2,843 research outputs found
Hispanic Familism Reconsidered
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93710/1/tsq1252.pd
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Functional Properties and Toxin Pharmacology of a Dorsal Root Ganglion Sodium Channel Viewed through its Voltage Sensors
The voltage-activated sodium (Nav) channel Nav1.9 is expressed in dorsal root ganglion (DRG) neurons where it is believed to play an important role in nociception. Progress in revealing the functional properties and pharmacological sensitivities of this non-canonical Nav channel has been slow because attempts to express this channel in a heterologous expression system have been unsuccessful. Here, we use a protein engineering approach to dissect the contributions of the four Nav1.9 voltage sensors to channel function and pharmacology. We define individual S3b–S4 paddle motifs within each voltage sensor, and show that they can sense changes in membrane voltage and drive voltage sensor activation when transplanted into voltage-activated potassium channels. We also find that the paddle motifs in Nav1.9 are targeted by animal toxins, and that these toxins alter Nav1.9-mediated currents in DRG neurons. Our results demonstrate that slowly activating and inactivating Nav1.9 channels have functional and pharmacological properties in common with canonical Nav channels, but also show distinctive pharmacological sensitivities that can potentially be exploited for developing novel treatments for pain
Quintessence and the Curvature of the Universe after WMAP
We study quintessence models with a constant (effective) equation of state.
It is investigated whether such quintessence models are consistent with a
negative spatial curvature of the Universe with respect to the anisotropy of
the cosmic microwave background radiation measured by the WMAP mission. If the
reionization is negligibly small, it is found that such models with negative
curvature are admissible due to a geometrical degeneracy. However, a very high
optical depth tau to the surface of last scattering, as indicated by the
polarization measurements of WMAP, would rule out such models.Comment: enlarged version which includes a discussion of reionizatio
Isospin splitting in heavy baryons and mesons
A recent general analysis of light-baryon isospin splittings is updated and
extended to charmed baryons.
The measured and splittings stand out as being difficult
to understand in terms of two-body forces alone.
We also discuss heavy-light mesons; though the framework here is necessarily
less general, we nevertheless obtain some predictions that are not strongly
model-dependent.Comment: 12 pages REVTEX 3, plus 4 uuencoded ps figures, CMU-HEP93-
NASA's In-Space Manufacturing Project: Materials and Manufacturing Process Development Update
No abstract availabl
MFA11 (MFA 2011)
Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum, May 6-Aug. 1, 2011. Content includes Introduction / Buzz Spector -- Patricia Olynyk -- Marshall N. Klimasewiski -- John Talbott Allen -- Meghan Bean -- Shira Berkowitz / Maggie Stanley Majors -- Darrick Byers, Bryce Olen Robinson -- Jisun Choi -- Zlatko Ćosić -- James R. Daniels -- Kara Daving -- Andrea Degener -- Kristin Fleischmann / Randi Shapiro -- William Frank / Lawrence Ypil -- Nicholas Kania -- Katherine McCullough -- Jordan McGirk / Aditi Machado -- Zachary Miller -- Esther Murphy / Maggie Stanley Majors -- Kathryn Neale -- Christopher Ottinger / Melissa Olson -- Maia Palmer -- Nicole Petrescu / Melissa Olson -- Lauren Pressler / Randi Shapiro -- Whitney Sage / Aliya A. Reich -- Donna Smith.https://openscholarship.wustl.edu/books/1005/thumbnail.jp
Search for Higgs bosons of the minimal supersymmetric standard model in p-pbar collisions at sqrt(s)=1.96 TeV
We report results from searches for neutral Higgs bosons produced in p-pbar
collisions recorded by the Dzero experiment at the Fermilab Tevatron Collider.
We study the production of inclusive neutral Higgs boson in the tautau final
state and in association with a b quark in the btautau and bbb final states.
These results are combined to improve the sensitivity to the production of
neutral Higgs bosons in the context of the minimal supersymmetric standard
model (MSSM). The data are found to be consistent with expectation from
background processes. Upper limits on MSSM Higgs boson production are set for
Higgs boson masses ranging from 90 to 300 GeV. We exclude tanBeta>20-30 for
Higgs boson masses below 180 GeV. These are the most stringent constraints on
MSSM Higgs boson production in p-pbar collisions.Comment: Submitted to Phys. Lett.
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