
obtained from the MACRO detector at the Gran Sasso Laboratory. In a sample of
12.2 10^6 single muons, corresponding to a detector livetime of 1.55 y, 243
events are observed having an up-going particle associated with a down-going
muon. These events are analysed to determine the range and emission angle
distributions of the up-going particle, corrected for detection and
reconstruction efficiency. Measurements of the muon neutrino flux by
underground detectors are often based on the observation of through-going and
stopping muons produced in interactions in the rock below the
detector. Up-going particles produced by an undetected down-going muon are a
potential background source in these measurements. The implications of this
background for neutrino studies using MACRO are discussed.Comment: 18 pages, 9 figures. Accepted by Astrop. Physic
Final results of magnetic monopole searches with the MACRO experiment
We present the final results obtained by the MACRO experiment in the search
for GUT magnetic monopoles in the penetrating cosmic radiation, for the range
. Several searches with all the MACRO sub-detectors
(i.e. scintillation counters, limited streamer tubes and nuclear track
detectors) were performed, both in stand alone and combined ways. No candidates
were detected and a 90% Confidence Level (C.L.) upper limit to the local
magnetic monopole flux was set at the level of cm
s sr. This result is the first experimental limit obtained in
direct searches which is well below the Parker bound in the whole range
in which GUT magnetic monopoles are expected.Comment: 12 pages, Latex, 9 figures and 2 Table
Nuclearite search with the MACRO detector at Gran Sasso
In this paper we present the results of a search for nuclearites in the
penetrating cosmic radiation using the scintillator and track-etch subdetectors
of the MACRO apparatus. The analyses cover the beta =v/c range at the detector
depth (3700 hg/cm^2) 10^-5 < beta < 1; for beta = 2 x 10^-3 the flux limit is
2.7 x 10^-16 cm^-2 s^-1 sr^-1 for an isotropic flux of nuclearites, and twice
this value for a flux of downgoing nuclearites.Comment: 16 pages, 4 Encapsulated Postscript figures, uses article.sty.
Submitted to The European Physical Journal
Atmospheric neutrino induced muons in the MACRO detector
A measurement of the flux of neutrino-induced muons using the MACRO detector
is presented. Different event topologies, corresponding to different neutrino
parent energies can be detected. The upward throughgoing muon sample is the
larger event sample. The observed upward-throughgoing muons are 26% fewer than
expected and the zenith angle distribution does not fit with the expected one.
Assuming neutrino oscillations, both measurements suggest maximum mixing and
Dm2 of a few times 10-3 eV2. The other samples are due to the internally
produced events and to upward-going stopping muons. These data show a regular
deficit of observed events in each angular bin, as expected assuming neutrino
oscillations with maximum mixing, in agreement with the analysis of the
upward-throughgoing muon sample.Comment: 7 pages 6 figures to appear in the proceedings of XVIII International
Conference on Neutrino Physics and Astrophysics (Neutrino'98), Takayama,
Japan 4-9 June, 199
New MACRO results on atmospheric neutrino oscillations
The final results of the MACRO experiment on atmospheric neutrino
oscillations are presented and discussed. The data concern different event
topologies with average neutrino energies of ~3 and ~50 GeV. Multiple Coulomb
Scattering of the high energy muons in absorbers was used to estimate the
neutrino energy of each event. The angular distributions, the L/E_nu
distribution, the particle ratios and the absolute fluxes all favour nu_mu -->
nu_tau oscillations with maximal mixing and Delta m^2 =0.0023 eV^2. A
discussion is made on the Monte Carlos used for the atmospheric neutrino flux.
Some results on neutrino astrophysics are also briefly discussed.Comment: Invited Paper at the NANP03 Int. Conf., Dubna, 200
Moon and Sun shadowing effect in the MACRO detector
Using data collected by the MACRO experiment from 1989 to the end of its
operations in 2000, we have studied in the underground muon flux the shadowing
effects due to both the Moon and the Sun. We have observed the Moon shadowing
effect with a significance of 6.5 sigma and the Sun shadowing effect with a
significance of 4.3 sigma. The observed displacement of the Sun shadow, due to
the configurations of the solar and interplanetary magnetic fields, has been
used to quote the antiproton/proton flux limits for primaries of about 20 TeV
energy.Comment: 23 pages, 11 figures, submitted to Astrop.Phy
Oxidative protein labeling in mass-spectrometry-based proteomics
Oxidation of proteins and peptides is a common phenomenon, and can be employed as a labeling technique for mass-spectrometry-based proteomics. Nonspecific oxidative labeling methods can modify almost any amino acid residue in a protein or only surface-exposed regions. Specific agents may label reactive functional groups in amino acids, primarily cysteine, methionine, tyrosine, and tryptophan. Nonspecific radical intermediates (reactive oxygen, nitrogen, or halogen species) can be produced by chemical, photochemical, electrochemical, or enzymatic methods. More targeted oxidation can be achieved by chemical reagents but also by direct electrochemical oxidation, which opens the way to instrumental labeling methods. Oxidative labeling of amino acids in the context of liquid chromatography(LC)–mass spectrometry (MS) based proteomics allows for differential LC separation, improved MS ionization, and label-specific fragmentation and detection. Oxidation of proteins can create new reactive groups which are useful for secondary, more conventional derivatization reactions with, e.g., fluorescent labels. This review summarizes reactions of oxidizing agents with peptides and proteins, the corresponding methodologies and instrumentation, and the major, innovative applications of oxidative protein labeling described in selected literature from the last decade
Alignment of the ALICE Inner Tracking System with cosmic-ray tracks
37 pages, 15 figures, revised version, accepted by JINSTALICE (A Large Ion Collider Experiment) is the LHC (Large Hadron Collider) experiment devoted to investigating the strongly interacting matter created in nucleus-nucleus collisions at the LHC energies. The ALICE ITS, Inner Tracking System, consists of six cylindrical layers of silicon detectors with three different technologies; in the outward direction: two layers of pixel detectors, two layers each of drift, and strip detectors. The number of parameters to be determined in the spatial alignment of the 2198 sensor modules of the ITS is about 13,000. The target alignment precision is well below 10 micron in some cases (pixels). The sources of alignment information include survey measurements, and the reconstructed tracks from cosmic rays and from proton-proton collisions. The main track-based alignment method uses the Millepede global approach. An iterative local method was developed and used as well. We present the results obtained for the ITS alignment using about 10^5 charged tracks from cosmic rays that have been collected during summer 2008, with the ALICE solenoidal magnet switched off.Peer reviewe
Alzheimer disease models and human neuropathology: similarities and differences
Animal models aim to replicate the symptoms, the lesions or the cause(s) of Alzheimer disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its lesions: the extracellular deposits of Aβ peptide and the intracellular accumulation of tau protein. Mutated human APP transgenes result in the deposition of Aβ peptide, similar but not identical to the Aβ peptide of human senile plaque. Amyloid angiopathy is common. Besides the deposition of Aβ, axon dystrophy and alteration of dendrites have been observed. All of the mutations cause an increase in Aβ 42 levels, except for the Arctic mutation, which alters the Aβ sequence itself. Overexpressing wild-type APP alone (as in the murine models of human trisomy 21) causes no Aβ deposition in most mouse lines. Doubly (APP × mutated PS1) transgenic mice develop the lesions earlier. Transgenic mice in which BACE1 has been knocked out or overexpressed have been produced, as well as lines with altered expression of neprilysin, the main degrading enzyme of Aβ. The APP transgenic mice have raised new questions concerning the mechanisms of neuronal loss, the accumulation of Aβ in the cell body of the neurons, inflammation and gliosis, and the dendritic alterations. They have allowed some insight to be gained into the kinetics of the changes. The connection between the symptoms, the lesions and the increase in Aβ oligomers has been found to be difficult to unravel. Neurofibrillary tangles are only found in mouse lines that overexpress mutated tau or human tau on a murine tau −/− background. A triply transgenic model (mutated APP, PS1 and tau) recapitulates the alterations seen in AD but its physiological relevance may be discussed. A number of modulators of Aβ or of tau accumulation have been tested. A transgenic model may be analyzed at three levels at least (symptoms, lesions, cause of the disease), and a reading key is proposed to summarize this analysis
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