A Claperon

A Gentilini

A Techasen

A Villanueva

AE Sirica

AEA Bergquist

AFV Holczbauer

AG Cox

B Glimelius

B Goeppert

B Sripa

BMY Fan

BS Ding

C Chuaysri

C Raggi

C Subimerb

CD Fingas

CK Ong

CM Weisend

D Hanahan

D Malka

D Yamada

D Zhou

DJ Murphy

E Stocker

EG Fritcher

EG Huntzicker

GA Michelotti

GK Bonney

GK Michalopoulos

H Clevers

H Hasita

H Okabe

J Milano

J Valle

JB Andersen

JC Mertens

JM Banales

K Kajiyama

K Overturf

K Yanger

KP Lee

L Boulter

L Planas-Paz

M Cadamuro

M Ducreux

M El Khatib

M Fausther

M Huch

M Komuta

M Lardelli

M Swiderska-Syn

MSB Komuta

N Tokumoto

P Beatus

P Marti

P Wang

Q Gao

R Carpentier

R Espanol-Suner

RV Guest

S Attia

S Darwish Murad

S Ohira

S Rao

S Sekiya

S Zender

SJ Bray

SJ Lubner

SL Zhou

T Ikenoue

T Oda

T Okusaka

T Zhan

TG Bird

TY Choi

V Gebbia

W Loilome

WR Gordon

WY Lu

Y Kim

YPA Zong

ZD Burke

English

Guest, Rachel

Boulter, Luke

Dwyer, Benjamin

Forbes, Stuart

Edinburgh Research Explorer

Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma

AbstractCancer frequently arises in epithelial tissues subjected to repeated cycles of injury and repair. Improving our understanding of tissue regeneration is, therefore, likely to reveal novel processes with inherent potential for aberration that can lead to carcinoma. These highly conserved regenerative mechanisms are increasingly understood and in the liver are associated with special characteristics that underlie the organ’s legendary capacity for restoration of size and function following even severe or chronic injury. The nature of the injury can determine the cellular source of epithelial regeneration and the signalling mechanisms brought to play. These observations are shaping how we understand and experimentally investigate primary liver cancer, in particular cholangiocarcinoma; a highly invasive malignancy of the bile ducts, resistant to chemotherapy and whose pathogenesis has hitherto been poorly understood. Interestingly, signals that drive liver development become activated in the formation of cholangiocarcinoma, such as Notch and Wnt and may be potential future therapeutic targets. In this review, we summarise the work which has led to the current understanding of the cellular source of cholangiocarcinoma, how the tumour recruits, sustains and is educated by its supporting stromal environment, and the tumour-derived signals that drive the progression and invasion of the cancer. With few current treatments of any true efficacy, advances that will improve our understanding of the mechanisms driving this aggressive malignancy are welcome and may help drive therapeutic developments.</jats:p

R. V. Guest

L. Boulter

B. J. Dwyer

S. J. Forbes

Crossref

npj Regenerative Medicine

https://www.research.ed.ac.uk/portal/files/36572119/art_10.1038_s41536_017_0018_z.pdf

Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma

Abstract

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