Comment on \u201cApplication of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction\u201d

Comment on \u201cApplication of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction\u201

Comment on “Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction”

Comment on “Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction

Dual role of scaffolding on motor-cognitive development in early childhood education

The link between motor and executive function (EF) development is unclear. To test whether learning difficult motor task drives EF development, we measured EF changes in 5-year-old children from 3 kindergartens in north-eastern Italy engaged in a specific motor program including a difficult motor task (walking on unstable bar). One-hundred children divided in 2 groups participated for 1 hour/week for 10 weeks: Group A was supported by a teacher and group B no. The capacity to perform the difficult task was assessed at the beginning and end of the study; the children able (Groups A1 and B1) or unable (Groups A2 and B2) to perform the task at the Pre-test were similar in the 2 groups. To assess EF, the day/night test (Gerstadt et al., 1994) was used. Dynamic balance results. Time at spring bar: Group A pre 69.2 post 29.6 - Group B pre 71.8 post 48.8. EF results. Group A1 pre 4.90 post 2.71 - Group B1 pre 3.62 post 3.54. Group A2 pre 4.64 post 1.22 - Group B2 pre 5.30 post 3.55. Conclusions. Teacher support significantly promoted improvement of motor skill; teacher’s scaffolding significantly promoted EF development in children with initial low motor competence only.This research was supported by Comitato Olimpico Nazionale Italiano CONI-Treviso and A.S.D. Laboratorio 0246, Treviso, Italy

Parco giochi "Primo Sport 0246". Il parco per lo sviluppo senso-motorio del bambino

Linee guida per la progettazione di parchi gioco e spazi all'aperto che promuovano lo sviluppo motorio nella fascia d'et\ue0 0-6 anni secondo criteri verificati dai dati della ricerca scientific

PRIMO SPORT L’ambiente e il movimento ideali per crescere sani

Necessità per un sano sviluppo nell'infanzia, linee guida, raccomandazioni e dati della ricerca scientifica internazionale per genitori e educatori. Concept e utilizzo del nuovo parco PrimoSport 024

Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues.

International audience: Allogeneic stem cell (SC)-based therapy is a promising tool for the treatment of a range of human degenerative and inflammatory diseases. Many reports highlighted the immune modulatory properties of some SC types, such as mesenchymal stromal cells (MSCs), but a comparative study with SCs of different origin, to assess whether immune regulation is a general SC property, is still lacking. To this aim, we applied highly standardized methods employed for MSC characterization to compare the immunological properties of bone marrow-MSCs, olfactory ectomesenchymal SCs, leptomeningeal SCs, and three different c-Kit-positive SC types, that is, amniotic fluid SCs, cardiac SCs, and lung SCs. We found that all the analyzed human SCs share a common pattern of immunological features, in terms of expression of activation markers ICAM-1, VCAM-1, HLA-ABC, and HLA-DR, modulatory activity toward purified T, B, and NK cells, lower immunogenicity of inflammatory-primed SCs as compared to resting SCs, and indoleamine-2,3-dioxygenase-activation as molecular inhibitory pathways, with some SC type-related peculiarities. Moreover, the SC types analyzed exert an anti-apoptotic effect toward not-activated immune effector cells (IECs). In addition, we found that the inhibitory behavior is not a constitutive property of SCs, but is acquired as a consequence of IEC activation, as previously described for MSCs. Thus, immune regulation is a general property of SCs and the characterization of this phenomenon may be useful for a proper therapeutic use of SCs

Therapeutic Induction of Energy Metabolism Reduces Neural Tissue Damage and Increases Microglia Activation in Severe Spinal Cord Injury

: Neural tissue has high metabolic requirements. Following spinal cord injury (SCI), the damaged, tissue suffers from a severe metabolic impairment, which aggravates axonal degeneration and, neuronal loss. Impaired cellular energetic, tricarboxylic acid (TCA) cycle and oxidative, phosphorylation metabolism in neuronal cells has been demonstrated to be a major cause of neural tissue death and regeneration failure following SCI. Therefore, rewiring the spinal cord cell metabolism may be an innovative therapeutic strategy for the treatment of SCI. In this study, we evaluated the therapeutic effect of the recovery of oxidative metabolism in a mouse model of severe contusive SCI. Oral administration of TCA cycle intermediates, co-factors, essential amino acids, and branched-chain amino acids was started 3 days post-injury and continued until the end of the experimental procedures. Metabolomic, immunohistological, and biochemical analyses were performed on the injured spinal cord sections. Administration of metabolic precursors enhanced spinal cord oxidative metabolism. In line with this metabolic shift, we observed the activation of the mTORC1 anabolic pathway, the increase in mitochondrial mass, and ROS defense which effectively prevented the injury-induced neural cell apoptosis in treated animals. Consistently, we found more choline acetyltransferase (ChAT)-expressing motor neurons and increased neurofilament positive corticospinal axons in the spinal cord parenchyma of the treated mice. Interestingly, oral administration of the metabolic precursors increased the number of activated microglia expressing the CD206 marker suggestive of a, pro-resolutive, M2-like phenotype. These molecular and histological modifications observed in treated animals ultimately led to a significant, although partial, improvement of the motor functions. Our data demonstrate that rewiring the cellular metabolism can represent an effective strategy to treat SCI

Structured and shared CT radiological report of gastric cancer: a consensus proposal by the Italian Research Group for Gastric Cancer (GIRCG) and the Italian Society of Medical and Interventional Radiology (SIRM)

Objectives Written radiological report remains the most important means of communication between radiologist and referring medical/surgical doctor, even though CT reports are frequently just descriptive, unclear, and unstructured. The Italian Society of Medical and Interventional Radiology (SIRM) and the Italian Research Group for Gastric Cancer (GIRCG) promoted a critical shared discussion between 10 skilled radiologists and 10 surgical oncologists, by means of multi-round consensus-building Delphi survey, to develop a structured reporting template for CT of GC patients. Methods Twenty-four items were organized according to the broad categories of a structured report as suggested by the European Society of Radiology (clinical referral, technique, findings, conclusion, and advice) and grouped into three "CT report sections" depending on the diagnostic phase of the radiological assessment for the oncologic patient (staging, restaging, and follow-up). Results In the final round, 23 out of 24 items obtained agreement ( >= 8) and consensus ( 0.05). Conclusions The structured report obtained, shared by surgical and medical oncologists and radiologists, allows an appropriate, clearer, and focused CT report essential to high-quality patient care in GC, avoiding the exclusion of key radiological information useful for multidisciplinary decision-making

Climate change impacts and adaptation in Europe

The JRC PESETA IV study shows that ecosystems, people and economies in the EU will face major impacts from climate change if we do not urgently mitigate greenhouse gas emissions or adapt to climate change. The burden of climate change shows a clear north-south divide, with southern regions in Europe much more impacted, through the effects of extreme heat, water scarcity, drought, forest fires and agriculture losses. Limiting global warming to well below 2°C would considerably reduce climate change impacts in Europe. Adaptation to climate change would further minimize unavoidable impacts in a cost-effective manner, with considerable co-benefits from nature-based solutions.JRC.C.6-Economics of Climate Change, Energy and Transpor