Modified Reference SPS with Solid State Transmitting Antenna

The development of solid state microwave power amplifiers for a solar power satellite transmitting antenna is discussed. State-of-the-art power-added efficiency, gain, and single device power of various microwave solid state devices are compared. The GaAs field effect transistors and the Si-bipolar transistors appear potentially feasible for solar power satellite use. The integration of solid state devices into antenna array elements is examined and issues concerning antenna integration and consequent satellite configurations are examined

SPS phase control studies

To properly point and form the satellite microwave power beam, the outputs of the power amplifiers in the transmitting array must be phased in a specific and coherent fashion. A retrodirective CW phase conjugating system using a spread spectrum uplink signal and a reference phase signal that is distributed via fiber optics, was selected as the control system for SPS. The design details are presented and applications of the system are discussed

Is there regime behavior in monsoon convection in the late 20th century?

Mixture model techniques are applied to a daily index of monsoon convection from ERA‐40 reanalysis to show regime behavior. The result is the existence of two significant regimes showing preferred locations of convection within the Asia/Western‐North Pacific domain, with some resemblance to active‐break events over India. Simple trend analysis over 1958–2001 shows that the first regime has become less frequent while the second becomes much more dominant. Both undergo a change in structure contributing to the total OLR trend over the ERA‐40 period. Stratifying the data according to a large‐scale dynamical index of monsoon interannual variability, we show the regime occurrence to be strongly perturbed by the seasonal condition, in agreement with conceptual ideas. This technique could be used to further examine predictability issues relating the seasonal mean and intraseasonal monsoon variability or to explore changes in monsoon behavior in centennial‐scale model integrations

Attempts to generate atheroprotective lecithin:cholesterol acyltransferase (LCAT) phenotypes by chimeraplasty

Lecithin-cholesterol acyltransferase (LCAT) is a high-density lipoprotein (HDL)-associated enzyme, which is secreted mainly by the liver. By esterifying cholesterol in the surface of immature HDL, LCAT drives reverse cholesterol transport, an important process in preventing atherosclerosis. Specific point mutations in the LCAT gene, producing serine to alanine amino acid substitutions at positions 208 or 216, are reported to increase enzymatic activity up to 14 times. Here, I attempt to create these mutations using a new technology, termed chimeraplasty targeted gene repair in situ using synthetic RNA-DNA oligonucleotides (chimeraplasts). First, I demonstrated that the Ser208Ala and Ser216Ala mutations do increase LCAT specific activity by comparing recombinant Ghinese hamster ovary (CHO) cells secreting wild-type LCAT (CHO-LCAT), LCATser2i6Aia, or LCATser208Aia+ser2i6Aia. I then targeted CHO-LCAT cells, and a human hepatoma cell line (HepG2), in vitro with chimeraplasts directed at the Ser208 and Ser216 sites. However, I was unable to create the required mymidine to guanine nucleotide substitution required using standard procedures, even by varying transfection conditions, repeat targeting, or altering chimeraplast design. I studied, therefore, chimeraplast uptake into the nucleus with various polyethylemmine (PEI)-based transfection reagents by using fluorescently-labelled oligonucleotides and a validated chimeraplast, able to mutate the apolipoprotein E (APOE) gene. I found that melittin-PEI, transferrin-PEI and galactose4-PEI were superior to linear PEI, but targeting the LCAT gene with these optimal reagents failed to produce either Ser208Ala or Ser216Ala mutations. Moreover, co-targeting cells simultaneously with LCAT and apoE chimeraplasts mutated the APOE gene, but not the LCAT gene. Finally, to investigate possible gene position or sequence effects I produced recombinant CHO cells expressing both LCAT and apoE targeting regions adjacent to each other. When these cells were co-targeted the Ser216Ala mutation was successful. I conclude that chimeraplast-directed gene mutation/ repair is a promising technique but further investigation is required to explain inconsistent results when targeting different cell lines

Morphometric differences in the grasshopper Cornops aquaticum (Bruner, 1906) from South America and South Africa

The semi-aquatic grasshopper Cornops aquaticum is native to South America and inhabits lowlands from southern Mexico to Central Argentina and Uruguay. It is host-specific to aquatic plants in the genera Eichhornia and Pontederia. A quarantine population has existed in South Africa for 10 y, and it is planned to release it there as a biological control agent of water hyacinth, E. crassipes. Various studies of C. aquaticum are coordinated under HICWA (www.mpil-ploen.mpg.de). This paper compares the morphometry of the release population and 11 native populations in South America. We tested four hypotheses: 1) South African and South American populations of C. aquaticum differ in morphology; 2) the South African laboratory population is more similar to other isolated populations in South America than to nonisolated populations; 3) morphology differs across sites; 4) morphology differs with host plant. South African populations differed from continental nonisolated populations, but not from continental isolated ones. Isolated populations presented smaller individuals than nonisolated, but there was also a change in male morphology: while in nonisolated populations male wing length was similar to their body length, in isolated populations, male wings were smaller than body length. Females were larger when on Eicchornia azurea than on E. crassipes, while males presented larger wings than their body on E. azurea, and similar lengths on E. crassipes. These morphological changes may have resulted from phenotypic plasticity, selection for small size, or because of a loss of genetic diversity in quantitative traits.Fil: Adis, Joachim. Institute for Limnology; AlemaniaFil: Sperber, Carlos F. Universidade Federal de Viçosa; BrasilFil: Brede, Edward G. Institute for Limnology; AlemaniaFil: Capello, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; ArgentinaFil: Franceschini, Maria Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; ArgentinaFil: Hill, Martin. Rhodes University; SudáfricaFil: Lhano, Marcos G. Universidade Federal de Viçosa; BrasilFil: Marques, Marinê. A;z M.. Universidade Federal de Mato Grosso; BrasilFil: Nunes, Ana L.. Muséu Paraense Emílio Goeldi; BrasilFil: Polar, Perry. CAB International; Trinidad y Tobag

The role of the basic state in the ENSO-monsoon relationship and implications for predictability

The impact of systematic model errors on a coupled simulation of the Asian Summer monsoon and its interannual variability is studied. Although the mean monsoon climate is reasonably well captured, systematic errors in the equatorial Pacific mean that the monsoon-ENSO teleconnection is rather poorly represented in the GCM. A system of ocean-surface heat flux adjustments is implemented in the tropical Pacific and Indian Oceans in order to reduce the systematic biases. In this version of the GCM, the monsoon-ENSO teleconnection is better simulated, particularly the lag-lead relationships in which weak monsoons precede the peak of El Nino. In part this is related to changes in the characteristics of El Nino, which has a more realistic evolution in its developing phase. A stronger ENSO amplitude in the new model version also feeds back to further strengthen the teleconnection. These results have important implications for the use of coupled models for seasonal prediction of systems such as the monsoon, and suggest that some form of flux correction may have significant benefits where model systematic error compromises important teleconnections and modes of interannual variability

Epistemic Vigilance

Humans massively depend on communication with others, but this leaves them open to the risk of being accidentally or intentionally misinformed. To ensure that, despite this risk, communication remains advantageous, humans have, we claim, a suite of cognitive mechanisms for epistemic vigilance. Here we outline this claim and consider some of the ways in which epistemic vigilance works in mental and social life by surveying issues, research and theories in different domains of philosophy, linguistics, cognitive psychology and the social sciences

From Marx to Gramsci to us: Laboratory to prison, and back

Marx and Gramsci remain two of the most constant presences and inspirations for those on the left. Yet there is a persistent sense that we have still to get them right. Perhaps this indicates that sources like this are now fully classics, to be returned, and returned to. In the case of Marx and Gramsci, a series of major works published in the Brill Historical Materialism series breaks new ground as well as returning to older controversies, both resolved and unresolved. Apart from remaining arguments concerning the status of materials unpublished in their own lifetimes, the major tension that emerges here is that between the task of immanent, contextual philology and the challenge of reading ‘Marx for today’ or ‘Gramsci for today’. The tension between text and context, and the question of what travels, conceptually persists