Predictors of Success in a Co-Correctional Halfway House: A Discriminant Analysis

Considerable research and debate have focused on the effectiveness of community correctional programs. Much of the research does not address the issue of the effectiveness of programs for persons with different types of problems or criminal histories. This article utilizes discriminant analysis to determine the characteristics of persons most likely to succeed in one halfway house. The results indicate that strong socializing and integrating ties in the community and few previous contacts with the criminal justice system are major predictors of success in a halfway house program. The seven discriminators for females are used to accurately predict 87 percent of the female misdemeanants while the nine discriminators for male felons correctly predict 63 percent of the cases

Client Success or Failure in a Halfway House

Halfway houses today are diverse entities. Seiter, et al. (1977) found that almost 60 percent of the houses in the United States are private nonprofit organizations. One-third were state operations with the remainder being federal, local or private profit organizations. The programs in the houses varied from those providing supervision and custody to those providing a full range of intensive in-house treatments for particular client needs. Some halfway houses handle only particular types of offenders (e.g., drug addicts) while others handle a wide range of offenders. Latessa and Allen (1982) suggest that the sociodemographic and criminal history backgrounds of clients differ depending upon the referral sources to the halfway house. Allen and Seiter (1981) developed three alternative models of halfway houses based on where they fit in the criminal justice system. In the first model, the inmate resides in the halfway house during the initial parole period. The second model covers those situations in which the inmate is transferred to a halfway house before parole is granted. In the third model, the inmates are granted parole and placed in the community on their own. The parolee is placed in the halfway house if problems begin to develop. Latessa and Allen (1982) call for further research on the types of clients in halfway houses and on client risk, their need levels and special problems. This research addresses these issues. This article describes one halfway house, Cope House, in Dayton, Ohio. It is a diversified halfway house which does not fit any of the alternative models suggested by Allen and Seiter (1981). Cope House accepts adult male and female referrals from the Federal Bureau of Prisons, the Department of Corrections of the State of Ohio, the Montgomery County Probation Department, and female referrals only from the City of Dayton Municipal Court. Cope House became co-correctional in January of 1981

Radiosensitization by BRAF inhibitor therapy—mechanism and frequency of toxicity in melanoma patients

This study shows radiosensitization by BRAF inhibitors in clinical practice and ex vivo by fluorescence in situ hybridization of chromosomal breaks. Nevertheless, radiotherapy with concomitant BRAF inhibitor therapy is feasible with an acceptable increase in toxicity. Vemurafenib is a more potent radiosensitizer than dabrafenib in both the patient study and the ex vivo experiment

A Novel Therapy for Melanoma Developed in Mice: Transformation of Melanoma into Dendritic Cells with Listeria monocytogenes

Listeria monocytogenes is a gram-positive bacteria and human pathogen widely used in cancer immunotherapy because of its capacity to induce a specific cytotoxic T cell response in tumours. This bacterial pathogen strongly induces innate and specific immunity with the potential to overcome tumour induced tolerance and weak immunogenicity. Here, we propose a Listeria based vaccination for melanoma based in its tropism for these tumour cells and its ability to transform in vitro and in vivo melanoma cells into matured and activated dendritic cells with competent microbicidal and antigen processing abilities. This Listeria based vaccination using low doses of the pathogen caused melanoma regression by apoptosis as well as bacterial clearance. Vaccination efficacy is LLO dependent and implies the reduction of LLO-specific CD4+ T cell responses, strong stimulation of innate pro-inflammatory immune cells and a prevalence of LLO-specific CD8+ T cells involved in tumour regression and Listeria elimination. These results support the use of low doses of pathogenic Listeria as safe melanoma therapeutic vaccines that do not require antibiotics for bacterial removal

Original article title: "Comparison of therapeutic efficacy of topical corticosteroid and oral zinc sulfate-topical corticosteroid combination in the treatment of vitiligo patients: a clinical trial"

<p>Abstract</p> <p>Background</p> <p>Vitiligo is the most prevalent pigmentary disorder which occurs worldwide, with an incidence rate between 0.1-4 percent. It is anticipated that the discovery of biological pathways of vitiligo pathogenesis will provide novel therapeutic and prophylactic targets for future approaches to the treatment and prevention of vitiligo. The purposes of this study were evaluating the efficacy of supplemental zinc on the treatment of vitiligo.</p> <p>Methods</p> <p>This randomized clinical trial was conducted for a period of one year. Thirty five patients among 86 participants were eligible to entrance to the study. The patients in two equal randomized groups took topical corticosteroid and combination of oral zinc sulfate-topical corticosteroid.</p> <p>Results</p> <p>The mean of responses in the corticosteroid group and the zinc sulfate-corticosteroid combination group were 21.43% and 24.7%, respectively.</p> <p>Conclusion</p> <p>Although, the response to corticosteroid plus zinc sulfate was more than corticosteroid, there was no statistically significant difference between them. It appeared that more robust long-term randomized controlled trials on more patients, maybe with higher doses of zinc sulfate, are needed to fully establish the efficacy of oral zinc in management of vitiligo.</p> <p>Trial Registration</p> <p>chiCTRTRC10000930</p

An argument against the focus on Community Resilience in Public Health

Background - It has been suggested that Public Health professionals focus on community resilience in tackling chronic problems, such as poverty and deprivation; is this approach useful? Discussion - Resilience is always i) of something ii) to something iii) to an endpoint, as in i) a rubber ball, ii) to a blunt force, iii) to its original shape. “Community resilience” might be: of a neighbourhood, to a flu pandemic, with the endpoint, to return to normality. In these two examples, the endpoint is as-you-were. This is unsuitable for some examples of resilience. A child that is resilient to an abusive upbringing has an endpoint of living a happy life despite that upbringing: this is an as-you-should-be endpoint. Similarly, a chronically deprived community cannot have the endpoint of returning to chronic deprivation: so what is its endpoint? Roughly, it is an as-you-should-be endpoint: to provide an environment for inhabitants to live well. Thus resilient communities will be those that do this in the face of challenges. How can they be identified? One method uses statistical outliers, neighbourhoods that do better than would be expected on a range of outcomes given a range of stressors. This method tells us that a neighbourhood is resilient but not why it is. In response, a number of researchers have attributed characteristics to resilient communities; however, these generally fail to distinguish characteristics of a good community from those of a resilient one. Making this distinction is difficult and we have not seen it successfully done; more importantly, it is arguably unnecessary. There already exist approaches in Public Health to assessing and developing communities faced with chronic problems, typically tied to notions such as Social Capital. Communityresilience to chronic problems, if it makes sense at all, is likely to be a property that emerges from the various assets in a community such as human capital, built capital and natural capital. Summary - Public Health professionals working with deprived neighbourhoods would be better to focus on what neighbourhoods have or could develop as social capital for living well, rather than on the vague and tangential notion of community resilience.</p

Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach

Understanding the biological factors that are characteristic of metastasis in melanoma remains a key approach to improving treatment. In this study, we seek to identify a gene signature of metastatic melanoma. We configured a new network-based computational pipeline, combined with a machine learning method, to mine publicly available transcriptomic data from melanoma patient samples. Our method is unbiased and scans a genome-wide protein-protein interaction network using a novel formulation for network scoring. Using this, we identify the most influential, differentially expressed nodes in metastatic as compared to primary melanoma. We evaluated the shortlisted genes by a machine learning method to rank them by their discriminatory capacities. From this, we identified a panel of 6 genes, ALDH1A1, HSP90AB1, KIT, KRT16, SPRR3 and TMEM45B whose expression values discriminated metastatic from primary melanoma (87% classification accuracy). In an independent transcriptomic data set derived from 703 primary melanomas, we showed that all six genes were significant in predicting melanoma specific survival (MSS) in a univariate analysis, which was also consistent with AJCC staging. Further, 3 of these genes, HSP90AB1, SPRR3 and KRT16 remained significant predictors of MSS in a joint analysis (HR = 2.3, P = 0.03) although, HSP90AB1 (HR = 1.9, P = 2 × 10−4) alone remained predictive after adjusting for clinical predictors

Predictors of Success in a Co-Correctional Halfway House

Considerable research and debate have focused on the effectiveness of community correctional programs. Much of the research does not address the issue of the effectiveness of programs for persons with different types of problems or criminal histories. This article utilizes discriminant analysis to determine the characteristics of persons most likely to succeed in one halfway house. The results indicate that strong socializing and integrating ties in the community and few previous contacts with the criminal justice system are major predictors of success in a halfway house program. The seven discriminators for females are used to accurately predict 87 percent of the female misdemeanants while the nine discriminators for male felons correctly predict 63 percent of the cases