Inherent and learnt abilities for relative pitch in the vibrotactile domain using the fingertip

This paper reports experimental results concerning relative pitch discrimination. This is defined as the ability to distinguish one musical note as being higher or lower than another. Seventeen participants with normal hearing undertook a pitch discrimination experiment using the fingertip over a 16 session training period with a full baseline test before and after the training sessions. Two sinusoidal tones were presented, each of Is duration separated by a Is gap. A total of 24 tones were chosen to cover 12 intervals ranging from a semi-tone to an octave over the frequency range C3 to B4. The results show a high success rate for relative pitch discrimination with and without training. For intervals of 4 to 12 semitones, the success rates were >70% with or without the 16 training sessions. As a result of training, a significant improvement was found for individual intervals between 9 and 12 semitones when comparing the number of correct responses between pre-training and post-training tests. Comparison of pre- and post-training tests also showed an appreciable and significant improvement for the whole group of 12 intervals. In addition, reaction times to identify relative pitch tended to decrease over the training period

Experimental and numerical investigation of an axisymmetric supersonic jet

21 pages, 10 figures, 2 tables.A comprehensive study of a steady axisymmetric supersonic jet of CO2, including experiment, theory, and numerical calculation, is presented. The experimental part, based on high-sensitivity Raman spectroscopy mapping, provides absolute density and rotational temperature maps covering the significant regions of the jet: the zone of silence, barrel shock, Mach disk, and subsonic region beyond the Mach disk. The interpretation is based on the quasi-gasdynamic (QGD) system of equations, and its generalization (QGDR) considering the translational–rotational breakdown of thermal equilibrium. QGD and QGDR systems of equations are solved numerically in terms of a finite-difference algorithm with the steady state attained as the limit of a time-evolving process. Numerical results show a good global agreement with experiment, and provide information on those quantities not measured in the experiment, like velocity field, Mach numbers, and pressures. According to the calculation the subsonic part of the jet, downstream of the Mach disk, encloses a low-velocity recirculation vortex ring.This research was supported by the Spanish Dirección General de Investigación Científica y Enseñanza Superior (DGICYES), Research Projects PB94{1526 and PB97{1203, and by the Fund for Fundamental Investigations of the Russian Academy of Sciences N 98-01-00155.Peer reviewe

An ontology-based secure design framework for graph-based databases

Graph-based databases are concerned with performance and flexibility. Most of the existing approaches used to design secure NoSQL databases are limited to the final implementation stage, and do not involve the design of security and access control issues at higher abstraction levels. Ensuring security and access control for Graph-based databases is difficult, as each approach differs significantly depending on the technology employed. In this paper, we propose the first technology-ascetic framework with which to design secure Graph-based databases. Our proposal raises the abstraction level by using ontologies to simultaneously model database and security requirements together. This is supported by the TITAN framework, which facilitates the way in which both aspects are dealt with. The great advantages of our approach are, therefore, that it: allows database designers to focus on the simultaneous protection of security and data while ignoring the implementation details; facilitates the secure design and rapid migration of security rules by deriving specific security measures for each underlying technology, and enables database designers to employ ontology reasoning in order to verify whether the security rules are consistent. We show the applicability of our proposal by applying it to a case study based on a hospital data access control.This work has been developed within the AETHER-UA (PID2020-112540RB-C43), AETHER-UMA (PID2020-112540RB-C41) and AETHER-UCLM (PID2020-112540RB-C42), ALBA (TED2021-130355B-C31, TED2021-130355B-C33), PRESECREL (PID2021-124502OB-C42) projects funded by the “Ministerio de Ciencia e Innovación”, Andalusian PAIDI program with grant (P18-RT-2799) and the BALLADER Project (PROMETEO/2021/088) funded by the “Consellería de Innovación, Universidades, Ciencia Sociedad Digital”, Generalitat Valenciana

In-situ early-age hydration study of sulfobelite cements by synchrotron powder diffraction

Eco-friendly belite calcium sulfoaluminate (BCSA) cement hydration behavior is not yet well understood. Here,we report an in-situ synchrotron X-ray powder diffraction study for the first hours of hydration of BCSA cements. Rietveld quantitative phase analysis has been used to establish the degree of reaction (α). The hydration of a mixture of ye'elimite and gypsum revealed that ettringite formation (α ~70% at 50 h) is limited by ye'elimite dissolution. Two laboratory-prepared BCSA cements were also studied: non-active-BCSA and active-BCSA cements, with β- and α′H-belite as main phases, respectively. Ye'elimite, in the non-active-BCSA system, dissolves at higher pace (α ~25% at 1 h) than in the active-BCSA one (α ~10% at 1 h),with differences in the crystallization of ettringite (α ~30% and α ~5%, respectively). This behavior has strongly affected subsequent belite and ferrite reactivities, yielding stratlingite and other layered phases in non-active-BCSA. The dissolution and crystallization processes are reported and discussed in detail.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Processing and characterisation of standard and doped alite-belite-ye'elimite ecocement pastes and mortars

Supplementary data to this article can be found online at https://doi.org/10.1016/j.cemconres.2019.105911.Cement and Concrete Research 127 (2020) 105911Here, we report the processing optimisation of two laboratory-prepared alite-belite-ye'elimite ecocements (standard and doped) that release to the atmosphere ~13% less CO2 than Portland Cement during fabrication. The processing was optimised through rheological measurements, where homogeneous pastes and mortars were finally prepared through the study and optimisation of both the superplasticiser content and the water-to-cement ratio. Both parameters were correlated with the phase assembly of selected pastes and compressive strength of the corresponding mortars. After optimisation, mortars with high compressive strengths (~72 and ~77 MPa for the standard mortar, and ~41 and ~75 MPa for the doped one, at 7 and 28 days, respectively) were prepared. Furthermore, the important increase in compressive strength from 7 to 28 days of the optimised mortar prepared from the doped ecocement is due to its composition (the higher content of belite jointly with the reaction of its active polymorph (α'H-belite)).This work is part of the PhD of Mr. Jesus D. Zea-Garcia. This research has been supported by Spanish MINECO and FEDER [BIA2017- 82391-R research project and I3 (IEDI-2016-0079) program]

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic

CTCF is a haploinsufficient tumour suppressor gene with diverse normal functions in genome structure and gene regulation. However the mechanism by which CTCF haploinsufficiency contributes to cancer development is not well understood. CTCF is frequently mutated in endometrial cancer. Here we show that most CTCF mutations effectively result in CTCF haploinsufficiency through nonsense-mediated decay of mutant transcripts, or loss-of-function missense mutation. Conversely, we identified a recurrent CTCF mutation K365T, which alters a DNA binding residue, and acts as a gain-of-function mutation enhancing cell survival. CTCF genetic deletion occurs predominantly in poor prognosis serous subtype tumours, and this genetic deletion is associated with poor overall survival. In addition, we have shown that CTCF haploinsufficiency also occurs in poor prognosis endometrial clear cell carcinomas and has some association with endometrial cancer relapse and metastasis. Using shRNA targeting CTCF to recapitulate CTCF haploinsufficiency, we have identified a novel role for CTCF in the regulation of cellular polarity of endometrial glandular epithelium. Overall, we have identified two novel pro-tumorigenic roles (promoting cell survival and altering cell polarity) for genetic alterations of CTCF in endometrial cancer

DAQUA-MASS: An ISO 8000-61 Based Data Quality Management Methodology for Sensor Data

The Internet-of-Things (IoT) introduces several technical and managerial challenges when it comes to the use of data generated and exchanged by and between various Smart, Connected Products (SCPs) that are part of an IoT system (i.e., physical, intelligent devices with sensors and actuators). Added to the volume and the heterogeneous exchange and consumption of data, it is paramount to assure that data quality levels are maintained in every step of the data chain/lifecycle. Otherwise, the system may fail to meet its expected function. While Data Quality (DQ) is a mature field, existing solutions are highly heterogeneous. Therefore, we propose that companies, developers and vendors should align their data quality management mechanisms and artefacts with well-known best practices and standards, as for example, those provided by ISO 8000-61. This standard enables a process-approach to data quality management, overcoming the difficulties of isolated data quality activities. This paper introduces DAQUA-MASS, a methodology based on ISO 8000-61 for data quality management in sensor networks. The methodology consists of four steps according to the Plan-Do-Check-Act cycle by Deming.This work was primarily funded by DQIoT project (Eureka program, E!11737; and CDTI (Centro Para el Desarrollo Tecnológico Industrial), INNO-20171086). Additionally, this work was partially funded by SEQUOIA project (TIN2015-63502-C3-1-R and TIN2015-63502-C3-3-R) (MINECO/FEDER); GEMA SBPLY/17/180501/000293, Consejería de Educación, Cultura y Deporte de la Dirección General de Universidades, Investigación e Innovación de la JCCM); ECD project (Evaluación y Certificación de la Calidad de Datos) (PTQ-16-08504) (Torres Quevedo Program, MINECO). Finally, it was also supported through a grant to Ricardo Pérez-Castillo enjoys from JCCM within the initiatives for talent retention and return in line with RIS3 goals

Influence of fly ash blending on hydration and physical behavior of Belite-Alite-Ye'elimite cements

A cement powder, composed of belite, alite and ye’elimite, was blended with 0, 15 and 30 wt% of fly ash and the resulting lended cements were further characterized. During hydration, the presence of fly ash caused the partial inhibition of both AFt degradation and belite reactivity, even after 180 days. The compressive strength of the corresponding mortars increased by increasing the fly ash content (68, 73 and 82 MPa for mortars with 0, 15 and 30 wt% of fly ash, respectively, at 180 curing days), mainly due to the diminishing porosity and pore size values. Although pozzolanic reaction has not been directly proved there are indirect evidences.This work is part of the Ph.D. of D. Londono-Zuluaga funded by Beca Colciencias 646—Doctorado en el exterior and Enlaza Mundos 2013 program grant. Cement and Building materials group (CEMATCO) from National University of Colombia is acknowledged for providing the calorimetric measurements. Funding from Spanish MINECO BIA2017-82391-R and I3 (IEDI-2016-0079) grants, co-funded by FEDER, are acknowledged

Molecular excitation in the Interstellar Medium: recent advances in collisional, radiative and chemical processes

We review the different excitation processes in the interstellar mediumComment: Accepted in Chem. Re