Changes in the high latitude Southern Hemisphere through the Eocene-Oligocene Transition:a model-data comparison

International audienceAbstract. The global and regional climate changed dramatically with the expansion of the Antarctic Ice Sheet at the Eocene–Oligocene transition (EOT). These large-scale changes are generally linked to declining atmospheric pCO2 levels and/or changes in Southern Ocean gateways such as the Drake Passage around this time. To better understand the Southern Hemisphere regional climatic changes and the impact of glaciation on the Earth's oceans and atmosphere at the EOT, we compiled a database of 10 ocean and 4 land-surface temperature reconstructions from a range of proxy records and compared this with a series of fully coupled, low-resolution climate model simulations from two models (HadCM3BL and FOAM). Regional patterns in the proxy records of temperature show that cooling across the EOT was less at high latitudes and greater at mid-latitudes. While certain climate model simulations show moderate–good performance at recreating the temperature patterns shown in the data before and after the EOT, in general the model simulations do not capture the absolute latitudinal temperature gradient shown by the data, being too cold, particularly at high latitudes. When taking into account the absolute temperature before and after the EOT, as well as the change in temperature across it, simulations with a closed Drake Passage before and after the EOT or with an opening of the Drake Passage across the EOT perform poorly, whereas simulations with a drop in atmospheric pCO2 in combination with ice growth generally perform better. This provides further support for previous research that changes in atmospheric pCO2 are more likely to have been the driver of the EOT climatic changes, as opposed to the opening of the Drake Passage

Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis: Results of a 2-year study

Summary: Strontium ranelate appears to influence more than alendronate distal tibia bone microstructure as assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT), and biomechanically relevant parameters as assessed by micro-finite element analysis (μFEA), over 2years, in postmenopausal osteoporotic women. Introduction: Bone microstructure changes are a target in osteoporosis treatment to increase bone strength and reduce fracture risk. Methods: Using HR-pQCT, we investigated the effects on distal tibia and radius microstructure of strontium ranelate (SrRan; 2g/day) or alendronate (70mg/week) for 2years in postmenopausal osteoporotic women. This exploratory randomized, double-blind trial evaluated HR-pQCT and FEA parameters, areal bone mineral density (BMD), and bone turnover markers. Results: In the intention-to-treat population (n = 83, age: 64 ± 8years; lumbar T-score: −2.8 ± 0.8 [DXA]), distal tibia Cortical Thickness (CTh) and Density (DCort), and cancellous BV/TV increased by 6.3%, 1.4%, and 2.5%, respectively (all P < 0.005), with SrRan, but not with alendronate (0.9%, 0.4%, and 0.8%, NS) (P < 0.05 for all above between-group differences). Difference for CTh evaluated with a distance transformation method was close to significance (P = 0.06). The estimated failure load increased with SrRan (+2.1%, P < 0.005), not with alendronate (−0.6%, NS) (between-group difference, P < 0.01). Cortical stress was lower with SrRan (P < 0.05); both treatments decreased trabecular stress. At distal radius, there was no between-group difference other than DCort (P < 0.05). Bone turnover markers decreased with alendronate; bALP increased (+21%) and serum-CTX-I decreased (−1%) after 2years of SrRan (between-group difference at each time point for both markers, P < 0.0001). Both treatments were well tolerated. Conclusions: Within the constraints of HR-pQCT method, and while a possible artefactual contribution of strontium cannot be quantified, SrRan appeared to influence distal tibia bone microstructure and FEA-determined biomechanical parameters more than alendronate. However, the magnitude of the differences is unclear and requires confirmation with another metho

Observation of macroscopic valley-polarized monolayer exciton-polaritons at room temperature

Funding: the State of Bavaria and the ERC (unlimit-2D), the DFG via SFB689, GRK 1570 and KO3612/1-1.In this Rapid Communication, we address the chiral properties of valley exciton-polaritons in a monolayer of WS2 in the regime of strong light-matter coupling with a Tamm-plasmon resonance. We observe that the effect of valley polarization, which manifests in the circular polarization of the emitted photoluminescence as the sample is driven by a circularly polarized laser, is strongly enhanced in comparison to bare WS2 monolayers and can even be observed under strongly nonresonant excitation at ambient conditions. In order to explain this effect in more detail, we study the relaxation and decay dynamics of exciton-polaritons in our device, elaborate the role of the dark state, and present a microscopic model to explain the wave-vector-dependent valley depolarization by the linear polarization splitting inherent to the microcavity. We believe that our findings are crucial for designing novel polariton-valleytronic devices which can be operated at room temperature.PostprintPeer reviewe

Tracing North Atlantic volcanism and seaway connectivity across the Paleocene–Eocene Thermal Maximum (PETM)

Abstract. There is a temporal correlation between the peak activity of the North Atlantic Igneous Province (NAIP) and the Paleocene–Eocene Thermal Maximum (PETM), suggesting that the NAIP may have initiated and/or prolonged this extreme warming event. However, corroborating a causal relationship is hampered by a scarcity of expanded sedimentary records that contain both climatic and volcanic proxies. One locality hosting such a record is the island of Fur in Denmark, where an expanded pre- to post-PETM succession containing hundreds of NAIP ash layers is exceptionally well preserved. We compiled a range of environmental proxies, including mercury (Hg) anomalies, paleotemperature proxies, and lithium (Li) and osmium (Os) isotopes, to trace NAIP activity, hydrological changes, weathering, and seawater connectivity across this interval. Volcanic proxies suggest that NAIP activity was elevated before the PETM and appears to have peaked during the body of the δ13C excursion but decreased considerably during the PETM recovery. This suggests that the acme in NAIP activity, dominated by flood basalt volcanism and thermogenic degassing from contact metamorphism, was likely confined to just ∼ 200 kyr (ca. 56.0–55.8 Ma). The hundreds of thick (&gt; 1 cm) basaltic ashes in the post-PETM strata likely represent a change from effusive to explosive activity, rather than an increase in NAIP activity. Detrital δ7Li values and clay abundances suggest that volcanic ash production increased the basaltic reactive surface area, likely enhancing silicate weathering and atmospheric carbon sequestration in the early Eocene. Signals in lipid biomarkers and Os isotopes, traditionally used to trace paleotemperature and weathering changes, are used here to track seaway connectivity. These proxies indicate that the North Sea was rapidly cut off from the North Atlantic in under 12 kyr during the PETM recovery due to NAIP thermal uplift. Our findings reinforce the hypothesis that the emplacement of the NAIP had a profound and complex impact on Paleocene–Eocene climate, both directly through volcanic and thermogenic degassing and indirectly by driving regional uplift and changing seaway connectivity

Effects of redox variability and early diagenesis on marine sedimentary Hg records

Volcanism is a dominant natural source of mercury (Hg) to the atmosphere, biosphere, ocean and sediments. In recent years, sedimentary Hg contents have emerged as a tool to reconstruct volcanic activity, and particularly activity of (subaerially emplaced) large igneous provinces in geological deep time. More specifically, Hg has shown potential as a useful proxy to illuminate the previously elusive impact of such large-scale volcanism on marine and terrestrial paleo-environments. While Hg is now widely applied as volcanism tracer, non-volcanic factors controlling sedimentary Hg content are generally not well constrained. Part of this uncertainty stems from our inability to directly observe a natural unperturbed “steady-state” environment as a baseline, as the modern Hg cycle is heavily influenced by anthropogenic activity. Here we focus on the effects of ambient redox conditions in the water column and shallow sediments (early diagenesis), quantify their influence on the geological Hg record and thereby contribute to constraining their potential impact on the use of Hg as a proxy for deep-time volcanic activity. Constraining these factors is of critical importance for the application of Hg as such a proxy. Many periods in the geological past for which records have been generated, such as the Mesozoic Oceanic Anoxic Events, are marked by a variety of high-amplitude environmental perturbations, including widespread deoxygenation and deposition of organic-rich sediments. We estimate the impact of redox changes and early diagenesis on the geological Hg record using a suite of (sub)recent–Pleistocene and Upper Cretaceous sediments representing oxic to euxinic marine conditions. Our sample set includes a transect through an oxygen minimum zone and cores that record transient shifts in oxygenation state, as well as post-depositional effects – all unrelated to volcanism, to the best of our knowledge. We find substantial alterations to the Hg record and the total organic carbon and total sulfur content, which are typically assumed to be the most common carrier phases of Hg in marine sediments. Moreover, these biases can lead to signal alteration on a par with those interpreted to result from volcanic activity. Geochemical modifications are ubiquitous and their potential magnitude implies that the factors leading to biases in the geological record warrant careful consideration before interpretation. Factors of particular concern to proxy application are (1) the disproportionate loss of organic carbon and sulfur relative to Hg during oxidation that strongly modulates normalized Hg records, (2) the evasion of Hg in anoxic and mildly euxinic sediments and (3) sharp focusing of Hg during post-depositional oxidation of organic matter. We suggest that paired analyses of additional redox-sensitive trace elements such as molybdenum, and organic-matter characteristics, particularly the type of organic matter, could provide first-order constraints on the role that redox and diagenetic changes played in shaping the Hg record as part of checking the attribution of enrichments to volcanic activity

Revisiting the Geographical Extent of Exceptional Warmth in the Early Paleogene Southern Ocean

To assess zonal temperature and biogeographical patterns in the Southern Ocean during the Paleogene, we present new multi-proxy air- and sea-surface temperature data for the latest Paleocene (∼57–56 Ma) and the Paleocene-Eocene Thermal Maximum (PETM; ∼56 Ma) from the northern margin of the Australo-Antarctic Gulf (AAG). The various proxy data sets document the well-known late Paleocene warming and, superimposed, two transient late Paleocene pre-cursor warming events, hundreds of kyr prior to the PETM. Remarkably, temperature reconstructions for the AAG and southwest Pacific during the latest Paleocene, PETM and Early Eocene Climatic Optimum (∼53–49 Ma) show similar trends as well as similar absolute temperatures east and west of the closed Tasmanian Gateway. Our data imply that the exceptional warmth as recorded by previous studies for the southwest Pacific extended westward into the AAG. This contrasts with modeling-derived circulation and temperature patterns. We suggest that simulations of ocean circulation underestimate heat transport in the southwest Pacific due to insufficient resolution, not allowing for mesoscale eddy-related heat transport. We argue for a systematic approach to tackle model and proxy biases that may occur in marginal marine settings and non-analog high-latitude climates to assess the temperature reconstructions

Paleocene–Eocene age glendonites from the Mid-Norwegian Margin – indicators of cold snaps in the hothouse?

The International Ocean Discovery Program (IODP) Expedition 396 to the mid-Norwegian margin recovered &gt; 1300 m of pristinely preserved, volcanic-ash-rich sediments deposited during the late Paleocene and early Eocene from close to the centre of the North Atlantic Igneous Province (NAIP). Remarkably, many of these cores contain glendonites, pseudomorphs after the purported cold-water mineral ikaite, from sediments dated to the late Paleocene and early Eocene. These time intervals span some of the hottest climates of the Cenozoic, including the Paleocene–Eocene Thermal Maximum (PETM). Global deep-ocean temperatures are not thought to have dropped below 10 ∘C at any point during this time, making the occurrence of supposedly cold-water (near-freezing temperature) glendonite pseudomorphs seemingly paradoxical. This study presents a detailed sedimentological, geochemical, and microscopic study of the IODP Exp. 396 glendonites and presents an updated model for the ikaite-to-calcite transformation for these glendonites. Specifically, we show that early diagenesis of basaltic ashes of the NAIP appear to have chemically promoted ikaite growth in the sediments in this region. Together with existing knowledge of late Paleocene and early Eocene glendonites from Svalbard to the north and early Eocene glendonites from Denmark to the south, these new glendonite finds possibly imply episodic, short-duration, and likely localized cooling in the Nordic Seas region, which may have been directly or indirectly linked to the emplacement of the NAIP.</p

Expense and benefit of neoadjuvant treatment in squamous cell carcinoma of the esophagus

BACKGROUND: The effectiveness of neoadjuvant treatment (NT) prior to resection of squamous cell carcinoma of the esophagus (SCCE) in terms of prolonged survival has not been proven by randomized trials. Facing considerable financial expenses and with concerns regarding the consumption of the patient's remaining survival time, this study aims to provide rationales for pretreating resection candidates. METHODS: From March 1986 to March 1999, patients undergoing resection for SCCE were documented prospectively. Since 1989, NT was offered to patients with mainly upper and middle third T3 or T4 tumors or T2 N1 stage who were fit for esophagectomy. Until 1993, NT consisted of chemotherapy. Since that time chemoradiation has also been applied. The parameters for expense and benefit of NT are costs, pretreatment time required, postoperative morbidity and mortality, clinical and histopathological response, and actuarial survival. RESULTS: Two hundred and three patients were treated, 170 by surgery alone and 33 by NT + surgery. Postoperative morbidity and mortality were 52% to 30% and 12% to 6%, respectively (p = n.s.). The response to NT was detected in 23 patients (70%). In 11 instances (33%), the primary tumor lesion was histopathologically eradicated. Survival following NT + surgery was significantly prolonged in node-positive patients with a median survival of 12 months to 19 months (p = 0.0193). The average pretreatment time was 113 ± 43 days, and reimbursement for NT to the hospital amounted to Euro 9.834. CONCLUSIONS: NT did not increase morbidity and mortality. Expenses for pretreatment, particularly time and costs, are considerable. However, taking into account that the results are derived from a non-randomized study, patients with regionally advanced tumor stages seem to benefit, as seen by their prolonged survival

Northeast Atlantic breakup volcanism and consequences for Paleogene climate change - MagellanPlus Workshop report

The northeast Atlantic encompasses archetypal examples of volcanic rifted margins. Twenty-five years after the last ODP (Ocean Drilling Program) leg on these volcanic margins, the reasons for excess melting are still disputed with at least three competing hypotheses being discussed. We are proposing a new drilling campaign that will constrain the timing, rates of volcanism, and vertical movements of rifted margins. This will allow us to parameterise geodynamic models that can distinguish between the hypotheses. Furthermore, the drilling-derived data will help us to understand the role of breakup magmatism as a potential driver for the Palaeocene–Eocene thermal maximum (PETM) and its influence on the oceanographic circulation in the earliest phase of the northeast Atlantic Ocean formation. Tackling these questions with a new drilling campaign in the northeast Atlantic region will advance our understanding of the long-term interactions between tectonics, volcanism, oceanography, and climate and the functioning of subpolar northern ecosystems and climate during intervals of extreme warmth