108 research outputs found
ALMA Observations of Gas-Rich Galaxies in z~1.6 Galaxy Clusters: Evidence for Higher Gas Fractions in High-Density Environments
We present ALMA CO (2-1) detections in 11 gas-rich cluster galaxies at z~1.6,
constituting the largest sample of molecular gas measurements in z>1.5 clusters
to date. The observations span three galaxy clusters, derived from the Spitzer
Adaptation of the Red-sequence Cluster Survey. We augment the >5sigma
detections of the CO (2-1) fluxes with multi-band photometry, yielding stellar
masses and infrared-derived star formation rates, to place some of the first
constraints on molecular gas properties in z~1.6 cluster environments. We
measure sizable gas reservoirs of 0.5-2x10^11 solar masses in these objects,
with high gas fractions and long depletion timescales, averaging 62% and 1.4
Gyr, respectively. We compare our cluster galaxies to the scaling relations of
the coeval field, in the context of how gas fractions and depletion timescales
vary with respect to the star-forming main sequence. We find that our cluster
galaxies lie systematically off the field scaling relations at z=1.6 toward
enhanced gas fractions, at a level of ~4sigma, but have consistent depletion
timescales. Exploiting CO detections in lower-redshift clusters from the
literature, we investigate the evolution of the gas fraction in cluster
galaxies, finding it to mimic the strong rise with redshift in the field. We
emphasize the utility of detecting abundant gas-rich galaxies in high-redshift
clusters, deeming them as crucial laboratories for future statistical studies.Comment: 8 pages, 3 figures, published in ApJ Letters; updated to match
published versio
An extreme proto-cluster of luminous dusty starbursts in the early Universe
We report the identification of an extreme proto-cluster of galaxies in the
early Universe whose core (nicknamed Distant Red Core, DRC) is formed by at
least ten dusty star-forming galaxies (DSFGs), confirmed to lie at via detection of [CI](1-0), CO(6-5), CO(4-3),
CO(2-1) and emission lines, detected
using ALMA and ATCA. The spectroscopically-confirmed components of the
proto-cluster are distributed over a region
and have a collective obscured star-formation rate (SFR) of , considerably higher than has been seen before in any
proto-cluster of galaxies or over-densities of DSFGs at . Most of
the star formation is taking place in luminous DSFGs since no Ly
emitters are detected in the proto-cluster core, apart from a Ly blob
located next to one of the DRC dusty components and extending over . The total obscured SFR of the proto-cluster could rise to if all the members of an over-density
of bright DSFGs discovered around DRC in a wide-field LABOCA 870-m image
are part of the same structure. The total halo mass of DRC could be as high as
and could be the progenitor of a Coma-like
cluster at . The relatively short gas-depletion times of the DRC
components suggest either the presence of a mechanism able to trigger extreme
star formation simultaneously in galaxies spread over a few hundred kpc or the
presence of gas flows from the cosmic web able to sustain star formation over
several hundred million years.Comment: Submitted to ApJ. Minor updates added, including a change of the
source name. Comments welcom
The astrometric Gaia-FUN-SSO observation campaign of 99 942 Apophis
Astrometric observations performed by the Gaia Follow-Up Network for Solar
System Objects (Gaia-FUN-SSO) play a key role in ensuring that moving objects
first detected by ESA's Gaia mission remain recoverable after their discovery.
An observation campaign on the potentially hazardous asteroid (99 942) Apophis
was conducted during the asteroid's latest period of visibility, from
12/21/2012 to 5/2/2013, to test the coordination and evaluate the overall
performance of the Gaia-FUN-SSO . The 2732 high quality astrometric
observations acquired during the Gaia-FUN-SSO campaign were reduced with the
Platform for Reduction of Astronomical Images Automatically (PRAIA), using the
USNO CCD Astrograph Catalogue 4 (UCAC4) as a reference. The astrometric
reduction process and the precision of the newly obtained measurements are
discussed. We compare the residuals of astrometric observations that we
obtained using this reduction process to data sets that were individually
reduced by observers and accepted by the Minor Planet Center. We obtained 2103
previously unpublished astrometric positions and provide these to the
scientific community. Using these data we show that our reduction of this
astrometric campaign with a reliable stellar catalog substantially improves the
quality of the astrometric results. We present evidence that the new data will
help to reduce the orbit uncertainty of Apophis during its close approach in
2029. We show that uncertainties due to geolocations of observing stations, as
well as rounding of astrometric data can introduce an unnecessary degradation
in the quality of the resulting astrometric positions. Finally, we discuss the
impact of our campaign reduction on the recovery process of newly discovered
asteroids.Comment: Accepted for publication in A&
Neurobiologia do parkinsonismo: I. substratos neurais e neuroquΓmica dos gΓ’nglios basais
Metagenomic Profile of the Bacterial Communities Associated with Ixodes ricinus Ticks
Assessment of the microbial diversity residing in arthropod vectors of medical importance is crucial for monitoring endemic infections, for surveillance of newly emerging zoonotic pathogens, and for unraveling the associated bacteria within its host. The tick Ixodes ricinus is recognized as the primary European vector of disease-causing bacteria in humans. Despite I. ricinus being of great public health relevance, its microbial communities remain largely unexplored to date. Here we evaluate the pathogen-load and the microbiome in single adult I. ricinus by using 454- and Illumina-based metagenomic approaches. Genomic DNA-derived sequences were taxonomically profiled using a computational approach based on the BWA algorithm, allowing for the identification of known tick-borne pathogens at the strain level and the putative tick core microbiome. Additionally, we assessed and compared the bacterial taxonomic profile in nymphal and adult I. ricinus pools collected from two distinct geographic regions in Northern Italy by means of V6-16S rRNA amplicon pyrosequencing and community based ecological analysis. A total of 108 genera belonging to representatives of all bacterial phyla were detected and a rapid qualitative assessment for pathogenic bacteria, such as Borrelia, Rickettsia and Candidatus Neoehrlichia, and for other bacteria with mutualistic relationship or undetermined function, such as Wolbachia and Rickettsiella, was possible. Interestingly, the ecological analysis revealed that the bacterial community structure differed between the examined geographic regions and tick life stages. This finding suggests that the environmental context (abiotic and biotic factors) and host-selection behaviors affect their microbiome
Secretion of Novel SEL1L Endogenous Variants Is Promoted by ER Stress/UPR via Endosomes and Shed Vesicles in Human Cancer Cells
We describe here two novel endogenous variants of the human endoplasmic reticulum (ER) cargo receptor SEL1LA, designated p38 and p28. Biochemical and RNA interference studies in tumorigenic and non-tumorigenic cells indicate that p38 and p28 are N-terminal, ER-anchorless and more stable relative to the canonical transmembrane SEL1LA. P38 is expressed and constitutively secreted, with increase after ER stress, in the KMS11 myeloma line and in the breast cancer lines MCF7 and SKBr3, but not in the non-tumorigenic breast epithelial MCF10A line. P28 is detected only in the poorly differentiated SKBr3 cell line, where it is secreted after ER stress. Consistently with the presence of p38 and p28 in culture media, morphological studies of SKBr3 and KMS11 cells detect N-terminal SEL1L immunolabeling in secretory/degradative compartments and extracellularly-released membrane vesicles. Our findings suggest that the two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells. P38 and p28 could therefore be relevant as diagnostic markers and/or therapeutic targets in cancer
The extreme HBL behaviour of Markarian 501 during 2012
A multiwavelength campaign was organized to take place between March and July of 2012. Excellent temporal coverage was obtained with more than 25 instruments, including the MAGIC, FACT and VERITAS Cherenkov telescopes, the instruments on board the Swift and Fermi spacecraft, and the telescopes operated by the GASP-WEBT collaboration. Mrk 501 showed a very high energy (VHE) gamma-ray flux above 0.2 TeV of 0.5 times the Crab Nebula flux (CU) for most of the campaign. The highest activity occurred on 2012 June 9, when the VHE flux was 3 CU, and the peak of the high-energy spectral component was found to be at 2 TeV. This study reports very hard X-ray spectra, and the hardest VHE spectra measured to date for Mrk 501. The fractional variability was found to increase with energy, with the highest variability occurring at VHE, and a significant correlation between the X-ray and VHE bands. The unprecedentedly hard X-ray and VHE spectra measured imply that their low- and high-energy components peaked above 5 keV and 0.5 TeV, respectively, during a large fraction of the observing campaign, and hence that Mrk 501 behaved like an extreme high-frequency- peaked blazar (EHBL) throughout the 2012 observing season. This suggests that being an EHBL may not be a permanent characteristic of a blazar, but rather a state which may change over time. The one-zone synchrotron self-Compton (SSC) scenario can successfully describe the segments of the SED where most energy is emitted, with a significant correlation between the electron energy density and the VHE gamma-ray activity, suggesting that most of the variability may be explained by the injection of high-energy electrons. The one-zone SSC scenario used reproduces the behaviour seen between the measured X-ray and VHE gamma-ray fluxes, and predicts that the correlation becomes stronger with increasing energy of the X-rays
Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells)
In recent years, the development of powerful viral gene transfer techniques has greatly facilitated the study of gene function. This review summarises some of the viral delivery systems routinely used to mediate gene transfer into cell lines, primary cell cultures and in whole animal models. The systems described were originally discussed at a 1-day European Tissue Culture Society (ETCS-UK) workshop that was held at University College London on 1st April 2009. Recombinant-deficient viral vectors (viruses that are no longer able to replicate) are used to transduce dividing and post-mitotic cells, and they have been optimised to mediate regulatable, powerful, long-term and cell-specific expression. Hence, viral systems have become very widely used, especially in the field of neurobiology. This review introduces the main categories of viral vectors, focusing on their initial development and highlighting modifications and improvements made since their introduction. In particular, the use of specific promoters to restrict expression, translational enhancers and regulatory elements to boost expression from a single virion and the development of regulatable systems is described
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