Turbulent transport mechanisms in oscillating bubble plumes

The detailed investigation of an unstable meandering bubble plume created in a 2-m-diameter vessel with a water depth of 1.5 m is reported for void fractions up to 4% and bubble size of the order of 2.5 mm. Simultaneous particle image velocity (PIV) measurements of bubble and liquid velocities and video recordings of the projection of the plume on two vertical perpendicular planes were produced in order to characterize the state of the plume by the location of its centreline and its equivalent diameter. The data were conditionally ensemble averaged using only PIV sets corresponding to plume states in a range as narrow as possible, separating the small-scale fluctuations of the flow from the large-scale motions, namely plume meandering and instantaneous cross-sectional area fluctuations. Meandering produces an apparent spreading of the average plume velocity and void fraction profiles that were shown to remain self-similar in the instantaneous plume cross-section. Differences between the true local time-average relative velocities and the difference of the averaged phase velocities were measured; the complex variation of the relative velocity was explained by the effects of passing vortices and by the fact that the bubbles do not reach an equilibrium velocity as they migrate radially, producing momentum exchanges between high- and low-velocity regions. Local entrainment effects decrease with larger plume diameters, contradicting the classical dependence of entrainment on the time-averaged plume diameter. Small plume diameters tend to trigger ‘entrainment eddies' that promote the inward-flow motion. The global turbulent kinetic energy was found to be dominated by the vertical stresses. Conditional averages according to the plume diameter showed that the large-scale motions did not affect the instantaneous turbulent kinetic energy distribution in the plume, suggesting that large scales and small scales are not correlated. With conditional averaging, meandering was a minor effect on the global kinetic energy and the Reynolds stresses. In contrast, plume diameter fluctuations produce a substantial effect on these quantitie

A variability analysis of low-latitude unidentified gamma-ray sources

We present a study of 40 low-latitude unidentified 3EG gamma-ray sources which were found to be not positionally coincident with any known class of potential gamma-ray emitters in the Galaxy (Romero, Benaglia & Torres, 1999). We have performed a variability analysis which reveals that many of these 40 sources are variable. These sources have, in addition, a steep mean value of the gamma-ray spectral index, $= 2.41 \pm 0.2$, which, combined with the high level of variability seems to rule out a pulsar origin. The positional coincidences with uncatalogued candidates to supernova remnants were also studied. Only 7 sources in the sample are spatially coincident with these candidates, a result that is shown to be consistent with the expected level of pure chance association. A complementary search for weak radio counterparts was also conducted and the results are presented as an extensive table containing all significant point-like radio sources within the 40 EGRET fields. We argue that in order to produce the high variability, steep gamma-ray spectra, and absence of strong radio counterparts observed in some of the gamma-ray sources of our sample a new class of objects should be postulated, and we analyze a viable candidate.Comment: Paper updated to match the accepted version to appear in Astronomy and Astrophysics, 2001. Tables 5,6,7 and 8 are in ascii format and need to be printed separately. they can also be obtained from http://www.iar.unlp.edu.ar/garra Table 5 is 62 pages long. Download the source to obtain the table

A first EGRET-UNID-related agenda for the next-generation Cherenkov telescopes

The next generation of Imaging Atmospheric Cherenkov Telescopes (IACTs) will open the regime between approx. 30 GeV and 200 GeV to ground-based gamma observations with unprecedented point source sensitivity and source location accuracy. I examine the prospects of observing the unidentified objects (UNIDs) of the Third EGRET Catalog using the IACT observatories currently under construction by the CANGAROO, HESS, MAGIC and VERITAS collaborations. Assuming a modest spectral steepening similar to that observed in the inverse Compton component of the Crab Nebula spectrum and taking into account the sensitivity of the instruments and its zenith angle dependence, a detailed list of 78 observable objects is derived which is then further constrained to 38 prime candidates. The characteristics of this agenda are discussed.Comment: 21 pages, 5 figures, to be published in Carraminana, Reimer & Thompson (eds.) Proc. "The nature of unidentified high-energy gamma-ray sources (Tonantzintla, Mexico, October 2000)", Kluwer Academi

Pulsar Results with the Fermi Large Area Telescope

The launch of the Fermi Gamma-ray Space Telescope has heralded a new era in the study of gamma-ray pulsars. The population of confirmed gamma-ray pulsars has gone from 6-7 to more than 60, and the superb sensitivity of the Large Area Telescope (LAT) on Fermi has allowed the detailed study of their spectra and light curves. Twenty-four of these pulsars were discovered in blind searches of the gamma-ray data, and twenty-one of these are, at present, radio quiet, despite deep radio follow-up observations. In addition, millisecond pulsars have been confirmed as a class of gamma-ray emitters, both individually and collectively in globular clusters. Recently, radio searches in the direction of LAT sources with no likely counterparts have been highly productive, leading to the discovery of a large number of new millisecond pulsars. Taken together, these discoveries promise a great improvement in the understanding of the gamma-ray emission properties and Galactic population of pulsars. We summarize some of the results stemming from these newly-detected pulsars and their timing and multi-wavelength follow-up observations.Comment: 21 pages, 9 figures, to appear in Proceedings of ICREA Workshop on The High-Energy Emission from Pulsars and their Systems, Sant Cugat, Spain, 2010 April 12-16 (Springer

XMM-Newton and ESO observations of the two unidentified gamma-ray sources 3EG J0616-3310 and 3EG J1249-8330

The limited angular resolution of gamma-ray telescopes prevents a direct identification of the majority of sources detected so far. This is particularly true for the low latitude, probably galactic, ones only 10 % of which has been identified. Most counterparts of the identified low-latitude gamma-ray sources are Isolated Neutron Stars (INS), both radio-loud and radio-quiet (Geminga-like) objects, which are characterised by an extremely high value of the X-ray-to-optical flux ratio f_X/f_opt. Therefore, the systematic X-ray and optical coverage of low-latitude unidentified gamma-ray sources aiming at high f_X/f_opt sources seems one of the most promising ways to spot INS candidate counterparts. Since low latitude sources are heavily affected by the interstellar absorption at both X-ray and optical wavelengths, we have focussed on two middle-latitude, probably galactic, GRO/EGRET sources: 3EG J0616-3310 and 3EG J1249-8330. These two sources, which could belong to a local galactic population, have been selected owing to their relatively good positional accuracy, spectral shape and lack of candidate extragalactic radio counterparts. Here we report on X-ray observations of the two gamma-ray error boxes performed with XMM-Newton and on their optical follow-up carried on with the Wide Field Imager at the ESO/MPG 2.2m telescope. Less than half of the ~300 sources detected by the X-ray coverage have no optical counterparts. Among those, we have selected few interesting sources with f_X/f_opt > 100, which we consider promising INS candidates.Comment: 18 pages, 10 figures, 8 tables. Accepted for publication by Astronomy & Astrophysic

Checkpoint inhibition enhances cell contacts between CD4+ T cells and Hodgkin-Reed-Sternberg cells of classic Hodgkin lymphoma

Although checkpoint molecules like CTLA-4 and PD1 have been described several years ago, checkpoint inhibitors such as Nivolumab (an anti-PD-1 antibody) have only recently been used to treat classic Hodgkin lymphoma (cHL). Several studies have shown convincing therapeutic effects of Nivolumab in cHL. However, the mechanism of action of Nivolumab in cHL is not fully understood. The aim of this study was to monitor changes in cell motility and cell contacts after administration of Nivolumab to an in vitro model of cHL as well as to native hyperplastic lymphoid tissue and native human tissue from cHL. In both tissue and in vitro, CD4+, CD8+, CD30+ and CD20+ cell velocities were unchanged after Nivolumab incubation. In contrast, in primary cHL tissue, the duration of cell contacts between CD4+ T cells and HRS cells was significantly increased after 5 h Nivolumab treatment, and the number of contacts with HRS cells was also slightly increased for CD4+ T cells (not significant), suggesting that CD4+ T cells in particular contribute to the cytotoxicity observed as a result of Nivolumab therapy. There was no change in the duration of cell contacts in the hyperplastic lymphoid tissue after Nivolumab incubation. In conclusion, we show here for the first time by imaging of native lymphoma tissue an enhanced interaction of CD4+ T cells and HRS cells in cHL after Nivolumab administration

Fermi-LAT Search for Pulsar Wind Nebulae around gamma-ray Pulsars

The high sensitivity of the Fermi-LAT (Large Area Telescope) offers the first opportunity to study faint and extended GeV sources such as pulsar wind nebulae (PWNe). After one year of observation the LAT detected and identified three pulsar wind nebulae: the Crab Nebula, Vela-X and the PWN inside MSH 15-52. In the meantime, the list of LAT detected pulsars increased steadily. These pulsars are characterized by high energy loss rates from ~3 \times 10^{33} erg s$^{-1}$ to 5 \times 10$^{38}$ erg s$^{-1}$ and are therefore likely to power a PWN. This paper summarizes the search for PWNe in the off-pulse windows of 54 LAT-detected pulsars using 16 months of survey observations. Ten sources show significant emission, seven of these likely being of magnetospheric origin. The detection of significant emission in the off-pulse interval offers new constraints on the gamma-ray emitting regions in pulsar magnetospheres. The three other sources with significant emission are the Crab Nebula, Vela-X and a new pulsar wind nebula candidate associated with the LAT pulsar PSR J1023-5746, coincident with the TeV source HESS J1023-575. We further explore the association between the H.E.S.S. and the Fermi source by modeling its spectral energy distribution. Flux upper limits derived for the 44 remaining sources are used to provide new constraints on famous PWNe that have been detected at keV and/or TeV energies.Comment: Accepted for publication in Astrophysical Journal, 42 pages, 17 figure

Gamma ray astrophysics: the EGRET results

Cosmic gamma rays provide insight into some of the most dynamic processes in the Universe. At the dawn of a new generation of gamma-ray telescopes, this review summarizes results from the Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory, the principal predecessor mission studying high-energy photons in the 100 MeV energy range. EGRET viewed a gamma-ray sky dominated by prominent emission from the Milky Way, but featuring an array of other sources, including quasars, pulsars, gamma-ray bursts, and many sources that remain unidentified. A central feature of the EGRET results was the high degree of variability seen in many gamma-ray sources, indicative of the powerful forces at work in objects visible to gamma-ray telescopes.Comment: 23 pages, 24 figure