49 research outputs found

    Regional climate models' performance in representing precipitation and temperature over selected Mediterranean areas

    Get PDF
    This paper discusses the relative performance of several climate models in providing reliable forcing for hydrological modeling in six representative catchments in the Mediterranean region. We consider 14 Regional Climate Models (RCMs), from the EU-FP6 ENSEMBLES project, run for the A1B emission scenario on a common 0.22° (about 24 km) rotated grid over Europe and the Mediterranean region. In the validation period (1951 to 2010) we consider daily precipitation and surface temperatures from the observed data fields (E-OBS) data set, available from the ENSEMBLES project and the data providers in the ECA&D project. Our primary objective is to rank the 14 RCMs for each catchment and select the four best-performing ones to use as common forcing for hydrological models in the six Mediterranean basins considered in the EU-FP7 CLIMB project. Using a common suite of four RCMs for all studied catchments reduces the (epistemic) uncertainty when evaluating trends and climate change impacts in the 21st century. We present and discuss the validation setting, as well as the obtained results and, in some detail, the difficulties we experienced when processing the data. In doing so we also provide useful information and advice for researchers not directly involved in climate modeling, but interested in the use of climate model outputs for hydrological modeling and, more generally, climate change impact studies in the Mediterranean region

    HESS Opinions: "Climate, hydrology, energy, water: recognizing uncertainty and seeking sustainability"

    Get PDF
    Since 1990 extensive funds have been spent on research in climate change. Although Earth Sciences, including climatology and hydrology, have benefited significantly, progress has proved incommensurate with the effort and funds, perhaps because these disciplines were perceived as “tools” subservient to the needs of the climate change enterprise rather than autonomous sciences. At the same time, research was misleadingly focused more on the “symptom”, i.e. the emission of greenhouse gases, than on the “illness”, i.e. the unsustainability of fossil fuel-based energy production. Unless energy saving and use of renewable resources become the norm, there is a real risk of severe socioeconomic crisis in the not-too-distant future. A framework for drastic paradigm change is needed, in which water plays a central role, due to its unique link to all forms of renewable energy, from production (hydro and wave power) to storage (for time-varying wind and solar sources), to biofuel production (irrigation). The extended role of water should be considered in parallel to its other uses, domestic, agricultural and industrial. Hydrology, the science of water on Earth, must move towards this new paradigm by radically rethinking its fundamentals, which are unjustifiably trapped in the 19thcentury myths of deterministic theories and the zeal to eliminate uncertainty. Guidance is offered by modern statistical and quantum physics, which reveal the intrinsic character of uncertainty/entropy in nature, thus advancing towards a new understanding and modelling of physical processes, which is central to the effective use of renewable energy and water resources

    Spatiotemporal Infectious Disease Modeling: A BME-SIR Approach

    Get PDF
    This paper is concerned with the modeling of infectious disease spread in a composite space-time domain under conditions of uncertainty. We focus on stochastic modeling that accounts for basic mechanisms of disease distribution and multi-sourced in situ uncertainties. Starting from the general formulation of population migration dynamics and the specification of transmission and recovery rates, the model studies the functional formulation of the evolution of the fractions of susceptible-infected-recovered individuals. The suggested approach is capable of: a) modeling population dynamics within and across localities, b) integrating the disease representation (i.e. susceptible-infected-recovered individuals) with observation time series at different geographical locations and other sources of information (e.g. hard and soft data, empirical relationships, secondary information), and c) generating predictions of disease spread and associated parameters in real time, while considering model and observation uncertainties. Key aspects of the proposed approach are illustrated by means of simulations (i.e. synthetic studies), and a real-world application using hand-foot-mouth disease (HFMD) data from China.J.M. Angulo and A.E. Madrid have been partially supported by grants MTM2009-13250 and MTM2012-32666 of SGPI, and P08-FQM-3834 of the Andalusian CICE, Spain. H-L Yu has been partially supported by a grant from National Science Council of Taiwan (NSC101-2628-E-002-017-MY3 and NSC102-2221-E-002-140-MY3). A. Kolovos was supported by SpaceTimeWorks, LLC. G. Christakos was supported by a Yongqian Chair Professorship (Zhejiang University, China)

    Genome of <i>Leptomonas pyrrhocoris</i>:a high-quality reference for monoxenous trypanosomatids and new insights into evolution of <i>Leishmania</i>

    Get PDF
    Many high-quality genomes are available for dixenous (two hosts) trypanosomatid species of the genera Trypanosoma, Leishmania, and Phytomonas, but only fragmentary information is available for monoxenous (single-host) trypanosomatids. In trypanosomatids, monoxeny is ancestral to dixeny, thus it is anticipated that the genome sequences of the key monoxenous parasites will be instrumental for both understanding the origin of parasitism and the evolution of dixeny. Here, we present a high-quality genome for Leptomonas pyrrhocoris, which is closely related to the dixenous genus Leishmania. The L. pyrrhocoris genome (30.4 Mbp in 60 scaffolds) encodes 10,148 genes. Using the L. pyrrhocoris genome, we pinpointed genes gained in Leishmania. Among those genes, 20 genes with unknown function had expression patterns in the Leishmania mexicana life cycle suggesting their involvement in virulence. By combining differential expression data for L. mexicana, L. major and Leptomonas seymouri, we have identified several additional proteins potentially involved in virulence, including SpoU methylase and U3 small nucleolar ribonucleoprotein IMP3. The population genetics of L. pyrrhocoris was also addressed by sequencing thirteen strains of different geographic origin, allowing the identification of 1,318 genes under positive selection. This set of genes was significantly enriched in components of the cytoskeleton and the flagellum

    Definition of a temporal distribution index for high temporal resolution precipitation data over Peninsular Spain and the Balearic Islands: the fractal dimension; and its synoptic implications

    Get PDF
    Precipitation on the Spanish mainland and in the Balearic archipelago exhibits a high degree of spatial and temporal variability, regardless of the temporal resolution of the data considered. The fractal dimension indicates the property of self-similarity, and in the case of this study, wherein it is applied to the temporal behaviour of rainfall at a fine (10-min) resolution from a total of 48 observatories, it provides insights into its more or less convective nature. The methodology of Jenkinson & Collison which automatically classifies synoptic situations at the surface, as well as an adaptation of this methodology at 500 hPa, was applied in order to gain insights into the synoptic implications of extreme values of the fractal dimension. The highest fractal dimension values in the study area were observed in places with precipitation that has a more random behaviour over time with generally high totals. Four different regions in which the atmospheric mechanisms giving rise to precipitation at the surface differ from the corresponding above-ground mechanisms have been identified in the study area based on the fractal dimension. In the north of the Iberian Peninsula, high fractal dimension values are linked to a lower frequency of anticyclonic situations, whereas the opposite occurs in the central region. In the Mediterranean, higher fractal dimension values are associated with a higher frequency of the anticyclonic type and a lower frequency of the advective type from the east. In the south, lower fractal dimension values indicate higher frequency with respect to the anticyclonic type from the east and lower frequency with respect to the cyclonic type

    Anti-trypanosomatid drug discovery:an ongoing challenge and a continuing need

    Get PDF

    Hydrological post-processing using stacked generalization of quantile regression algorithms: Large-scale application over CONUS

    No full text
    Post-processing of hydrological model simulations using machine learning algorithms can be applied to quantify the uncertainty of hydrological predictions. Combining multiple diverse machine learning algorithms (referred to as base-learners) using stacked generalization (stacking, i.e. a type of ensemble learning) is considered to improve predictions relative to the base-learners. Here we propose stacking of quantile regression and quantile regression forests. Stacking is performed by minimising the interval score of the quantile predictions provided by the ensemble learner, which is a linear combination of quantile regression and quantile regression forests. The proposed ensemble learner post-processes simulations of the GR4J hydrological model for 511 basins in the contiguous US. We illustrate its significantly improved performance relative to the base-learners used and a less prominent improvement relative to the “hard to beat in practice” equal-weight combiner. © 2019 Elsevier B.V
    corecore