Coaching as Servant Leadership: Applying the Social Change Model of Leadership Development to Youth Basketball Programs

This paper presents an original interpretation of the Social Change Model of Leadership Development (SCM) in order to provide youth basketball coaches with a tool for practicing and teaching servant leadership principles in their program. Because scholars and coaches both have a long tradition of borrowing leadership styles from other areas of study, adapting them, and examining their potential applicability to sport (Westre, 2003), many youth basketball coaches use servant leadership theory to inform their approach to coaching. While this is sufficient for coaching philosophy development, Robert Greenleaf (1977) did not identify the specific skills that define servant leaders, nor did he provide a standard model for putting his theory into practice and teaching its principles to others. As a result, many coaches who want to use his theory to inform their practice have difficulty doing so, as there is no model available for implementing it in a youth sport context. The author argues that SCM is a reasonable model for actualizing the goals and principles of servant leadership theory given the value each framework places on (a) contributing to the individual growth of others, (b) highlighting the connection between individual, community, and society, and (c) creating positive social change. Then, based on the suggestion that curricular leadership development models can be effectively adapted for use in extracurricular contexts (Sherman et al., 2017), the author adapts SCM for use in a youth basketball program. Ideally, this research will empower youth basketball coaches to use the game as a platform for teaching young people the values, skills, and competencies needed to build and sustain a more just, equitable, and inclusive society

SeekFusion - A Clinically Validated Fusion Transcript Detection Pipeline for PCR-Based Next-Generation Sequencing of RNA

Detecting gene fusions involving driver oncogenes is pivotal in clinical diagnosis and treatment of cancer patients. Recent developments in next-generation sequencing (NGS) technologies have enabled improved assays for bioinformatics-based gene fusions detection. In clinical applications, where a small number of fusions are clinically actionable, targeted polymerase chain reaction (PCR)-based NGS chemistries, such as the QIAseq RNAscan assay, aim to improve accuracy compared to standard RNA sequencing. Existing informatics methods for gene fusion detection in NGS-based RNA sequencing assays traditionally use a transcriptome-based spliced alignment approach or a de-novo assembly approach. Transcriptome-based spliced alignment methods face challenges with short read mapping yielding low quality alignments. De-novo assembly-based methods yield longer contigs from short reads that can be more sensitive for genomic rearrangements, but face performance and scalability challenges. Consequently, there exists a need for a method to efficiently and accurately detect fusions in targeted PCR-based NGS chemistries. We describe SeekFusion, a highly accurate and computationally efficient pipeline enabling identification of gene fusions from PCR-based NGS chemistries. Utilizing biological samples processed with the QIAseq RNAscan assay and in-silico simulated data we demonstrate that SeekFusion gene fusion detection accuracy outperforms popular existing methods such as STAR-Fusion, TOPHAT-Fusion and JAFFA-hybrid. We also present results from 4,484 patient samples tested for neurological tumors and sarcoma, encompassing details on some novel fusions identified

Descompensação aguda da insuficiência cardíaca : comparação entre hospital universitário brasileiro e norte-americano

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Barrett's esophagus: endoscopic diagnosis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87018/1/j.1749-6632.2011.06045.x.pd

Morbi-mortalidade cardiovascular na insuficiência cardíaca : preditores clínicos na era dos beta-bloqueadores

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The role of magnetic resonance imaging and endoscopic retrograde cholangiography in the evaluation of disease activity and severity in primary sclerosing cholangitis

Background & Aims Endoscopic retrograde cholangiography (ERCP) has been considered the gold standard for the diagnosis and follow-up of primary sclerosing cholangitis, but it has been replaced by less invasive magnetic resonance imaging and cholangiopancreatography (MRI-MRCP). However, the role of these two techniques in the evaluation of disease activity and severity needs to be elucidated. Methods Patients with primary sclerosing cholangitis (n: 48, male 31, median age: 35.7; 28.0-44.2) who underwent ERCP and MRI-MRCP within +/- 3 months for diagnosis or follow-up, were reviewed. ERCP and MRI-MRCP images were scored using the modified Amsterdam score. Serum and biliary cytology markers of disease activity and severity were related to the imaging findings. Agreement on the assessment of the ERCP/MRCP score was calculated by kappa-statistics. Spearman ' s rho was calculated when appropriate. Results The agreement between ERCP and MRCP in scoring bile duct changes for disease severity was only moderate (weighted kappa: 0.437; 95% CI: 0.211-0.644 for intra- and 0.512; 95% CI: 0.303-0.720 for extra-hepatic bile ducts). ERCP and MRCP intra-hepatic scores were associated to the surrogate marker alkaline phosphatase (P = .02 for both). A weak correlation between MRCP score for extra-hepatic bile ducts and liver transplantation/death was found (Spearman's rho = .362, 95% CI: 0.080-0.590, P = .022). A weak correlation between intra- (Spearman ' s rho = .322, 95% CI: 0.048-0.551, P = .022) and extra-hepatic (Spearman`s rho = .319, 95% CI: 0.045-0.549, P = .025) peribiliary enhancement on contrast-enhanced MRI and severity of biliary cytologic classification was found. Conclusions The overall agreement between ERCP and MRI-MRCP in assessing disease severity was moderate for intra- and extra-hepatic bile ducts. MRI-MRCP seems to have a minor role as surrogate marker of disease activity and progression in PSC.Peer reviewe

Bird and Small Mammal Populations in Relation to Seral Stage of Mixed-Grass Prairie, For Pierre National Grassland, South Dakota

The Nebraska National Forest uses a multivariate technique to classify seral stages of clay range sites in mixed-grass prairie. Mean canopy cover x frequency of occurrence indices for buffalo grass lliuchloe dactyloides), western wheatgrass (Agropyron smithii), and green needlegrass (Stipa viridula) are used to classify clay range sites into one of four seral stages. Managers lack necessary information to assess how wildlife communities are affected by changes in seral stage. I estimated bird species density, bird species richness, bird species diversity and small mammal abundance at 3 7 sites (7 low seral stage; 5 low-intermediate seral stage; 19 high-intermediate seral stage; 6 high seral stage). Vegetation structure and composition characteristics were also measured at each site. Bird species richness did not differ (P = 0. 12) among seral stages. Density of grasshopper sparrows, bobolinks, dickcissels, and brown-headed cowbirds increased (P \u3c 0.10) from low to high seral stages. Burrowing owls, upland sandpipers, chestnut-collared longspurs, and horned larks decreased (P \u3c 0.10) from low to high seral stages. Western meadowlarks were abundant in all seral stages but densities were greater (P \u3c 0.10) in low and low-intermediate seral stage compared to high seral stage. Red-winged blackbird density did not differ (P \u3e 0 .10) among seral stages. Bird species whose habitat requirements include tall grasses and increased residual grass cover were more abundant in higher seral stages. Lower seral stages were beneficial to birds that prefer short grass and sparse vegetative cover. Multiple regression analyses indicated that sera1 stage was a satisfactory predictor of density for most bird species. Vegetation structure and composition variables were collinear with seral stage regressors. No significant model was generated for red-winged blackbirds (P \u3e 0.10) using seral stage regressors or vegetation variables. Western meadowlarks were modeled (P \u3c 0.01) using only vegetation variables. Small mammal abundances were variable between years and within seral stages. Abundance of grasshopper mice (Onychomys leucogaster) decreased (P \u3c 0.01) as seral stage changed from low to high. Macro- and micro-scale features of the habitat must be investigated to understand small mammal occurrence and abundance. Seral stage seems to be an adequate predictor of small mammal abundance at a course scale, but may not be reflective of small mammal abundance at a particular site and time. A habitat capability (HABCAP) model, based on relative densities of grassland birds in seral stages of clay range sites, was developed using 1996 data and evaluated using 1997 data. Only minor revisions were necessary to predict grassland bird densities from HABCAP model coefficients developed in 1996 suggesting that model coefficients accurately predicted bird species densities. Managers should maintain a mosaic of seral stages within the landscape to provide all seral conditions for grassland wildlife. Further research is needed to develop separate HABCAP model coefficients for feeding and breeding habitats for upland sandpipers and brown-headed cowbirds and to incorporate species not emphasized in this study into the HABCAP model. Changes in management actions which affect the seral stage of the prairie landscape can influence bird and small mammal populations. This research enables managers to predict the effects of management actions that change the ecological stage of clay range sites on bird and small mammal populations