SSME main combustion chamber life prediction

Typically, low cycle fatigue life is a function of the cyclic strain range, the material properties, and the operating temperature. The reusable life is normally defined by the number of strain cycles that can be accrued before severe material degradation occurs. Reusable life is normally signified by the initiation or propagation of surface cracks. Hot-fire testing of channel wall combustors has shown significant mid-channel wall thinning or deformation during accrued cyclic testing. This phenomenon is termed cyclic-creep and appears to be significantly accelerated at elevated surface temperatures. This failure mode was analytically modelled. The cyclic life of the baseline SSME-MCC based on measured calorimeter heat transfer data, and the life sensitivity of local hot spots caused by injector effects were determined. Four life enhanced designs were assessed

The role of galectin-1 in type 2 diabetes. Clinical and experimental studies

Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes. Study I: Through a combination of microdialysis and mass-spectrometry, we found increased galectin-1 levels in the subcutaneous adipose tissue in a small experimental study of 15 men with and without type 2 diabetes. Study II and Study III: Serum galectin-1 was also independently associated with type 2 diabetes and body-mass index in of 989 individuals from the cross-sectional population based SCAPIS pilot study. Furthermore, high serum-levels of galectin-1 predicted an increased risk of incident type 2 diabetes in 4022 individuals from the longitudinal Malmö Diet-Cancer Study-Cardiovascular Cohort, after adjustment for known risk factors. Study IV: In addition, serum levels of galectin-1 were associated with all major adipose tissue depots and presented a similar metabolic association profile as circulating galectin-3 in 502 individuals from the cross-sectional population based POEM-study. Study V: In a small experimental study of 25 individuals from the MD-Lipolysis study, fasting serum galectin-1 correlated with insulin, and the lipid metabolism markers glycerol and free fatty acids during an oral glucose tolerance test, and adipose tissue LGALS1 expression correlated with markers of lipid metabolism. Modulation of galectin-1 activity in a cultured human preadipocyte cell-line indicated effects on triglyceride content, and genetic markers of lipid uptake, lipogenesis and glucose uptake during differentiation to mature adipocytes. Interpretation: Galectin-1 is altered in the blood in type 2 diabetes, and may have a direct metabolic role in the adipose tissue and in type 2 diabetes development

The Emergent View of IT and Organizational Change

In the modern business world it is impossible to distinguish between technology and organization. All activities are somehow supported by technology and the nature and structure of organizations influence the technological development. For that reason it is crucial to recognize the reciprocal relationship between technology and organization, and acknowledge the phenomena as highly intertwined. This is the case in practice but it should also be reflected in associated research. In this paper, a bibliometric approach serves as the foundation for a study of whether a dynamic view of technology and organization is represented in affiliated scientific writings the last decade. More specifically, research in connection to information technology and organizational change is considered. The results from the investigation paint a scattered picture lacking clear indications of a tendency suggesting a move from a deterministic towards an emergent scientific view of these concepts

Making school children’s participation in planning processes a routine practice

Children’s participation in planning has been investigated to some extent. There are, however, unexplored topics, particularly concerning what is needed for children’s participation to become a regular process. Based on case studies in Sweden, this article draws some conclusions. It is quite possible to organize ordinary processes where children participate in community building, in collaboration with planners, as part of their schoolwork. The key question is how this can be done. Clearly, it needs to occur in close collaboration with teachers and pupils, however it also needs to be implemented in a system-challenging manner. Thus, rather than looking for tools with potential to work in the existing school and planners’ world, it is important to design research that aims to create learning processes that have the potential to change praxis. Hence, it is not the case that tools are not needed, rather that children need to help to develop them

Bibliometric Study of Academic Interaction: IT, Organization, and Change

This paper explores the degree and nature of the research interaction between the academic fields of Information Technology, Organization, and Organizational Change. This is done so as to see if, and how, the highly digitized modern business world is reflected in related research. The paper analyses 9.669 articles published in 1995-2006 that are derived from major journals within each field. Then the articles are reviewed through the use of the bibliometric methods: frequency, cross-reference, cocitation, shared references, and network analyses. The findings detect a dearth of consistent research interaction between the fields of Information Technology, Organization, and Organizational Change. This fact is critiqued on the basis of previous practical and academic calls for interactional research. The paper provides important insights about the degree and nature of the research interaction and, in addition, recommendations and guidelines for future cross-fertilization between the academic fields are provided

Domesticating Space: Media Production Pedagogy for the Empowerment of Marginalized Youth

This article inquires into the role of space in media and information literacy (MIL), especially when supporting learners’ production skills. The MIL framework is to a great extent focused on deconstruction of messages in a private position of reception, while the theoretical, didactic and ethical components of the production pedagogy are less developed. This multiple-case study analyses the situated agency of young people in a vulnerable position with regard to the spaces where agency is sustained. We develop the concept of production context into a more specific concept of production space and apply it to the film club in a suburb in Sweden. We combine qualitative analysis of critical situations in selected spaces with theoretical development of the idea of production space, to arrive at increased understanding of production skills and related media pedagogy

Domesticating space: Media production pedagogy for the empowerment of marginalized youth

This article investigates the role of space in media and information literacy (MIL), especially when supporting learners’ production skills. The MIL framework is to a great extent focused on deconstruction of messages in a private position of reception, while the theoretical, didactic and ethical components of the production pedagogy are less developed. This multiple-case study analyses the situated agency of young people in a vulnerable position with regard to the spaces where agency is sustained. We develop the concept of production context into a more specific concept of production space and apply it to the film club in a suburb in Sweden. We combine qualitative analysis of critical situations in selected spaces with theoretical development of the idea of production space, to arrive at increased understanding of production skills and related media pedagogy

Dyes, flies, and sunny skies: photodynamic therapy and neglected tropical diseases

Photodynamic therapy, in its various applications, represents the focused combination of electromagnetic radiation, a chemical (usually a dye) capable of its absorption and conversion, and oxygen to provide cytotoxicity (cell killing). The effect has been known for over a century, and there is considerable clinical use in terms of its application to various cancers. However, the antimicrobial properties of the technology, which are considerable, have received only a lukewarm reception by healthcare providers, and the possibilities for tropical disease therapy are mainly unexplored. This is particularly vexatious given both the inexpensive nature of the photosensitisers and light sources available and the lack of conventional forward progress in widespread diseases such as leishmaniasis, trypanosomiasis, and tuberculosis in the Developing World. The following review therefore covers the use, or potential use, of the photodynamic approach in this area, mainly with reference to tropical diseases having current ‘neglected’ status according to the World Health Organisation. © 2016 The Authors. Coloration Technology © 2016 Society of Dyers and Colourist

Stenberg, Jenny, Maria Zwanenburg & Lasse Fryk (2017). Can top-down policy meet local diversity in urban transformation processes?

This book summarizes the work carried out by oikonet, an Erasmus Network project dedicated to promoting pedagogic innovation in the field of housing studies which was carried out from 2013 to 2016 with the support of the Lifelong Learning Programme of the European Union