Trajectory optimization and guidance law development for national aerospace plane applications

The work completed to date is comprised of the following: a simple vehicle model representative of the aerospace plane concept in the hypersonic flight regime, fuel-optimal climb profiles for the unconstrained and dynamic pressure constrained cases generated using a reduced order dynamic model, an analytic switching condition for transition to rocket powered flight as orbital velocity is approached, simple feedback guidance laws for both the unconstrained and dynamic pressure constrained cases derived via singular perturbation theory and a nonlinear transformation technique, and numerical simulation results for ascent to orbit in the dynamic pressure constrained case

Rapid near-optimal trajectory generation and guidance law development for single-stage-to-orbit airbreathing vehicles

General problems associated with on-board trajectory optimization, propulsion system cycle selection, and with the synthesis of guidance laws were addressed for an ascent to low-earth-orbit of an air-breathing single-stage-to-orbit vehicle. The NASA Generic Hypersonic Aerodynamic Model Example and the Langley Accelerator aerodynamic sets were acquired and implemented. Work related to the development of purely analytic aerodynamic models was also performed at a low level. A generic model of a multi-mode propulsion system was developed that includes turbojet, ramjet, scramjet, and rocket engine cycles. Provisions were made in the dynamic model for a component of thrust normal to the flight path. Computational results, which characterize the nonlinear sensitivity of scramjet performance to changes in vehicle angle of attack, were obtained and incorporated into the engine model. Additional trajectory constraints were introduced: maximum dynamic pressure; maximum aerodynamic heating rate per unit area; angle of attack and lift limits; and limits on acceleration both along and normal to the flight path. The remainder of the effort focused on required modifications to a previously derived algorithm when the model complexity cited above was added. In particular, analytic switching conditions were derived which, under appropriate assumptions, govern optimal transition from one propulsion mode to another for two cases: the case in which engine cycle operations can overlap, and the case in which engine cycle operations are mutually exclusive. The resulting guidance algorithm was implemented in software and exercised extensively. It was found that the approximations associated with the assumed time scale separation employed in this work are reasonable except over the Mach range from roughly 5 to 8. This phenomenon is due to the very large thrust capability of scramjets in this Mach regime when sized to meet the requirement for ascent to orbit. By accounting for flight path angle and flight path angle rate in construction of the flight path over this Mach range, the resulting algorithm provides the means for rapid near-optimal trajectory generation and propulsion cycle selection over the entire Mach range from take-off to orbit

Experimental test and numerical shape optimization of a point pivoted absorber for wave energy conversion

This paper presents a numerical study on an innovative system for converting energy from waves. It consists of a point pivoted body which oscillates in presence of waves. The system uses a linear electrical generator which converts floating movements of the buoyant body into electrical power. The buoyant body floats, describing an arc, by means of two hinges. A suitable Power Take-off Device (PTO) is placed between buoy support arms and the fixed structure and has the function to convert the mechanical power of the linear oscillating motion of the connecting piston into electrical power. A design assumption is made on the PTO control system: PTO reaction force is assumed to be linearly dependent on piston oscillation velocity with a given force-speed gain. This coefficient is strictly connected to electrical generator characteristics and its value has an effect on power conversion efficiency . A scaled model of this system has also been tested in the wave/towing tank facility of Department of industrial Engineering (DII) of University of Naples “Federico II”. A variety of numerical analyses, such as potential flow simulations and Unsteady Reynolds Averaged Navier-Stokes (URANS) simulations, have been performed to predict the system performances. Numerical and experimental analyses have included the performances of the baseline geometry, both in free response and under wave excitation, in order to characterize the response of the system, and results have been used to understand which parameters affect more the power production. Finally a numerical optimization procedure has been carried out to optimize the shape of the converter with the final objective of increasing the generated power, eventually imposing a constraint on the amount of immersed volume. In this way, a modified configuration has been predicted with higher power output and the same value of submerged volume, but with different shape

In vivo retroviral-mediated transfer of a marker-gene in ornithine transcarbamylase-deficient Spf(ash) mice.

Gene therapy is a new therapeutic approach for inherited metabolic hepatopathies. The authors studied the potential application of such a strategy to the correction of ornithine transcarbamylase (OTC) deficiency by in vivo protocol of retroviral-mediated gene transfer to the liver. A partial hepatectomy was followed (24 to 48 hours later) by asanguinous perfusion of the regenerating liver with beta-galactosidase (beta-gal) recombinant retrovirus. This protocol allowed beta-gal gene transfer in normal C57B6 mice liver with 60 +/- 52 positive cells per square centimeter. This proportion never exceeded 20 cells per square centimeter in OTC-deficient spf(ash) mice. The high mortality rate for spf(ash) mice was explained by an important sensitivity of those mice to the protein catabolism rather than by technical difficulties during intraportal perfusion. This first in vivo retroviral-mediated gene transfer study in animals with a life-threatening metabolic inherited hepatopathy showed that, despite efficiency of gene therapy in normal animal models, several experimental difficulties should be overcome before human application of this protocol is considered

Technical and economic analysis of the reconversion of an existing biogas plant to biomethane production: a case study.

The paper deals with the technical and economic analysis of a project aimed at transforming an existing plant, used for the anaerobic digestion of zoo-technical and agroforest biomass and including a CHP system of about 1 MW of electric capacity, into a facility producing bio-methane for automotive and/or stationary power applications. A comparison of different biogas upgrading technologies is performed, aimed at selecting the technology most appropriate to the size and typology of application under evaluation. Similarly, an analysis is performed to evaluate the opportunity of installing a bio-methane liquefaction facility, to simplify the management and transportation of the fuel, to be used in vehicles. The economic analysis is performed by considering the incentives presently available in Italy for bio-methane producers. Different scenarios are analyzed and discussed, and it was concluded that the conversion of the existing plant into a facility to produce bio-methane to be liquified and sold as fuel for vehicles represents at this moment a very attractive and profitable option

Modeling the target strength of Meganyctiphanes norvegica

Abstract only. Journal home page: http://scitation.aip.org/jasa

Flettner Rotor Concept for Marine Applications: A Systematic Study

The concept of Flettner rotor, a rotating cylinder immersed in a fluid current, with a top-mounted disk, has been analyzed by means of unsteady Reynolds averaged Navier-Stokes simulations, with the aim of creating a suitable tool for the preliminary design of the Flettner rotor as a ship's auxiliary propulsion system. The simulation has been executed to evaluate the performance sensitivity of the Flettner rotor with respect to systematic variations of several parameters, that is, the spin ratio, the rotor aspect ratio, the effect of the end plates, and their dimensions. The Flettner rotor device has been characterized in terms of lift and drag coefficients, and these data were compared with experimental trends available in literature. A verification study has been conducted in order to evaluate the accuracy of the simulation results and the main sources of numerical uncertainty. All the simulation results were used to achieve a surrogate model of lift and drag coefficients. This model is an effective mathematical tool for the preliminary design of Flettner rotor. Finally, an example of assessment of the Flettner rotor performance as an auxiliary propulsion device on a real tanker ship is reported

Surgical Approach for Long-term Survival of Patients With Intrahepatic Cholangiocarcinoma: A Multi-institutional Analysis of 434 Patients.

OBJECTIVES To examine the outcomes of a hepatectomy for intrahepatic cholangiocarcinoma (IHC) and to clarify the prognostic impact of a lymphadenectomy and the surgical margin. Large series of patients who were surgically treated for IHC are scarce. Thus, prognostic factors and long-term survival after resection of IHC remain uncertain. DESIGN Prospective study of patients who were surgically treated for IHC. Clinicopathologic, operative, and long-term survival data were analyzed. SETTING Prospectively collected data of all consecutive patients with pathologically confirmed IHC who had undergone liver resection with a curative intent at 1 of 16 tertiary referral centers were entered into a multi-institutional registry. PATIENTS All consecutive patients who underwent a hepatectomy with a curative intent for IHC (1990-2008) were identified from a multi-institutional registry. RESULTS A total of 434 patients were included in the analysis. Most patients underwent a major or extended hepatectomy (70.0%) and a systematic lymphadenectomy (62.2%). The incidence of lymph node metastases (overall, 36.9%) increased with increased tumor size, with 24.4% of patients with a small IHC (diameter 643 cm) having N1 disease. Almost one-third of patients required an additional major procedure to obtain a R0 resection in 84.6% of the cases. In these patients, the median time of survival was 39 months, and the 5-year survival rate was 39.8%. Lymph node metastases (hazard ratio, 2.21; P < .001), multiple tumors (hazard ratio, 1.50; P = .009), and an elevated preoperative cancer antigen 19.9 level (hazard ratio, 1.62; P = .006) independently predicted an adverse prognosis. Conversely, survival was not influenced by the width of a negative resection margin (P = .61). The potential survival benefit of a lymphadenectomy was assessed with the therapeutic value index, which was calculated to be 5.9 points. CONCLUSIONS Survival rates after a hepatectomy with a curative intent for IHC at tertiary referral centers exceed the survival rates reported in most study series in single institutions, which strengthens the value of an aggressive approach to radical resection. Lymph node metastases and multiple tumors are associated with decreased survival rates, but they should not be considered selection criteria that prevent other patients from undergoing a potentially curative resection. Lymphadenectomy should be considered for all patients