Diseño y construcción de una máquina interactiva que ilustre la formación de las dunas en el desierto para el Parque Interactivo Explora

En este proyecto se muestra el desarrollo de una máquina interactiva para la sala Colombia Geodiversa del Parque Explora, teniendo en cuenta el fenómeno geomorfológico de la formación de las dunas en el desierto -- Este proyecto surgió con el objetivo de desarrollar una máquina interactiva que ilustre de manera lúdica el fenómeno de la formación de las dunas -- La experiencia estará dirigida a los usuarios de museos interactivos entre los 10 y 17años de edad -- Dunar es la máquina que ilustra la formación de Las DUNAS, mostrando el resultado de una gran acumulación de arena, presentando ondulaciones producidas por la interacción de elementos naturales como la corriente costera, el oleaje y el viento, creando así diferentes tipos de DUNAS como: Duna Lateral -- Duna de Estela -- Duna Transversal -- “Dunar” como su nombre lo indica nace de la palabra dunas, las cuales se refieren a comunidades vegetales y plantas que prosperan en los suelos arenosos móviles de las dunas a las cuales ayudan a fijar -- En nuestros territorios, tales montículos de arena movidos por el viento existen más que todo en las playas y en zonas litorales -- Este fenómeno genera en las personas atracción por el enigma que la palabra produce y crea expectativa acerca de la explicación de dicho fenómeno -- La finalidad del proyecto es diseñar y fabricar un modelo funcional, con un alto nivel de exigencia en la calidad y el diseño, logrando captar la atención del usuario, permitiendo que se divierta y transmitiendo conocimiento mediante la interacción del usuario con la experiencia acerca de los desiertos colombianos y lo que allí ocurre -- El desarrollo de este modelo surgió de la necesidad del proyecto que desarrolla la Universidad EAFIT junto con el Parque EXPLORA para desarrollar experiencias para el museo que expliquen fenómenos naturale

Laboratory of Artistic and Media Interferences. Processes of artistic research about experimental visuality

[ES] El Laboratorio de Interferencias Artísticas y Mediales (IAM-lab) es un grupo de investigación interdisciplinar inscrito en el Departamento de Arte de la Universidad Miguel Hernández de Elche, y cuyos miembros imparten docencia en la Facultad de Bellas Artes de Altea. Nuestras líneas de investigación se centran en el desarrollo de proyectos en el ámbito de las prácticas artísticas audiovisuales, intermedia y transmedia, dedicando una especial atención a los diálogos entre medios, cuestiones tecnológicas, aspectos contextuales y procesuales. Entendemos la práctica artística como un laboratorio de posibilidades, que vinculamos a nuestro interés por el arte y la cultura contemporánea, los estudios visuales, el arte público, las prácticas colaborativas y los procesos pedagógicos y de mediación. Nuestra investigación apuesta por una práctica reflexiva que indaga formas de producción de sentido, y se interroga y experimenta sobre la imagen y las metodologías de investigación en las artes. En esta comunicación se muestran algunos aspectos metodológicos que consideramos clave en nuestro proceso de investigación, como son: la aplicación creativa del concepto de interferencia como acción disruptiva que cuestiona inercias asumidas, el viaje como marco activador y articulador de procesos, la experimentación lúdica y los procesos colaborativos, así como la exploración de diversos formatos de ensayo visual para vehicular los resultados de las investigaciones.[EN] The Laboratory of Artistic and Media Interferences (IAM-lab) is an interdisciplinary research group registered in the Art Department of the Miguel Hernández University of Elche, and whose members teach at the Faculty of Fine Arts of Altea. Our lines of research are focused on the development of projects in the field of audiovisual, intermediate and transmedia artistic practices, with a special focus on dialogues between media, technological issues, contextual and procedural aspects. These practices are part of our interest in contemporary culture, visual studies, public art, collaborative practices and pedagogical and mediation processes. Our research is committed to a reflective practice that explores ways of producing meaning, and interrogates and experiments on the image and research methodologies in the arts. In this presentation we propose some methodological aspects that we consider key in our research process, such as: the creative application of the concept of interference as a disruptive action that questions assumed inertias, travel as an activating and articulating frame of processes, playful experimentation and processes co-laboratories, as well as the exploration of various formats of visual test to convey the results of the investigations.Marín García, T.; Lozano Chiarlones, E.; Villalonga Campos, R.; Marín Sánchez, E.; Maldonado Gómez, J.; Esacario Jover, P.; Gómez Moreno, B. (2019). Laboratorio de Interferencias Artísticas y Mediales. Procesos de investigación artística sobre visualidades experimentales. En IV Congreso Internacional de investigación en artes visuales: ANIAV 2019 Imagen [N] visible. Editorial Universitat Politècnica de València. 455-461. https://doi.org/10.4995/ANIAV.2019.2019.9018OCS45546

Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders

Increasing evidence in the last years indicates that the vast amount of regulatory information contained in mammalian genomes is organized in precise 3D chromatin structures. However, the impact of this spatial chromatin organization on gene expression and its degree of evolutionary conservation is still poorly understood. The Six homeobox genes are essential developmental regulators organized in gene clusters conserved during evolution. Here, we reveal that the Six clusters share a deeply evolutionarily conserved 3D chromatin organization that predates the Cambrian explosion. This chromatin architecture generates two largely independent regulatory landscapes (RLs) contained in two adjacent topological associating domains (TADs). By disrupting the conserved TAD border in one of the zebrafish Six clusters, we demonstrate that this border is critical for preventing competition between promoters and enhancers located in separated RLs, thereby generating different expression patterns in genes located in close genomic proximity. Moreover, evolutionary comparison of Six-associated TAD borders reveals the presence of CCCTC-binding factor (CTCF) sites with diverging orientations in all studied deuterostomes. Genome-wide examination of mammalian HiC data reveals that this conserved CTCF configuration is a general signature of TAD borders, underscoring that common organizational principles underlie TAD compartmentalization in deuterostome evolution

Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients

Background: S. pneumoniae is the leading cause of community-acquired pneumonia in the solid organ transplant recipient (SOTR); nevertheless, the prevalence of colonization and of the colonizing/infecting serotypes has not been studied in this population. In this context, the aim of the present study was to describe the rate, characteristics, and clinical impact of S. pneumoniae nasopharyngeal carriage. Methods: A prospective observational cohort of Solid Organ Transplant recipients (SOTR) was held at the University Hospital Virgen del Rocío, Seville, Spain with the aim to evaluate the S. pneumoniae colonization and the serotype prevalence in SOTR. Two different pharyngeal swabs samples from 500 patients were included in two different seasonal periods winter and spring/summer. Optochin and bile solubility tests were performed for the isolation of thew strains. Antimicrobial susceptibility studies (MICs, mg/l) of levofloxacin, trimethoprim-sulfamethoxazole, penicillin, amoxicillin, cefotaxime, ceftriaxone, erythromycin, azithromycin and vancomycin for each isolate were determined by E-test strips. Capsular typing was done by sequential multiplex PCR reactions. A multivariate logistic regression analysis of factors potentially associated with pneumococcal nasopharyngeal carriage and disease was performed. Results: Twenty-six (5.6%) and fifteen (3.2%) patients were colonized in winter and spring/summer periods, respectively. Colonized SOT recipients compared to non-colonized patients were more frequently men (79.5% vs. 63.1%, P < 0.05) and cohabitated regularly with children (59% vs. 32.2%, P < 0.001). The most prevalent serotype in both studied periods was 35B. Forty-five percent of total isolates were included in the pneumococcal vaccine PPV23. Trimethoprim-sulfamethoxazole and macrolides were the less active antibiotics. Three patients had non- bacteremic pneumococcal pneumonia, and two of them died. Conclusions: Pneumococcal colonization in SOTR is low with the most colonizing serotypes not included in the pneumococcal vaccines.Pfizer, 2014 ASPIRE Awards in Vaccine Research in Europe (Pfizer Reference # WI191483)Plan Nacional de I + D + i 2013–2016 , Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad REIPI RD16/0016/0009 Fondo Regional de Desarrollo Europeo "Una forma de alcanzar Europa", Programa operativo Crecimiento inteligente 2014–2020

Ritmos contemporáneos. Género, política y sociedad en los siglos XIX y XX

INTRODUCCIÓN. Laura Branciforte y Rocío Orsi Portalo (Universidad Carlos III de Madrid).- I. LOS CAMINOS DE LA MODERNIZACIÓN (SIGLOS XIX Y XX): CIENCIA, EDUCACIÓN Y ACTIVISMOS POLÍTICO: CAPÍTULO 1. Montserrat Huguet Santos (Universidad Carlos III de Madrid): La derrota del progreso. Especie y género en los discursos científicosociales (de los siglos XIX y XX).- CAPÍTULO 2. Elisa Povedano Marrugat (Universidad Carlos III de Madrid): Mujeres y Educación artística en el siglo XIX.- CAPÍTULO 3. María Luisa Rico Gómez (Instituto de Historia - CSIC): Mujeres, conciencia y profesión en España: 1880-1930.- CAPÍTULO 4. Sandra Souto Kustrín (Instituto de Historia - CSIC): Tradición, modernidad y necesidades bélicas: organización y movilización de la mujer joven en la República en guerra.- CAPÍTULO 5. Celia Valiente Fernández (Universidad Carlos III de Madrid): ¿Ha existido un movimiento feminista católico en España? Mujeres de Acción Católica durante el franquismo -- II. DIALÉCTICAS DEL FEMINISMO: CAPÍTULO 6. Irene Strazzeri (Università degli Studi di Foggia): Riconoscimento e sfera pubblica. La differenza fuori e dentro le istituzioni.- CAPÍTULO 7. Carmen González Marín (Universidad Carlos III de Madrid): Contra la institución del feminismo.- CAPÍTULO 7. Sonia Reverter Bañón (Instituto Universitario de Estudios Feministas y de Génerp - Universitat Jaume I de Castellón): Feminismo institucional ¿Un feminismo líquido?.- CAPÍTULO 8. Begonya Saez Tajafuerce (Departament de filosofía / Universitat Autònoma de Barcelona): Feminismos de frontera: memoria y representación.- CAPÍTULO 9. Rocío Orsi Portalo (Universidad Carlos III de Madrid): De las mujeres y otros monstruos. A propósito de la novela de Mary Wollstonecraft Shelle

Propuesta de mejora de la asignatura TFG del Grado en Nutrición Humana y Diétetica. Implantación de la prueba ECOE

Depto. de Farmacología y ToxicologíaFac. de MedicinaFALSEsubmitte

miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk

Myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PV) and essential thrombocythemia (ET), and remarkably shortens survival. Although JAK2V617F and CALR allele burden are the main transformation risk factors, inflammation plays a critical role by driving clonal expansion toward end-stage disease. NF-κB is a key mediator of inflammation-induced carcinogenesis. Here, we explored the involvement of miR-146a, a brake in NF-κB signaling, in MPN susceptibility and progression. rs2910164 and rs2431697, that affect miR-146a expression, were analyzed in 967 MPN (320 PV/333 ET/314 MF) patients and 600 controls. We found that rs2431697 TT genotype was associated with MF, particularly with post-PV/ET MF (HR = 1.5; p < 0.05). Among 232 PV/ET patients (follow-up time=8.5 years), 18 (7.8%) progressed to MF, being MF-free-survival shorter for rs2431697 TT than CC + CT patients (p = 0.01). Multivariate analysis identified TT genotype as independent predictor of MF progression. In addition, TT (vs. CC + CT) patients showed increased plasma inflammatory cytokines. Finally, miR-146a−/− mice showed significantly higher Stat3 activity with aging, parallel to the development of the MF-like phenotype. In conclusion, we demonstrated that rs2431697 TT genotype is an early predictor of MF progression independent of the JAK2V617F allele burden. Low levels of miR-146a contribute to the MF phenotype by increasing Stat3 signaling

Diseño para el consumo cultural, la innovación y la inclusión social

Esta obra presenta diversos trabajos de investigación que tienen en común propuestas de diseño desde la cultura, la inclusión y la innovación social, desarrolladas por investigadores nacionales e internacionales adscritos a diversas universidades, así como a programas de posgrado

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality