Contrastive grammar : a theory and practice handbook

En consonancia con los lineamientos del programa vigente de Gramática Contrastiva, materia incluida en el programa de estudios del Traductorado de Inglés de la Facultad de Lenguas, Universidad Nacional de Córdoba, el objetivo principal de Contrastive Grammar: A Theory and Practice Handbook es brindar a los estudiantes un manual que combine las gramáticas descriptivas del inglés y del español. No pretende ser una revisión completa de todas las diferencias lingüísticas existentes entre ambas lenguas: por el contrario, el objetivo del presente manual es combinar información teórica clave con prácticas variadas respecto de estructuras dispares que representan la fuente más frecuente de interferencia entre los dos sistemas.Fil: Gómez Calvillo, M. Natalia. Universidad Nacional de Córdoba. Facultad de Lenguas; Argentina.Fil: Meehan, Patricia. Universidad Nacional de Córdoba. Facultad de Lenguas; Argentina.Fil: Díaz, M. Josefina. Universidad Nacional de Córdoba. Facultad de Lenguas; Argentina.Fil: Rolfi, Laura. Universidad Nacional de Córdoba. Facultad de Lenguas; Argentina

Plan de Marketing Diana Tous Accesorios SAS : NIT: 900746440-4

49 páginas : ilustraciones, gráficas, fotografíasEl objetivo del presente trabajo es realizar una propuesta de plan de mercadeo 2018 para Diana Tous accesorios. Pyme Colombiana que fue creada en el año 2008 inspirada en la cultura Zenú con un portafolio que cuenta con: collares, pulseras, brazaletes, anillos y aretes. Se realizó un análisis interno y externo de la empresa empezando con una entrevista a la fundadora donde se identificaron 3 áreas de oportunidad para trabajar y proponer mejoras como: estructura y formalización del área de mercadeo, comunicación y consumidor y cliente. También se realizó un análisis financiero de la empresa donde se evidenció la disminución de las ventas en el último año. Además, se realizó una entrevista a 102 consumidoras de accesorios personales donde el 81% confirma que compra más de dos veces al año accesorios para combinar con el vestuario. De acuerdo con el análisis realizado para Diana Tous accesorios, es necesario formalizar un área de mercadeo que defina los objetivos corporativos. Para el área de mercadeo se implementará un plan de marketing digital dirigido al segmento objetivo. La integración de la página web y RRSS con un contenido que logre un mejor posicionamiento en la mente del consumidor nacional e internacional. La estrategia de marca consta de la división de las líneas creando una marca para cada DT joyería la marca Premium y la de la línea de bisutería sería Diana Tous accesorios.The objective of this work is to make a proposal of 2018 for Diana Tous accessories marketing plan. Colombian SME, which was created in 2008 inspired by culture Zenu with a portfolio that features necklaces, bracelets, bangles, rings and earrings. Held an internal and external analysis of the company starting with an interview with the founder where three opportunity areas were identified for work and propose improvements as structure and formalizaci6n of the area of marketing, comunication and consumer and customer. I was also conducted a financial analysis of the company where the decrease in sales was evident in the last year. In an addition held an interview with 102 consumers of personal accessories where 81% confirms that more than two times a year buy accessories to match the costume. According to the analysis performed for Diana tous accessories, it is necessary to formalize an area of marketing that defined corporate objectives. The integration of the wedsite and social networks with content that achieves a better positioning in the minds of national and international consumers. Brand strategy consists of the division of lines creating a Brand for each DT JEWELRY Brand Premium and the bijoux line would be Diana Tous accessories.Especialista en Gerencia de MercadeoEspecializació

El cuidado como responsabilidad: Consecuencias no deseadas en la aplicación de la Ley de Dependencia

El pensamiento y la actividad del movimiento feminista se ha traducido en una conquista de realidades nuevas y diferentes tendentes a lograr la transformación de la situación de dependencia y sumisión de las mujeres respecto a los hombres. Si bien es cierto que a lo largo de este proceso de emancipación las mujeres han cosechado un innegable éxito en las sociedades democráticas, al menos en lo que se refiere a la construcción legislativa, se mantiene una desigual posición de hombres y mujeres en ámbitos diversos. En este sentido, la aplicación de la Ley de Dependencia, ejemplo en nuestro país de ampliación de los derechos sociales, puede tener el efecto no deseado de contribuir al mantenimiento de los roles tradicionales de hombres y mujeres.Feminism made possible the achievement of new and different realities that reversed the former situation of women in terms of submissiveness and dependence on men. As a result of this process, women’s emancipation in democratic societies has been successful in many aspects, particularly those related to legislative development. However, despite this progress, full equality has not been achieved yet. As an example, the Spanish Dependency law has radically enlarged social rights in recent times in Spain but at the same time, as an undesired effect, some specific aspects of its implementation seem to contribute to maintaining the traditional roles of women and men

Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death

Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving an interaction of the phosphatase calcineurin with the transcription factor FOXO3 is a major driver in AD associated pathological inflammation, suggesting a potential new druggable target for this devastating disease. We have now developed decoy molecules to interfere with calcineurin/FOXO3 interactions, and tested them in astrocytes and neuronal co-cultures exposed to amyloid-β (Aβ) toxicity. We observed that interference of calcineurin/FOXO3 interactions exerts a protective action against A-induced neuronal death and favors the production of a set of growth factors that we hypothesize form part of a cytoprotective pathway to resolve inflammation. Furthermore, interference of the A-induced interaction of calcineurin with FOXO3 by decoy compounds significantly decreased amyloid-β protein precursor (AβPP) synthesis, reduced the AβPP amyloidogenic pathway, resulting in lower Alevels, and blocked the expression of pro-inflammatory cytokines TNFα and IL-6 in astrocytes. Collectively, these data indicate that interrupting pro-inflammatory calcineurin/FOXO3 interactions in astrocytes triggered by Aβ accumulation in brain may constitute an effective new therapeutic approach in AD. Future studies with intranasal delivery, or brain barrier permeable decoy compounds, are warranted

Celos y emociones : factores de la relación de pareja en la reacción ante la infidelidad

Esta investigación está orientada a conocer las diferencias entre hombres y mujeres en las situaciones desencadenantes de celos y cómo estas reacciones son afectadas por ciertas características de las relaciones de pareja. 372 personas (250 mujeres y 122 hombres) que han participado en esta investigación responden ante una hipotética infidelidad de su pareja (infidelidad emocional e infidelidad sexual) con un supuesto rival y a un cuestionario sobre ciertos aspectos de su relación de pareja. Los resultados revelan que las mujeres experimentan una mayor intensidad emocional que los hombres cuando piensan sobre la infidelidad de su pareja, ya sea emocional o sexual. No hay diferencias importantes entre hombres y mujeres en cuanto al tipo de infidelidad que más les molesta: la infidelidad emocional. Además se ha analizado la influencia del tipo de relación de pareja que mantienen los participantes en la experiencia emocional provocada por la infidelidad.This present study explores the differences between women's and men's responses to (hypothetical) infidelity, and how these responses are influenced by the characteristics of the couple's relationship. 372 subjects completed questionnaires (a) itemising their jealous reaction to a partner's hypothetical infidelity (emotional or sexual); and (b) the state of their relationship. A survey of 250 women and 122 men revealed that the women reported higher intensity of emotional distress than the men. in regard to both emotional and sexual infidelity. There were no significant differences between men and women in their reports of which infidelity troubled them more: both genders are troubled more by emotional infidelity. We also report the influence that the type of relationship has on the emotions provoked by the infidelity

Influence of Mild Bottom Slopes on the Overtopping Flow over Mound Breakwaters under Depth-Limited Breaking Wave Conditions

[EN] The crest elevation of mound breakwaters is usually designed considering a tolerable mean wave overtopping discharge. However, pedestrian safety, characterized by the overtopping layer thickness (OLT) and the overtopping flow velocity (OFV), is becoming more relevant due to the reduction of the crest freeboards of coastal structures. Studies in the literature focusing on OLT and OFV do not consider the bottom slope effect, even if it has a remarkable impact on mound breakwater design under depth-limited breaking wave conditions. Therefore, this research focuses on the influence of the bottom slope on OLT and OFV exceeded by 2% of incoming waves, hc,2% and uc,2%. A total of 235 2D physical tests were conducted on conventional mound breakwaters with a single-layer Cubipod® and double-layer rock and cube armors with 2% and 4% bottom slopes. Neural networks were used to determine the optimum point to estimate wave characteristics for hc,2% and uc,2% calculation; that point was located at a distance from the model toe of three times the water depth at the toe (hs) of the structure. The influence of the bottom slope is studied using trained neural networks with fixed wave conditions in the wave generation zone; hc,2% slightly decreases and uc,2% increases as the gradient of the bottom slope increases.This research was funded by Ministerio de Economia y Competitividad and the Fondo Europeo de Desarrollo Regional (FEDER) under grant BIA2015-70436-R and RTI2018-101073-B-I00. The first author was also financially supported by the Ministerio de Educacion, Cultura y Deporte through the FPU program (Formacion de Profesorado Universitario) under grant FPU16/05081.Mares-Nasarre, P.; Gómez-Martín, ME.; Medina, JR. (2020). Influence of Mild Bottom Slopes on the Overtopping Flow over Mound Breakwaters under Depth-Limited Breaking Wave Conditions. Journal of Marine Science and Engineering. 8(1):1-16. https://doi.org/10.3390/jmse8010003S11681www.overtopping-manual.comMolines, J., & Medina, J. R. (2016). Explicit Wave-Overtopping Formula for Mound Breakwaters with Crown Walls Using CLASH Neural Network–Derived Data. Journal of Waterway, Port, Coastal, and Ocean Engineering, 142(3), 04015024. doi:10.1061/(asce)ww.1943-5460.0000322Nørgaard, J. Q. H., Lykke Andersen, T., & Burcharth, H. F. (2014). Distribution of individual wave overtopping volumes in shallow water wave conditions. Coastal Engineering, 83, 15-23. doi:10.1016/j.coastaleng.2013.09.003Molines, J., Herrera, M. P., Gómez-Martín, M. E., & Medina, J. R. (2019). Distribution of individual wave overtopping volumes on mound breakwaters. Coastal Engineering, 149, 15-27. doi:10.1016/j.coastaleng.2019.03.006Mares-Nasarre, P., Argente, G., Gómez-Martín, M. E., & Medina, J. R. (2019). Overtopping layer thickness and overtopping flow velocity on mound breakwaters. Coastal Engineering, 154, 103561. doi:10.1016/j.coastaleng.2019.103561Herrera, M. P., Gómez-Martín, M. E., & Medina, J. R. (2017). Hydraulic stability of rock armors in breaking wave conditions. Coastal Engineering, 127, 55-67. doi:10.1016/j.coastaleng.2017.06.010Van Gent, M. R. A. (2003). WAVE OVERTOPPING EVENTS AT DIKES. Coastal Engineering 2002. doi:10.1142/9789812791306_0185Schüttrumpf, H., Möller, J., & Oumeraci, H. (2003). OVERTOPPING FLOW PARAMETERS ON THE INNER SLOPE OF SEADIKES. Coastal Engineering 2002. doi:10.1142/9789812791306_0178Gent, M. R. A. van. (2001). Wave Runup on Dikes with Shallow Foreshores. Journal of Waterway, Port, Coastal, and Ocean Engineering, 127(5), 254-262. doi:10.1061/(asce)0733-950x(2001)127:5(254)Van der Meer, J. W., Hardeman, B., Steendam, G. J., Schuttrumpf, H., & Verheij, H. (2011). FLOW DEPTHS AND VELOCITIES AT CREST AND LANDWARD SLOPE OF A DIKE, IN THEORY AND WITH THE WAVE OVERTOPPING SIMULATOR. Coastal Engineering Proceedings, 1(32), 10. doi:10.9753/icce.v32.structures.10Lorke, S., Scheres, B., Schüttrumpf, H., Bornschein, A., & Pohl, R. (2012). PHYSICAL MODEL TESTS ON WAVE OVERTOPPING AND FLOW PROCESSES ON DIKE CRESTS INFLUENCED BY WAVE-CURRENT INTERACTION. Coastal Engineering Proceedings, 1(33), 34. doi:10.9753/icce.v33.waves.34Herrera, M. P., & Medina, J. R. (2015). Toe berm design for very shallow waters on steep sea bottoms. Coastal Engineering, 103, 67-77. doi:10.1016/j.coastaleng.2015.06.005Gómez-Martín, M. E., & Medina, J. R. (2014). Heterogeneous Packing and Hydraulic Stability of Cube and Cubipod Armor Units. Journal of Waterway, Port, Coastal, and Ocean Engineering, 140(1), 100-108. doi:10.1061/(asce)ww.1943-5460.0000223Argente, G., Gómez-Martín, M., & Medina, J. (2018). Hydraulic Stability of the Armor Layer of Overtopped Breakwaters. Journal of Marine Science and Engineering, 6(4), 143. doi:10.3390/jmse6040143Gómez-Martín, M., Herrera, M., Gonzalez-Escriva, J., & Medina, J. (2018). Cubipod® Armor Design in Depth-Limited Regular Wave-Breaking Conditions. Journal of Marine Science and Engineering, 6(4), 150. doi:10.3390/jmse6040150Battjes, J. A., & Groenendijk, H. W. (2000). Wave height distributions on shallow foreshores. Coastal Engineering, 40(3), 161-182. doi:10.1016/s0378-3839(00)00007-7Victor, L., van der Meer, J. W., & Troch, P. (2012). Probability distribution of individual wave overtopping volumes for smooth impermeable steep slopes with low crest freeboards. Coastal Engineering, 64, 87-101. doi:10.1016/j.coastaleng.2012.01.003Verhagen, H. J., van Vledder, G., & Arab, S. E. (2009). A PRACTICAL METHOD FOR DESIGN OF COASTAL STRUCTURES IN SHALLOW WATER. Coastal Engineering 2008. doi:10.1142/9789814277426_0241Van Gent, M. R. A., van den Boogaard, H. F. P., Pozueta, B., & Medina, J. R. (2007). Neural network modelling of wave overtopping at coastal structures. Coastal Engineering, 54(8), 586-593. doi:10.1016/j.coastaleng.2006.12.001Molines, J., Herrera, M. P., & Medina, J. R. (2018). Estimations of wave forces on crown walls based on wave overtopping rates. Coastal Engineering, 132, 50-62. doi:10.1016/j.coastaleng.2017.11.00

Synthesis of borasiloxanes by oxidative hydrolysis of silanes and pinacolborane using Cu3(BTC)2 as a solid catalyst

[EN] A convenient method for the synthesis of borasiloxanes from silanes and pinacolboranes using Cu-3(BTC)(2) as a heterogeneous catalyst in acetonitrile at 70 degrees C is reported. This procedure is more convenient than Ru and Pd based homogeneous catalysts because it avoids the use of noble metals, easy handling of starting materials and the catalyst can be reused.AD thanks the University Grants Commission (UGC), New Delhi, for the award of an Assistant Professorship under its Faculty Recharge Programme. AD also thanks the Department of Science and Technology, India, for the financial support through Extra Mural Research Funding (EMR/2016/006500). Financial support by the Spanish Ministry of Economy and Competitiveness (Severo Ochoa and CTQ2015-69153-CO2-1) is gratefully acknowledged.Dhakshinamoorthy, A.; Asiri, AM.; Concepción Heydorn, P.; García Gómez, H. (2017). Synthesis of borasiloxanes by oxidative hydrolysis of silanes and pinacolborane using Cu3(BTC)2 as a solid catalyst. Chemical Communications. 53(72):9998-10001. https://doi.org/10.1039/c7cc05221aS9998100015372Liu, W., Pink, M., & Lee, D. (2009). Conjugated Polymer Sensors Built on π-Extended Borasiloxane Cages. Journal of the American Chemical Society, 131(24), 8703-8707. doi:10.1021/ja902333pKhelevina, O. G., & Malyasova, A. S. (2014). Cross-linking of borosiloxane oligomers and properties of materials with vulcanized borosiloxane coating. Russian Journal of Applied Chemistry, 87(4), 480-484. doi:10.1134/s10704272140400144Puneet, P., Vedarajan, R., & Matsumi, N. (2016). Alternating Poly(borosiloxane) for Solid State Ultrasensitivity Toward Fluoride Ions in Aqueous Media. ACS Sensors, 1(10), 1198-1202. doi:10.1021/acssensors.6b00346Han, Y.-K., Yoo, J., & Yim, T. (2016). Distinct Reaction Characteristics of Electrolyte Additives for High-Voltage Lithium-Ion Batteries: Tris(trimethylsilyl) Phosphite, Borate, and Phosphate. Electrochimica Acta, 215, 455-465. doi:10.1016/j.electacta.2016.08.131Makarova, E. A., Shimizu, S., Matsuda, A., Luk’yanets, E. A., & Kobayashi, N. (2008). meso-Aryl tribenzosubporphyrin—a totally substituted subporphyrin species. Chemical Communications, (18), 2109. doi:10.1039/b801712cNeville, L. A., Spalding, T. R., & Ferguson, G. (2000). A Novel Borosilicate Cage Compound with an Incomplete B4Si4 Cube Structure: [(tBuSi)4(CH2=CHC6H4B)4O10]. Angewandte Chemie, 39(20), 3598-3601. doi:10.1002/1521-3773(20001016)39:203.0.co;2-aMingotaud, A.-F., Héroguez, V., & Soum, A. (1998). Synthesis of difunctional borasiloxanes and their behavior in metathesis reactions. Journal of Organometallic Chemistry, 560(1-2), 109-115. doi:10.1016/s0022-328x(98)00498-7Beckett, M. A., Rugen-Hankey, M. P., & Sukumar Varma, K. (2003). Synthesis and characterisation of cyclo-boratetrasiloxane, (RBO)(Me2SiO)3 (R=nBu, Ar), derivatives. Polyhedron, 22(25-26), 3333-3337. doi:10.1016/s0277-5387(03)00478-9Schiavon, M. A., Armelin, N. A., & Yoshida, I. V. P. (2008). Novel poly(borosiloxane) precursors to amorphous SiBCO ceramics. Materials Chemistry and Physics, 112(3), 1047-1054. doi:10.1016/j.matchemphys.2008.07.041Brisdon, B. J., Mahon, M. F., Molloy, K. C., & Schofield, P. J. (1992). Synthesis and structural characterization of cycloborasiloxanes: The X-ray crystal structures of cyclo-1,3,3,5,5-pentaphenyl-1-bora-3,5-disiloxane and cyclo-1,3,3,5,7,7-hexaphenyl-1,5-dibora-3,7-disiloxane. Journal of Organometallic Chemistry, 436(1), 11-22. doi:10.1016/0022-328x(92)85022-oMurphy, D., Sheehan, J. P., Spalding, T. R., Ferguson, G., Lough, A. J., & Gallagher, J. F. (1993). Compounds containing B–O–X bonds (X = Si, Ge, Sn, Pb). Part 4.—Crystal structures of B(OSiPh3)3, PhB(OSiPh3)2and PhB(OGePh3)2. J. Mater. Chem., 3(12), 1275-1283. doi:10.1039/jm9930301275Zhao, Z., Cammidge, A. N., & Cook, M. J. (2009). Towards black chromophores: μ-oxo linked phthalocyanine–porphyrin dyads and phthalocyanine–subphthalocyanine dyad and triad arrays. Chemical Communications, (48), 7530. doi:10.1039/b916649aFujdala, K. L., Oliver, A. G., Hollander, F. J., & Tilley, T. D. (2003). Tris(tert-butoxy)siloxy Derivatives of Boron, Including the Boronous Acid HOB[OSi(OtBu)3]2and the Metal (Siloxy)boryloxide Complex Cp2Zr(Me)OB[OSi(OtBu)3]2:  A Remarkable Crystal Structure with 18 Independent Molecules in Its Asymmetric Unit. Inorganic Chemistry, 42(4), 1140-1150. doi:10.1021/ic0205482Kleeberg, C., Cheung, M. S., Lin, Z., & Marder, T. B. (2011). Copper-Mediated Reduction of CO2with pinB-SiMe2Ph via CO2Insertion into a Copper–Silicon Bond. Journal of the American Chemical Society, 133(47), 19060-19063. doi:10.1021/ja208969dMetcalfe, R. A., Kreller, D. I., Tian, J., Kim, H., Taylor, N. J., Corrigan, J. F., & Collins, S. (2002). Organoborane-Modified Silica Supports for Olefin Polymerization:  Soluble Models for Metallocene Catalyst Deactivation. Organometallics, 21(8), 1719-1726. doi:10.1021/om010284bKijima, I., Yamamoto, T., & Abe, Y. (1971). Alkoxysilanes. VIII. The Preparation of Alkoxysiloxy Derivatives of Aluminum and Boron. Bulletin of the Chemical Society of Japan, 44(11), 3193-3194. doi:10.1246/bcsj.44.3193Marciniec, B., & Walkowiak, J. (2008). New catalytic route to borasiloxanes. Chemical Communications, (23), 2695. doi:10.1039/b801013gOhmura, T., Torigoe, T., & Suginome, M. (2012). Catalytic Functionalization of Methyl Group on Silicon: Iridium-Catalyzed C(sp3)–H Borylation of Methylchlorosilanes. Journal of the American Chemical Society, 134(42), 17416-17419. doi:10.1021/ja307956wYoshimura, A., Yoshinaga, M., Yamashita, H., Igarashi, M., Shimada, S., & Sato, K. (2017). A convenient and clean synthetic method for borasiloxanes by Pd-catalysed reaction of silanols with diborons. Chemical Communications, 53(43), 5822-5825. doi:10.1039/c7cc02420gIto, M., Itazaki, M., & Nakazawa, H. (2014). Selective Boryl Silyl Ether Formation in the Photoreaction of Bisboryloxide/Boroxine with Hydrosilane Catalyzed by a Transition-Metal Carbonyl Complex. Journal of the American Chemical Society, 136(17), 6183-6186. doi:10.1021/ja500465xChatterjee, B., & Gunanathan, C. (2017). Ruthenium-catalysed multicomponent synthesis of borasiloxanes. Chemical Communications, 53(16), 2515-2518. doi:10.1039/c7cc00787fHuang, Y.-B., Liang, J., Wang, X.-S., & Cao, R. (2017). Multifunctional metal–organic framework catalysts: synergistic catalysis and tandem reactions. Chemical Society Reviews, 46(1), 126-157. doi:10.1039/c6cs00250aDhakshinamoorthy, A., Asiri, A. M., & Garcia, H. (2016). Mixed-metal or mixed-linker metal organic frameworks as heterogeneous catalysts. Catalysis Science & Technology, 6(14), 5238-5261. doi:10.1039/c6cy00695gDhakshinamoorthy, A., Alvaro, M., & Garcia, H. (2010). Aerobic Oxidation of Benzylic Alcohols Catalyzed by Metal−Organic Frameworks Assisted by TEMPO. ACS Catalysis, 1(1), 48-53. doi:10.1021/cs1000703Schlichte, K., Kratzke, T., & Kaskel, S. (2004). Improved synthesis, thermal stability and catalytic properties of the metal-organic framework compound Cu3(BTC)2. Microporous and Mesoporous Materials, 73(1-2), 81-88. doi:10.1016/j.micromeso.2003.12.027Dhakshinamoorthy, A., Alvaro, M., & Garcia, H. (2010). Metal-Organic Frameworks as Efficient Heterogeneous Catalysts for the Regioselective Ring Opening of Epoxides. Chemistry - A European Journal, 16(28), 8530-8536. doi:10.1002/chem.201000588Dhakshinamoorthy, A., Alvaro, M., & Garcia, H. (2009). Metal organic frameworks as efficient heterogeneous catalysts for the oxidation of benzylic compounds with t-butylhydroperoxide. Journal of Catalysis, 267(1), 1-4. doi:10.1016/j.jcat.2009.08.001Opanasenko, M., Dhakshinamoorthy, A., Shamzhy, M., Nachtigall, P., Horáček, M., Garcia, H., & Čejka, J. (2013). Comparison of the catalytic activity of MOFs and zeolites in Knoevenagel condensation. Catal. Sci. Technol., 3(2), 500-507. doi:10.1039/c2cy20586fChui, S. S. (1999). A Chemically Functionalizable Nanoporous Material [Cu3(TMA)2(H2O)3]n. Science, 283(5405), 1148-1150. doi:10.1126/science.283.5405.1148Dhakshinamoorthy, A., Concepcion, P., & Garcia, H. (2016). Dehydrogenative coupling of silanes with alcohols catalyzed by Cu3(BTC)2. Chemical Communications, 52(13), 2725-2728. doi:10.1039/c5cc10216bDhakshinamoorthy, A., Alvaro, M., & Garcia, H. (2017). HKUST-1 catalyzed room temperature hydrogenation of acetophenone by silanes. Catalysis Communications, 97, 74-78. doi:10.1016/j.catcom.2017.03.023Bennett, E., Wilson, T., Murphy, P. J., Refson, K., Hannon, A. C., Imberti, S., … Parker, S. F. (2015). How the Surface Structure Determines the Properties of CuH. Inorganic Chemistry, 54(5), 2213-2220. doi:10.1021/ic502700

Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea.

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1-3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages

Latent tuberculosis infection screening in healthcare workers in four large hospitals in Santiago, Chile

Indexación: Web of Science; Scielo.Introducción: Se desconoce en la actualidad cuál es la real prevalencia de infección tuberculosa latente en el personal de salud en Chile; sin embargo, este grupo ha sido descrito como con mayor riesgo de desarrollar tuberculosis activa que la población general. Objetivo: Determinar la prevalencia de infección tuberculosa latente en funcionarios de la salud en diferentes áreas laborales de riesgo. Metodología: Estudio de corte transversal, descriptivo, realizado en funcionarios pertenecientes a laboratorios clínicos o áreas de atención broncopulmonar de cuatro hospitales de la Región Metropolitana en quienes se hizo test de Quantiferon TB Gold®In tube(QFT). Resultados: Se evidenció infección tuberculosa latente en 20 de las 76 (26,3%) personas estudiadas. En aquellos funcionarios que referían antecedente de contacto en el pasado en la comunidad con enfermos de tuberculosis, la positividad del test llegó a 62,5%; en aquellos que pertenecían al Programa Nacional de Control de la Tuberculosis, a 50% y en los que realizaban toma de esputo inducido, baciloscopias o cultivo de micobacterias, a 38%. La proporción de individuos con QFT positivo fue significativamente menor en aquellos funcionarios que no tenían estos antecedentes (15,7%, p = 0,03). Se encontró además una mayor proporción de infección tuberculosa latente a mayor edad del individuo estudiado. Conclusión: La infección tuberculosa latente medida por QFT resultó altamente prevalente en el personal de la salud incluido en el presente estudio. Es necesario seguir profundizando en los posibles escenarios de implementación y limitaciones del uso de esta nueva herramienta diagnóstica, haciendo énfasis en el personal de la salud de mayor riesgo y menor edad.Background: It is currently unknown which is the prevalence of latent tuberculosis infection in healthcare workers in Chile, but this group has been described as at higher risk of developing active tuberculosis than general population. Objectives: To determine the prevalence of latent tuberculosis infection in a sample of healthcare workers from at risk areas. Methodology: A cross-sectional, descriptive study, conducted in health care workers from clinical laboratories or respiratory care areas in four hospitals in Santiago. Latent tuberculosis infection detection was determined by Quantiferon® TB Gold In Tube testing (QFT). Results: QFT resulted positive in 20 of 76 (26.3%) of the individuals tested. Test positivity reached 62.5% among the personnel that reported history of past TB contact in the community, 50% among the personnel who belonged to the national tuberculosis control program and 38% among those doing induced sputum, acid fast smear or mycobacterial cultures. The proportion of individuals with positive QFT was significantly lower in those personnel who had no such risk factors (15.7%, p = 0.03). The proportion of latent tuberculosis infection also increased in direct relation to the age of the subject. Conclusion: Latent tuberculosis infection as detected by QFT testing was highly prevalent in healthcare workers included in the present study. Further exploring the limitations and possible scenarios for this new diagnostic tool is needed, with emphasis on health personnel at higher-risk and younger individuals.http://www.scielo.cl/pdf/rci/v31n3/art02.pd

Hydraulic stability of cube-armored mound breakwaters in depth-limited breaking wave conditions

[EN] Armor erosion due to wave attack has been studied intensively since it is considered the main failure mode of mound breakwaters. Cube-armored mound breakwaters in depth-limited breaking wave conditions are common in practice but have received limited attention in the literature. In this study, 2D physical tests were performed on non-overtopped double-layer randomly-placed cube-armored mound breakwater models with armor slope cot¿ = 1.5 and bottom slope m = 2% in breaking wave conditions. Using the experimental results, a new hydraulic stability formula was derived with a coefficient of determination R2 = 0.85 based on a power relationship between the armor damage and the stability number and the dimensionless water depth. A lower hydraulic stability was found for the front slope of non-overtopped cube-armored structures in breaking wave conditions when compared to formulas given in the literature.The authors acknowledge the support from grant RTI2018-101073B-I00 funded by MCIN/AEI/10.13039/501100011033 and "ERDF A way of making Europe", the Spanish Ministry of Economy and Competitiveness under grant BIA2012-33967, the Generalitat Valenciana under the grant AEST/2021/045 and FEDER. The authors thank Debra Westall for revising the manuscript.Mares-Nasarre, P.; Molines, J.; Gómez-Martín, ME.; Medina, JR. (2022). Hydraulic stability of cube-armored mound breakwaters in depth-limited breaking wave conditions. Ocean Engineering. 259:1-13. https://doi.org/10.1016/j.oceaneng.2022.11184511325