923 research outputs found
Maine’s Investment Imperative
In the past two decades, Maine’s per capita income ranking has not topped 27th, and in recent years, the state’s relative position has dropped to 36th. More importantly, the gap between Maine and the United States has increased since 1990. In this article, Maine’s State Economist Laurie Lachance lays out a long-term investment strategy for Maine that focuses on education, research and development, comprehensive tax reform, greater efficiencies in the delivery of state and local services, and limits on government spending. Lachance argues that choices must be made even in times of fiscal crisis. Failure to invest means failure, period
Daily associations between sleep and physical activity : a systematic review and meta-analysis
The day-to-day variations of sleep and physical activity are associated with various health outcomes in adults, and previous studies suggested a bidirectional association between these behaviors. The daily associations between sleep and physical activity have been examined in observational or interventional contexts. The primary goal of the current systematic review and meta-analysis was to summarize existing evidence about daily associations between sleep and physical activity outcomes at inter- and intra-individual level in adults. A systematic search of records in eight databases from inception to July 2019 identified 33 peer-reviewed empirical publications that examined daily sleep – physical activity association in adults. The qualitative and quantitative analyses of included studies did not support a bidirectional daily association between sleep outcomes and physical activity. Multilevel meta-analyses showed that three sleep parameters were associated with physical activity the following day: sleep quality, sleep efficiency, and wake after sleep onset. However, the associations were small, and varied in terms of direction and level of variability (e.g. inter- or intra-individual). Daytime physical activity was associated with lower total sleep time the following night at an inter-person level with a small effect size. From a clinical perspective, care providers should monitor the effects of better sleep promotion on physical activity behaviours in their patients. Future studies should examine sleep and physical activity during a longer period and perform additional sophisticated statistical analyses
Prospectives
Tiré de: Prospectives, vol. 17, no 4, déc. 1981Titre de l'écran-titre (visionné le 24 janv. 2013
No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins.
INTRODUCTION: Intervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to the blood circulation could be detected systemically. The work here assesses whether the presence of disc degeneration is associated with detectable blood level changes of five inflammatory markers and whether chronic LBP is associated with these changes. MATERIALS AND METHODS: Two hundred and forty TwinsUK cohort participants with both MRI disc degeneration grade and Modic change extent, and IL-6, IL-8, IL-8 TNF, and CX3CL1 protein blood concentration measurements were included in this work. Linear mixed effects models were used to test the association of blood cytokine concentration with disc degeneration score and Modic change volumetric score. Association of chronic LBP status from questionnaires with disc degeneration, Modic change, and cytokine blood concentration was also tested. RESULTS: No statistically significant association between disc degeneration or Modic change with cytokine blood concentration was found. Instead, regression analysis pointed strong association between cytokine blood concentration with body mass index for IL-6 and with age for IL-6 and TNF. Mild association was found between IL-8 blood concentration and body mass index. Additionally, LBP status was associated with Modic change volumetric score but not associated with any cytokine concentration. CONCLUSIONS: We found no evidence that Modic change and disc degeneration are able to produce changes in tested blood cytokine concentration. However, age and body mass index have strong influence on cytokine concentration and both are associated with the conditions studied which may confound associations found in the literature. It is then unlikely that cytokines produced in the disc or vertebral bone marrow induce chronic LBP
Cavity Magnonics
Cavity magnonics deals with the interaction of magnons - elementary excitations in magnetic materials - and confined electromagnetic fields. We introduce the basic physics and review the experimental and theoretical progress of this young field that is gearing up for integration in future quantum technologies. Much of its appeal is derived from the strong magnon-photon coupling and the easily-reached nonlinear regime in microwave cavities. The interaction of magnons with light as detected by Brillouin light scattering is enhanced in magnetic optical resonators, which can be employed to manipulate magnon distributions. The cavity photon-mediated coupling of a magnon mode to a superconducting qubit enables measurements in the single magnon limit
Nitric oxide co-operates with hydrogen peroxide in inducing DNA fragmentation and cell lysis in murine lymphoma cells
Examination of the rumen bacteria and methanogenic archaea of wild impalas (Aepyceros melampus melampus) from Pongola, South Africa
Although the rumen microbiome of domesticated
ruminants has been evaluated, few studies have explored the
rumen microbiome of wild ruminants, and no studies have
identified the rumen microbiome in the impala (Aepyceros
melampus melampus). In the present study, next-generation
sequencing and real-time polymerase chain reaction were
used to investigate the diversity and density of the bacteria
and methanogenic archaea residing in the rumen of five adult
male impalas, culled during the winter dry season in Pongola,
South Africa. A total of 15,323 bacterial 16S rRNA gene
sequences (from five impala), representing 3,892 different
phylotypes, were assigned to 1,902 operational taxonomic
units (OTUs). A total of 20,124 methanogen 16S rRNA gene
sequence reads (from four impala), of which 5,028 were
unique, were assigned to 344 OTUs. From the total sequence
reads, Bacteroidetes, Proteobacteria, and Firmicutes were the
most abundant bacterial phyla. While the majority of the
bacterial genera found were unclassified, Prevotella and
Cupriavidus were the most abundant classified genera. For
methanogens, the genera Methanobrevibacter and
Methanosphaera represented 94.3 % and 4.0 % of the classified
sequences, respectively. Most notable was the identification
of Methanobrevibacter thaueri-like 16S rRNA gene sequence
reads in all four impala samples, representing greater than 30 % of each individual’s total sequences. Both data sets
are accessible through NCBI’s Sequence Read Archive (SRA),
under study accession number SRP [048619]. The densities of
bacteria (1.26×1010–3.82×1010 cells/ml whole rumen contents)
and methanogens (4.48×108–7.2×109 cells/ml of whole
rumen contents) from five individual impala were similar to
those typically observed in domesticated ruminants.http://link.springer.com/journal/2482016-04-30hb201
U and Th content in the Central Apennines continental crust: a contribution to the determination of the geo-neutrinos flux at LNGS
The regional contribution to the geo-neutrino signal at Gran Sasso National
Laboratory (LNGS) was determined based on a detailed geological, geochemical
and geophysical study of the region. U and Th abundances of more than 50
samples representative of the main lithotypes belonging to the Mesozoic and
Cenozoic sedimentary cover were analyzed. Sedimentary rocks were grouped into
four main "Reservoirs" based on similar paleogeographic conditions and
mineralogy. Basement rocks do not outcrop in the area. Thus U and Th in the
Upper and Lower Crust of Valsugana and Ivrea-Verbano areas were analyzed. Based
on geological and geophysical properties, relative abundances of the various
reservoirs were calculated and used to obtain the weighted U and Th abundances
for each of the three geological layers (Sedimentary Cover, Upper and Lower
Crust). Using the available seismic profile as well as the stratigraphic
records from a number of exploration wells, a 3D modelling was developed over
an area of 2^{\circ}x2^{\circ} down to the Moho depth, for a total volume of
about 1.2x10^6 km^3. This model allowed us to determine the volume of the
various geological layers and eventually integrate the Th and U contents of the
whole crust beneath LNGS. On this base the local contribution to the
geo-neutrino flux (S) was calculated and added to the contribution given by the
rest of the world, yielding a Refined Reference Model prediction for the
geo-neutrino signal in the Borexino detector at LNGS: S(U) = (28.7 \pm 3.9) TNU
and S(Th) = (7.5 \pm 1.0) TNU. An excess over the total flux of about 4 TNU was
previously obtained by Mantovani et al. (2004) who calculated, based on general
worldwide assumptions, a signal of 40.5 TNU. The considerable thickness of the
sedimentary rocks, almost predominantly represented by U- and Th- poor
carbonatic rocks in the area near LNGS, is responsible for this difference.Comment: 45 pages, 5 figures, 12 tables; accepted for publication in GC
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